JP6006242B2 - アルキン置換キナゾリン化合物および使用方法 - Google Patents

アルキン置換キナゾリン化合物および使用方法 Download PDF

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Publication number
JP6006242B2
JP6006242B2 JP2013556664A JP2013556664A JP6006242B2 JP 6006242 B2 JP6006242 B2 JP 6006242B2 JP 2013556664 A JP2013556664 A JP 2013556664A JP 2013556664 A JP2013556664 A JP 2013556664A JP 6006242 B2 JP6006242 B2 JP 6006242B2
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cancer
compound
chloro
salt
ethynyl
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Japanese (ja)
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JP2014518544A (ja
JP2014518544A5 (enrdf_load_stackoverflow
Inventor
ワン シェン，
ワン シェン，
エイミン チャン，
エイミン チャン，
ジャック マウン，
ジャック マウン，
シャオリン チェン，
シャオリン チェン，
Original Assignee
ニューゲン セラピューティクス， インコーポレイテッド
ニューゲン セラピューティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013556664A 2011-03-04 2012-03-02 アルキン置換キナゾリン化合物および使用方法 Active JP6006242B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449088P 2011-03-04 2011-03-04
US61/449,088 2011-03-04
PCT/US2012/027614 WO2012122058A2 (en) 2011-03-04 2012-03-02 Alkyne substituted quinazoline compound and methods of use

Publications (3)

Publication Number Publication Date
JP2014518544A JP2014518544A (ja) 2014-07-31
JP2014518544A5 JP2014518544A5 (enrdf_load_stackoverflow) 2015-04-16
JP6006242B2 true JP6006242B2 (ja) 2016-10-12

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JP2013556664A Active JP6006242B2 (ja) 2011-03-04 2012-03-02 アルキン置換キナゾリン化合物および使用方法

Country Status (14)

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US (5) US9090588B2 (enrdf_load_stackoverflow)
EP (1) EP2680850B1 (enrdf_load_stackoverflow)
JP (1) JP6006242B2 (enrdf_load_stackoverflow)
KR (4) KR102061743B1 (enrdf_load_stackoverflow)
CN (1) CN103998040B (enrdf_load_stackoverflow)
AU (3) AU2012225693A1 (enrdf_load_stackoverflow)
BR (1) BR112013022552B1 (enrdf_load_stackoverflow)
CA (1) CA2828713C (enrdf_load_stackoverflow)
IL (1) IL228072A (enrdf_load_stackoverflow)
MX (1) MX344302B (enrdf_load_stackoverflow)
RU (1) RU2013144571A (enrdf_load_stackoverflow)
SG (3) SG193291A1 (enrdf_load_stackoverflow)
TW (1) TWI617556B (enrdf_load_stackoverflow)
WO (1) WO2012122058A2 (enrdf_load_stackoverflow)

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CN102898386B (zh) * 2011-07-27 2015-07-29 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
TWI609012B (zh) 2013-04-28 2017-12-21 廣東東陽光藥業有限公司 氨基喹唑啉類衍生物及其鹽和使用方法
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
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CN113527215B (zh) * 2020-04-17 2023-12-05 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、制备方法及其应用
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CN120769850A (zh) * 2023-03-02 2025-10-10 江苏康缘药业股份有限公司 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用

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Also Published As

Publication number Publication date
JP2014518544A (ja) 2014-07-31
TWI617556B (zh) 2018-03-11
SG193291A1 (en) 2013-10-30
US20140128417A1 (en) 2014-05-08
KR20140020955A (ko) 2014-02-19
CN103998040A (zh) 2014-08-20
BR112013022552A2 (pt) 2016-12-06
WO2012122058A2 (en) 2012-09-13
KR20220031732A (ko) 2022-03-11
US20190382382A1 (en) 2019-12-19
SG10201913982WA (en) 2020-03-30
KR102061743B1 (ko) 2020-01-03
KR20210043016A (ko) 2021-04-20
US11524956B2 (en) 2022-12-13
CN103998040B (zh) 2017-03-29
US20180093975A1 (en) 2018-04-05
TW201249835A (en) 2012-12-16
CA2828713C (en) 2022-08-16
MX344302B (es) 2016-12-13
US20210047303A1 (en) 2021-02-18
SG10201601711SA (en) 2016-04-28
AU2017200984A1 (en) 2017-03-02
AU2018267622B2 (en) 2020-05-14
BR112013022552B1 (pt) 2021-11-23
EP2680850B1 (en) 2018-05-23
WO2012122058A3 (en) 2014-04-24
US20160031860A1 (en) 2016-02-04
CA2828713A1 (en) 2012-09-13
RU2013144571A (ru) 2015-04-10
KR20200003933A (ko) 2020-01-10
IL228072A0 (en) 2013-09-30
IL228072A (en) 2016-08-31
US9090588B2 (en) 2015-07-28
MX2013010016A (es) 2013-11-20
AU2012225693A1 (en) 2013-09-19
AU2018267622A1 (en) 2018-12-13
EP2680850A2 (en) 2014-01-08
EP2680850A4 (en) 2015-01-28

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