SG10201801668WA - Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity - Google Patents

Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity

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Publication number
SG10201801668WA
SG10201801668WA SG10201801668WA SG10201801668WA SG10201801668WA SG 10201801668W A SG10201801668W A SG 10201801668WA SG 10201801668W A SG10201801668W A SG 10201801668WA SG 10201801668W A SG10201801668W A SG 10201801668WA SG 10201801668W A SG10201801668W A SG 10201801668WA
Authority
SG
Singapore
Prior art keywords
pyrimidine
compositions
production
methods
inhibitory activity
Prior art date
Application number
SG10201801668WA
Other languages
English (en)
Inventor
Brian L Hodous
Lesley Liu-Bujalski
Reinaldo Jones
Donald Bankston
Theresa L Johnson
Igor Mochalkin
Ngan Nguyen
Hui Qiu
Andreas Goutopoulos
Nadia Brugger
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG10201801668WA publication Critical patent/SG10201801668WA/en

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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