SG10201913982WA - Alkyne Substituted Quinazoline Compound And Methods Of Use - Google Patents
Alkyne Substituted Quinazoline Compound And Methods Of UseInfo
- Publication number
- SG10201913982WA SG10201913982WA SG10201913982WA SG10201913982WA SG10201913982WA SG 10201913982W A SG10201913982W A SG 10201913982WA SG 10201913982W A SG10201913982W A SG 10201913982WA SG 10201913982W A SG10201913982W A SG 10201913982WA SG 10201913982W A SG10201913982W A SG 10201913982WA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- quinazoline compound
- substituted quinazoline
- alkyne substituted
- alkyne
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449088P | 2011-03-04 | 2011-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913982WA true SG10201913982WA (en) | 2020-03-30 |
Family
ID=46798728
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913982WA SG10201913982WA (en) | 2011-03-04 | 2012-03-02 | Alkyne Substituted Quinazoline Compound And Methods Of Use |
| SG2013066352A SG193291A1 (en) | 2011-03-04 | 2012-03-02 | Alkyne substituted quinazoline compound and methods of use |
| SG10201601711SA SG10201601711SA (en) | 2011-03-04 | 2012-03-02 | Alkyne Substituted Quinazoline Compound And Methods Of Use |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013066352A SG193291A1 (en) | 2011-03-04 | 2012-03-02 | Alkyne substituted quinazoline compound and methods of use |
| SG10201601711SA SG10201601711SA (en) | 2011-03-04 | 2012-03-02 | Alkyne Substituted Quinazoline Compound And Methods Of Use |
Country Status (14)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2828713C (en) | 2011-03-04 | 2022-08-16 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compounds and methods of use |
| CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| WO2013013640A1 (zh) * | 2011-07-27 | 2013-01-31 | 上海医药集团股份有限公司 | 喹唑啉衍生物、其制备方法、中间体、组合物及其应用 |
| WO2014177038A1 (en) | 2013-04-28 | 2014-11-06 | Sunshine Lake Pharma Co., Ltd. | Aminoquinazoline derivatives and their salts and methods of use thereof |
| CN103254156B (zh) * | 2013-05-10 | 2015-08-26 | 苏州明锐医药科技有限公司 | 阿法替尼中间体的制备方法 |
| CN103254183B (zh) * | 2013-05-10 | 2015-11-11 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
| CN108430972B (zh) | 2015-12-24 | 2022-12-27 | 协和麒麟株式会社 | α,β不饱和酰胺化合物 |
| DE102016224889B4 (de) * | 2016-12-14 | 2019-11-07 | Airbus Defence and Space GmbH | Verfahren zur Vorbeugung einer Ablösung einer Fluidströmung, Strömungskörpersystem und Luftfahrzeug |
| US11083492B2 (en) * | 2018-06-06 | 2021-08-10 | Lifetech Scientific (Shenzhen) Co., Ltd | Method for implanting an interventional medical device |
| US10973321B2 (en) | 2018-09-04 | 2021-04-13 | Steelcase Inc. | Workspace system and components and method for the use thereof |
| CN113382986A (zh) | 2018-09-25 | 2021-09-10 | 黑钻治疗公司 | 酪氨酸激酶抑制剂组合物、其制备方法和使用方法 |
| US20220298120A1 (en) * | 2019-08-15 | 2022-09-22 | Black Diamond Therapeutics, Inc. | Alkynyl quinazoline compounds |
| CN113527215B (zh) * | 2020-04-17 | 2023-12-05 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、制备方法及其应用 |
| WO2021209039A1 (zh) * | 2020-04-17 | 2021-10-21 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、制备方法及其应用 |
| WO2024179451A1 (zh) * | 2023-03-02 | 2024-09-06 | 江苏康缘药业股份有限公司 | 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4062881A (en) | 1974-07-26 | 1977-12-13 | Cincinnati Milacron Chemicals, Inc. | Sulfide containing tin stabilizers |
| US4343940A (en) | 1979-02-13 | 1982-08-10 | Mead Johnson & Company | Anti-tumor quinazoline compounds |
