SG10201503327QA - Production of nucleic acid - Google Patents

Production of nucleic acid

Info

Publication number
SG10201503327QA
SG10201503327QA SG10201503327QA SG10201503327QA SG10201503327QA SG 10201503327Q A SG10201503327Q A SG 10201503327QA SG 10201503327Q A SG10201503327Q A SG 10201503327QA SG 10201503327Q A SG10201503327Q A SG 10201503327QA SG 10201503327Q A SG10201503327Q A SG 10201503327QA
Authority
SG
Singapore
Prior art keywords
production
nucleic acid
nucleic
acid
Prior art date
Application number
SG10201503327QA
Other languages
English (en)
Inventor
Arvydas Janulaitis
Remigijus Skirgaila
Dangira Siksniene
Original Assignee
Thermo Fisher Scientific Baltics Uab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Fisher Scientific Baltics Uab filed Critical Thermo Fisher Scientific Baltics Uab
Publication of SG10201503327QA publication Critical patent/SG10201503327QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1276RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07049RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201503327QA 2008-04-10 2009-04-09 Production of nucleic acid SG10201503327QA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0806562.5A GB0806562D0 (en) 2008-04-10 2008-04-10 Production of nucleic acid

Publications (1)

Publication Number Publication Date
SG10201503327QA true SG10201503327QA (en) 2015-06-29

Family

ID=39433452

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201503327QA SG10201503327QA (en) 2008-04-10 2009-04-09 Production of nucleic acid

Country Status (14)

