SG10201509145XA - Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers - Google Patents

Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Info

Publication number
SG10201509145XA
SG10201509145XA SG10201509145XA SG10201509145XA SG10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA SG 10201509145X A SG10201509145X A SG 10201509145XA
Authority
SG
Singapore
Prior art keywords
receptor alpha
folate receptor
diagnostic
prognostic marker
expressing cancers
Prior art date
Application number
SG10201509145XA
Other languages
English (en)
Inventor
Daniel J O'shannessy
Luigi Grasso
Shanhong Wan
Qimin Chao
Elizabeth Brooke Somers
Original Assignee
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphotek Inc filed Critical Morphotek Inc
Publication of SG10201509145XA publication Critical patent/SG10201509145XA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57423Specifically defined cancers of lung
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57449Specifically defined cancers of ovaries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201509145XA 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers SG10201509145XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41049710P 2010-11-05 2010-11-05
US201161508444P 2011-07-15 2011-07-15

Publications (1)

Publication Number Publication Date
SG10201509145XA true SG10201509145XA (en) 2015-12-30

Family

ID=45003076

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201701933XA SG10201701933XA (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
SG10201509145XA SG10201509145XA (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
SG2013030424A SG189957A1 (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201701933XA SG10201701933XA (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013030424A SG189957A1 (en) 2010-11-05 2011-11-04 Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers

Country Status (14)

Country Link
US (1) US20120207771A1 (de)
EP (2) EP3130605B1 (de)
JP (2) JP6224456B2 (de)
KR (2) KR102057438B1 (de)
CN (2) CN108562744A (de)
AU (3) AU2011323124C1 (de)
BR (1) BR112013011072B1 (de)
CA (1) CA2816991C (de)
ES (2) ES2780192T3 (de)
IL (2) IL225871B (de)
MX (2) MX368394B (de)
RU (2) RU2764592C2 (de)
SG (3) SG10201701933XA (de)
WO (1) WO2012061759A2 (de)

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EP2680839A1 (de) * 2011-03-02 2014-01-08 Morphotek, Inc. Gleichzeitige verabreichung von eribulin und farletuzumab zur behandlung von brustkrebs
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PL2731972T3 (pl) * 2011-07-15 2018-06-29 Eisai R&D Management Co., Ltd. Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania
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NZ726258A (en) * 2012-08-31 2019-07-26 Immunogen Inc Antibodies and uses thereof to detect folate receptor 1
JP6383787B2 (ja) * 2013-06-20 2018-08-29 モルフォテック, インコーポレイテッド 卵巣癌の治療方法
SG10201907501QA (en) 2013-08-30 2019-10-30 Immunogen Inc Antibodies and assays for detection of folate receptor 1
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US11344628B2 (en) 2016-08-12 2022-05-31 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
US10822410B2 (en) 2016-11-23 2020-11-03 Eisai R&D Management Co., Ltd. Anti-folate receptor alpha antibodies and uses thereof
CN107446021B (zh) * 2017-07-26 2020-08-11 中国药科大学 叶酸受体α特异性结合肽5及其应用
CN107353325B (zh) * 2017-07-26 2020-08-11 中国药科大学 叶酸受体α特异性结合肽1及其应用
CN107446020B (zh) * 2017-07-28 2019-10-01 中国药科大学 叶酸受体α特异性结合肽2及其应用
RU2759410C2 (ru) * 2017-09-05 2021-11-12 Иммьюноджен, Инк. Способы обнаружения фолатного рецептора 1 в образце пациента
EP3749316A4 (de) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC Alpha-polyglutamatiertes pralatrexat und verwendungen davon
US12076402B2 (en) 2018-02-07 2024-09-03 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル.イー.エー.エフ. ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
EP3752156A4 (de) 2018-02-14 2021-10-27 L.E.A.F Holdings Group LLC Gamma-polyglutamiertse pralatrexat und verwendungen davon
US11771700B2 (en) 2018-02-14 2023-10-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
EP3755335A4 (de) 2018-02-14 2022-06-22 L.E.A.F Holdings Group LLC Gamma-polyglutamierte tetrahydrofolate und deren verwendungen
SG11202007494TA (en) * 2018-03-13 2020-09-29 Phanes Therapeutics Inc Anti-folate receptor 1 antibodies and uses thereof
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Also Published As

Publication number Publication date
EP3130605A1 (de) 2017-02-15
SG189957A1 (en) 2013-06-28
IL225871B (en) 2018-08-30
RU2013125772A (ru) 2014-12-10
MX343607B (es) 2016-11-11
ES2780192T3 (es) 2020-08-24
BR112013011072B1 (pt) 2021-02-02
MX368394B (es) 2019-10-01
IL225871A0 (en) 2013-06-27
RU2017129266A (ru) 2019-02-04
JP2018036270A (ja) 2018-03-08
BR112013011072A2 (pt) 2017-06-20
JP2013544354A (ja) 2013-12-12
AU2016203408A1 (en) 2016-06-16
KR20140024838A (ko) 2014-03-03
MX2013005067A (es) 2013-07-02
EP3130605B1 (de) 2020-01-08
AU2011323124A1 (en) 2013-05-09
CA2816991A1 (en) 2012-05-10
WO2012061759A2 (en) 2012-05-10
AU2011323124B2 (en) 2016-02-25
AU2018201760B2 (en) 2019-07-25
CN108562744A (zh) 2018-09-21
US20120207771A1 (en) 2012-08-16
CA2816991C (en) 2020-06-09
IL260590B (en) 2020-01-30
EP2635304A2 (de) 2013-09-11
ES2627061T3 (es) 2017-07-26
AU2011323124C1 (en) 2016-09-22
RU2764592C2 (ru) 2022-01-18
EP2635304B1 (de) 2017-03-08
KR102057438B1 (ko) 2019-12-20
AU2018201760A1 (en) 2018-04-05
JP6224456B2 (ja) 2017-11-01
KR20180137587A (ko) 2018-12-27
RU2630608C2 (ru) 2017-09-11
JP6554152B2 (ja) 2019-07-31
CN103687618A (zh) 2014-03-26
KR101931936B1 (ko) 2018-12-26
RU2017129266A3 (de) 2021-01-25
WO2012061759A3 (en) 2012-07-26
SG10201701933XA (en) 2017-05-30

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