JP2015536157A - モグロシド化合物の生合成のための方法および材料 - Google Patents

モグロシド化合物の生合成のための方法および材料 Download PDF

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JP2015536157A
JP2015536157A JP2015545996A JP2015545996A JP2015536157A JP 2015536157 A JP2015536157 A JP 2015536157A JP 2015545996 A JP2015545996 A JP 2015545996A JP 2015545996 A JP2015545996 A JP 2015545996A JP 2015536157 A JP2015536157 A JP 2015536157A
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enzyme
cucurbitadienol
mogrol
mogroside
catalyzing
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JP2015536157A5 (https=
Inventor
リウ，ヤオクアン
ハンセン，ヨルゲン
ホートン−ラーセン，ジェンス
パンチャパゲサ ムラリ，ムスルワミー
パンチャパゲサ ムラリ，ムスルワミー
クマー，サティシュ
ラスムッセン，ニナ，ニコリン
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Evolva Holding SA
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Evolva AG
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    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
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    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13132—Squalene monooxygenase (1.14.13.132)

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JP2015545996A 2012-12-04 2013-12-04 モグロシド化合物の生合成のための方法および材料 Pending JP2015536157A (ja)

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Application Number Priority Date Filing Date Title
US201261733220P 2012-12-04 2012-12-04
US61/733,220 2012-12-04
PCT/EP2013/075510 WO2014086842A1 (en) 2012-12-04 2013-12-04 Methods and materials for biosynthesis of mogroside compounds

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JP2015536157A true JP2015536157A (ja) 2015-12-21
JP2015536157A5 JP2015536157A5 (https=) 2017-01-19

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US (4) US9932619B2 (https=)
EP (1) EP2929043A1 (https=)
JP (1) JP2015536157A (https=)
AU (3) AU2015200486A1 (https=)
BR (1) BR112015013129A2 (https=)
CA (1) CA2893462A1 (https=)
HK (1) HK1215053A1 (https=)
MX (1) MX367859B (https=)
SG (2) SG10201704575XA (https=)
WO (1) WO2014086842A1 (https=)

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JP2019519212A (ja) * 2016-05-16 2019-07-11 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
JP2022512931A (ja) * 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
JP2022512932A (ja) * 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides

