HUP0100401A2 - Szelektív 5-HT1A antagonista és szelektív h5-HT1B antagonista vagy parciális agonista kombinációját tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents
Szelektív 5-HT1A antagonista és szelektív h5-HT1B antagonista vagy parciális agonista kombinációját tartalmazó gyógyszerkészítmények és eljárás előállításukraInfo
- Publication number
- HUP0100401A2 HUP0100401A2 HU0100401A HUP0100401A HUP0100401A2 HU P0100401 A2 HUP0100401 A2 HU P0100401A2 HU 0100401 A HU0100401 A HU 0100401A HU P0100401 A HUP0100401 A HU P0100401A HU P0100401 A2 HUP0100401 A2 HU P0100401A2
- Authority
- HU
- Hungary
- Prior art keywords
- selective
- antagonist
- combination
- group
- partial agonist
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000004031 partial agonist Substances 0.000 title abstract 2
- 239000003727 serotonin 1A antagonist Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 morpholino, morpholino-carbonyl Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgyát egy általános képletű szelektív 5-HT1A antagonista- ahol R1 propil- vagy ciklobutilcsoport; R2 izopropil-, terc-butil-vagy cikloalkilcsoport; R3 hidrogénatom; és R4 hidrogénatom.vagymetilcsoport - és egy általános képletű szelektív h5-HT1B antagonistavagy parciális agonista - ahol X metincsoport vagy oxigénatom; R1hidrogénatom, alkil- vagy cikloalkilcsoport; R2 hidrogén- vagyhalogénatom, alkil- vagy alkoxicsoport; R3 morfolino-, morfolino-karbonil-, 4-oxo-piperidino-, trifluor-metil- vagy karbamoilcsoport -kombinációját tartalmazó termék és előállítása, a kombinációttartalmazó gyógyszerkészítmény és alkalmazásuk képezik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703374A SE9703374D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
| PCT/SE1998/001600 WO1999013876A1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100401A2 true HUP0100401A2 (hu) | 2002-01-28 |
| HUP0100401A3 HUP0100401A3 (en) | 2003-01-28 |
Family
ID=20408294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100401A HUP0100401A3 (en) | 1997-09-18 | 1998-09-09 | Medicaments containing a combination of a selective 5-ht1a antagonist and a selective h5-ht1b antagonist or partial agonist, and method for producing |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6159972A (hu) |
| EP (1) | EP1021183B1 (hu) |
| JP (1) | JP2001516717A (hu) |
| KR (1) | KR20010024075A (hu) |
| CN (1) | CN1182847C (hu) |
| AR (1) | AR015447A1 (hu) |
| AT (1) | ATE261728T1 (hu) |
| AU (1) | AU752718B2 (hu) |
| BR (1) | BR9812234A (hu) |
| CA (1) | CA2302383A1 (hu) |
| DE (1) | DE69822490T2 (hu) |
| DK (1) | DK1021183T3 (hu) |
| EE (1) | EE04142B1 (hu) |
| ES (1) | ES2216307T3 (hu) |
| HK (1) | HK1032740A1 (hu) |
| HU (1) | HUP0100401A3 (hu) |
| IL (1) | IL134774A0 (hu) |
| IS (1) | IS5408A (hu) |
| MY (1) | MY116281A (hu) |
| NO (1) | NO20001398L (hu) |
| NZ (1) | NZ503174A (hu) |
| PL (1) | PL339370A1 (hu) |
| PT (1) | PT1021183E (hu) |
| RU (1) | RU2215528C2 (hu) |
| SE (1) | SE9703374D0 (hu) |
| SK (1) | SK2842000A3 (hu) |
| TR (1) | TR200000734T2 (hu) |
| TW (1) | TW568786B (hu) |
| WO (1) | WO1999013876A1 (hu) |
| ZA (1) | ZA987810B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2002066454A1 (en) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Chromene derivatives |
| WO2003007956A1 (en) * | 2001-07-20 | 2003-01-30 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| USD969017S1 (en) | 2021-06-28 | 2022-11-08 | Koninklijke Asscher Diamant Maatschappij B.V. | Rose marquise diamond article |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9410512D0 (en) * | 1994-05-25 | 1994-07-13 | Smithkline Beecham Plc | Novel treatment |
| SE9501567D0 (sv) * | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| FI961247A0 (fi) * | 1996-03-18 | 1996-03-18 | Finnish Peroxides Ab Oy | Foerfarande foer loesning av uppsvaellningsproblem i en avfalls vattenreningsanordning foer kontroll av traodartiga bakterier |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703374A patent/SE9703374D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987810A patent/ZA987810B/xx unknown
- 1998-08-29 TW TW087114345A patent/TW568786B/zh not_active IP Right Cessation
- 1998-09-09 AT AT98944374T patent/ATE261728T1/de not_active IP Right Cessation
