SG100767A1 - Sulfonamides for treatment of endothelin-mediated disorders - Google Patents
Sulfonamides for treatment of endothelin-mediated disordersInfo
- Publication number
- SG100767A1 SG100767A1 SG200106591A SG200106591A SG100767A1 SG 100767 A1 SG100767 A1 SG 100767A1 SG 200106591 A SG200106591 A SG 200106591A SG 200106591 A SG200106591 A SG 200106591A SG 100767 A1 SG100767 A1 SG 100767A1
- Authority
- SG
- Singapore
- Prior art keywords
- endothelin
- sulfonamides
- treatment
- mediated disorders
- mediated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/847,797 US5783705A (en) | 1997-04-28 | 1997-04-28 | Process of preparing alkali metal salys of hydrophobic sulfonamides |
US08/938,444 US6248767B1 (en) | 1997-04-28 | 1997-09-26 | Formulation of sulfonamides for treatment of endothelin-mediated disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
SG100767A1 true SG100767A1 (en) | 2003-12-26 |
Family
ID=27126732
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200106590A SG100766A1 (en) | 1997-04-28 | 1998-04-02 | Sulfonamides for treatment of endothelin-mediated disorders |
SG200106591A SG100767A1 (en) | 1997-04-28 | 1998-04-02 | Sulfonamides for treatment of endothelin-mediated disorders |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200106590A SG100766A1 (en) | 1997-04-28 | 1998-04-02 | Sulfonamides for treatment of endothelin-mediated disorders |
Country Status (26)
Country | Link |
---|---|
US (3) | US6432994B1 (zh) |
EP (1) | EP0980369B1 (zh) |
JP (3) | JP3455233B2 (zh) |
CN (2) | CN1179961C (zh) |
AP (1) | AP9901643A0 (zh) |
AT (1) | ATE292129T1 (zh) |
AU (1) | AU749167B2 (zh) |
BR (1) | BR9812258A (zh) |
CA (2) | CA2496680A1 (zh) |
CZ (1) | CZ301452B6 (zh) |
DE (2) | DE69829558T2 (zh) |
EA (1) | EA003993B1 (zh) |
EE (1) | EE04156B1 (zh) |
ES (1) | ES2241133T3 (zh) |
HK (1) | HK1028033A1 (zh) |
HU (1) | HU227183B1 (zh) |
ID (1) | ID25921A (zh) |
IL (2) | IL131318A (zh) |
NO (1) | NO995221L (zh) |
NZ (1) | NZ336898A (zh) |
OA (1) | OA11167A (zh) |
PL (1) | PL197843B1 (zh) |
SG (2) | SG100766A1 (zh) |
SK (1) | SK143399A3 (zh) |
TR (3) | TR200202738T2 (zh) |
WO (1) | WO1998049162A1 (zh) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
JP3050424B2 (ja) * | 1991-07-12 | 2000-06-12 | 塩野義製薬株式会社 | ヒトエンドセリンリセプター |
US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
PL197843B1 (pl) * | 1997-04-28 | 2008-05-30 | Encysive Pharmaceuticals Inc | Farmaceutycznie dopuszczalne sole metali alkalicznych ze związkami sulfonoamidowymi, środek farmaceutyczny, zastosowanie farmaceutycznie dopuszczalnych soli metali alkalicznych ze związkami sulfonoamidowymi, sposób wytwarzania liofilizowanego proszku i sposób wytwarzania farmaceutycznie dopuszczalnych soli metali alkalicznych ze związkami sulfonoamidowymi |
EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE |
CZ302691B6 (cs) | 1998-07-08 | 2011-09-07 | Sanofi - Aventis Deutschland GmbH | N-Arylamidová sloucenina, zpusob její prípravy, farmaceutický prostredek tuto slouceninu obsahující, tato sloucenina pro použití jako aktivátor a pro použití k terapii nebo profylaxi |
EP1533311B1 (en) * | 1999-12-31 | 2007-04-25 | Encysive Pharmaceuticals, Inc | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
WO2001049289A1 (en) * | 1999-12-31 | 2001-07-12 | Texas Biotechnology Corporation | Pharmaceutical and veterinary uses of endothelin antagonists |
HUP0203935A3 (en) * | 1999-12-31 | 2006-02-28 | Encysive Pharmaceuticals Inc H | Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
ATE438637T1 (de) * | 2001-06-11 | 2009-08-15 | Virochem Pharma Inc | Thiophenderivate als antivirale mittel gegen flavivirus-infektion |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
ATE411279T1 (de) * | 2002-01-30 | 2008-10-15 | Amgen Inc | Arylsulfonamidobenzylverbindungen |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
US7402608B2 (en) * | 2002-12-10 | 2008-07-22 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
