SG11201606264SA - Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor - Google Patents

Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor

Info

Publication number
SG11201606264SA
SG11201606264SA SG11201606264SA SG11201606264SA SG11201606264SA SG 11201606264S A SG11201606264S A SG 11201606264SA SG 11201606264S A SG11201606264S A SG 11201606264SA SG 11201606264S A SG11201606264S A SG 11201606264SA SG 11201606264S A SG11201606264S A SG 11201606264SA
Authority
SG
Singapore
Prior art keywords
plp
cofactor
pharmaceutical composition
dependent enzyme
erythrocytes encapsulating
Prior art date
Application number
SG11201606264SA
Inventor
Yann Godfrin
Vanessa Bourgeaux
Fabien Gay
Thomas Cortese
Original Assignee
Erytech Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50729647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201606264S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erytech Pharma filed Critical Erytech Pharma
Publication of SG11201606264SA publication Critical patent/SG11201606264SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01005—Tyrosine transaminase (2.6.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y404/00—Carbon-sulfur lyases (4.4)
    • C12Y404/01—Carbon-sulfur lyases (4.4.1)
    • C12Y404/01011—Methionine gamma-lyase (4.4.1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
SG11201606264SA 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor SG11201606264SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1451100A FR3017299B1 (en) 2014-02-12 2014-02-12 PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES ENCAPSULATING A PLP ENZYME AND ITS COFACTOR
PCT/EP2015/052962 WO2015121348A2 (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor

Publications (1)

Publication Number Publication Date
SG11201606264SA true SG11201606264SA (en) 2016-08-30

Family

ID=50729647

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201606264SA SG11201606264SA (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor
SG10201907367QA SG10201907367QA (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201907367QA SG10201907367QA (en) 2014-02-12 2015-02-12 Pharmaceutical composition comprising erythrocytes encapsulating a plp-dependent enzyme and its cofactor

Country Status (17)

Country Link
US (3) US10046009B2 (en)
EP (2) EP3718562A1 (en)
JP (1) JP6563958B2 (en)
KR (1) KR102354103B1 (en)
CN (2) CN111358941B (en)
AU (2) AU2015217045B2 (en)
BR (1) BR112016017337B1 (en)
CA (1) CA2938469C (en)
CL (1) CL2016002020A1 (en)
ES (1) ES2808849T3 (en)
FR (1) FR3017299B1 (en)
IL (1) IL246941B (en)
JO (1) JO3522B1 (en)
MX (1) MX2016010235A (en)
RU (2) RU2744659C2 (en)
SG (2) SG11201606264SA (en)
WO (1) WO2015121348A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458170B2 (en) 2014-02-12 2022-10-04 Erytech Pharma Pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and, a non-phosphate PLP precursor

