SG10201704575XA - Methods and materials for biosynthesis of mogroside compounds - Google Patents
Methods and materials for biosynthesis of mogroside compoundsInfo
- Publication number
- SG10201704575XA SG10201704575XA SG10201704575XA SG10201704575XA SG10201704575XA SG 10201704575X A SG10201704575X A SG 10201704575XA SG 10201704575X A SG10201704575X A SG 10201704575XA SG 10201704575X A SG10201704575X A SG 10201704575XA SG 10201704575X A SG10201704575X A SG 10201704575XA
- Authority
- SG
- Singapore
- Prior art keywords
- biosynthesis
- materials
- methods
- mogroside compounds
- mogroside
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229930189775 mogroside Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y303/00—Hydrolases acting on ether bonds (3.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99033—Cucurbitadienol synthase (5.4.99.33)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
- C12Y114/13132—Squalene monooxygenase (1.14.13.132)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261733220P | 2012-12-04 | 2012-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201704575XA true SG10201704575XA (en) | 2017-07-28 |
Family
ID=49709683
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201704575XA SG10201704575XA (en) | 2012-12-04 | 2013-12-04 | Methods and materials for biosynthesis of mogroside compounds |
| SG11201503757RA SG11201503757RA (en) | 2012-12-04 | 2013-12-04 | Methods and materials for biosynthesis of mogroside compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201503757RA SG11201503757RA (en) | 2012-12-04 | 2013-12-04 | Methods and materials for biosynthesis of mogroside compounds |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9932619B2 (https=) |
| EP (1) | EP2929043A1 (https=) |
| JP (1) | JP2015536157A (https=) |
| AU (3) | AU2015200486A1 (https=) |
| BR (1) | BR112015013129A2 (https=) |
| CA (1) | CA2893462A1 (https=) |
| HK (1) | HK1215053A1 (https=) |
| MX (1) | MX367859B (https=) |
| SG (2) | SG10201704575XA (https=) |
| WO (1) | WO2014086842A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014012543A2 (pt) | 2011-11-23 | 2017-06-13 | Evolva Sa | métodos e materiais para síntese enzimática de compostos de mogrosídeo |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
| CA2972739A1 (en) * | 2014-09-11 | 2016-03-17 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of producing mogrosides and compositions comprising same and uses thereof |
| CA2963300C (en) * | 2014-10-01 | 2024-04-30 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
| CA2968331C (en) * | 2014-10-17 | 2024-02-06 | Suntory Holdings Limited | Mogrol glycosyltransferase and gene encoding same |
| CN104988167A (zh) * | 2014-11-21 | 2015-10-21 | 中国科学院天津工业生物技术研究所 | 罗汉果葫芦二烯醇合成酶基因SgCbQ及其应用 |
| CN105801658B (zh) * | 2014-12-30 | 2019-03-19 | 北京农学院 | 甜甙及其类似物的制备及作为stat3、erk信号通路靶位点药物在抗肿瘤中的应用 |
| CN106350564A (zh) * | 2015-07-20 | 2017-01-25 | 中国科学院天津工业生物技术研究所 | 罗汉果醇合成途径中萜类化合物及其糖基化产物的合成方法 |
| CA3003163A1 (en) | 2015-10-29 | 2017-05-04 | Senomyx, Inc. | High intensity sweeteners |
| CN105713060A (zh) * | 2016-01-29 | 2016-06-29 | 滁州润海甜叶菊高科有限公司 | 一种罗汉果中提取糖分工艺 |
| CN105713061A (zh) * | 2016-03-03 | 2016-06-29 | 湖南绿蔓生物科技股份有限公司 | 一种罗汉果苷v含量≥95％的罗汉果提取物的制备方法 |
| CN105777837A (zh) * | 2016-05-06 | 2016-07-20 | 深圳以诺生物制药有限公司 | 一种新型罗汉果醇衍生物单体 |
| WO2017198681A1 (en) * | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP6605179B2 (ja) * | 2017-03-01 | 2019-11-13 | 桂林莱菌生物科技股▲ふん▼有限公司 | ラカンカ懸濁細胞中のモグロシドｖ含有量を高める方法 |
| US11060124B2 (en) | 2017-05-03 | 2021-07-13 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CA3064334A1 (en) | 2017-06-02 | 2018-12-06 | Givaudan Sa | Compositions |
| EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
| CN109385377A (zh) * | 2017-08-04 | 2019-02-26 | 中国科学院天津工业生物技术研究所 | 用于生产葫芦二烯醇的工程菌及其制备方法与应用 |