Country Link
US (5) US8835148B2 (enrdf_load_stackoverflow)
EP (4) EP2639300B1 (enrdf_load_stackoverflow)
JP (5) JP5642662B2 (enrdf_load_stackoverflow)
KR (4) KR101653775B1 (enrdf_load_stackoverflow)
CN (2) CN102057039A (enrdf_load_stackoverflow)
AU (1) AU2009235368B2 (enrdf_load_stackoverflow)
CA (1) CA2721117A1 (enrdf_load_stackoverflow)
ES (1) ES2647272T3 (enrdf_load_stackoverflow)
GB (1) GB0806562D0 (enrdf_load_stackoverflow)
IL (2) IL208578A (enrdf_load_stackoverflow)
NZ (1) NZ588468A (enrdf_load_stackoverflow)
PL (1) PL2281035T3 (enrdf_load_stackoverflow)
SG (1) SG10201503327QA (enrdf_load_stackoverflow)
WO (1) WO2009125006A2 (enrdf_load_stackoverflow)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9771565B2 (en) * 2000-05-26 2017-09-26 Life Technologies Corporation Thermostable reverse transcriptases and uses thereof
WO2004024749A2 (en) 2002-09-13 2004-03-25 Invitrogen Corporation Thermostable reverse transcriptases and uses thereof
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
GB0806562D0 (en) * 2008-04-10 2008-05-14 Fermentas Uab Production of nucleic acid
EP3225695A1 (en) * 2009-10-15 2017-10-04 Ibis Biosciences, Inc. Multiple displacement amplification
JPWO2012020759A1 (ja) * 2010-08-13 2013-10-28 国立大学法人京都大学 変異型逆転写酵素
KR101818126B1 (ko) 2011-02-09 2018-01-15 (주)바이오니아 열안정성이 증가된 역전사효소
JP6261500B2 (ja) 2011-07-22 2018-01-17 プレジデント アンド フェローズ オブ ハーバード カレッジ ヌクレアーゼ切断特異性の評価および改善
US9745571B2 (en) * 2013-03-07 2017-08-29 Bio-Rad Laboratories, Inc. Repetitive reverse transcription partition assay
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
WO2015075842A1 (ja) * 2013-11-25 2015-05-28 国立大学法人京都大学 変異型逆転写酵素
US9840699B2 (en) 2013-12-12 2017-12-12 President And Fellows Of Harvard College Methods for nucleic acid editing
CN106164261A (zh) * 2014-01-22 2016-11-23 生命技术公司 适用于高温核酸合成的新颖逆转录酶
CN106414704B (zh) 2014-03-14 2020-11-03 生命技术公司 用于核酸扩增和检测的集成系统
CN104250642A (zh) * 2014-04-30 2014-12-31 厦门安普利生物工程有限公司 一种提取纯化m-mlv逆转录酶的方法
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
KR102333255B1 (ko) * 2015-05-11 2021-12-01 일루미나, 인코포레이티드 치료제의 발견 및 분석을 위한 플랫폼
EP3365357B1 (en) 2015-10-23 2024-02-14 President and Fellows of Harvard College Evolved cas9 proteins for gene editing
EP3443079A1 (en) 2016-04-12 2019-02-20 Solis Biodyne Synthetic reverse transcriptases and uses thereof
CA3032699A1 (en) 2016-08-03 2018-02-08 President And Fellows Of Harvard College Adenosine nucleobase editors and uses thereof
EP3497214B1 (en) 2016-08-09 2023-06-28 President and Fellows of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
US9580698B1 (en) * 2016-09-23 2017-02-28 New England Biolabs, Inc. Mutant reverse transcriptase
EP3526320A1 (en) 2016-10-14 2019-08-21 President and Fellows of Harvard College Aav delivery of nucleobase editors
US11220677B2 (en) 2016-12-14 2022-01-11 Takara Bio Inc. Heat-resistant reverse transcriptase mutant
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
WO2018165504A1 (en) 2017-03-09 2018-09-13 President And Fellows Of Harvard College Suppression of pain by gene editing
WO2018165631A1 (en) 2017-03-09 2018-09-13 President And Fellows Of Harvard College Cancer vaccine
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
KR102687373B1 (ko) 2017-03-23 2024-07-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
WO2018189184A1 (en) 2017-04-11 2018-10-18 Roche Diagnostics Gmbh Mutant reverse transcriptase with increased thermal stability as well as products, methods and uses involving the same
US20180312822A1 (en) * 2017-04-26 2018-11-01 10X Genomics, Inc. Mmlv reverse transcriptase variants
SG11201908596WA (en) * 2017-04-26 2019-11-28 10X Genomics Inc Mmlv reverse transcriptase variants
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
WO2019051097A1 (en) 2017-09-08 2019-03-14 The Regents Of The University Of California RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USING SAME
