SG10201710013RA - Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof - Google Patents

Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof

Info

Publication number
SG10201710013RA
SG10201710013RA SG10201710013RA SG10201710013RA SG10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA
Authority
SG
Singapore
Prior art keywords
pai
antibodies
plasminogen activator
activator inhibitor
inhibitor
Prior art date
Application number
SG10201710013RA
Other languages
English (en)
Inventor
Alla Pritsker
Patrick Grailhe
Alexey Rak
Magali Mathieu
Christopher Ryan Morgan
Nicolas Baurin
Bruno Poirier
Cyril Daveu
Francis Duffieux
Han Li
Dorothea KOMINOS
Philip Janiak
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG10201710013RA publication Critical patent/SG10201710013RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
SG10201710013RA 2013-08-13 2014-08-13 Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof SG10201710013RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361865451P 2013-08-13 2013-08-13
EP14305757 2014-05-22

Publications (1)

Publication Number Publication Date
SG10201710013RA true SG10201710013RA (en) 2018-01-30

Family

ID=56194112

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201710013RA SG10201710013RA (en) 2013-08-13 2014-08-13 Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof

Country Status (17)

Country Link
US (4) US9845363B2 (ja)
JP (4) JP6696899B2 (ja)
KR (1) KR20160035077A (ja)
CN (2) CN112142845A (ja)
BR (1) BR112016002753A2 (ja)
CL (1) CL2016000324A1 (ja)
CR (2) CR20190319A (ja)
DO (1) DOP2016000042A (ja)
EA (1) EA033403B1 (ja)
ES (1) ES2770507T3 (ja)
HK (1) HK1221725A1 (ja)
MX (2) MX2016001851A (ja)
PE (1) PE20160244A1 (ja)
PH (1) PH12016500239A1 (ja)
SG (1) SG10201710013RA (ja)
TN (1) TN2016000048A1 (ja)
UA (1) UA118267C2 (ja)

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DK3395353T3 (da) 2015-12-18 2024-03-11 Talengen Int Ltd Plasminogen til anvendelse til behandling eller forebyggelse af diabetes-mellitus-nerveskade
WO2017101870A1 (zh) 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 一种预防或治疗糖尿病性视网膜病变的方法
WO2018107694A1 (zh) * 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗皮肤纤维化的方法
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WO2018107686A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种治疗动脉粥样硬化及其并发症的方法
US20190343930A1 (en) * 2016-12-15 2019-11-14 Talengen International Limited Method for preventing and treating pathological renal tissue injury
CN108210900A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗肥胖症的药物及其用途
EP3556379A4 (en) 2016-12-15 2020-08-19 Talengen International Limited METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY
CN108210897A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗肺纤维化的药物及其用途
CA3067890A1 (en) 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
TW201904990A (zh) * 2017-06-23 2019-02-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN110662765B (zh) 2017-08-03 2023-09-29 艾利妥 抗cd33抗体及其使用方法
WO2021066062A1 (ja) 2019-09-30 2021-04-08 株式会社レナサイエンス 免疫チェックポイント分子の発現抑制剤
US11827709B2 (en) * 2019-12-05 2023-11-28 Seagen Inc. Anti-AVB6 antibodies and antibody-drug conjugates
EP4094776A4 (en) * 2020-02-11 2023-05-17 Talengen International Limited METHODS AND MEDICATIONS FOR THE TREATMENT OF VIRAL PENMONIA
CN111072780B (zh) * 2020-03-24 2020-06-23 深圳汉盛汇融再生医学科技有限公司 白血病干细胞抑制剂及其在治疗慢性粒细胞白血病中的应用
CN114605550B (zh) * 2020-12-08 2023-09-22 东莞市朋志生物科技有限公司 抗ca19-9的抗体、其应用和检测ca19-9的试剂盒
CN114686441B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 一种能分泌tPAI-C单克隆抗体的杂交瘤细胞株及其应用
CN114686442B (zh) * 2020-12-31 2023-11-07 广州万孚生物技术股份有限公司 一种杂交瘤细胞株及其应用

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Also Published As

Publication number Publication date
MX2019008803A (es) 2019-09-16
US20230015181A1 (en) 2023-01-19
US20190359729A1 (en) 2019-11-28
HK1221725A1 (zh) 2017-06-09
CR20160117A (es) 2016-05-20
JP2016529255A (ja) 2016-09-23
PE20160244A1 (es) 2016-05-10
CL2016000324A1 (es) 2016-10-21
MX2016001851A (es) 2016-05-16
CN112142845A (zh) 2020-12-29
CN105705520A (zh) 2016-06-22
PH12016500239A1 (en) 2016-05-16
BR112016002753A2 (pt) 2017-11-21
ES2770507T3 (es) 2020-07-01
JP6907380B2 (ja) 2021-07-21
US9845363B2 (en) 2017-12-19
CR20190319A (es) 2019-08-29
US20180155444A1 (en) 2018-06-07
TN2016000048A1 (en) 2017-07-05
CN105705520B (zh) 2020-09-25
DOP2016000042A (es) 2016-04-04
JP2020125333A (ja) 2020-08-20
JP7223069B2 (ja) 2023-02-15
JP2023055852A (ja) 2023-04-18
JP6696899B2 (ja) 2020-05-20
EA033403B1 (ru) 2019-10-31
JP2021155440A (ja) 2021-10-07
US20160200831A1 (en) 2016-07-14
EA201690377A1 (ru) 2016-06-30
KR20160035077A (ko) 2016-03-30
UA118267C2 (uk) 2018-12-26

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