| CN112041457A (zh) * | 2018-02-27 | 2020-12-04 | 马努斯生物合成股份有限公司 | 包括罗汉果苷在内的三萜类化合物的微生物产生 |
| JP6814182B2 (ja) * | 2018-09-10 | 2021-01-13 | アナリティコン ディスカバリー ゲーエムベーハー | 甘味料または甘味増強剤として使用される新規なトリペルテングリコシド |
| CN109679987A (zh) * | 2018-09-27 | 2019-04-26 | 怀化兴科创生物技术有限公司 | 一个提高甜甙含量相关基因的应用 |
| JP2022512931A (ja) * | 2018-11-07 | 2022-02-07 | フィルメニッヒ インコーポレイテッド | 高甘味度甘味料の製造方法 |
| CA3118467A1 (en) * | 2018-11-07 | 2020-05-14 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN110066785B (zh) * | 2019-01-30 | 2021-01-26 | 中国医学科学院药用植物研究所 | 一种罗汉果葫芦二烯醇合酶突变体及其构建方法和应用 |
| US12557831B2 (en) * | 2019-02-26 | 2026-02-24 | The Coca-Cola Company | Mogrosides and uses of the same |
| JP7707084B2 (ja) * | 2019-06-25 | 2025-07-14 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア | トリテルペンの製造 |
| CN112194568B (zh) * | 2019-07-08 | 2023-04-14 | 福建中医药大学 | 一种长链三萜类化合物及其制备方法和用途 |
| CN110283224B (zh) * | 2019-07-16 | 2020-08-28 | 湖南华诚生物资源股份有限公司 | 一种罗汉果甜苷v的半合成方法 |
| WO2021126960A1 (en) * | 2019-12-16 | 2021-06-24 | Manus Bio, Inc. | Microbial production of mogrol and mogrosides |
| MX2022011627A (es) * | 2020-03-17 | 2022-12-15 | Coca Cola Co | Nuevo sistema y métodos de producción de mogrósidos. |
| EP4138574A1 (en) | 2020-04-20 | 2023-03-01 | Givaudan SA | Compositions |
| GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
| CN112903835B (zh) * | 2021-01-12 | 2022-08-12 | 广州泽力医药科技有限公司 | 罗汉果橘红固体饮料的指纹图谱构建方法及检测方法 |
| KR20240005708A (ko) * | 2021-04-02 | 2024-01-12 | 징코 바이오웍스, 인크. | 이소프레노이드 및 그의 전구체의 생합성 |
| EP4314272A1 (en) * | 2021-04-02 | 2024-02-07 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| WO2023278226A1 (en) * | 2021-06-29 | 2023-01-05 | Firmenich Incorporated | Mogroside compounds and their comestible use |
| WO2023278976A2 (en) | 2021-06-29 | 2023-01-05 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN113755355A (zh) * | 2021-09-30 | 2021-12-07 | 河北维达康生物科技有限公司 | 一种以葡萄糖为底物生物合成罗汉果醇的工程菌株、构建及其应用 |
| TWI843509B (zh) * | 2022-03-31 | 2024-05-21 | 國立臺灣大學 | 製備三萜類化合物的方法 |
| CN114854722B (zh) * | 2022-05-11 | 2024-01-09 | 成都普睿法药物研发有限公司 | 一种季也蒙念珠菌外切β-1,3-葡聚糖酶及其突变体及应用 |
| CN115896136B (zh) * | 2022-12-22 | 2025-12-16 | 云南农业大学 | 与葫芦二烯醇羟化相关的细胞色素p450基因及其编码产物 |
| WO2024218244A1 (en) | 2023-04-20 | 2024-10-24 | Dsm Ip Assets B.V. | Strains and methods for the production of mogrosides |
| WO2025144795A1 (en) | 2023-12-28 | 2025-07-03 | Dsm Ip Assets B.V. | Cells and methods for the production of glycosylated compounds |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399321B1 (en) | 1999-08-18 | 2002-06-04 | National Research Council Of Canada | Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT |
| EP1510573A1 (en) | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
| US7569389B2 (en) * | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| WO2007087815A2 (en) * | 2004-12-17 | 2007-08-09 | Metanomics Gmbh | Process for the control of production of fine chemicals |
| CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
| RU2437573C2 (ru) | 2005-11-23 | 2011-12-27 | Дзе Кока-Кола Компани | Композиция интенсивного подсластителя с кальцием и подслащенные ею композиции |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| WO2008062165A2 (en) | 2006-11-22 | 2008-05-29 | The University Of York | Monoterpenoid modifying enzymes |
| US20100132073A1 (en) | 2006-12-01 | 2010-05-27 | The University Of York | Sesquiterpenoid modifying enzymes |
| DE112008002456T5 (de) * | 2007-09-21 | 2011-01-13 | Basf Plant Science Gmbh | Pflanzen mit erhöhtem Ertrag |
| GB0904639D0 (en) | 2009-03-18 | 2009-04-29 | Univ York | Assay |
| EP2575432B1 (en) * | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| BR112014012543A2 (pt) * | 2011-11-23 | 2017-06-13 | Evolva Sa | métodos e materiais para síntese enzimática de compostos de mogrosídeo |