JP2021500036A (ja) 2017-10-16 2021-01-07 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. アデノシン塩基編集因子の使用
WO2019118949A1 (en) 2017-12-15 2019-06-20 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
US20200392562A1 (en) 2017-12-22 2020-12-17 Thermo Fisher Scientific Baltics Uab Polymerase chain reaction composition comprising amines
EP3797160A1 (en) 2018-05-23 2021-03-31 The Broad Institute Inc. Base editors and uses thereof
US12188014B1 (en) 2018-07-25 2025-01-07 10X Genomics, Inc. Compositions and methods for nucleic acid processing using blocking agents
US20220411783A1 (en) * 2018-10-12 2022-12-29 The Broad Institute, Inc. Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
US12281338B2 (en) 2018-10-29 2025-04-22 The Broad Institute, Inc. Nucleobase editors comprising GeoCas9 and uses thereof
CN112969527A (zh) * 2018-11-08 2021-06-15 深圳华大生命科学研究院 一种微流控芯片及其制备方法和dna合成方法
WO2020132966A1 (zh) * 2018-12-26 2020-07-02 深圳华大生命科学研究院 酶活性提高的逆转录酶及其应用
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
SG11202109679VA (en) 2019-03-19 2021-10-28 Broad Inst Inc Methods and compositions for editing nucleotide sequences
CN114174503B (zh) * 2019-07-26 2024-06-28 东洋纺株式会社 稳定性优异的突变型逆转录酶
AU2020361681A1 (en) 2019-10-10 2022-05-05 1859, Inc. Methods and systems for microfluidic screening
CN112795547B (zh) * 2019-11-13 2024-05-31 广州达安基因股份有限公司 高逆转录效率的逆转录酶突变体
CN112795546B (zh) * 2019-11-13 2024-02-27 广州达安基因股份有限公司 一种具有高逆转录效率的耐高温逆转录酶突变体及其应用
CN112795548A (zh) * 2019-11-13 2021-05-14 中山大学达安基因股份有限公司 具有高逆转录效率的耐高温逆转录酶突变体及其应用
CN112795549B (zh) * 2019-11-13 2023-11-28 广州达安基因股份有限公司 一种逆转录酶突变体
CN112795551B (zh) * 2019-11-13 2024-01-30 广州达安基因股份有限公司 一种耐高温逆转录酶突变体及其应用
EP4461810A3 (en) 2019-12-11 2025-04-09 10X Genomics, Inc. Reverse transcriptase variants
WO2021165508A1 (en) 2020-02-21 2021-08-26 Biogemma Prime editing technology for plant genome engineering
KR20230003467A (ko) * 2020-03-19 2023-01-06 인텔리아 테라퓨틱스, 인크. 지시된 게놈 편집을 위한 방법 및 조성물
CN116096873A (zh) 2020-05-08 2023-05-09 布罗德研究所股份有限公司 同时编辑靶标双链核苷酸序列的两条链的方法和组合物
CN111849938B (zh) * 2020-06-05 2022-02-15 广州英赞生物科技有限公司 一种突变型逆转录酶及其制备方法与应用
CN111647576B (zh) * 2020-06-24 2021-02-09 南京诺唯赞生物科技股份有限公司 一种热稳定性逆转录酶突变体及其应用
EP4182449A4 (en) * 2020-07-20 2024-10-09 Integrated DNA Technologies Inc. REVERSE TRANSCRIPTASE MUTANTS WITH INCREASED ACTIVITY AND THERMOSTABILITY
CN114480331A (zh) * 2020-11-13 2022-05-13 广州达安基因股份有限公司 Mmlv酶组合突变体
CN114480332B (zh) * 2020-11-13 2023-12-05 广州达安基因股份有限公司 耐高温m-mlv酶突变体及其应用
CN114480336B (zh) * 2020-11-13 2023-10-20 广州达安基因股份有限公司 含有逆转录酶突变体的核酸检测试剂盒
CN114480330B (zh) * 2020-11-13 2024-11-01 广州达安基因股份有限公司 多突变位点的逆转录酶突变体
CN114480335B (zh) * 2020-11-13 2024-06-07 广州达安基因股份有限公司 逆转录酶及逆转录检测试剂
US20240002818A1 (en) * 2020-11-24 2024-01-04 Saliogen Therapeutics, Inc. Mammalian mobile element compositions, systems and therapeutic applications
CN112481234B (zh) * 2020-12-03 2023-09-22 重庆工业职业技术学院 一种焦磷酸酶突变体合成核酸糖类似物及其应用
CN112251423B (zh) * 2020-12-08 2021-03-19 北京健为医学检验实验室有限公司 一种m-mlv逆转录酶体及其应用
CN113234858A (zh) * 2021-05-20 2021-08-10 阿吉安(福州)基因医学检验实验室有限公司 一种covid-19的检测试剂盒
MX2023013896A (es) * 2021-05-26 2023-12-12 Etherna Immunotherapies Nv Metodo para reducir la formacion de subproductos de arn bicatenario.
CN113174381B (zh) * 2021-06-08 2023-05-12 翌圣生物科技(上海)股份有限公司 增强型mmlv逆转录酶突变体及其应用
JPWO2023112947A1 (enrdf_load_stackoverflow) * 2021-12-17 2023-06-22
CN114214299A (zh) * 2022-01-26 2022-03-22 苏州译酶生物科技有限公司 一种m-mlv逆转录酶及其制备方法
CN114657165B (zh) * 2022-03-25 2023-04-07 江苏百时美生物科技有限公司 一种提高热稳定性和抑制剂耐受性的逆转录酶突变体及其应用
CN114591930B (zh) * 2022-05-10 2022-08-12 翌圣生物科技(上海)股份有限公司 增强型逆转录酶、编码dna、试剂盒及其在rna文库构建中的应用
CN117106745B (zh) * 2022-06-01 2025-02-14 北京擎科生物科技股份有限公司 逆转录突变体及其应用
CN116064460B (zh) * 2022-08-01 2023-09-26 南京诺唯赞生物科技股份有限公司 一种mmlv突变体及其应用
CN117586983A (zh) * 2022-08-11 2024-02-23 菲鹏生物股份有限公司 一种逆转录酶、核酸分子及合成cDNA的方法
CN115747186B (zh) * 2022-09-13 2025-05-27 天罗诊断科技江苏有限公司 一种耐热的高效率逆转录酶突变体及其应用
CN116042569B (zh) * 2023-02-01 2023-08-15 珠海宝锐生物科技有限公司 Mmlv逆转录酶突变体及其应用