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015073587A2 (en) 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
DK3125927T3 (en) 2014-04-01 2021-04-19 Rubius Therapeutics Inc METHODS AND COMPOSITIONS FOR IMMUNU MODULATION
EP3187190A1 (en) * 2015-12-31 2017-07-05 Erytech Pharma Method of treating a mammal, including human, against cancer using methionine and asparagine depletion
CA3009063A1 (en) 2016-01-11 2017-07-20 Rubius Therapeutics, Inc. Compositions and methods related to multimodal therapeutic cell systems for cancer indications
US11090364B2 (en) 2016-06-02 2021-08-17 Sanofi Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
EP3648740A1 (en) 2017-07-07 2020-05-13 EpicentRx, Inc. Compositions for parenteral administration of therapeutic agents
JP7176921B2 (en) 2017-10-19 2022-11-22 アンチキャンサー インコーポレーテッド Preparations containing recombinant methioninase for cancer treatment, prevention and anti-aging
WO2019106122A1 (en) 2017-12-01 2019-06-06 Sanofi Novel conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3880309A1 (en) 2018-11-15 2021-09-22 Erytech Pharma Synergistic combinations of methionine depletion agents and immune checkpoint modulators
AU2020263513A1 (en) 2019-04-26 2021-11-18 Rubius Therapeutics, Inc. Buffered compositions including enucleated erythroid cells
JP2022533252A (en) 2019-05-24 2022-07-21 ルビウス セラピューティクス， インコーポレイテッド How to generate enucleated red blood cells
AU2020379755A1 (en) 2019-11-04 2022-05-26 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells using myo-inositol
AU2020377948A1 (en) 2019-11-04 2022-05-26 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells using taurine or hypotaurine
WO2021228832A1 (en) 2020-05-11 2021-11-18 Erytech Pharma Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof
TW202241470A (en) 2021-01-08 2022-11-01 美商盧比亞斯治療公司 Methods of treating a tumor in a human subject
TW202241471A (en) 2021-01-08 2022-11-01 美商盧比亞斯治療公司 Methods of increasing nkp30-positive lymphocytes in a subject and uses thereof
WO2022197548A1 (en) 2021-03-14 2022-09-22 Rubius Therapeutics, Inc. Methods of increasing nkg2d-positive lymphocytes in a subject and uses thereof
BR112023024198A2 (en) * 2021-05-21 2024-01-30 Codexis Inc RECOMBINANT METHIONINE GAMMA-LYASE FRAGMENT AND/OR BIOLOGICALLY ACTIVE RECOMBINANT METHIONINE GAMMA-LYASE, RECOMBINANT AND/OR BIOLOGICALLY ACTIVE METHIONINE GAMMA-LYASE M FRAGMENT THEREOF, RECOMBINANT METHIONINE GAMMA-LYASE, RECOMBINANT POLYNUCLEOTIDE, EXPRESSION VECTOR, HOST CELL, M PRODUCTION METHODS A RECOMBINANT METHIONINE GAMMA LYASE AND FOR TREATING AND/OR PREVENTING THE SYMPTOMS OF HOMOCYTINURIA IN AN INDIVIDUAL, PHARMACEUTICAL COMPOSITION, AND, USE OF A RECOMBINANT METHIONINE GAMMA LYASE POLYPEPTIDE OR THE COMPOSITION
TW202317179A (en) 2021-06-03 2023-05-01 美商盧比亞斯治療公司 Methods of treating hpv16-positive or hpv16-associated cancer in a subject
CN113481253B (en) * 2021-06-09 2022-05-24 连云港杰瑞药业有限公司 Method for preparing pyridoxal phosphate by biocatalysis
WO2023067200A1 (en) 2021-10-24 2023-04-27 Erytech Pharma Asparaginase encapsulated in red blood cells for the treatment of pancreatic cancer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1354204A (en) 1963-01-22 1964-03-06 Auxiliaire De L Entpr Soc Accident prevention device for loading skips, in particular for a concrete mixer
FR2529463B1 (en) * 1982-07-05 1986-01-10 Centre Nat Rech Scient METHOD AND DEVICE FOR THE ENCAPSULATION IN ERYTHROCYTES OF AT LEAST ONE BIOLOGICALLY ACTIVE SUBSTANCE, IN PARTICULAR ALLOSTERIC EFFECTORS OF HEMOGLOBIN AND ERYTHROCYTES OBTAINED THEREBY
US5254572A (en) * 1987-11-27 1993-10-19 Vesta Medicines (Pty) Ltd. Method and composition for supplementing vitamin B6 where the PN-PLP pathway is disturbed
US5631271A (en) * 1986-11-29 1997-05-20 Serfontein; Willem J. Methods and preparations for the treatment and prophylaxis of metabolic disturbances
DE69837005T2 (en) 1997-03-13 2007-11-15 Anticancer Inc., San Diego PROCESS FOR PREPARING CRYSTALS OF L-METHIONINE GAMMA LYASE
AU2002211512A1 (en) * 2000-10-06 2002-04-15 Millennium Pharmaceuticals, Inc. 25219, a novel human aminotransferase and uses therefor
US20050036981A1 (en) * 2003-07-31 2005-02-17 Shigeo Yagi USE OF PLP WITH PEG-rMETase IN VIVO FOR ENHANCED EFFICACY
FR2873925B1 (en) 2004-08-05 2006-10-13 Erytech Pharma Soc Par Actions METHOD AND DEVICE FOR LYSE-RESCALING FOR THE INCORPORATION OF ACTIVE PRINCIPLE, IN PARTICULAR ASPARAGINASE OR INOSITOL HEXAPHOSPHATE, IN ERYTHROCYTES
FR2884717B1 (en) 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions ERYTHROCYTES CONTAINING ARGININE DEIMINASE
RU2362572C2 (en) * 2007-07-17 2009-07-27 Юрий Георгиевич Каминский Way of depression of concentration of ammonia in blood by means of ammocytes and incapsulated glutamin synthetase
FR2919804B1 (en) 2007-08-08 2010-08-27 Erytech Pharma COMPOSITION AND ANTI-TUMOR THERAPEUTIC VACCINE
FR2925339B1 (en) 2007-12-24 2010-03-05 Erytech Pharma DRUG FOR THE TREATMENT OF PANCREATIC CANCER
US20100316620A1 (en) 2008-02-13 2010-12-16 Vanessa Bourgeaux Formulation and Method for the Prevention and Treatment of Skeletal Manifestation of Gaucher's Disease
FR2928270B1 (en) 2008-03-10 2011-01-21 Erytech Pharma FORMULATION METHOD FOR THE PREVENTION OR TREATMENT OF BONE METASTASES AND OTHER BONE DISEASES
FR2938332B1 (en) 2008-11-07 2011-11-25 Erytech Pharma PREDICTIVE TEST FOR NEUTRALIZATION OF ASPARAGINASE ACTIVITY
CN101429506A (en) * 2008-12-15 2009-05-13 吉林大学 Fish-in-net immobilized enzyme based on rubricyte carrier
FR2944106B1 (en) 2009-04-03 2012-09-28 Erytech Pharma METHOD OF DETERMINING INOSITOL HEXAPHOSPHATE (IHP).
ES2600932T3 (en) 2009-10-27 2017-02-13 Erytech Pharma Composition to induce a specific immune tolerance
SG11201405919QA (en) * 2012-03-21 2014-10-30 Erytech Pharma Medicament for the treatment of acute myeloid leukemia (aml)
FR3005420B1 (en) 2013-05-07 2015-09-18 Erytech Pharma METHOD OF STABILIZING SUSPENSIONS OF ERYTHROCYTES ENCAPSULATING AN ACTIVE INGREDIENT, SUSPENSIONS OBTAINED
EP2813234A1 (en) 2013-06-11 2014-12-17 Erytech Pharma Composition of erythrocytes encapsulating phenylalanine hydroxylase and therapeutic use thereof
FR3017299B1 (en) * 2014-02-12 2018-05-18 Erytech Pharma PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES ENCAPSULATING A PLP ENZYME AND ITS COFACTOR
EP3187190A1 (en) * 2015-12-31 2017-07-05 Erytech Pharma Method of treating a mammal, including human, against cancer using methionine and asparagine depletion

