HUP0202728A2 - Eljárás fenil-ecetsav-származékok előállítására - Google Patents
Eljárás fenil-ecetsav-származékok előállításáraInfo
- Publication number
- HUP0202728A2 HUP0202728A2 HU0202728A HUP0202728A HUP0202728A2 HU P0202728 A2 HUP0202728 A2 HU P0202728A2 HU 0202728 A HU0202728 A HU 0202728A HU P0202728 A HUP0202728 A HU P0202728A HU P0202728 A2 HUP0202728 A2 HU P0202728A2
- Authority
- HU
- Hungary
- Prior art keywords
- fluorine
- hydrogen
- chlorine
- methyl
- general formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 1
- 229910052731 fluorine Chemical group 0.000 abstract 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 5
- 239000011737 fluorine Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
- C07C211/56—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány (I) általános képletű vegyületek - amelyek képletében Rjelentése metil- vagy etilcsoport; R1 jelentése klór- vagy fluoratom;R2 jelentése hidrogén- vagy fluoratom; R3 jelentése hidrogén-, fluor-,klóratom, metil-, etil-, metoxi-, etoxi- vagy hidroxicsoport; R4jelentése hidrogén- vagy fluoratom; és R5 jelentése klór-, fluoratom,trifluor-metil- vagy metilcsoport; azzal a megkötéssel, hogy R1, R2,R4 és R5 mindegyike nem jelenthet fluoratomot, ha R jelentéseetilcsoport, és R3 jelentése hidrogénatom - és gyógyászatilagelfogadható sóik, valamint gyógyászatilag elfogadható prodrog-észtereik előállítási eljárásaira vonatkozik, amelynek során egy (II)általános képletű laktámot - amelynek képletében R, Rl, R2, R3, R4 ésR5 jelentése a fentiekben meghatározott - egy bázissal hasítanak. Atalálmány kiterjed a találmány szerinti eljárás prekurzoraira és ezekelőállítási eljárásaira is. Az (I) általános képletű vegyületekgyógyászati hatóanyagok, amely a ciklooxigenáz II szelektívinhibitorai. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922830.6A GB9922830D0 (en) | 1999-09-27 | 1999-09-27 | Processes |
| PCT/EP2000/009346 WO2001023346A2 (en) | 1999-09-27 | 2000-09-25 | Process for phenylacetic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0202728A2 true HUP0202728A2 (hu) | 2002-12-28 |
| HUP0202728A3 HUP0202728A3 (en) | 2003-11-28 |
Family
ID=10861676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202728A HUP0202728A3 (en) | 1999-09-27 | 2000-09-25 | Process for preparation of phenylacetic acid derivatives |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US20080249318A1 (hu) |
| EP (2) | EP2275403A1 (hu) |
| JP (1) | JP2003510303A (hu) |
| KR (1) | KR100745341B1 (hu) |
| CN (1) | CN100412053C (hu) |
| AR (2) | AR031529A1 (hu) |
| AT (1) | ATE447547T1 (hu) |
| AU (1) | AU775416B2 (hu) |
| BR (1) | BR0014314A (hu) |
| CA (1) | CA2379553C (hu) |
| CO (1) | CO5210865A1 (hu) |
| CY (1) | CY1110539T1 (hu) |
| CZ (1) | CZ20021027A3 (hu) |
| DE (1) | DE60043261D1 (hu) |
| DK (1) | DK1216226T3 (hu) |
| EC (2) | ECSP003680A (hu) |
| ES (1) | ES2338209T3 (hu) |
| GB (1) | GB9922830D0 (hu) |
| HK (1) | HK1047739A1 (hu) |
| HU (1) | HUP0202728A3 (hu) |
| IL (2) | IL148330A0 (hu) |
| MY (1) | MY125201A (hu) |
| NO (1) | NO327912B1 (hu) |
| NZ (1) | NZ517461A (hu) |
| PE (1) | PE20010644A1 (hu) |
| PL (1) | PL207777B1 (hu) |
