SE9702001D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9702001D0
SE9702001D0 SE9702001A SE9702001A SE9702001D0 SE 9702001 D0 SE9702001 D0 SE 9702001D0 SE 9702001 A SE9702001 A SE 9702001A SE 9702001 A SE9702001 A SE 9702001A SE 9702001 D0 SE9702001 D0 SE 9702001D0
Authority
SE
Sweden
Prior art keywords
novel compounds
pyrimidinediones
thieno
processes
production
Prior art date
Application number
SE9702001A
Other languages
English (en)
Swedish (sv)
Inventor
David Cheshire
Andrew Cooke
Martin Cooper
David Donald
Mark Furber
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9702001A priority Critical patent/SE9702001D0/xx
Publication of SE9702001D0 publication Critical patent/SE9702001D0/xx
Priority to KR1019997011086A priority patent/KR100561988B1/ko
Priority to BR9809481-5A priority patent/BR9809481A/pt
Priority to SK1513-99A priority patent/SK283589B6/sk
Priority to US09/117,426 priority patent/US6180635B1/en
Priority to DE69808765T priority patent/DE69808765T2/de
Priority to EP98924705A priority patent/EP0991653B1/en
Priority to HU0003355A priority patent/HU226627B1/hu
Priority to JP50056599A priority patent/JP2002500666A/ja
Priority to DK98924705T priority patent/DK0991653T3/da
Priority to CA002289509A priority patent/CA2289509C/en
Priority to UA99127140A priority patent/UA61111C2/ru
Priority to PL337126A priority patent/PL199567B1/pl
Priority to IDW991450A priority patent/ID28432A/id
Priority to PCT/SE1998/000935 priority patent/WO1998054190A1/en
Priority to AU76808/98A priority patent/AU723708B2/en
Priority to NZ500853A priority patent/NZ500853A/en
Priority to PT98924705T priority patent/PT991653E/pt
Priority to ES98924705T priority patent/ES2184270T3/es
Priority to CN98807378A priority patent/CN1122037C/zh
Priority to EEP199900539A priority patent/EE04018B1/xx
Priority to AT98924705T priority patent/ATE226205T1/de
Priority to TR1999/02904T priority patent/TR199902904T2/xx
Priority to RU99128111/04A priority patent/RU2225410C2/ru
Priority to CZ0420199A priority patent/CZ297536B6/cs
Priority to IL13276398A priority patent/IL132763A0/xx
Priority to IL132763A priority patent/IL132763A/en
Priority to IS5264A priority patent/IS1983B/is
Priority to NO19995810A priority patent/NO323752B1/no
Priority to US09/693,896 priority patent/US6342502B1/en
Priority to US09/977,944 priority patent/US6469014B1/en
Priority to US10/265,201 priority patent/US6984644B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Liquid Crystal (AREA)
SE9702001A 1997-05-28 1997-05-28 Novel compounds SE9702001D0 (sv)