JPWO2004058826A1 (ja) * | 2002-12-25 | 2006-04-27 | 三菱レイヨン株式会社 | ビニル系重合体、ビニル系重合体の製造方法、熱硬化性被覆用組成物、及び塗料 |
US20060011305A1 (en) * | 2003-09-19 | 2006-01-19 | Donald Sandell | Automated seal applicator |
US7871632B2 (en) | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
EP2546246A3 (en) * | 2005-05-13 | 2013-04-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
AU2011205048B2 (en) * | 2005-05-13 | 2013-05-02 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
US20070219825A1 (en) * | 2005-11-23 | 2007-09-20 | Maetzold Derek J | Method of managing and reducing side effects associated with exposure to a drug |
MX2008011227A (es) * | 2006-03-03 | 2009-02-10 | Torrent Pharmaceuticals Ltd | Receptores antagonistas de accion nueva y doble en los receptores at1 y eta. |
CN101404981A (zh) * | 2006-03-13 | 2009-04-08 | 恩希赛弗制药公司 | 治疗舒张性心力衰竭的方法和组合物 |
MX2008011844A (es) * | 2006-03-13 | 2008-10-02 | Encysive Pharmaceuticals Inc | Formulaciones de sitaxsentano de sodio. |
US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
CA2670260A1 (en) | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
US8357711B2 (en) | 2007-03-23 | 2013-01-22 | Pfizer Limited | Heterocyclic sulfonamides as inhibitors of ion channels |
JP2009026126A (ja) * | 2007-07-20 | 2009-02-05 | Nec Electronics Corp | 半導体装置 |
TW200924768A (en) * | 2007-10-12 | 2009-06-16 | Astrazeneca Ab | Composition |
EP2511263A1 (en) | 2011-04-14 | 2012-10-17 | Phenex Pharmaceuticals AG | Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
US10463656B2 (en) | 2017-01-05 | 2019-11-05 | Iowa State University Research Foundation, Inc. | Methods and compositions for prevention of feedlot bovine respiratory disease |
CN106831736A (zh) * | 2017-02-15 | 2017-06-13 | 浙江华海药业股份有限公司 | 一种制备帕罗西汀杂质的方法 |
GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
WO2020254946A1 (en) | 2019-06-18 | 2020-12-24 | Pfizer Inc. | Benzisoxazole sulfonamide derivatives |
WO2022197658A1 (en) * | 2021-03-15 | 2022-09-22 | The Board Of Trustees Of The University Of Illinois | Compounds, compositions, and methods for treating type 2 diabetes and dementia |
TW202317555A (zh) | 2021-06-22 | 2023-05-01 | 日商亞克醫藥股份有限公司 | 化合物、內皮素a受體拮抗劑及醫藥組合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
Family Cites Families (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB804036A (en) | 1956-03-02 | 1958-11-05 | Hoffmann La Roche | A process for the manufacture of a sulphanilamide of the isoxazole series |
US2888455A (en) | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US3225085A (en) | 1961-09-15 | 1965-12-21 | Monsanto Co | Succinic acid derivatives |
NO117180B (zh) | 1963-12-23 | 1969-07-14 | Shionogi & Co | |
FR1404615A (fr) | 1964-05-22 | 1965-07-02 | Kuhlmann Ets | Nouveaux colorants pour fibres à base de polyesters |
NL128672C (zh) | 1964-08-08 | |||
US3660383A (en) | 1968-08-14 | 1972-05-02 | Shionogi & Co | Production of iodoisoxazole compounds |
US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
GB1473433A (zh) | 1975-10-09 | 1977-05-11 | Banyu Pharmaceutical Co Ltd Hi | |
US4315014A (en) | 1980-09-24 | 1982-02-09 | Warner-Lambert Company | Antibacterial amide compounds and pharmaceutical composition containing the same |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
EP0076072B1 (en) | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulphonamides |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
EP0194548A3 (de) | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US4914112A (en) | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
DE3735555A1 (de) * | 1987-03-07 | 1988-09-15 | Bayer Ag | Aminomethylheterocyclen |
IL87019A (en) * | 1987-07-10 | 1993-07-08 | Hoffmann La Roche | Substituted alkene carboxamides and derivatives, their manufacture and pharmaceutical compositions containing them |
