SG10201907367QA - Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor - Google Patents
Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactorInfo
- Publication number
- SG10201907367QA SG10201907367QA SG10201907367QA SG10201907367QA SG10201907367QA SG 10201907367Q A SG10201907367Q A SG 10201907367QA SG 10201907367Q A SG10201907367Q A SG 10201907367QA SG 10201907367Q A SG10201907367Q A SG 10201907367QA SG 10201907367Q A SG10201907367Q A SG 10201907367QA
- Authority
- SG
- Singapore
- Prior art keywords
- plp
- dependent enzyme
- pharmaceutical composition
- cofactor
- erythrocytes
- Prior art date
Links
- 108090000790 Enzymes Proteins 0.000 title abstract 4
- 102000004190 Enzymes Human genes 0.000 title abstract 4
- 230000001419 dependent effect Effects 0.000 title abstract 4
- 210000003743 erythrocyte Anatomy 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 abstract 12
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 abstract 6
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 abstract 6
- 229960001327 pyridoxal phosphate Drugs 0.000 abstract 6
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- 102100034976 Cystathionine beta-synthase Human genes 0.000 abstract 1
- 108010073644 Cystathionine beta-synthase Proteins 0.000 abstract 1
- 108010043135 L-methionine gamma-lyase Proteins 0.000 abstract 1
- 108091000100 Tyrosine Phenol-Lyase Proteins 0.000 abstract 1
- 102000016540 Tyrosine aminotransferases Human genes 0.000 abstract 1
- 108010042606 Tyrosine transaminase Proteins 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01005—Tyrosine transaminase (2.6.1.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y404/00—Carbon-sulfur lyases (4.4)
- C12Y404/01—Carbon-sulfur lyases (4.4.1)
- C12Y404/01011—Methionine gamma-lyase (4.4.1.11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1451100A FR3017299B1 (fr) | 2014-02-12 | 2014-02-12 | Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201907367QA true SG10201907367QA (en) | 2019-09-27 |
Family
ID=50729647
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201907367QA SG10201907367QA (en) | 2014-02-12 | 2015-02-12 | Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor |
| SG11201606264SA SG11201606264SA (en) | 2014-02-12 | 2015-02-12 | Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201606264SA SG11201606264SA (en) | 2014-02-12 | 2015-02-12 | Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10046009B2 (enExample) |
| EP (2) | EP3718562A1 (enExample) |
| JP (1) | JP6563958B2 (enExample) |
| KR (1) | KR102354103B1 (enExample) |
| CN (2) | CN111358941B (enExample) |
| AU (2) | AU2015217045B2 (enExample) |
| BR (1) | BR112016017337B1 (enExample) |
| CA (1) | CA2938469C (enExample) |
| CL (1) | CL2016002020A1 (enExample) |
| ES (1) | ES2808849T3 (enExample) |
| FR (1) | FR3017299B1 (enExample) |
| IL (1) | IL246941B (enExample) |
| JO (1) | JO3522B1 (enExample) |
| MX (1) | MX378781B (enExample) |
| RU (2) | RU2744659C2 (enExample) |
| SG (2) | SG10201907367QA (enExample) |
| WO (1) | WO2015121348A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6702866B2 (ja) | 2013-11-18 | 2020-06-03 | ルビウス セラピューティクス， インコーポレイテッド | 合成膜−レシーバー複合体 |
| FR3017299B1 (fr) * | 2014-02-12 | 2018-05-18 | Erytech Pharma | Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur |
| RU2736495C2 (ru) | 2014-04-01 | 2020-11-17 | Рубиус Терапьютикс, Инк. | Способ и композиции для иммуномодуляции |
| EP3187190A1 (en) | 2015-12-31 | 2017-07-05 | Erytech Pharma | Method of treating a mammal, including human, against cancer using methionine and asparagine depletion |
| AU2017207304B2 (en) | 2016-01-11 | 2022-05-26 | Epicentrx, Inc. | Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone |
