SG102603A1 - Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline - Google Patents
Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolineInfo
- Publication number
- SG102603A1 SG102603A1 SG200006869A SG200006869A SG102603A1 SG 102603 A1 SG102603 A1 SG 102603A1 SG 200006869 A SG200006869 A SG 200006869A SG 200006869 A SG200006869 A SG 200006869A SG 102603 A1 SG102603 A1 SG 102603A1
- Authority
- SG
- Singapore
- Prior art keywords
- carboxyamino
- tetrahydroquinoline
- substituted
- making
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16796799P | 1999-11-30 | 1999-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG102603A1 true SG102603A1 (en) | 2004-03-26 |
Family
ID=22609556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200006869A SG102603A1 (en) | 1999-11-30 | 2000-11-28 | Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline |
Country Status (45)
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
MXPA04005864A (es) * | 2001-12-19 | 2004-10-29 | Atherogenics Inc | Derivados de charcona y su uso para tratar enfermedades. |
US7202247B2 (en) | 2001-12-19 | 2007-04-10 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
AU2003230916A1 (en) * | 2002-04-11 | 2003-10-27 | Roar Holding Llc | Ex vivo method for determination of cetp activity and efficacy of heart disease treatment |
US20090181966A1 (en) * | 2002-10-04 | 2009-07-16 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
US7504508B2 (en) * | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
BR0315041A (pt) * | 2002-10-04 | 2005-08-16 | Millennium Pharm Inc | Métodos para inibir crth2 em um indivìduo que necessita inibição de crth2; composto; e composição farmacêutica |
US7223870B2 (en) * | 2002-11-01 | 2007-05-29 | Pfizer Inc. | Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
US20040181075A1 (en) * | 2002-12-19 | 2004-09-16 | Weingarten M. David | Process of making chalcone derivatives |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
ATE407670T1 (de) | 2002-12-20 | 2008-09-15 | Pfizer Prod Inc | Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer |
US20060100239A1 (en) * | 2003-03-04 | 2006-05-11 | Izuru Nagasaki | Method for producing optically active amines |
NZ542852A (en) * | 2003-03-17 | 2008-09-26 | Japan Tobacco Inc | Pharmaceutical compositions of CETP inhibitors |
CA2519458A1 (en) * | 2003-03-17 | 2004-09-30 | Japan Tobacco Inc. | Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate |
TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
EP2098512A1 (en) * | 2003-10-08 | 2009-09-09 | Eli Lilly & Company | Compounds and methods for treating dyslipidemia |
UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
WO2006012093A1 (en) * | 2004-06-24 | 2006-02-02 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
WO2006033001A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Quinoline compounds |
WO2006069162A1 (en) * | 2004-12-20 | 2006-06-29 | Reddy Us Therapeutics, Inc. | Novel heterocyclic compounds and their pharmaceutical compositions |
MX2007010215A (es) * | 2005-02-24 | 2007-11-07 | Millennium Pharm Inc | Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias. |
UY30244A1 (es) | 2006-03-30 | 2007-11-30 | Tanabe Seiyaku Co | Un proceso para preparar derivados de tetrahidroquinolina |
CL2008000684A1 (es) | 2007-03-09 | 2008-08-01 | Indigene Pharmaceuticals Inc | Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica. |
CN101429160B (zh) * | 2007-11-06 | 2011-10-19 | 上海药明康德新药开发有限公司 | 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法 |
TWI450896B (zh) * | 2009-06-30 | 2014-09-01 | Lilly Co Eli | 反式-4-〔〔(5s)-5-〔〔〔3,5-雙(三氟甲基)苯基〕甲基〕(2-甲基-2h-四唑-5-基)胺基〕-2,3,4,5-四氫-7,9-二甲基-1h-1-苯并氮呯-1-基〕甲基〕-環己基羧酸 |
US12006305B2 (en) | 2022-07-05 | 2024-06-11 | Newamsterdam Pharma B.V. | Salts of obicetrapib and processes for their manufacture and intermediates thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5231102A (en) * | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
EP0987251A1 (en) * | 1998-09-17 | 2000-03-22 | Pfizer Products Inc. | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors |
EP0992496A1 (en) * | 1998-09-17 | 2000-04-12 | Pfizer Products Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR7870M (ja) * | 1968-11-08 | 1970-04-27 | ||
US3971789A (en) | 1972-10-21 | 1976-07-27 | John Wyeth & Brother Limited | O-(4-Quinolylamino)benzamides |
GB8432091D0 (en) | 1984-12-19 | 1985-01-30 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
US4839368A (en) | 1986-05-02 | 1989-06-13 | Mochida Pharmaceutical Co., Ltd. | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives |
GB8804444D0 (en) | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
-
2000
- 2000-09-14 HN HN2000000203A patent/HN2000000203A/es unknown
- 2000-09-27 PA PA20008503801A patent/PA8503801A1/es unknown
- 2000-09-29 OA OA1200000268A patent/OA11494A/en unknown
- 2000-10-10 US US09/684,830 patent/US6313142B1/en not_active Expired - Fee Related
- 2000-11-03 GT GT200000190A patent/GT200000190A/es unknown
- 2000-11-09 CO CO00085289A patent/CO5261552A1/es not_active Application Discontinuation
- 2000-11-13 EP EP00310064A patent/EP1125929B1/en not_active Expired - Lifetime
- 2000-11-13 AT AT00310064T patent/ATE315028T1/de not_active IP Right Cessation
- 2000-11-13 DK DK00310064T patent/DK1125929T3/da active
- 2000-11-13 DE DE60025317T patent/DE60025317T2/de not_active Expired - Fee Related
- 2000-11-13 ES ES00310064T patent/ES2254109T3/es not_active Expired - Lifetime
- 2000-11-16 YU YU71500A patent/YU71500A/sh unknown
- 2000-11-17 IS IS5715A patent/IS5715A/is unknown
- 2000-11-22 HR HR20000804A patent/HRP20000804A2/hr not_active Application Discontinuation
- 2000-11-23 IL IL139849A patent/IL139849A/en not_active IP Right Cessation
- 2000-11-23 AU AU71789/00A patent/AU784694B2/en not_active Ceased
- 2000-11-24 SK SK1779-2000A patent/SK17792000A3/sk unknown
- 2000-11-24 TW TW089125066A patent/TW591016B/zh not_active IP Right Cessation
- 2000-11-27 ZA ZA200006947A patent/ZA200006947B/xx unknown
- 2000-11-27 ID IDP20001022D patent/ID28489A/id unknown
- 2000-11-27 CZ CZ20004407A patent/CZ20004407A3/cs unknown
- 2000-11-27 UY UY26451A patent/UY26451A1/es not_active Application Discontinuation
- 2000-11-28 PE PE2000001266A patent/PE20010913A1/es not_active Application Discontinuation
- 2000-11-28 CN CNB001283820A patent/CN1173953C/zh not_active Expired - Fee Related
- 2000-11-28 CA CA002327029A patent/CA2327029C/en not_active Expired - Fee Related
- 2000-11-28 SG SG200006869A patent/SG102603A1/en unknown
- 2000-11-28 UA UA2000116782A patent/UA65615C2/uk unknown
- 2000-11-29 MA MA26112A patent/MA25223A1/fr unknown
- 2000-11-29 NO NO20006039A patent/NO20006039L/no not_active Application Discontinuation
- 2000-11-29 DZ DZ000153A patent/DZ3079A1/xx active
- 2000-11-29 AR ARP000106287A patent/AR029775A1/es unknown
- 2000-11-29 KR KR10-2000-0071527A patent/KR100408177B1/ko not_active IP Right Cessation
- 2000-11-29 TN TNTNSN00230A patent/TNSN00230A1/fr unknown
- 2000-11-29 HU HU0004747A patent/HUP0004747A3/hu unknown
- 2000-11-29 JP JP2000362153A patent/JP3579345B2/ja not_active Expired - Fee Related
- 2000-11-29 NZ NZ508509A patent/NZ508509A/en unknown
- 2000-11-29 EA EA200001129A patent/EA003668B1/ru not_active IP Right Cessation
- 2000-11-30 PL PL00344208A patent/PL344208A1/xx not_active Application Discontinuation
- 2000-11-30 BG BG105009A patent/BG105009A/xx unknown
- 2000-11-30 BR BR0005636-7A patent/BR0005636A/pt not_active Application Discontinuation
- 2000-11-30 EE EEP200000659A patent/EE200000659A/xx unknown
- 2000-11-30 GE GEAP20005651A patent/GEP20022798B/en unknown
- 2000-11-30 AP APAP/P/2000/002011A patent/AP2000002011A0/en unknown
-
2001
- 2001-11-12 HK HK01107936A patent/HK1038007A1/xx not_active IP Right Cessation
-
2006
- 2006-03-01 CY CY20061100287T patent/CY1104989T1/el unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5231102A (en) * | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
EP0987251A1 (en) * | 1998-09-17 | 2000-03-22 | Pfizer Products Inc. | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors |
EP0992496A1 (en) * | 1998-09-17 | 2000-04-12 | Pfizer Products Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors |
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