CN116004568A (zh) * 2023-02-07 2023-04-25 北京诺派生物科技有限公司 一种可用于核酸检测的耐高温反转录酶及其制备方法与应用
WO2024211850A1 (en) * 2023-04-05 2024-10-10 Primrose Bio, Inc. Methods and compositions for protein engineering
CN118345060A (zh) * 2023-06-30 2024-07-16 翌圣生物科技(上海)股份有限公司 一种鼠白血病病毒逆转录酶突变体及其应用
CN116694598B (zh) * 2023-06-30 2024-12-13 翌圣生物科技(上海)股份有限公司 一种鼠白血病病毒逆转录酶突变体及其应用
CN116732141B (zh) * 2023-07-10 2024-04-02 海南大学 一种快速检测生物dna特异性的方法
CN117025724A (zh) * 2023-08-23 2023-11-10 翌圣生物科技(上海)股份有限公司 Rna链特异性建库试剂盒及建库方法
CN117925558B (zh) * 2023-12-13 2025-03-25 郑州玛特瑞斯生物科技有限公司 突变型逆转录酶及其应用
CN118406670B (zh) * 2024-05-06 2025-06-27 湖南艾科瑞生物工程有限公司 一种mmlv逆转录酶突变体及其应用
CN119955759B (zh) * 2025-01-07 2025-08-08 湖南艾科瑞生物工程有限公司 一种mmlv逆转录酶突变体及其应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6236563A (ja) 1985-08-12 1987-02-17 Koji Ando 可動導体型計器
US5244797B1 (en) 1988-01-13 1998-08-25 Life Technologies Inc Cloned genes encoding reverse transcriptase lacking rnase h activity
ATE168416T1 (de) 1989-10-05 1998-08-15 Optein Inc Zellfreie synthese und isolierung von genen und polypeptiden
US6183967B1 (en) * 1995-06-07 2001-02-06 Nexstar Pharmaceuticals Nucleic acid ligand inhibitors to DNA polymerases
WO1998023733A2 (en) 1996-11-27 1998-06-04 University Of Washington Thermostable polymerases having altered fidelity
US6989259B2 (en) 1997-04-22 2006-01-24 Invitrogen Corporation Recombinant methods for making reverse transcriptases and mutants thereof
EP1801214B1 (en) 1997-07-07 2010-11-10 Medical Research Council In vitro sorting method
US6136582A (en) 1998-01-20 2000-10-24 The Trustees Of Columbia University In The City Reverse transcriptase of moloney murine leukemia virus with RNA polymerase activity
JP4193079B2 (ja) 1998-11-10 2008-12-10 東洋紡績株式会社 変異型逆転写酵素
JP2002534125A (ja) * 1999-01-15 2002-10-15 モレキュラー バイオロジー リソーシーズ 生物学的に活性な逆転写酵素
AU2001247413B2 (en) 2000-03-15 2005-08-25 Invitrogen Corporation High fidelity reverse transcriptases and uses thereof
JP2003529369A (ja) 2000-03-31 2003-10-07 ケンブリッジ アンティボディー テクノロジー リミティド リボソーム・ディスプレイの改良
CA2406939A1 (en) * 2000-05-26 2001-12-06 Invitrogen Corporation Thermostable reverse transcriptases and uses thereof
US7078208B2 (en) 2000-05-26 2006-07-18 Invitrogen Corporation Thermostable reverse transcriptases and uses thereof
GB0022458D0 (en) 2000-09-13 2000-11-01 Medical Res Council Directed evolution method
CA2460546A1 (en) 2001-09-14 2003-03-27 Invitrogen Corporation Dna polymerases and mutants thereof
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7597700B2 (en) 2002-04-30 2009-10-06 Abbott Laboratories Lancet removal tool
EP2385118A1 (en) * 2002-09-06 2011-11-09 Isogenica Limited In vitro peptide expression library
GB0221053D0 (en) 2002-09-11 2002-10-23 Medical Res Council Single-molecule in vitro evolution
WO2004024749A2 (en) * 2002-09-13 2004-03-25 Invitrogen Corporation Thermostable reverse transcriptases and uses thereof
WO2005049787A2 (en) * 2003-11-24 2005-06-02 Yeda Research And Development Co.Ltd. Compositions and methods for in vitro sorting of molecular and cellular libraries
WO2005071072A1 (fr) 2004-01-13 2005-08-04 The Institute Of Biophysics Chinese Academy Of Sciences Transcriptase inverse du virus de la leucemie murine recombinee, gene codant pour ladite transcriptase inverse et methode permettant d'exprimer ladite transcriptase inverse
US7595179B2 (en) * 2004-04-19 2009-09-29 Applied Biosystems, Llc Recombinant reverse transcriptases
US20080004436A1 (en) 2004-11-15 2008-01-03 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Directed Evolution and Selection Using in Vitro Compartmentalization
JPWO2007011045A1 (ja) * 2005-07-20 2009-02-05 株式会社クラレ パージング剤
JP5203200B2 (ja) * 2005-08-10 2013-06-05 アジレント・テクノロジーズ・インク 変異体逆転写酵素および使用方法
DK2074211T3 (da) 2006-09-06 2013-06-17 Medical Res Council DNA polymeraser til inkorporation af farvestof-mærkede nukleotid-analoger
GB0806562D0 (en) * 2008-04-10 2008-05-14 Fermentas Uab Production of nucleic acid