- 1998-09-09 WO PCT/SE1998/001600 patent/WO1999013876A1/en not_active Application Discontinuation
- 1998-09-09 DE DE69822490T patent/DE69822490T2/de not_active Expired - Fee Related
- 1998-09-09 NZ NZ503174A patent/NZ503174A/en unknown
- 1998-09-09 IL IL13477498A patent/IL134774A0/xx unknown
- 1998-09-09 DK DK98944374T patent/DK1021183T3/da active
- 1998-09-09 CA CA002302383A patent/CA2302383A1/en not_active Abandoned
- 1998-09-09 HU HU0100401A patent/HUP0100401A3/hu unknown
- 1998-09-09 EP EP98944374A patent/EP1021183B1/en not_active Expired - Lifetime
- 1998-09-09 JP JP2000511498A patent/JP2001516717A/ja active Pending
- 1998-09-09 TR TR2000/00734T patent/TR200000734T2/xx unknown
- 1998-09-09 CN CNB988112493A patent/CN1182847C/zh not_active Expired - Fee Related
- 1998-09-09 RU RU2000109558/14A patent/RU2215528C2/ru not_active IP Right Cessation
- 1998-09-09 PL PL98339370A patent/PL339370A1/xx unknown
- 1998-09-09 ES ES98944374T patent/ES2216307T3/es not_active Expired - Lifetime
- 1998-09-09 EE EEP200000143A patent/EE04142B1/xx not_active IP Right Cessation
- 1998-09-09 US US09/171,581 patent/US6159972A/en not_active Expired - Fee Related
- 1998-09-09 KR KR1020007002821A patent/KR20010024075A/ko not_active Application Discontinuation
- 1998-09-09 AU AU91929/98A patent/AU752718B2/en not_active Ceased
- 1998-09-09 SK SK284-2000A patent/SK2842000A3/sk unknown
- 1998-09-09 BR BR9812234-7A patent/BR9812234A/pt not_active IP Right Cessation
- 1998-09-09 PT PT98944374T patent/PT1021183E/pt unknown
- 1998-09-16 MY MYPI98004226A patent/MY116281A/en unknown
- 1998-09-17 AR ARP980104633A patent/AR015447A1/es unknown
-
2000
- 2000-03-15 IS IS5408A patent/IS5408A/is unknown
- 2000-03-17 NO NO20001398A patent/NO20001398L/no not_active Application Discontinuation
- 2000-11-22 HK HK00107467A patent/HK1032740A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW347387B (en) | Piperidine derivatives | |
| CY2488B1 (en) | New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for trea. | |
| HUP0001192A2 (hu) | Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására | |
| HUP0300616A2 (hu) | Adamantánszármazékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0204587A2 (en) | 6-position substituted indoline, production and use thereof as a medicament | |
| HUP0100199A2 (hu) | Anilid-származékot tartalmazó gyógyászati készítmény CCR5 antagonizálására | |
| HUP0004595A2 (hu) | Aciklikus metalloproteáz inhibitorok | |
| BR0016543A (pt) | Novos derivados de piperidina e piperazina | |
| MY123193A (en) | Novel 2-(iminomethyl)amino-phenyl derivatives,preparation,application as medicines and compositions containing same | |
| KR100263496B1 (ko) | 탁솔 유도체 및 이의 제조방법 | |
| DK1499590T3 (da) | Piperidinderivater som kaliumkanalblokkere | |
| DE69503803D1 (de) | 3,5-dioxo-(2h,4h)-1,2,4-triazinderivate ihre herstellung und verwendung als medikament | |
| MY124146A (en) | Novel 2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same | |
| HUP0204246A2 (hu) | Új tiazolo[4,5-d]pirimidin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0402261A2 (hu) | Piperidinszármazékok és alkalmazásuk kemokin receptor aktivitás modulátoraiként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0303118A2 (hu) | Új 1,3-dihidro-2H-indolon-származékok, előállítási eljárásuk és azokat tartalmazó gyógyszerkészítmények | |
| NZ313185A (en) | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives | |
| HUP0402675A2 (hu) | HIV integráz inhibitor hatású hidroxilaminszármazékok, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| MX9803827A (es) | Derivados de quinolina antimalaria. | |
| HUP9801950A2 (hu) | 2-(Aril-fenil-amino)-imidazolin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0204354A2 (hu) | Új heterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0100401A2 (hu) | Szelektív 5-HT1A antagonista és szelektív h5-HT1B antagonista vagy parciális agonista kombinációját tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
| EP0825189A4 (en) | 1,4-BENZODIOXIN DERIVATIVES | |
| HUP0204394A2 (en) | Novel tetrahydropyridines, preparation method and pharmaceutical compositions containing same | |
| HUP0202728A2 (hu) | Eljárás fenil-ecetsav-származékok előállítására |