| GB2160201B (en) | 1984-06-14 | 1988-05-11 | Wyeth John & Brother Ltd | Quinazoline and cinnoline derivatives |
| EP0326307B1 (en) | 1988-01-23 | 1994-08-17 | Kyowa Hakko Kogyo Co., Ltd. | Novel pyridazinone derivatives and pharmaceutical preparations containing them |
| US5053227A (en) | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| JP3089901B2 (ja) | 1993-07-20 | 2000-09-18 | 株式会社豊田自動織機製作所 | クラッチレス圧縮機における動力伝達構造 |
| AU2096895A (en) | 1994-03-07 | 1995-09-25 | Sugen, Incorporated | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| GB9405355D0 (en) | 1994-03-18 | 1994-05-04 | Lucas Ind Plc | Vibrating element transducer |
| WO1996029331A1 (de) | 1995-03-20 | 1996-09-26 | Dr. Karl Thomae Gmbh | Imidazochinazoline, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| ATE446955T1 (de) | 1995-03-30 | 2009-11-15 | Pfizer Prod Inc | Chinazolinone derivate |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| ATE182148T1 (de) | 1995-05-12 | 1999-07-15 | Neurogen Corp | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| WO1996040648A1 (en) | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Quinazolines and pharmaceutical compositions |
| JP3290666B2 (ja) | 1995-06-07 | 2002-06-10 | ファイザー・インコーポレーテッド | 複素環式の縮合環ピリミジン誘導体 |
| ES2172670T3 (es) | 1995-07-06 | 2002-10-01 | Novartis Ag | Pirrolpirimidinas y procedimientos para su preparacion. |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| WO1997038973A1 (fr) | 1996-04-16 | 1997-10-23 | Ube Industries, Ltd. | Composes d'hydrazine, procede de preparation desdits composes et insecticides a usage agricole et horticole |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6225318B1 (en) * | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| AR020114A1 (es) | 1998-07-30 | 2002-04-10 | America Home Products Corp | Proceso para la preparacion de derivados de quinazolina sustituida y compuestos para su exclusivo uso en dicho proceso |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| US6627634B2 (en) | 2000-04-08 | 2003-09-30 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them |
| PL204958B1 (pl) | 2000-06-30 | 2010-02-26 | Glaxo Group Ltd | Ditosylany związków chinazolinowych, środek farmaceutyczny i zastosowanie tych związków |
| NZ525254A (en) | 2000-10-27 | 2006-02-24 | Novartis Ag | Treatment of gastrointestinal stromal tumors |
| DE10063435A1 (de) | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| ATE475652T1 (de) * | 2001-02-21 | 2010-08-15 | Mitsubishi Tanabe Pharma Corp | Chinazolinderivate |
| TW200813014A (en) | 2002-03-28 | 2008-03-16 | Astrazeneca Ab | Quinazoline derivatives |
| GB0215823D0 (en) * | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
| AU2003249212C1 (en) | 2002-07-15 | 2011-10-27 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
| DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| JP4353903B2 (ja) | 2005-01-07 | 2009-10-28 | 東京エレクトロン株式会社 | クラスタツールの処理システム |
| CA2609186A1 (en) * | 2005-05-25 | 2006-11-30 | Wyeth | Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof |
| JP5688877B2 (ja) * | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
| CA2639936C (en) | 2006-01-26 | 2014-06-17 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
| CN100345856C (zh) | 2006-03-10 | 2007-10-31 | 武汉化工学院 | 一种制备葡萄糖醛酸内酯的酯化及结晶工艺方法 |
| KR20090067169A (ko) | 2006-09-11 | 2009-06-24 | 쿠리스 인코퍼레이션 | 아연 결합 부분을 함유한 퀴나졸린 계열 ｅｇｆｒ 억제제 |
| BRPI0809646A2 (pt) | 2007-03-29 | 2014-09-23 | Hoffmann La Roche | Compostod antivirais heterocíclicos |