US4752613A (en) | 1987-08-03 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Sulphonamidothienylcarboxylic acid compounds |
US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5464853A (en) | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5112866A (en) * | 1988-09-06 | 1992-05-12 | Ortho Pharmaceutical Corporation | Ethanesulfonamide derivatives |
US4997836A (en) | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
EP0411150B1 (en) | 1989-02-10 | 1996-11-27 | Otsuka Pharmaceutical Co., Ltd. | Indole derivatives, preparation thereof, and drug for preventing and treating nephritis containing same |
US5082838A (en) | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
JPH0347163A (ja) | 1989-06-30 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | アントラキノン誘導体およびその製造 |
US5230999A (en) | 1989-07-24 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Monoclonal antibody to endothelin-3 or precursor thereof and use thereof |
CA2032559C (en) | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
US5284828A (en) | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
CA2043741C (en) | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
CA2056142A1 (en) | 1990-11-27 | 1992-05-28 | Hirotomo Masuya | Pyridopyridazine compounds and their use |
CA2059380A1 (en) | 1991-01-24 | 1992-07-25 | Yiu-Kuen T. Lam | Endothelin receptor antagonists isolated from microbispora |
WO1992012991A1 (en) | 1991-01-29 | 1992-08-06 | Shionogi Seiyaku Kabushiki Kaisha | Triterpene derivative |
US5352659A (en) | 1991-02-15 | 1994-10-04 | Takeda Chemical Industries | Endothelin analogs and uses thereof |
TW270116B (zh) | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
US5382569A (en) | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
FR2679906B1 (fr) | 1991-07-31 | 1995-01-20 | Adir | Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
GB2259450A (en) | 1991-09-11 | 1993-03-17 | Fujisawa Pharmaceutical Co | Compositions with endothelin antagonist activity |
US5198548A (en) | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
FR2687675B1 (fr) | 1992-01-31 | 1997-04-18 | Roussel Uclaf | Nouveaux derives bicycliques de la pyridine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
US5378715A (en) | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
TW224462B (zh) | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
LT3200B (en) | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
US5240910A (en) | 1992-04-17 | 1993-08-31 | Merck & Co., Inc. | Antihypertensive compounds produced by fermentation |
US5514696A (en) | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
NZ247440A (en) | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
WO1993023404A1 (en) | 1992-05-19 | 1993-11-25 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
ES2042421B1 (es) | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina. |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
TW287160B (zh) | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
US5420123A (en) | 1992-12-21 | 1995-05-30 | Bristol-Myers Squibb Company | Dibenzodiazepine endothelin antagonists |
US5352800A (en) | 1993-03-11 | 1994-10-04 | Merck & Co., Inc. | Process for the production of a novel endothelin antagonist |
US5420133A (en) | 1993-03-19 | 1995-05-30 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
US5334598A (en) | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
US5565485A (en) | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
ES2062943B1 (es) | 1993-03-23 | 1995-11-16 | Uriach & Cia Sa J | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
EP0626174A3 (en) | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Method and composition for the prophylaxis and / or treatment of underactive organs. |
US6030991A (en) | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
FR2707089B1 (fr) | 1993-06-30 | 1995-08-18 | Adir | Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5389620A (en) | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
