SE9703374D0 - A new combination - Google Patents
A new combinationInfo
- Publication number
- SE9703374D0 SE9703374D0 SE9703374A SE9703374A SE9703374D0 SE 9703374 D0 SE9703374 D0 SE 9703374D0 SE 9703374 A SE9703374 A SE 9703374A SE 9703374 A SE9703374 A SE 9703374A SE 9703374 D0 SE9703374 D0 SE 9703374D0
- Authority
- SE
- Sweden
- Prior art keywords
- combination
- pct
- enantiomer
- cyclobutyl
- sec
- Prior art date
Links
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- -1 R2 is H Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003727 serotonin 1A antagonist Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703374A SE9703374D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
| ZA987810A ZA987810B (en) | 1997-09-18 | 1998-08-27 | A combination of a selective 5HT1A antagonist and a selective h5-HT1B antagonist or partial agonist |
| TW087114345A TW568786B (en) | 1997-09-18 | 1998-08-29 | A combination, pharmaceutical formulation, and kit for use in the treatment of affective disorders |
| PT98944374T PT1021183E (pt) | 1997-09-18 | 1998-09-09 | Combinacao de um antagonista selectivo para 5-htla e de um antagonista selectivo para hs-ht1b ou agonista parcial |
| JP2000511498A JP2001516717A (ja) | 1997-09-18 | 1998-09-09 | 選択的５−ＨＴ１Ａアンタゴニストおよび選択的ｈ５−ＨＴ１Ｂアンタゴニストまたは部分的アゴニストの組み合わせ |
| TR2000/00734T TR200000734T2 (tr) | 1997-09-18 | 1998-09-09 | Seçici bir 5-HT1A/5-HT1B antagonistinin veya kısmi antagonistinin bir bileşimi. |
| PL98339370A PL339370A1 (en) | 1997-09-18 | 1998-09-09 | Composition containing selective antagonist of 5-ht 1a and selective antagonist or partial agonist of h5-ht 1b |
| SK284-2000A SK2842000A3 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVEì (54) H5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| HU0100401A HUP0100401A3 (en) | 1997-09-18 | 1998-09-09 | Medicaments containing a combination of a selective 5-ht1a antagonist and a selective h5-ht1b antagonist or partial agonist, and method for producing |
| CA002302383A CA2302383A1 (en) | 1997-09-18 | 1998-09-09 | A combination of a selective 5-ht1a antagonist and a selective h5-ht1b antagonist or partial agonist |
| IL13477498A IL134774A0 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| CNB988112493A CN1182847C (zh) | 1997-09-18 | 1998-09-09 | 选择性5－HT1A拮抗剂和选择性h5－HT1B拮抗剂或部分激动剂的联用产品 |
| RU2000109558/14A RU2215528C2 (ru) | 1997-09-18 | 1998-09-09 | Комбинация селективного антагониста 5-нт1a и селективного антагониста или частичного агониста н5-нт1b |
| SI9830629T SI1021183T1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| AT98944374T ATE261728T1 (de) | 1997-09-18 | 1998-09-09 | Kombination eines selektiven 5-ht1a antagonisten und eines selektiven h5-ht1b antagonisten oder partiellen agonisten |
| BR9812234-7A BR9812234A (pt) | 1997-09-18 | 1998-09-09 | Combinação de componentes, uso desta, processos para a preparação da mesma, para o tratamento de distúrbios afetivos, para o tratamento de depressão, e para melhorar o inìcio de ação terapêutica, formulação farmacêutica, e, kit |
| NZ503174A NZ503174A (en) | 1997-09-18 | 1998-09-09 | A synergistic combination of a benzopyran selective 5-HT 1A antagonist and a selective h5-HT 1B antagonist or partial agonist |
| EEP200000143A EE04142B1 (et) | 1997-09-18 | 1998-09-09 | Selektiivse 5-HT 1A antagonisti kombinatsioon selektiivse h5-HT 1B antagonisti või osalise agonistiga |