Priority Applications (32)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds
BR9809481-5A BR9809481A (pt) 1997-05-28 1998-05-18 Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente
PCT/SE1998/000935 WO1998054190A1 (en) 1997-05-28 1998-05-18 Novel compounds
PT98924705T PT991653E (pt) 1997-05-28 1998-05-18 Novos compostos
AU76808/98A AU723708B2 (en) 1997-05-28 1998-05-18 Novel compounds
US09/117,426 US6180635B1 (en) 1997-05-28 1998-05-18 Compounds
DE69808765T DE69808765T2 (de) 1997-05-28 1998-05-18 Verbindungen
EP98924705A EP0991653B1 (en) 1997-05-28 1998-05-18 Novel compounds
HU0003355A HU226627B1 (en) 1997-05-28 1998-05-18 Thieno[2,3-d]pyrimidinedione derivatives and pharmaceutical compositions containing them, process for their preparation and use thereof
JP50056599A JP2002500666A (ja) 1997-05-28 1998-05-18 新規な化合物
DK98924705T DK0991653T3 (da) 1997-05-28 1998-05-18 Nye forbindelser
CA002289509A CA2289509C (en) 1997-05-28 1998-05-18 Novel compounds
UA99127140A UA61111C2 (ru) 1997-05-28 1998-05-18 Новые соединения
PL337126A PL199567B1 (pl) 1997-05-28 1998-05-18 Związki tienopiryminodionu, zawierające je kompozycje farmaceutyczne, sposoby wytwarzania tych zwiazków i ich zastosowanie w terapii
IDW991450A ID28432A (id) 1997-05-28 1998-05-18 Senyawa-senyawa baru
KR1019997011086A KR100561988B1 (ko) 1997-05-28 1998-05-18 신규 화합물
SK1513-99A SK283589B6 (sk) 1997-05-28 1998-05-18 Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
IL13276398A IL132763A0 (en) 1997-05-28 1998-05-18 Novel compounds
NZ500853A NZ500853A (en) 1997-05-28 1998-05-18 Immunosuppressive thieno[2,3-d]pyrimidine derivatives
ES98924705T ES2184270T3 (es) 1997-05-28 1998-05-18 Nuevos compuestos.
CN98807378A CN1122037C (zh) 1997-05-28 1998-05-18 噻吩并[2,3－d]嘧啶二酮类化合物及其制法、用途和含其的药物组合物
EEP199900539A EE04018B1 (et) 1997-05-28 1998-05-18 Tieno[2,3-d]pürimidiindioonid, nende valmistamisemeetod ja neid sisaldavad ravimkoostised
AT98924705T ATE226205T1 (de) 1997-05-28 1998-05-18 Verbindungen
TR1999/02904T TR199902904T2 (xx) 1997-05-28 1998-05-18 Yeni bile�imler.
RU99128111/04A RU2225410C2 (ru) 1997-05-28 1998-05-18 ПРОИЗВОДНЫЕ ТИЕНО[2,3-d]ПИРИМИДИН-2,4(1Н,3Н)-ДИОНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, СПОСОБ ИММУНОСУПРЕССИИ И СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА ОБСТРУКЦИИ ДЫХАТЕЛЬНЫХ ПУТЕЙ
CZ0420199A CZ297536B6 (cs) 1997-05-28 1998-05-18 Thienopyrimidindionový derivát, jeho použití a způsoby přípravy, a farmaceutický prostředek s jeho obsahem a způsob jeho výroby
IL132763A IL132763A (en) 1997-05-28 1999-11-04 Theo [[2,3 – d] pyrimidine - 2, 4 (H1, H3) Diones - transformed at position 6, processes for their preparation, the compositions containing them and their use in healing
IS5264A IS1983B (is) 1997-05-28 1999-11-23 Ný þíeno[2,3-d]pýrimidíndíón, blöndur sem innihalda þau, aðferðir til framleiðslu þeirra og notkun þeirra í lækningalyf
NO19995810A NO323752B1 (no) 1997-05-28 1999-11-26 Nye tieno(2,3-d)pyrimidindioner, fremgangsmate for fremstilling derav, farmasoytisk preparat som inneholder slike, samt anvendelse derav i terapi.
US09/693,896 US6342502B1 (en) 1997-05-28 2000-10-23 Thieno[2,3-d]pyrimidine diones and their use in the treatment of reversible obstructive airways diseases
US09/977,944 US6469014B1 (en) 1997-05-28 2001-10-17 Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
US10/265,201 US6984644B2 (en) 1997-05-28 2002-10-07 Treatment of skin disorders using thieno[2,3-D]pyrimidinediones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds

Publications (1)

Publication Number Publication Date
SE9702001D0 true SE9702001D0 (sv) 1997-05-28

Family

ID=20407123

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds

Country Status (28)