| PT (1) | PT1216226E (hu) |
| RU (1) | RU2273628C2 (hu) |
| SI (1) | SI1216226T1 (hu) |
| SK (1) | SK287241B6 (hu) |
| TR (1) | TR200200745T2 (hu) |
| TW (1) | TWI270540B (hu) |
| WO (1) | WO2001023346A2 (hu) |
| ZA (1) | ZA200202367B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0209257D0 (en) * | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| EP1539134A4 (en) | 2002-06-11 | 2007-04-11 | Nitromed Inc | SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE |
| GB0224198D0 (en) * | 2002-10-17 | 2002-11-27 | Novartis Ag | Organic compounds |
| PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| US7161026B1 (en) | 2005-07-08 | 2007-01-09 | Property Development Corporation International, Ltd, Inc. | Method of preparation of methyl-benzyl-ketone |
| AR061623A1 (es) | 2006-06-26 | 2008-09-10 | Novartis Ag | Derivados de acido fenilacetico |
| WO2010056741A2 (en) | 2008-11-12 | 2010-05-20 | Auspex Pharmaceuticals, Inc. | Phenylacetic acid inhibitors of cyclooxygenase |
| CN102311355B (zh) * | 2011-09-26 | 2014-02-05 | 扬州天和药业有限公司 | 罗本考昔的一种制备方法 |
| CN107721901A (zh) * | 2017-11-12 | 2018-02-23 | 刘磊 | 一种2‑[2‑(2,3,5,6‑四氟苯胺基)苯基]乙酸的制备方法 |
| EA202190330A1 (ru) | 2018-07-27 | 2021-06-04 | КРКА, д.д., НОВО МЕСТО | Способ получения полиморфной формы робенакоксиба |
| KR20210041579A (ko) * | 2018-08-03 | 2021-04-15 | 닛산 가가쿠 가부시키가이샤 | 불화 방향족 제2급 아민 화합물의 제조 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| IT1097265B (it) | 1978-06-23 | 1985-08-31 | Acraf | Nouva sintesi di un acido fenilacetico |
| JPS5677246A (en) * | 1980-11-27 | 1981-06-25 | Nissan Chem Ind Ltd | Production of substituted phenylacetic acid |
| DE3404401C2 (de) | 1984-02-08 | 1994-02-10 | Hoechst Ag | Verwendung von Aryloxy-Verbindungen als Antidots |
| FR2578836B1 (fr) | 1985-03-12 | 1987-04-17 | Rhone Poulenc Spec Chim | Procede de chloration selective de composes phenoliques |
| DE58908857D1 (de) * | 1989-01-27 | 1995-02-16 | Heumann Pharma Gmbh & Co | Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten. |
| IT1248032B (it) * | 1991-06-11 | 1995-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina. |
| CN1091420A (zh) * | 1993-02-25 | 1994-08-31 | 永信药品工业股份有限公司 | 二苯胺衍生物的制备方法 |
| JPH0789951A (ja) | 1993-06-03 | 1995-04-04 | Sterling Winthrop Inc | インターロイキン−１β転換酵素阻害剤 |
| US5475139A (en) | 1993-10-22 | 1995-12-12 | Yung Shin Pharm. Ind. Co., Ltd. | Method for the preparation of substituted derivatives of diphenyl amine |
| MX9605196A (es) | 1994-04-29 | 1997-12-31 | Sanofi Winthrop Inc | Halometilamidas como inhibidores de la proteasa il-1b. |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| JPH0977664A (ja) * | 1995-09-13 | 1997-03-25 | Yakult Honsha Co Ltd | シクロオキシゲナーゼ−２特異的阻害剤及び抗炎症剤 |
| US6355680B1 (en) | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| US6034266A (en) | 1996-03-11 | 2000-03-07 | Fundacao Oswaldo Cruz-Fiocruz | Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses |
| BR9600975A (pt) * | 1996-03-11 | 1997-12-30 | Fundacao Oswaldo Cruz | Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas |
| CA2208900C (en) | 1996-07-18 | 2006-08-01 | Lonza Ag | Process for preparing 2-pyrimidinecarboxylates |