| CN115969987A (zh) | 2016-01-11 | 2023-04-18 | 鲁比厄斯治疗法股份有限公司 | 与免疫适应症的多模式治疗性细胞体系有关的组合物和方法 |
| BR112018074716A2 (pt) | 2016-06-02 | 2019-03-12 | Sanofi | conjugados de um agente farmacêutico e porção capaz de ligar-se a uma proteína sensível à glicose |
| IL311727A (en) | 2017-07-07 | 2024-05-01 | Epicentrx Inc | Preparations for intravenous administration of medical substances |
| EP3449935A1 (en) * | 2017-08-31 | 2019-03-06 | Erytech Pharma | Arginine deiminase encapsulated inside erythrocytes and their use in treating cancer and arginase-1 deficiency |
| US11001826B2 (en) | 2017-10-19 | 2021-05-11 | Anticancer, Inc. | Orally administered composition to lower serum methionine levels and method of use |
| US20210170033A1 (en) | 2017-12-01 | 2021-06-10 | Sanofi | Novel conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US20210403571A1 (en) | 2018-11-15 | 2021-12-30 | Erytech Pharma | Synergistic combinations of methionine depletion agents and immune checkpoint modulators |
| SG11202111842SA (en) | 2019-04-26 | 2021-11-29 | Rubius Therapeutics Inc | Buffered compositions including enucleated erythroid cells |
| CN114127252A (zh) | 2019-05-24 | 2022-03-01 | 鲁比厄斯治疗法股份有限公司 | 生成去核红系细胞的方法 |
| JP2023500327A (ja) | 2019-11-04 | 2023-01-05 | ルビウス セラピューティクス， インコーポレイテッド | ミオイノシトールを使用して除核赤芽球細胞を生成する方法 |
| KR20220093196A (ko) | 2019-11-04 | 2022-07-05 | 루비우스 테라퓨틱스, 아이엔씨. | 타우린 또는 하이포타우린을 사용하여 제핵 적혈구 세포를 생성하는 방법 |
| CA3178252A1 (en) | 2020-05-11 | 2021-11-18 | Erytech Pharma | Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof |
| TW202241470A (zh) | 2021-01-08 | 2022-11-01 | 美商盧比亞斯治療公司 | 治療人類個體腫瘤之方法 |
| TW202241471A (zh) | 2021-01-08 | 2022-11-01 | 美商盧比亞斯治療公司 | 提高個體中NKp30陽性淋巴球的方法及其用途 |
| TW202304482A (zh) | 2021-03-14 | 2023-02-01 | 美商盧比亞斯治療公司 | 於個體中增加nkg2d陽性淋巴球之方法及其用途 |
| EP4341395A4 (en) * | 2021-05-21 | 2025-07-23 | Syntis Bio Inc | MODIFIED METHIONINE GAMMA LYASE VARIANTS |
| TW202317179A (zh) | 2021-06-03 | 2023-05-01 | 美商盧比亞斯治療公司 | 在個體中治療ｈｐｖ１６－陽性或ｈｐｖ１６－相關的癌症之方法 |
| CN113481253B (zh) * | 2021-06-09 | 2022-05-24 | 连云港杰瑞药业有限公司 | 生物催化制备磷酸吡哆醛的方法 |
| WO2023067200A1 (en) | 2021-10-24 | 2023-04-27 | Erytech Pharma | Asparaginase encapsulated in red blood cells for the treatment of pancreatic cancer |
| WO2025219395A1 (en) | 2024-04-16 | 2025-10-23 | Chu D'angers | Treatment of cancers |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1354204A (fr) | 1963-01-22 | 1964-03-06 | Auxiliaire De L Entpr Soc | Dispositif de prévention d'accident pour benne de chargement notamment d'une bétonnière |
| FR2529463B1 (fr) * | 1982-07-05 | 1986-01-10 | Centre Nat Rech Scient | Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus |
| US5631271A (en) * | 1986-11-29 | 1997-05-20 | Serfontein; Willem J. | Methods and preparations for the treatment and prophylaxis of metabolic disturbances |
| US5254572A (en) * | 1987-11-27 | 1993-10-19 | Vesta Medicines (Pty) Ltd. | Method and composition for supplementing vitamin B6 where the PN-PLP pathway is disturbed |
| KR100530976B1 (ko) | 1997-03-13 | 2005-11-24 | 시오노기세이야쿠가부시키가이샤 | 엘-메티오닌 감마-리아제 결정의 제조방법 |
| AU2002211512A1 (en) * | 2000-10-06 | 2002-04-15 | Millennium Pharmaceuticals, Inc. | 25219, a novel human aminotransferase and uses therefor |
| CN1863551A (zh) * | 2003-07-31 | 2006-11-15 | 抗癌公司 | 用于提高在体内的效力的PLP和PEG－rMETase的用途 |
| FR2873925B1 (fr) | 2004-08-05 | 2006-10-13 | Erytech Pharma Soc Par Actions | Procede et dispositif de lyse-rescellement pour l'incorporation de principe actif notamment asparaginase ou inositol hexaphosphate, dans des erythrocytes |
| FR2884717B1 (fr) * | 2005-04-25 | 2009-07-03 | Erytech Pharma Soc Par Actions | Erythrocytes renfermant de l'arginine deiminase |