| EP2929043A1 (en) * | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
-
2013
- 2013-12-04 EP EP13799312.7A patent/EP2929043A1/en active Pending
- 2013-12-04 US US14/442,694 patent/US9932619B2/en active Active
- 2013-12-04 SG SG10201704575XA patent/SG10201704575XA/en unknown
- 2013-12-04 CA CA2893462A patent/CA2893462A1/en active Pending
- 2013-12-04 SG SG11201503757RA patent/SG11201503757RA/en unknown
- 2013-12-04 WO PCT/EP2013/075510 patent/WO2014086842A1/en not_active Ceased
- 2013-12-04 HK HK16102919.6A patent/HK1215053A1/zh unknown
- 2013-12-04 BR BR112015013129A patent/BR112015013129A2/pt not_active Application Discontinuation
- 2013-12-04 MX MX2015007039A patent/MX367859B/es active IP Right Grant
- 2013-12-04 JP JP2015545996A patent/JP2015536157A/ja active Pending
-
2014
- 2014-10-01 US US14/504,109 patent/US10011859B2/en active Active
-
2015
- 2015-02-02 AU AU2015200486A patent/AU2015200486A1/en not_active Abandoned
-
2018
- 2018-02-20 US US15/900,557 patent/US10662458B2/en active Active
- 2018-05-08 US US15/974,429 patent/US10465222B2/en active Active
-
2019
- 2019-10-16 AU AU2019250137A patent/AU2019250137B2/en active Active
-
2022
- 2022-06-23 AU AU2022204430A patent/AU2022204430A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019250137B2 (en) | 2022-03-24 |
| BR112015013129A2 (pt) | 2017-07-11 |
| JP2015536157A (ja) | 2015-12-21 |
| WO2014086842A9 (en) | 2015-06-18 |
| US10662458B2 (en) | 2020-05-26 |
| HK1215053A1 (zh) | 2016-08-12 |
| AU2022204430A1 (en) | 2022-07-14 |
| AU2019250137A1 (en) | 2019-10-31 |
| EP2929043A1 (en) | 2015-10-14 |
| US9932619B2 (en) | 2018-04-03 |
| US20180251806A1 (en) | 2018-09-06 |
| AU2015200486A1 (en) | 2015-03-05 |
| SG11201503757RA (en) | 2015-06-29 |
| WO2014086842A1 (en) | 2014-06-12 |
| US10465222B2 (en) | 2019-11-05 |
| US20150322473A1 (en) | 2015-11-12 |
| US20150064743A1 (en) | 2015-03-05 |
| CA2893462A1 (en) | 2014-06-12 |
| US10011859B2 (en) | 2018-07-03 |
| US20180346953A1 (en) | 2018-12-06 |
| MX367859B (es) | 2019-09-09 |
| MX2015007039A (es) | 2016-02-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201503757RA (en) | Methods and materials for biosynthesis of mogroside compounds | |
| SG11201401927PA (en) | Methods and materials for enzymatic synthesis of mogroside compounds | |
| GB2498228B (en) | Provision of an open instance of an application | |
| AP3965A (en) | Anthelminitic compounds and compositions and method of using thereof | |
| LT2920149T (lt) | 3-aminocikloalkilo junginiai, kaip ror-gama-t inhibitoriai, ir jų panaudojimas | |
| EP2736330A4 (en) | COMPOUNDS AND METHODS | |
| ZA201401653B (en) | Pyrazol-4yl-heterocyclyl-carboxamide compounds and methods of use | |
| EP2747560A4 (en) | CONNECTIONS AND METHODS | |
| EP2736332A4 (en) | CONNECTIONS AND METHODS | |
| EP2736329A4 (en) | COMPOUNDS AND METHODS | |
| ZA201405535B (en) | Inhibitors of iap | |
| EP2709999A4 (en) | QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE | |
| GB201119904D0 (en) | Analysis of methylation sites | |
| IL235805A (en) | Pyrimidinyl-Diazaspiro compound and process for preparation | |
| PL2888228T3 (pl) | Inhibitory oddziaływania CD40-TRAF6 | |
| EP2680843A4 (en) | DERIVATIVES OF PYRAZOLSUBSTITUTED AMINO-HETEROARYL COMPOUNDS | |
| ZA201502350B (en) | Solid form of hihydro-pyrido-oxazine derivative | |
| GB2519045B (en) | String of absorbent products | |
| GB201214567D0 (en) | Detector and method of operation | |
| AU2012903090A0 (en) | Compounds and methods of their use - IV | |
| GB201205098D0 (en) | Method of calibration | |
| GB201206142D0 (en) | Method and uses for improved sowing of cereals | |
| SI2928896T1 (sl) | Trdna oblika derivata dihidro-pirido-oksazina | |
| TWM438663U (en) | Mouse capable of adjusting sound volume | |
| AU2011903137A0 (en) | Compounds and methods of their use - IV |