Country Link
US (2) US6180635B1 (ru)
EP (1) EP0991653B1 (ru)
JP (1) JP2002500666A (ru)
KR (1) KR100561988B1 (ru)
CN (1) CN1122037C (ru)
AT (1) ATE226205T1 (ru)
AU (1) AU723708B2 (ru)
BR (1) BR9809481A (ru)
CA (1) CA2289509C (ru)
CZ (1) CZ297536B6 (ru)
DE (1) DE69808765T2 (ru)
DK (1) DK0991653T3 (ru)
EE (1) EE04018B1 (ru)
ES (1) ES2184270T3 (ru)
HU (1) HU226627B1 (ru)
ID (1) ID28432A (ru)
IL (2) IL132763A0 (ru)
IS (1) IS1983B (ru)
NO (1) NO323752B1 (ru)
NZ (1) NZ500853A (ru)
PL (1) PL199567B1 (ru)
PT (1) PT991653E (ru)
RU (1) RU2225410C2 (ru)
SE (1) SE9702001D0 (ru)
SK (1) SK283589B6 (ru)
TR (1) TR199902904T2 (ru)
UA (1) UA61111C2 (ru)
WO (1) WO1998054190A1 (ru)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9819384D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds II
GB2361917A (en) * 2000-05-04 2001-11-07 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones
EP1280806B1 (en) * 2000-05-04 2004-08-04 AstraZeneca AB THIENO 2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS
GB2363377B (en) * 2000-06-14 2004-06-09 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
MXPA03004926A (es) * 2001-02-14 2005-02-14 Warner Lambert Co Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
JP2005518391A (ja) * 2001-12-21 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ Ｇｋ活性化剤としてのアミド誘導体
KR101116627B1 (ko) * 2002-06-27 2012-10-09 노보 노르디스크 에이/에스 치료제로서 아릴 카르보닐 유도체
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
US7393854B2 (en) * 2003-01-17 2008-07-01 Astrazeneca Ab Thienopyrimidinedinones and their use in modulation of autoimmune disease
SE0300117D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel Compounds
ES2399052T3 (es) * 2004-01-06 2013-03-25 Novo Nordisk A/S Heteroaril-ureas y su uso como activadores de glucocinasa
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
JP2009500377A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス ジシクロアルキルウレア型グルコキナーゼ活性化剤
AU2006268589B2 (en) * 2005-07-14 2011-09-29 Vtv Therapeutics Llc Urea glucokinase activators
EP1989210A2 (en) * 2006-03-02 2008-11-12 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
US7776868B2 (en) * 2006-12-01 2010-08-17 Gilead Palo Alto, Inc. Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A2A adenosine receptor antagonists
EP2118083A1 (en) * 2007-01-09 2009-11-18 Novo Nordisk A/S Urea glucokinase activators
JP5226008B2 (ja) * 2007-01-11 2013-07-03 ノボ・ノルデイスク・エー／エス ウレアグルコキナーゼアクチベーター
EP2008656A1 (en) * 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
PT2411395E (pt) * 2009-03-23 2013-06-06 Glenmark Pharmaceuticals Sa Derivados de furopirimidinadiona como moduladores de trpa1
MX370976B (es) * 2011-11-11 2020-01-10 Gilead Apollo Llc Inhibidores de acetil coa carboxilasa (acc) y usos de los mismos.
WO2014042176A1 (ja) * 2012-09-14 2014-03-20 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
MX2016004250A (es) * 2013-10-07 2016-07-12 Bayer Pharma AG Tienouracilcarboxamidas ciclicas y usos de las mismas.
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
JP2018536661A (ja) 2015-11-25 2018-12-13 ギリアド アポロ， エルエルシー トリアゾールａｃｃ阻害剤およびその使用
JP2019503338A (ja) 2015-11-25 2019-02-07 ギリアド アポロ， エルエルシー ２，４−ジオキソ−１，４−ジヒドロチエノ［２，３−ｄ］ピリミジンの誘導体を含む殺真菌組成物
WO2017091602A1 (en) 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
SI3380480T1 (sl) 2015-11-25 2023-04-28 Gilead Apollo, Llc Pirazolni inhibitorji ACC in uporabe le-teh
TWI844474B (zh) 2016-03-02 2024-06-01 美商基利阿波羅有限責任公司 噻吩并嘧啶二酮acc抑制劑之固體型式及其製造方法
WO2018041771A1 (de) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
JP2019529452A (ja) * 2016-09-23 2019-10-17 バイエル・アクチエンゲゼルシヤフト Ｎ３−環状置換チエノウラシルおよびその使用
WO2018183193A1 (en) 2017-03-28 2018-10-04 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
AU2019287437A1 (en) 2018-06-12 2020-09-10 Vtv Therapeutics Llc Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989002432A1 (en) * 1987-09-16 1989-03-23 Taiho Pharmaceutical Company, Limited Thienopyrimidine derivatives
TW276256B (ru) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
FR2750862B1 (fr) * 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques

Also Published As

Publication number Publication date
NO995810D0 (no) 1999-11-26
CN1122037C (zh) 2003-09-24
US6180635B1 (en) 2001-01-30
EP0991653A1 (en) 2000-04-12
DE69808765D1 (de) 2002-11-21
RU2225410C2 (ru) 2004-03-10
DE69808765T2 (de) 2003-07-24
CN1264382A (zh) 2000-08-23
IL132763A0 (en) 2001-03-19
HUP0003355A2 (hu) 2001-02-28
DK0991653T3 (da) 2003-01-06
KR100561988B1 (ko) 2006-03-17
ID28432A (id) 2001-05-24
SK151399A3 (en) 2000-05-16
AU7680898A (en) 1998-12-30
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ATE226205T1 (de) 2002-11-15
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