SE9701127D0 - Antigenic fusionprotein carrying GALal, 3GAL epitopes - Google Patents

Antigenic fusionprotein carrying GALal, 3GAL epitopes

Info

Publication number
SE9701127D0
SE9701127D0 SE9701127A SE9701127A SE9701127D0 SE 9701127 D0 SE9701127 D0 SE 9701127D0 SE 9701127 A SE9701127 A SE 9701127A SE 9701127 A SE9701127 A SE 9701127A SE 9701127 D0 SE9701127 D0 SE 9701127D0
Authority
SE
Sweden
Prior art keywords
polypeptide
galal
fusion protein
plasma
blood
Prior art date
Application number
SE9701127A
Other languages
English (en)
Swedish (sv)
Inventor
Jan Holgersson
Jining Liu
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE9701127A priority Critical patent/SE9701127D0/xx
Publication of SE9701127D0 publication Critical patent/SE9701127D0/xx
Priority to AT98912863T priority patent/ATE315047T1/de
Priority to EP98912863A priority patent/EP0923606B1/en
Priority to US09/194,396 priority patent/US6943239B2/en
Priority to JP54556998A priority patent/JP4099239B2/ja
Priority to DE69833106T priority patent/DE69833106T2/de
Priority to EP06075010A priority patent/EP1700868A3/en
Priority to CA002255765A priority patent/CA2255765A1/en
Priority to PCT/SE1998/000555 priority patent/WO1998042750A1/en
Priority to AU67551/98A priority patent/AU751760B2/en
Priority to ES98912863T priority patent/ES2258297T3/es
Priority to DK98912863T priority patent/DK0923606T3/da
Priority to BR9804826-0A priority patent/BR9804826A/pt
Priority to US11/153,082 priority patent/US20050255099A1/en
Priority to US12/507,626 priority patent/US20090286963A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE9701127A 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes SE9701127D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes
BR9804826-0A BR9804826A (pt) 1997-03-26 1998-03-26 Proteìna de fusão antigênica portando epìtopos galoc 1,3 gal
EP06075010A EP1700868A3 (en) 1997-03-26 1998-03-26 A method for removing an antibody from blood or plasma
PCT/SE1998/000555 WO1998042750A1 (en) 1997-03-26 1998-03-26 ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES
US09/194,396 US6943239B2 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying Galα1,3Gal epitopes
JP54556998A JP4099239B2 (ja) 1997-03-26 1998-03-26 ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質
DE69833106T DE69833106T2 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten.
AT98912863T ATE315047T1 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.
CA002255765A CA2255765A1 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying gal.alpha.1,3gal epitopes
EP98912863A EP0923606B1 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying galalpha1,3gal epitopes
AU67551/98A AU751760B2 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying galalpha1,3Gal epitopes
ES98912863T ES2258297T3 (es) 1997-03-26 1998-03-26 Proteina de fusion antigenica portadora de epitopos gal-alfa-1,3gal.
DK98912863T DK0923606T3 (da) 1997-03-26 1998-03-26 Antigent fusionsprotein med GALALPHA1,3GAL epitoper
US11/153,082 US20050255099A1 (en) 1997-03-26 2005-06-15 Antigenic fusion protein carrying Galalpha 1,3Gal epitopes
US12/507,626 US20090286963A1 (en) 1997-03-26 2009-07-22 Antigenic fusion protein carrying gal alpha1,3gal epitopes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Publications (1)

Publication Number Publication Date
SE9701127D0 true SE9701127D0 (sv) 1997-03-26

Family

ID=20406335

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Country Status (12)

Country Link
US (3) US6943239B2 (enExample)
EP (2) EP0923606B1 (enExample)
JP (1) JP4099239B2 (enExample)
AT (1) ATE315047T1 (enExample)
AU (1) AU751760B2 (enExample)
BR (1) BR9804826A (enExample)
CA (1) CA2255765A1 (enExample)
DE (1) DE69833106T2 (enExample)
DK (1) DK0923606T3 (enExample)
ES (1) ES2258297T3 (enExample)
SE (1) SE9701127D0 (enExample)
WO (1) WO1998042750A1 (enExample)

