SG10201914126RA - Anti-ox40 antibodies and their uses - Google Patents

Anti-ox40 antibodies and their uses

Info

Publication number
SG10201914126RA
SG10201914126RA SG10201914126RA SG10201914126RA SG10201914126RA SG 10201914126R A SG10201914126R A SG 10201914126RA SG 10201914126R A SG10201914126R A SG 10201914126RA SG 10201914126R A SG10201914126R A SG 10201914126RA SG 10201914126R A SG10201914126R A SG 10201914126RA
Authority
SG
Singapore
Prior art keywords
antibodies
making
methods
nucleic acids
acids encoding
Prior art date
Application number
SG10201914126RA
Other languages
English (en)
Inventor
Fiona A Harding
Original Assignee
Abbvie Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Biotherapeutics Inc filed Critical Abbvie Biotherapeutics Inc
Publication of SG10201914126RA publication Critical patent/SG10201914126RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201914126RA 2016-12-15 2017-12-15 Anti-ox40 antibodies and their uses SG10201914126RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662434761P 2016-12-15 2016-12-15

Publications (1)

Publication Number Publication Date
SG10201914126RA true SG10201914126RA (en) 2020-02-27

Family

ID=60937946

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201914126RA SG10201914126RA (en) 2016-12-15 2017-12-15 Anti-ox40 antibodies and their uses

Country Status (36)

Country Link
US (7) US10556962B2 (zh)
EP (2) EP3504242B1 (zh)
JP (2) JP6772385B2 (zh)
KR (2) KR102341926B1 (zh)
CN (1) CN110573527A (zh)
AR (1) AR110526A1 (zh)
AU (1) AU2017377036B2 (zh)
BR (2) BR112019012328A2 (zh)
CA (1) CA3045940A1 (zh)
CL (1) CL2019001646A1 (zh)
CO (1) CO2019007288A2 (zh)
CR (1) CR20190330A (zh)
CY (1) CY1123274T1 (zh)
DK (1) DK3504242T3 (zh)
DO (1) DOP2019000165A (zh)
EC (1) ECSP19050049A (zh)
ES (1) ES2813057T3 (zh)
HR (1) HRP20201259T1 (zh)
HU (1) HUE050399T2 (zh)
IL (1) IL267070A (zh)
LT (1) LT3504242T (zh)
MA (1) MA53184A (zh)
MX (1) MX2019007121A (zh)
MY (1) MY198059A (zh)
PE (1) PE20191403A1 (zh)
PH (1) PH12019501357A1 (zh)
PL (1) PL3504242T3 (zh)
PT (1) PT3504242T (zh)
RS (1) RS60664B1 (zh)
RU (1) RU2753493C2 (zh)
SG (1) SG10201914126RA (zh)
SI (1) SI3504242T1 (zh)
TW (1) TWI734879B (zh)
UA (1) UA125041C2 (zh)
UY (1) UY37523A (zh)
WO (1) WO2018112346A1 (zh)