| CN101584696A (zh) | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| CN105037333A (zh) | 2009-12-21 | 2015-11-11 | 张强 | 新的喹唑啉衍生物 |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| CN102382106A (zh) | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| CA2828713C (en) | 2011-03-04 | 2022-08-16 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compounds and methods of use |
| CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
-
2012
- 2012-03-02 CA CA2828713A patent/CA2828713C/en active Active
- 2012-03-02 SG SG10201913982WA patent/SG10201913982WA/en unknown
- 2012-03-02 KR KR1020217010767A patent/KR20210043016A/ko not_active Ceased
- 2012-03-02 WO PCT/US2012/027614 patent/WO2012122058A2/en active Application Filing
- 2012-03-02 CN CN201280011384.6A patent/CN103998040B/zh active Active
- 2012-03-02 SG SG2013066352A patent/SG193291A1/en unknown
- 2012-03-02 JP JP2013556664A patent/JP6006242B2/ja active Active
- 2012-03-02 KR KR1020137026199A patent/KR102061743B1/ko active Active
- 2012-03-02 KR KR1020227006071A patent/KR20220031732A/ko not_active Ceased
- 2012-03-02 AU AU2012225693A patent/AU2012225693A1/en not_active Abandoned
- 2012-03-02 SG SG10201601711SA patent/SG10201601711SA/en unknown
- 2012-03-02 BR BR112013022552-1A patent/BR112013022552B1/pt active IP Right Grant
- 2012-03-02 RU RU2013144571/04A patent/RU2013144571A/ru not_active Application Discontinuation
- 2012-03-02 EP EP12754325.4A patent/EP2680850B1/en active Active
- 2012-03-02 MX MX2013010016A patent/MX344302B/es active IP Right Grant
- 2012-03-02 KR KR1020197038395A patent/KR20200003933A/ko not_active Ceased
- 2012-03-02 US US14/002,983 patent/US9090588B2/en active Active
- 2012-03-03 TW TW101107247A patent/TWI617556B/zh active
-
2013
- 2013-08-22 IL IL228072A patent/IL228072A/en active IP Right Grant
-
2015
- 2015-06-19 US US14/745,308 patent/US20160031860A1/en not_active Abandoned
-
2017
- 2017-02-14 AU AU2017200984A patent/AU2017200984A1/en not_active Abandoned
- 2017-08-11 US US15/675,438 patent/US20180093975A1/en not_active Abandoned
-
2018
- 2018-11-22 AU AU2018267622A patent/AU2018267622B2/en active Active
-
2019
- 2019-01-18 US US16/252,458 patent/US20190382382A1/en not_active Abandoned
-
2020
- 2020-03-27 US US16/833,020 patent/US11524956B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL228072A0 (en) | Alkyl-substituted quinazoline compounds and methods of use | |
| ZA201303793B (en) | Substituted quinoline compounds and methods of use | |
| ZA201401653B (en) | Pyrazol-4yl-heterocyclyl-carboxamide compounds and methods of use | |
| ZA201308859B (en) | Quinazolines as therapeutic compounds and related methods of use | |
| SG11201504049VA (en) | Compounds and their methods of use | |
| ZA201405248B (en) | Anesthetic compounds and related methods of use | |
| HUE043894T2 (hu) | Koagulációt elõsegítõ vegyületek és alkalmazásuk módszerei | |
| IL222227A0 (en) | Pyrazol - 4 - heterocyclyl-carboxamide compounds and methods of use | |
| EP2879676A4 (en) | SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE | |
| IL232055B (en) | Anti-1htra antibodies and methods of use | |
| SG10201707813YA (en) | Cd40l-specific tn3-derived scaffolds and methods of use thereof | |
| EP2731429A4 (en) | COMPOUNDS, METHODS OF PREPARATION AND METHODS OF USE | |
| EP2709999A4 (en) | QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE | |
| GB201102364D0 (en) | Lock means and method of use thereof | |
| GB201122402D0 (en) | Lock means and method of use thereof | |
| GB201101586D0 (en) | Lock means and method of use thereof | |
| HK1192235A (en) | Quinazolines as therapeutic compounds and related methods of use |