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WO2003010201A2 (en) * 2001-07-20 2003-02-06 Absorber, Ab Blood group antigen fusion polypeptides and methods of use thereof
AU2003228067B2 (en) * 2002-04-22 2008-05-29 Recopharma Ab Mucin fusion polypeptide vaccines, compositions and methods of use thereof
WO2003089450A2 (en) * 2002-04-22 2003-10-30 Recopharma Ab Fusion polypeptides and methods for inhibiting microbial adhesion
JP5183010B2 (ja) 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
AU2003245595A1 (en) * 2002-07-03 2004-01-23 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
US7638323B2 (en) * 2002-08-09 2009-12-29 Recopharma Ab Fusion proteins and methods of producing same
US20050076759A1 (en) * 2003-10-08 2005-04-14 Brian Westfall Linear saw with stab-cut bevel capability
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US7459523B2 (en) * 2003-11-12 2008-12-02 Wisconsin Alumni Research Foundation Equine P-selectin glycoprotein ligand-1 and uses thereof
CA2546784A1 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
WO2006001348A1 (ja) * 2004-06-23 2006-01-05 Japan Science And Technology Agency 浸潤抑制及び細胞殺傷剤
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
WO2007021721A2 (en) * 2005-08-09 2007-02-22 Glycomimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
SI2264043T1 (en) 2005-09-02 2018-01-31 Glycomimetics, Inc. HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
WO2007033221A2 (en) * 2005-09-13 2007-03-22 The General Hospital Corporation Methods and compositions for inhibition of immune responses
WO2007132355A2 (en) * 2006-01-26 2007-11-22 Recopharma Ab Compositions and methods for inhibiting viral adhesion
US20070178447A1 (en) * 2006-01-31 2007-08-02 Bethyl Laboratories, Inc. Method for decreasing interference in results of immunochemical methods
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
US7964569B2 (en) 2006-10-12 2011-06-21 Glycomimetics, Inc. Glycomimetic replacements for hexoses and N-acetyl hexosamines
US7998486B2 (en) 2006-10-25 2011-08-16 Newlink Genetics Corporation Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
WO2008100453A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) * 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8518896B2 (en) * 2008-06-13 2013-08-27 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
AU2010241807B2 (en) 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CN103501804A (zh) * 2010-12-21 2014-01-08 雷科制药公司 眼泪替代物
EP2794626B3 (en) 2011-12-22 2020-08-05 GlycoMimetics, Inc. E-selectin antagonist compounds
HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US20210260250A1 (en) * 2018-06-12 2021-08-26 Rush University Medical Center Methods for Enhanced Endothelialization of Implanted Material
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (4)

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DE69226871T3 (de) * 1991-06-27 2009-09-24 Bristol-Myers Squibb Co. CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
AU677261B2 (en) 1992-10-23 1997-04-17 Genetics Institute, Llc Novel P-selectin ligand protein
CA2157659C (en) * 1993-03-16 2003-10-21 Mauro S. Sandrin Use of porcine gal .alpha. (1,3) galactosyl transferase in xenograft therapies
GB9517758D0 (en) * 1995-08-31 1995-11-01 Imutran Ltd Compositions and their uses

Also Published As

Publication number Publication date
US20090286963A1 (en) 2009-11-19
EP1700868A2 (en) 2006-09-13
DK0923606T3 (da) 2006-05-22
EP1700868A3 (en) 2007-12-12
ES2258297T3 (es) 2006-08-16
AU751760B2 (en) 2002-08-29
US20020028205A1 (en) 2002-03-07
CA2255765A1 (en) 1998-10-01
US20050255099A1 (en) 2005-11-17
DE69833106D1 (de) 2006-03-30
DE69833106T2 (de) 2006-08-31
ATE315047T1 (de) 2006-02-15
EP0923606A1 (en) 1999-06-23
BR9804826A (pt) 2000-01-25
WO1998042750A1 (en) 1998-10-01
JP4099239B2 (ja) 2008-06-11
US6943239B2 (en) 2005-09-13
EP0923606B1 (en) 2006-01-04
AU6755198A (en) 1998-10-20
JP2000511782A (ja) 2000-09-12

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