| ES98944374T ES2216307T3 (es) | 1997-09-18 | 1998-09-09 | Una combinacion de un antagonista de 5-ht1a selectivo y un antagonista o agonista parcial de h5-ht1b selectivo. |
| AU91929/98A AU752718B2 (en) | 1997-09-18 | 1998-09-09 | A combination of a selective 5-HT1A antagonist and a selective h5-HT1B antagonist or partial agonist |
| PCT/SE1998/001600 WO1999013876A1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| US09/171,581 US6159972A (en) | 1997-09-18 | 1998-09-09 | Combination of a selective 5-HT1A antagonist and a selective ub. h5-HT.s1B antagonist or partial agonist |
| HK00107467.9A HK1032740B (en) | 1997-09-18 | 1998-09-09 | A combination of a selective 5-ht1a antagonist and a selective h5-ht1b antagonist or partial agonist |
| EP98944374A EP1021183B1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| KR1020007002821A KR20010024075A (ko) | 1997-09-18 | 1998-09-09 | 선택적 5-ＨＴ1Ａ 길항제 및 선택적 ｈ5-ＨＴ1Ｂ 길항제또는 부분 작용제의 배합물 |
| DE69822490T DE69822490T2 (de) | 1997-09-18 | 1998-09-09 | KOMBINATION EINES SELEKTIVEN 5-HT1A ANTAGONISTEN UND EINES SELEKTIVEN h5-HT1B ANTAGONISTEN ODER PARTIELLEN AGONISTEN |
| DK98944374T DK1021183T3 (da) | 1997-09-18 | 1998-09-09 | En kombination af en selektiv 5-HT 1A-antagonist og en selektiv h5-HT 1B-antagonist eller partiel antagonist |
| MYPI98004226A MY116281A (en) | 1997-09-18 | 1998-09-16 | A combination of a selective 5-ht 1a antagonist and a selective h5-ht 1b antagonist or partial agonist. |
| ARP980104633A AR015447A1 (es) | 1997-09-18 | 1998-09-17 | COMBINACIoN DE UN ANTAGONISTA DE 5HT1A SELECTIVO Y UN ANTAGONISTA O AGONISTA PARCIAL DE H5-HT1B SELECTIVO, PROCESO PARA SU PREPARACIoN, FORMULACIONES FARMACÉUTICAS QUE LO CONTIENEN, SU USO PARA LA MANUFACTURA DE UN MEDICAMENTO PARA EL TRATAMIENTO DE TRASTORNOS AFECTIVOS Y KIT QUE CONTIENE DICHA COMB |
| IS5408A IS5408A (is) | 1997-09-18 | 2000-03-15 | Samsetning valvísra 5-HT1A mótlyfja og valvíss h5-HT1B mótlyfs eða gerandefnis með hlutaverkun |
| NO20001398A NO20001398L (no) | 1997-09-18 | 2000-03-17 | Kombinasjon av en 5-HT1A antagonist og en selektiv h5-HT1B antagonist eller partial antagonist |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703374A SE9703374D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9703374D0 true SE9703374D0 (sv) | 1997-09-18 |
Family
ID=20408294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9703374A SE9703374D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6159972A (https=) |
| EP (1) | EP1021183B1 (https=) |
| JP (1) | JP2001516717A (https=) |
| KR (1) | KR20010024075A (https=) |
| CN (1) | CN1182847C (https=) |
| AR (1) | AR015447A1 (https=) |
| AT (1) | ATE261728T1 (https=) |
| AU (1) | AU752718B2 (https=) |
| BR (1) | BR9812234A (https=) |
| CA (1) | CA2302383A1 (https=) |
| DE (1) | DE69822490T2 (https=) |
| DK (1) | DK1021183T3 (https=) |
| EE (1) | EE04142B1 (https=) |
| ES (1) | ES2216307T3 (https=) |
| HU (1) | HUP0100401A3 (https=) |
| IL (1) | IL134774A0 (https=) |
| IS (1) | IS5408A (https=) |
| MY (1) | MY116281A (https=) |
| NO (1) | NO20001398L (https=) |
| NZ (1) | NZ503174A (https=) |
| PL (1) | PL339370A1 (https=) |
| PT (1) | PT1021183E (https=) |
| RU (1) | RU2215528C2 (https=) |
| SE (1) | SE9703374D0 (https=) |
| SK (1) | SK2842000A3 (https=) |