| RU2362572C2 (ru) * | 2007-07-17 | 2009-07-27 | Юрий Георгиевич Каминский | Способ снижения концентрации аммиака в крови с помощью аммоцитов и инкапсулированной глутаминсинтетазы |
| FR2919804B1 (fr) | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
| FR2925339B1 (fr) | 2007-12-24 | 2010-03-05 | Erytech Pharma | Medicament pour le traitement du cancer du pancreas |
| EP2242507B1 (en) | 2008-02-13 | 2013-02-20 | Erytech Pharma | Formulation and method for the prevention and treatment of skeletal manifestation of gaucher's disease |
| FR2928270B1 (fr) | 2008-03-10 | 2011-01-21 | Erytech Pharma | Formulation methode pour la prevention ou le traitement des metastases osseuses et autres maladies de l'os |
| FR2938332B1 (fr) | 2008-11-07 | 2011-11-25 | Erytech Pharma | Test predictif de la neutralisation de l'activite asparaginase |
| CN101429506A (zh) * | 2008-12-15 | 2009-05-13 | 吉林大学 | 基于红细胞载体的fish-in-net固定化酶 |
| FR2944106B1 (fr) | 2009-04-03 | 2012-09-28 | Erytech Pharma | Methode de dosage de l'inositol hexaphosphate (ihp). |
| PT2493487T (pt) | 2009-10-27 | 2016-11-08 | Erytech Pharma | Composição para induzir uma tolerância imunitária específica |
| EP2827878A1 (en) | 2012-03-21 | 2015-01-28 | Erytech Pharma | Medicament for the treatment of acute myeloid leukemia (aml) |
| FR3005420B1 (fr) | 2013-05-07 | 2015-09-18 | Erytech Pharma | Procede de stabilisation de suspensions d'erythrocytes encapsulant un principe actif, suspensions obtenues. |
| EP2813234A1 (en) | 2013-06-11 | 2014-12-17 | Erytech Pharma | Composition of erythrocytes encapsulating phenylalanine hydroxylase and therapeutic use thereof |
| FR3017299B1 (fr) | 2014-02-12 | 2018-05-18 | Erytech Pharma | Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur |
| EP3187190A1 (en) * | 2015-12-31 | 2017-07-05 | Erytech Pharma | Method of treating a mammal, including human, against cancer using methionine and asparagine depletion |
-
2014
- 2014-02-12 FR FR1451100A patent/FR3017299B1/fr not_active Expired - Fee Related
-
2015
- 2015-02-12 BR BR112016017337-6A patent/BR112016017337B1/pt not_active IP Right Cessation
- 2015-02-12 RU RU2019123935A patent/RU2744659C2/ru active
- 2015-02-12 CN CN202010182496.4A patent/CN111358941B/zh active Active
- 2015-02-12 JP JP2016568136A patent/JP6563958B2/ja not_active Expired - Fee Related
- 2015-02-12 EP EP20173043.9A patent/EP3718562A1/en active Pending
- 2015-02-12 SG SG10201907367QA patent/SG10201907367QA/en unknown
- 2015-02-12 EP EP15705563.3A patent/EP3104875B1/en active Active
- 2015-02-12 CA CA2938469A patent/CA2938469C/en active Active
- 2015-02-12 CN CN201580007812.1A patent/CN106255506B/zh not_active Expired - Fee Related
- 2015-02-12 AU AU2015217045A patent/AU2015217045B2/en not_active Ceased
- 2015-02-12 RU RU2016133315A patent/RU2697086C2/ru active
- 2015-02-12 WO PCT/EP2015/052962 patent/WO2015121348A2/en not_active Ceased
- 2015-02-12 ES ES15705563T patent/ES2808849T3/es active Active
- 2015-02-12 US US15/117,588 patent/US10046009B2/en active Active
- 2015-02-12 KR KR1020167022067A patent/KR102354103B1/ko not_active Expired - Fee Related
- 2015-02-12 MX MX2016010235A patent/MX378781B/es unknown
- 2015-02-12 JO JOP/2015/0030A patent/JO3522B1/ar active
- 2015-02-12 SG SG11201606264SA patent/SG11201606264SA/en unknown
-
2016
- 2016-07-25 IL IL246941A patent/IL246941B/en active IP Right Grant
- 2016-08-10 CL CL2016002020A patent/CL2016002020A1/es unknown
-
2018
- 2018-02-21 AU AU2018201237A patent/AU2018201237B2/en not_active Ceased
- 2018-08-13 US US16/102,171 patent/US10780126B2/en active Active
-
2020
- 2020-09-22 US US17/028,383 patent/US11458170B2/en active Active
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