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UA125041C2 (uk) * 2016-12-15 2021-12-29 Еббві Байотерапьютікс Інк. Анти-ox40 антитіла і їх застосування
EP3635011A1 (en) * 2017-06-09 2020-04-15 GlaxoSmithKline Intellectual Property Development Limited Combination therapy with icos agonist and ox40 agonist to treat cancer
US11242398B2 (en) * 2017-08-01 2022-02-08 Remd Biotherapeutics, Inc. Anti-OX40 antibodies and methods of activating OX40
CN110790837A (zh) * 2018-08-02 2020-02-14 上海君实生物医药科技股份有限公司 抗btla抗体
WO2020119789A1 (en) * 2018-12-14 2020-06-18 Wuxi Biologics (Shanghai) Co., Ltd. Fully human antibodies against ox40, method for preparing the same, and use thereof
US20220017632A1 (en) * 2018-12-25 2022-01-20 Hanx Biopharmaceutics, Inc Anti-ox40 monoclonal antibody and application thereof
CN110172090B (zh) * 2019-06-03 2020-04-03 中山标佳生物科技有限公司 Cd134单克隆抗体及其制备方法和癌症治疗中的应用
WO2021098851A1 (en) * 2019-11-20 2021-05-27 Eucure (Beijing) Biopharma Co., Ltd Anti-ctla4/ox40 bispecific antibodies and uses thereof
EP4077383A1 (en) 2019-12-17 2022-10-26 Amgen Inc. Dual interleukin-2 /tnf receptor agonist for use in therapy
CN113045654A (zh) * 2019-12-27 2021-06-29 南开大学 抗ox40抗体及其用途
CN111303285B (zh) * 2019-12-27 2023-06-02 百力司康生物医药(杭州)有限公司 靶向ox40的抗体及其制备方法和应用
JP2023519584A (ja) * 2020-03-23 2023-05-11 バイオ － テラ ソリューションズ、リミテッド 免疫細胞活性化剤の開発及び応用
CN115461371A (zh) * 2020-06-30 2022-12-09 和铂医药(上海)有限责任公司 靶向ox40的抗体及其制备方法和应用
CN111704671B (zh) * 2020-08-19 2020-11-24 广东赛尔生物科技有限公司 Ox40抗体及其在治疗癌症中的应用
CN112442121A (zh) * 2020-08-20 2021-03-05 山东兴瑞生物科技有限公司 Ox40抗体、其编码基因、及抗体的制备方法和在增强人体免疫功能中的应用
CN114106173A (zh) * 2020-08-26 2022-03-01 上海泰槿生物技术有限公司 抗ox40抗体、其药物组合物及应用
CN111763258B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 抗ox40抗体及其用途
JP2024508207A (ja) 2020-12-02 2024-02-26 ブイアイビー ブイゼットダブリュ がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト
CN115260312A (zh) * 2021-04-30 2022-11-01 保诺科技（北京）有限公司 结合ox40的抗体或抗原结合片段

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Also Published As

Publication number Publication date
CR20190330A (es) 2019-12-19
RU2019121895A (ru) 2021-01-15
RU2753493C2 (ru) 2021-08-17
US20200048363A1 (en) 2020-02-13
US10604584B2 (en) 2020-03-31
US20200181282A1 (en) 2020-06-11
JP6772385B2 (ja) 2020-10-21
BR122020025629B1 (pt) 2022-05-31
CA3045940A1 (en) 2018-06-21
LT3504242T (lt) 2020-09-10
RS60664B1 (sr) 2020-09-30
KR20210157471A (ko) 2021-12-28
US20180194855A1 (en) 2018-07-12
AU2017377036A1 (en) 2019-07-11
US10556962B2 (en) 2020-02-11
US20220112304A1 (en) 2022-04-14
UY37523A (es) 2018-07-31
AR110526A1 (es) 2019-04-10
CL2019001646A1 (es) 2019-08-23
PH12019501357A1 (en) 2020-01-20
TW201825520A (zh) 2018-07-16
HUE050399T2 (hu) 2020-12-28
PE20191403A1 (es) 2019-10-04
MX2019007121A (es) 2020-02-05
JP2020504101A (ja) 2020-02-06
CN110573527A (zh) 2019-12-13
US10040864B2 (en) 2018-08-07
WO2018112346A1 (en) 2018-06-21
CO2019007288A2 (es) 2019-08-20
IL267070A (en) 2019-08-29
CY1123274T1 (el) 2021-12-31
DK3504242T3 (da) 2020-08-17
MY198059A (en) 2023-07-31
PT3504242T (pt) 2020-08-26
SI3504242T1 (sl) 2020-10-30
MA53184A (fr) 2021-05-26
KR20190092552A (ko) 2019-08-07
ECSP19050049A (es) 2019-07-31
EP3504242B1 (en) 2020-06-24
US20180346593A1 (en) 2018-12-06
ES2813057T3 (es) 2021-03-22
KR102341926B1 (ko) 2021-12-23
US20180171023A1 (en) 2018-06-21
UA125041C2 (uk) 2021-12-29
JP2021019603A (ja) 2021-02-18
RU2019121895A3 (zh) 2021-02-15
EP3725809A1 (en) 2020-10-21
US20210017289A1 (en) 2021-01-21
EP3504242A1 (en) 2019-07-03
HRP20201259T1 (hr) 2020-11-13
PL3504242T3 (pl) 2020-11-16
TWI734879B (zh) 2021-08-01
BR112019012328A2 (pt) 2019-11-19
AU2017377036B2 (en) 2022-06-23
DOP2019000165A (es) 2019-07-15

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