SG11201401716XA - Novel purine derivatives and their use in the treatment of disease - Google Patents
Novel purine derivatives and their use in the treatment of diseaseInfo
- Publication number
- SG11201401716XA SG11201401716XA SG11201401716XA SG11201401716XA SG11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA SG 11201401716X A SG11201401716X A SG 11201401716XA
- Authority
- SG
- Singapore
- Prior art keywords
- disease
- treatment
- purine derivatives
- novel purine
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552746P | 2011-10-28 | 2011-10-28 | |
| PCT/IB2012/055929 WO2013061305A1 (en) | 2011-10-28 | 2012-10-26 | Novel purine derivatives and their use in the treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201401716XA true SG11201401716XA (en) | 2014-05-29 |
Family
ID=47326252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201401716XA SG11201401716XA (en) | 2011-10-28 | 2012-10-26 | Novel purine derivatives and their use in the treatment of disease |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9334271B2 (es) |
| EP (1) | EP2771342B1 (es) |
| JP (1) | JP6059731B2 (es) |
| KR (1) | KR20140090218A (es) |
| CN (1) | CN104039790B (es) |
| AP (1) | AP2014007601A0 (es) |
| AU (1) | AU2012327954B2 (es) |
| BR (1) | BR112014009890A2 (es) |
| CA (1) | CA2853256C (es) |
| CL (1) | CL2014001049A1 (es) |
| CO (1) | CO6950473A2 (es) |
| CU (1) | CU20140048A7 (es) |
| EA (1) | EA023935B1 (es) |
| ES (1) | ES2587533T3 (es) |
| IL (1) | IL232256A0 (es) |
| MX (1) | MX340452B (es) |
| PL (1) | PL2771342T3 (es) |
| PT (1) | PT2771342T (es) |
| SG (1) | SG11201401716XA (es) |
| TN (1) | TN2014000175A1 (es) |
| WO (1) | WO2013061305A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| ES2611885T3 (es) | 2011-01-31 | 2017-05-11 | Novartis Ag | Derivados heterocíclicos novedosos |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| EP3848034A1 (en) | 2014-03-26 | 2021-07-14 | Astex Therapeutics Limited | Cmet-inhibitors for use in delaying the emergence in resistance to fgfr inhibitors |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| HUE053653T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR inhibitor és IGF1R inhibitor kombinációi |
| WO2015178955A1 (en) * | 2014-05-19 | 2015-11-26 | Eternity Bioscience Inc. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
| CA2971687C (en) | 2014-12-30 | 2024-05-28 | University Of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| CN108137546B (zh) | 2015-09-23 | 2021-07-27 | 詹森药业有限公司 | 双杂芳基取代的1,4-苯并二氮杂卓化合物及其用于治疗癌症的用途 |
| CA2996857C (en) | 2015-09-23 | 2024-05-21 | Janssen Pharmaceutica Nv | Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer |
| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| PE20190800A1 (es) | 2016-08-15 | 2019-06-10 | Bayer Cropscience Ag | Derivados del heterociclo biciclico condensado como agentes de control de plagas |
| EP3923974A4 (en) * | 2019-02-06 | 2023-02-08 | Synthorx, Inc. | IL-2 CONJUGATES AND METHODS OF USE THEREOF |
| CZ308800B6 (cs) * | 2019-02-12 | 2021-05-26 | Univerzita Palackého v Olomouci | Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci |
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-
2012
- 2012-10-26 PL PL12798854.1T patent/PL2771342T3/pl unknown
- 2012-10-26 MX MX2014005132A patent/MX340452B/es active IP Right Grant
- 2012-10-26 EA EA201490888A patent/EA023935B1/ru not_active IP Right Cessation
- 2012-10-26 AP AP2014007601A patent/AP2014007601A0/xx unknown
- 2012-10-26 CN CN201280064734.5A patent/CN104039790B/zh not_active Expired - Fee Related
- 2012-10-26 US US14/353,950 patent/US9334271B2/en not_active Expired - Fee Related
- 2012-10-26 SG SG11201401716XA patent/SG11201401716XA/en unknown
- 2012-10-26 KR KR1020147013841A patent/KR20140090218A/ko active IP Right Grant
- 2012-10-26 AU AU2012327954A patent/AU2012327954B2/en not_active Ceased
- 2012-10-26 ES ES12798854.1T patent/ES2587533T3/es active Active
- 2012-10-26 BR BR112014009890-5A patent/BR112014009890A2/pt not_active Application Discontinuation
- 2012-10-26 EP EP12798854.1A patent/EP2771342B1/en not_active Not-in-force
- 2012-10-26 PT PT127988541T patent/PT2771342T/pt unknown
- 2012-10-26 JP JP2014537802A patent/JP6059731B2/ja not_active Expired - Fee Related
- 2012-10-26 CA CA2853256A patent/CA2853256C/en not_active Expired - Fee Related
- 2012-10-26 WO PCT/IB2012/055929 patent/WO2013061305A1/en active Application Filing
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2014
- 2014-04-24 CL CL2014001049A patent/CL2014001049A1/es unknown
- 2014-04-24 TN TNP2014000175A patent/TN2014000175A1/en unknown
- 2014-04-24 IL IL232256A patent/IL232256A0/en unknown
- 2014-04-28 CU CU2014000048A patent/CU20140048A7/es unknown
- 2014-04-29 CO CO14092008A patent/CO6950473A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013061305A1 (en) | 2013-05-02 |
| CA2853256A1 (en) | 2013-05-02 |
| CO6950473A2 (es) | 2014-05-20 |
| CN104039790A (zh) | 2014-09-10 |
| BR112014009890A2 (pt) | 2020-10-27 |
| US9334271B2 (en) | 2016-05-10 |
| MX340452B (es) | 2016-07-08 |
| EA201490888A1 (ru) | 2014-09-30 |
| EP2771342B1 (en) | 2016-05-18 |
| CN104039790B (zh) | 2016-04-13 |
| US20140336166A1 (en) | 2014-11-13 |
| AU2012327954A1 (en) | 2014-06-19 |
| CL2014001049A1 (es) | 2014-10-24 |
| PL2771342T3 (pl) | 2016-11-30 |
| CA2853256C (en) | 2019-05-14 |
| TN2014000175A1 (en) | 2015-09-30 |
| ES2587533T3 (es) | 2016-10-25 |
| IL232256A0 (en) | 2014-06-30 |
| AU2012327954B2 (en) | 2015-11-26 |
| MX2014005132A (es) | 2014-10-06 |
| CU20140048A7 (es) | 2014-12-26 |
| NZ624366A (en) | 2015-12-24 |
| KR20140090218A (ko) | 2014-07-16 |
| JP2014530903A (ja) | 2014-11-20 |
| EP2771342A1 (en) | 2014-09-03 |
| AP2014007601A0 (en) | 2014-04-30 |
| JP6059731B2 (ja) | 2017-01-11 |
| PT2771342T (pt) | 2016-08-17 |
| EA023935B1 (ru) | 2016-07-29 |
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