| TR (1) | TR200000734T2 (https=) |
| TW (1) | TW568786B (https=) |
| WO (1) | WO1999013876A1 (https=) |
| ZA (1) | ZA987810B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| SE9703375D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | A new combination |
| WO2002066454A1 (fr) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Derives de chromene |
| ATE424825T1 (de) * | 2001-07-20 | 2009-03-15 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| USD969016S1 (en) | 2021-06-28 | 2022-11-08 | Koninklijke Asscher Diamant Maatschappij B.V. | Rose oval diamond article |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA90673B (en) * | 1989-02-02 | 1990-10-31 | Yamanouchi Pharma Co Ltd | Tetrahydrobenzimidazole derivatives |
| PT533268E (pt) * | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
| GB9410512D0 (en) * | 1994-05-25 | 1994-07-13 | Smithkline Beecham Plc | Novel treatment |
| SE9501567D0 (sv) * | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| FI961247A0 (fi) * | 1996-03-18 | 1996-03-18 | Finnish Peroxides Ab Oy | Foerfarande foer loesning av uppsvaellningsproblem i en avfalls vattenreningsanordning foer kontroll av traodartiga bakterier |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703374A patent/SE9703374D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987810A patent/ZA987810B/xx unknown
- 1998-08-29 TW TW087114345A patent/TW568786B/zh not_active IP Right Cessation
- 1998-09-09 US US09/171,581 patent/US6159972A/en not_active Expired - Fee Related
- 1998-09-09 CN CNB988112493A patent/CN1182847C/zh not_active Expired - Fee Related
- 1998-09-09 ES ES98944374T patent/ES2216307T3/es not_active Expired - Lifetime
- 1998-09-09 AT AT98944374T patent/ATE261728T1/de not_active IP Right Cessation
- 1998-09-09 PT PT98944374T patent/PT1021183E/pt unknown
- 1998-09-09 RU RU2000109558/14A patent/RU2215528C2/ru not_active IP Right Cessation
- 1998-09-09 NZ NZ503174A patent/NZ503174A/en unknown
- 1998-09-09 BR BR9812234-7A patent/BR9812234A/pt not_active IP Right Cessation
- 1998-09-09 EE EEP200000143A patent/EE04142B1/xx not_active IP Right Cessation
- 1998-09-09 HU HU0100401A patent/HUP0100401A3/hu unknown
- 1998-09-09 CA CA002302383A patent/CA2302383A1/en not_active Abandoned
- 1998-09-09 KR KR1020007002821A patent/KR20010024075A/ko not_active Ceased
- 1998-09-09 SK SK284-2000A patent/SK2842000A3/sk unknown
- 1998-09-09 JP JP2000511498A patent/JP2001516717A/ja active Pending
- 1998-09-09 DE DE69822490T patent/DE69822490T2/de not_active Expired - Fee Related
- 1998-09-09 PL PL98339370A patent/PL339370A1/xx unknown
- 1998-09-09 EP EP98944374A patent/EP1021183B1/en not_active Expired - Lifetime
- 1998-09-09 AU AU91929/98A patent/AU752718B2/en not_active Ceased
- 1998-09-09 TR TR2000/00734T patent/TR200000734T2/xx unknown
- 1998-09-09 WO PCT/SE1998/001600 patent/WO1999013876A1/en not_active Ceased
- 1998-09-09 IL IL13477498A patent/IL134774A0/xx unknown
- 1998-09-09 DK DK98944374T patent/DK1021183T3/da active
- 1998-09-16 MY MYPI98004226A patent/MY116281A/en unknown
- 1998-09-17 AR ARP980104633A patent/AR015447A1/es unknown
-
2000
- 2000-03-15 IS IS5408A patent/IS5408A/is unknown
- 2000-03-17 NO NO20001398A patent/NO20001398L/no not_active Application Discontinuation
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