KR960703901A (ko) | 1993-08-19 | 1996-08-31 | 로즈 암스트롱 | 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists) |
US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
US5661152A (en) | 1993-10-15 | 1997-08-26 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6063911A (en) | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
IL111959A (en) | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
JP3328045B2 (ja) | 1994-02-08 | 2002-09-24 | 日清製粉株式会社 | 粉体サンプル調整装置 |
GB9504854D0 (en) | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
DE4440066A1 (de) | 1994-11-10 | 1996-05-15 | Basf Ag | Methin- und Azamethinfarbstoffe auf Basis von Trifluormethylpyridonen |
ES2180664T3 (es) | 1994-12-20 | 2003-02-16 | Hoffmann La Roche | Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina. |
CA2168154A1 (en) | 1995-02-06 | 1996-08-07 | Natesan Murugesan | Substituted biphenyl sulfonamide endothelin antagonists |
US5599811A (en) | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
DE19509950A1 (de) | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
EA199900808A1 (ru) * | 1995-04-04 | 2000-06-26 | Тексаз Байотекнолоджи Корпорейшн | Бифенилсульфонамиды и их производные, модулирующие активность эндотелина |
UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
US5922759A (en) | 1996-06-21 | 1999-07-13 | Warner-Lambert Company | Butenolide endothelin antagonists |
US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
PL326700A1 (en) * | 1995-11-17 | 1998-10-26 | Warner Lambert Co | Sulphonamide-based inhibitors of intercellular substance metaloproteinases |
ATE201202T1 (de) | 1995-12-20 | 2001-06-15 | Yamanouchi Pharma Co Ltd | Arylethensulfonamid-derivate und diese enthaltende medikamente |
US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
ES2205183T3 (es) * | 1996-02-22 | 2004-05-01 | Tularik, Inc. | Pentafluorobencenosulfonamidas y analogos. |
US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US6133263A (en) | 1996-04-10 | 2000-10-17 | Warner-Lambert Company | Endothelin antagonists with ether-linked groups |
AU2529297A (en) | 1996-04-10 | 1997-10-29 | Warner-Lambert Company | Ketoacid endothelin antagonists |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
GB9702194D0 (en) * | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
PL197843B1 (pl) * | 1997-04-28 | 2008-05-30 | Encysive Pharmaceuticals Inc | Farmaceutycznie dopuszczalne sole metali alkalicznych ze związkami sulfonoamidowymi, środek farmaceutyczny, zastosowanie farmaceutycznie dopuszczalnych soli metali alkalicznych ze związkami sulfonoamidowymi, sposób wytwarzania liofilizowanego proszku i sposób wytwarzania farmaceutycznie dopuszczalnych soli metali alkalicznych ze związkami sulfonoamidowymi |
US6313119B1 (en) * | 1998-01-23 | 2001-11-06 | Adventis Pharma Deutschland Gmbh | Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
US6300341B1 (en) * | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6313123B1 (en) * | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
HUP0203935A3 (en) | 1999-12-31 | 2006-02-28 | Encysive Pharmaceuticals Inc H | Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use |
-
1998
- 1998-04-02 PL PL336290A patent/PL197843B1/pl not_active IP Right Cessation
- 1998-04-02 DE DE69829558T patent/DE69829558T2/de not_active Expired - Lifetime
- 1998-04-02 NZ NZ336898A patent/NZ336898A/en unknown
- 1998-04-02 CA CA002496680A patent/CA2496680A1/en not_active Abandoned
- 1998-04-02 SK SK1433-99A patent/SK143399A3/sk unknown
- 1998-04-02 SG SG200106590A patent/SG100766A1/en unknown
- 1998-04-02 CN CNB988046148A patent/CN1179961C/zh not_active Expired - Fee Related
- 1998-04-02 TR TR2002/02738T patent/TR200202738T2/xx unknown
- 1998-04-02 CA CA002281090A patent/CA2281090C/en not_active Expired - Fee Related
- 1998-04-02 EE EEP199900469A patent/EE04156B1/xx not_active IP Right Cessation