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BR112014012543A2 (pt) 2011-11-23 2017-06-13 Evolva Sa métodos e materiais para síntese enzimática de compostos de mogrosídeo
EP2929043A1 (en) 2012-12-04 2015-10-14 Evolva SA Methods and materials for biosynthesis of mogroside compounds
CA2972739A1 (en) * 2014-09-11 2016-03-17 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of producing mogrosides and compositions comprising same and uses thereof
CA2963300C (en) * 2014-10-01 2024-04-30 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
CA2968331C (en) * 2014-10-17 2024-02-06 Suntory Holdings Limited Mogrol glycosyltransferase and gene encoding same
CN104988167A (zh) * 2014-11-21 2015-10-21 中国科学院天津工业生物技术研究所 罗汉果葫芦二烯醇合成酶基因SgCbQ及其应用
CN105801658B (zh) * 2014-12-30 2019-03-19 北京农学院 甜甙及其类似物的制备及作为stat3、erk信号通路靶位点药物在抗肿瘤中的应用
CN106350564A (zh) * 2015-07-20 2017-01-25 中国科学院天津工业生物技术研究所 罗汉果醇合成途径中萜类化合物及其糖基化产物的合成方法
CA3003163A1 (en) 2015-10-29 2017-05-04 Senomyx, Inc. High intensity sweeteners
CN105713060A (zh) * 2016-01-29 2016-06-29 滁州润海甜叶菊高科有限公司 一种罗汉果中提取糖分工艺
CN105713061A (zh) * 2016-03-03 2016-06-29 湖南绿蔓生物科技股份有限公司 一种罗汉果苷v含量≥95％的罗汉果提取物的制备方法
CN105777837A (zh) * 2016-05-06 2016-07-20 深圳以诺生物制药有限公司 一种新型罗汉果醇衍生物单体
JP6605179B2 (ja) * 2017-03-01 2019-11-13 桂林莱菌生物科技股▲ふん▼有限公司 ラカンカ懸濁細胞中のモグロシドｖ含有量を高める方法
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CN109385377A (zh) * 2017-08-04 2019-02-26 中国科学院天津工业生物技术研究所 用于生产葫芦二烯醇的工程菌及其制备方法与应用
CN112041457A (zh) * 2018-02-27 2020-12-04 马努斯生物合成股份有限公司 包括罗汉果苷在内的三萜类化合物的微生物产生
JP6814182B2 (ja) * 2018-09-10 2021-01-13 アナリティコン ディスカバリー ゲーエムベーハー 甘味料または甘味増強剤として使用される新規なトリペルテングリコシド
CN109679987A (zh) * 2018-09-27 2019-04-26 怀化兴科创生物技术有限公司 一个提高甜甙含量相关基因的应用
CN110066785B (zh) * 2019-01-30 2021-01-26 中国医学科学院药用植物研究所 一种罗汉果葫芦二烯醇合酶突变体及其构建方法和应用
US12557831B2 (en) * 2019-02-26 2026-02-24 The Coca-Cola Company Mogrosides and uses of the same
JP7707084B2 (ja) * 2019-06-25 2025-07-14 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア トリテルペンの製造
CN112194568B (zh) * 2019-07-08 2023-04-14 福建中医药大学 一种长链三萜类化合物及其制备方法和用途
CN110283224B (zh) * 2019-07-16 2020-08-28 湖南华诚生物资源股份有限公司 一种罗汉果甜苷v的半合成方法
WO2021126960A1 (en) * 2019-12-16 2021-06-24 Manus Bio, Inc. Microbial production of mogrol and mogrosides
MX2022011627A (es) * 2020-03-17 2022-12-15 Coca Cola Co Nuevo sistema y métodos de producción de mogrósidos.
EP4138574A1 (en) 2020-04-20 2023-03-01 Givaudan SA Compositions
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112903835B (zh) * 2021-01-12 2022-08-12 广州泽力医药科技有限公司 罗汉果橘红固体饮料的指纹图谱构建方法及检测方法
KR20240005708A (ko) * 2021-04-02 2024-01-12 징코 바이오웍스, 인크. 이소프레노이드 및 그의 전구체의 생합성
EP4314272A1 (en) * 2021-04-02 2024-02-07 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2023278226A1 (en) * 2021-06-29 2023-01-05 Firmenich Incorporated Mogroside compounds and their comestible use
WO2023278976A2 (en) 2021-06-29 2023-01-05 Firmenich Incorporated Methods for making high intensity sweeteners
CN113755355A (zh) * 2021-09-30 2021-12-07 河北维达康生物科技有限公司 一种以葡萄糖为底物生物合成罗汉果醇的工程菌株、构建及其应用
TWI843509B (zh) * 2022-03-31 2024-05-21 國立臺灣大學 製備三萜類化合物的方法
CN114854722B (zh) * 2022-05-11 2024-01-09 成都普睿法药物研发有限公司 一种季也蒙念珠菌外切β-1,3-葡聚糖酶及其突变体及应用
CN115896136B (zh) * 2022-12-22 2025-12-16 云南农业大学 与葫芦二烯醇羟化相关的细胞色素p450基因及其编码产物
WO2024218244A1 (en) 2023-04-20 2024-10-24 Dsm Ip Assets B.V. Strains and methods for the production of mogrosides
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JP2019519212A (ja) * 2016-05-16 2019-07-11 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
JP2022512931A (ja) * 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
JP2022512932A (ja) * 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
JP2025000973A (ja) * 2018-11-07 2025-01-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
JP7642533B2 (ja) 2018-11-07 2025-03-10 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides

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US10662458B2 (en) 2020-05-26
HK1215053A1 (zh) 2016-08-12
AU2022204430A1 (en) 2022-07-14
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US20180251806A1 (en) 2018-09-06
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