Also Published As

Publication number Publication date
IL208578A (en) 2016-07-31
JP6140792B2 (ja) 2017-05-31
KR102082768B1 (ko) 2020-02-28
CA2721117A1 (en) 2009-10-15
US10358670B2 (en) 2019-07-23
EP3375870A1 (en) 2018-09-19
CN102057039A (zh) 2011-05-11
EP2281035B1 (en) 2015-01-21
JP2018046841A (ja) 2018-03-29
AU2009235368B2 (en) 2014-01-16
KR101828902B1 (ko) 2018-02-13
US20170298403A1 (en) 2017-10-19
JP5642662B2 (ja) 2014-12-17
JP2011516072A (ja) 2011-05-26
JP2014158473A (ja) 2014-09-04
US8580548B2 (en) 2013-11-12
EP3098308B1 (en) 2018-11-14
US20130288925A1 (en) 2013-10-31
US20120156752A1 (en) 2012-06-21
EP2639300A2 (en) 2013-09-18
KR20110065420A (ko) 2011-06-15
US8835148B2 (en) 2014-09-16
IL208578A0 (en) 2010-12-30
WO2009125006A2 (en) 2009-10-15
CN107058258A (zh) 2017-08-18
KR20180016635A (ko) 2018-02-14
PL2281035T3 (pl) 2015-07-31
EP2639300B1 (en) 2017-08-09
KR101653775B1 (ko) 2016-09-05
KR20160062213A (ko) 2016-06-01
US20180298414A1 (en) 2018-10-18
AU2009235368A1 (en) 2009-10-15
US9683251B2 (en) 2017-06-20
JP6473795B2 (ja) 2019-02-20
EP3375870B1 (en) 2020-08-05
EP3098308A1 (en) 2016-11-30
US20110065606A1 (en) 2011-03-17
NZ588468A (en) 2012-10-26
WO2009125006A3 (en) 2010-03-11
JP2016073298A (ja) 2016-05-12
EP2639300A3 (en) 2014-03-26
EP2281035A2 (en) 2011-02-09
IL246396B (en) 2018-04-30
ES2647272T3 (es) 2017-12-20
KR20190016132A (ko) 2019-02-15
JP2017169575A (ja) 2017-09-28
US10287614B2 (en) 2019-05-14
JP6236563B2 (ja) 2017-11-22
KR101947101B1 (ko) 2019-02-12
GB0806562D0 (en) 2008-05-14

Similar Documents

Publication Publication Date Title
SG10201503327QA (en) Production of nucleic acid
EP2285973A4 (en) PROCESS FOR PREPARING METHACRYLIC ACID
ZA201203615B (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
ZA200810206B (en) Microbiological production of 3-hydroxyisobutyric acid
GB0814570D0 (en) Isolation of nucleic acid
PL2539450T3 (pl) Sposób wytwarzania bibliotek kwasu nukleinowego
SG2014014617A (en) Nucleic acid analysis
GB0910302D0 (en) Nucleic acid amplification
EP2545183A4 (en) MONOCATERARY CIRCULAR NUCLEIC ACID PRODUCTION
EP2406209A4 (en) FORMIC ACID PRODUCTION
GB0803109D0 (en) Method of nucleic acid recombination
EP2118297A4 (en) GENERATION OF NUCLEIC ACID MOLECULES
ZA201005964B (en) Production of shaped silica-rich bodies
ZA200905851B (en) Method for the production of acrylic acid
GB2458818B (en) Production of butanol
GB0809169D0 (en) Method of L-lysine production
EP2397543A4 (en) METHOD FOR PRODUCING A DNA TAG
ZA201202210B (en) Improved nucleic acid quantitation method
PL385356A1 (pl) Sposób wytwarzania tadalafilu
GB0905458D0 (en) Method of altering nucleic acids
EP2251329A4 (en) PROCESS FOR THE PRODUCTION OF 3-AMINO-2-CHLORO-6-TRIFLUOROMETHYLPYRIDINE
GB0909660D0 (en) Method of altering nucleic acids
GB0816419D0 (en) Production of hydroelecticity
GB0906906D0 (en) Nucleic acid molecule
EP2448916A4 (en) PRODUCTION OF TRANS-4-AMINOCYCLOPENT-2-ENE-1-CARBOXYLIC ACID DERIVATIVES