- 1998-04-02 IL IL13131898A patent/IL131318A/en not_active IP Right Cessation
- 1998-04-02 TR TR1999/02401T patent/TR199902401T2/xx unknown
- 1998-04-02 CZ CZ0367599A patent/CZ301452B6/cs not_active IP Right Cessation
- 1998-04-02 WO PCT/US1998/006680 patent/WO1998049162A1/en active Application Filing
- 1998-04-02 BR BR9812258-4A patent/BR9812258A/pt not_active Application Discontinuation
- 1998-04-02 AT AT98915281T patent/ATE292129T1/de not_active IP Right Cessation
- 1998-04-02 JP JP54098298A patent/JP3455233B2/ja not_active Expired - Fee Related
- 1998-04-02 TR TR2001/01905T patent/TR200101905T2/xx unknown
- 1998-04-02 HU HU0001442A patent/HU227183B1/hu not_active IP Right Cessation
- 1998-04-02 EP EP98915281A patent/EP0980369B1/en not_active Expired - Lifetime
- 1998-04-02 IL IL15697798A patent/IL156977A/xx not_active IP Right Cessation
- 1998-04-02 ES ES98915281T patent/ES2241133T3/es not_active Expired - Lifetime
- 1998-04-02 SG SG200106591A patent/SG100767A1/en unknown
- 1998-04-02 AP APAP/P/1999/001643A patent/AP9901643A0/en unknown
- 1998-04-02 US US09/403,599 patent/US6432994B1/en not_active Expired - Lifetime
- 1998-04-02 CN CN2004100923126A patent/CN1636994B/zh not_active Expired - Fee Related
- 1998-04-02 EA EA199900966A patent/EA003993B1/ru not_active IP Right Cessation
- 1998-04-02 AU AU69504/98A patent/AU749167B2/en not_active Ceased
- 1998-04-02 DE DE69839534T patent/DE69839534D1/de not_active Expired - Lifetime
- 1998-04-02 ID IDW991119A patent/ID25921A/id unknown
-
1999
- 1999-10-22 OA OA9900233A patent/OA11167A/en unknown
- 1999-10-26 NO NO995221A patent/NO995221L/no unknown
-
2000
- 2000-11-17 HK HK00107366A patent/HK1028033A1/xx not_active IP Right Cessation
-
2001
- 2001-02-23 US US09/792,237 patent/US6458805B2/en not_active Expired - Fee Related
- 2001-12-20 US US10/029,561 patent/US6683103B2/en not_active Expired - Fee Related
-
2002
- 2002-12-04 JP JP2002352236A patent/JP4256150B2/ja not_active Expired - Fee Related
-
2007
- 2007-12-12 JP JP2007320895A patent/JP2008074875A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG100766A1 (en) | Sulfonamides for treatment of endothelin-mediated disorders | |
EE200300214A (et) | Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks | |
HUP0103856A3 (en) | Pharmaceutical composition for the treatment of acute disorders | |
HUP9904525A3 (en) | Pharmaceutical compositions for the treatment of neurological disorders comprising s-(-)-n-propargyl-1-amino indan | |
IL121170A0 (en) | Compositions for the treatment of dermatological disorders | |
PL339425A1 (en) | Treatment of behavioural disorders | |
IL127496A0 (en) | The use of MMP inhibitors for the treatment of ocular angiogenesis | |
EP0991412A4 (en) | AMINOACYL SULFAMIDES FOR TREATING HYPERPROLIFERATIVE DISORDERS | |
EP1126850A4 (en) | TREATMENT OF CONDITIONS OF THE RETINA | |
IL140540A0 (en) | Treatment of anxiety disorders | |
IL131347A0 (en) | Treatment of skin disorders | |
GB2326116B (en) | Treatment of chocolate | |
EP1107778A4 (en) | TREATMENT OF DISEASE CONDITIONS | |
AU2002301228A1 (en) | Sulfonamides for Treatment of Endothelin-mediated Disorders | |
GB9727001D0 (en) | Treatment of movement disorders | |
ZA986324B (en) | Composition for the treatment of immunodeficiency disease | |
GB2332626B (en) | Medicaments for treatment of disorders of the middle ear | |
GB9727275D0 (en) | Medicaments for treatment of disorders of the middle ear | |
GB9713581D0 (en) | Treatment of neuropsychiatric disorders | |
SI1007040T1 (en) | Use of phanquinone for the treatment of alzheimer's disease | |
GB9815188D0 (en) | Treatment of skin disorders | |
GB9821610D0 (en) | Treatment of neuropsychiatric disorders | |
SI0980242T1 (en) | Use of fumaric acid derivatives for the treatment of autoimmune diseases | |
GB2322623B (en) | Treatment of liquid | |
AUPO882597A0 (en) | Pharmaceutical composition for the treatment of skin disorders |