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458170B2 (en) 2014-02-12 2022-10-04 Erytech Pharma Pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and, a non-phosphate PLP precursor

Also Published As

Publication number Publication date
KR20160121532A (en) 2016-10-19
JP6563958B2 (en) 2019-08-21
CA2938469C (en) 2023-03-14
SG10201907367QA (en) 2019-09-27
CN106255506B (en) 2020-04-14
RU2016133315A3 (en) 2018-09-26
RU2697086C2 (en) 2019-08-12
WO2015121348A2 (en) 2015-08-20
MX2016010235A (en) 2016-10-28
FR3017299B1 (en) 2018-05-18
US10780126B2 (en) 2020-09-22
RU2019123935A (en) 2019-10-03
RU2744659C2 (en) 2021-03-12
RU2016133315A (en) 2018-02-16
IL246941A0 (en) 2016-09-29
AU2015217045B2 (en) 2018-03-08
US20210008114A1 (en) 2021-01-14
KR102354103B1 (en) 2022-01-24
AU2015217045A1 (en) 2016-08-18
CN111358941A (en) 2020-07-03
FR3017299A1 (en) 2015-08-14
US11458170B2 (en) 2022-10-04
BR112016017337A2 (en) 2017-08-08
CN106255506A (en) 2016-12-21
CL2016002020A1 (en) 2017-06-23
US20160361361A1 (en) 2016-12-15
US20180344771A1 (en) 2018-12-06
AU2018201237A1 (en) 2018-03-15
EP3104875B1 (en) 2020-05-06
US10046009B2 (en) 2018-08-14
JP2017506260A (en) 2017-03-02
BR112016017337B1 (en) 2022-08-09
WO2015121348A3 (en) 2015-10-08
EP3104875A2 (en) 2016-12-21
CA2938469A1 (en) 2015-08-20
AU2018201237B2 (en) 2019-09-26
RU2019123935A3 (en) 2020-03-26
EP3718562A1 (en) 2020-10-07
IL246941B (en) 2019-09-26
JO3522B1 (en) 2020-07-05
ES2808849T3 (en) 2021-03-02
CN111358941B (en) 2023-12-01

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