| US5817877A (en) | 1996-09-23 | 1998-10-06 | Yale University | Metal-catalyzed amination of organic sulfonates to organic amines |
| CO4960662A1 (es) * | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
-
1999
- 1999-09-27 GB GBGB9922830.6A patent/GB9922830D0/en not_active Ceased
-
2000
- 2000-09-25 AU AU79067/00A patent/AU775416B2/en not_active Ceased
- 2000-09-25 RU RU2002109239/04A patent/RU2273628C2/ru not_active IP Right Cessation
- 2000-09-25 DK DK00969292.2T patent/DK1216226T3/da active
- 2000-09-25 SI SI200031050T patent/SI1216226T1/sl unknown
- 2000-09-25 NZ NZ517461A patent/NZ517461A/en not_active IP Right Cessation
- 2000-09-25 AR ARP000105014A patent/AR031529A1/es active IP Right Grant
- 2000-09-25 EP EP09171648A patent/EP2275403A1/en not_active Withdrawn
- 2000-09-25 SK SK414-2002A patent/SK287241B6/sk not_active IP Right Cessation
- 2000-09-25 IL IL14833000A patent/IL148330A0/xx active IP Right Grant
- 2000-09-25 PE PE2000001007A patent/PE20010644A1/es not_active Application Discontinuation
- 2000-09-25 TR TR2002/00745T patent/TR200200745T2/xx unknown
- 2000-09-25 EC EC2000003680A patent/ECSP003680A/es unknown
- 2000-09-25 ES ES00969292T patent/ES2338209T3/es not_active Expired - Lifetime
- 2000-09-25 CA CA2379553A patent/CA2379553C/en not_active Expired - Fee Related
- 2000-09-25 WO PCT/EP2000/009346 patent/WO2001023346A2/en active IP Right Grant
- 2000-09-25 EP EP00969292A patent/EP1216226B1/en not_active Expired - Lifetime
- 2000-09-25 BR BR0014314-6A patent/BR0014314A/pt not_active IP Right Cessation
- 2000-09-25 CZ CZ20021027A patent/CZ20021027A3/cs unknown
- 2000-09-25 CN CNB008133972A patent/CN100412053C/zh not_active Expired - Fee Related
- 2000-09-25 PT PT00969292T patent/PT1216226E/pt unknown
- 2000-09-25 AT AT00969292T patent/ATE447547T1/de active
- 2000-09-25 PL PL365994A patent/PL207777B1/pl unknown
- 2000-09-25 HU HU0202728A patent/HUP0202728A3/hu unknown
- 2000-09-25 DE DE60043261T patent/DE60043261D1/de not_active Expired - Lifetime
- 2000-09-25 JP JP2001526501A patent/JP2003510303A/ja active Pending
- 2000-09-25 KR KR1020027003901A patent/KR100745341B1/ko not_active IP Right Cessation
- 2000-09-26 MY MYPI20004481 patent/MY125201A/en unknown
- 2000-09-27 CO CO00073348A patent/CO5210865A1/es not_active Application Discontinuation
- 2000-09-27 TW TWPROCESSFA patent/TWI270540B/zh not_active IP Right Cessation
-
2002
- 2002-02-21 IL IL148330A patent/IL148330A/en not_active IP Right Cessation
- 2002-03-19 NO NO20021368A patent/NO327912B1/no not_active IP Right Cessation
- 2002-03-25 ZA ZA200202367A patent/ZA200202367B/en unknown
- 2002-12-23 HK HK02109296.0A patent/HK1047739A1/xx not_active IP Right Cessation
-
2003
- 2003-01-10 AR ARP030100070A patent/AR042404A2/es unknown
-
2007
- 2007-08-16 US US11/893,481 patent/US20080249318A1/en not_active Abandoned
-
2009
- 2009-01-13 EC EC2009003680A patent/ECSP093680A/es unknown
- 2009-05-07 US US12/436,991 patent/US7906677B2/en not_active Expired - Fee Related
-
2010
- 2010-02-03 CY CY20101100105T patent/CY1110539T1/el unknown
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