ATE315047T1 - Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten. - Google Patents
Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.Info
- Publication number
- ATE315047T1 ATE315047T1 AT98912863T AT98912863T ATE315047T1 AT E315047 T1 ATE315047 T1 AT E315047T1 AT 98912863 T AT98912863 T AT 98912863T AT 98912863 T AT98912863 T AT 98912863T AT E315047 T1 ATE315047 T1 AT E315047T1
- Authority
- AT
- Austria
- Prior art keywords
- gal
- polypeptide
- alpha
- fusion proteins
- proteins containing
- Prior art date
Links
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 239000008280 blood Substances 0.000 abstract 4
- 210000004369 blood Anatomy 0.000 abstract 4
- 230000004927 fusion Effects 0.000 abstract 2
- 102000030902 Galactosyltransferase Human genes 0.000 abstract 1
- 108060003306 Galactosyltransferase Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 abstract 1
- 108010054395 P-selectin ligand protein Proteins 0.000 abstract 1
- 102000003800 Selectins Human genes 0.000 abstract 1
- 108090000184 Selectins Proteins 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9701127A SE9701127D0 (sv) | 1997-03-26 | 1997-03-26 | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE315047T1 true ATE315047T1 (de) | 2006-02-15 |
Family
ID=20406335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98912863T ATE315047T1 (de) | 1997-03-26 | 1998-03-26 | Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6943239B2 (enExample) |
| EP (2) | EP1700868A3 (enExample) |
| JP (1) | JP4099239B2 (enExample) |
| AT (1) | ATE315047T1 (enExample) |
| AU (1) | AU751760B2 (enExample) |
| BR (1) | BR9804826A (enExample) |
| CA (1) | CA2255765A1 (enExample) |
| DE (1) | DE69833106T2 (enExample) |
| DK (1) | DK0923606T3 (enExample) |
| ES (1) | ES2258297T3 (enExample) |
| SE (1) | SE9701127D0 (enExample) |
| WO (1) | WO1998042750A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7355017B2 (en) * | 2001-07-20 | 2008-04-08 | Absorber Ab | Blood group antigen fusion polypeptides and methods of use thereof |
| AU2003233008B2 (en) * | 2002-04-22 | 2008-04-24 | Recopharma Ab | Fusion polypeptides and methods for inhibiting microbial adhesion |
| EP1517700B1 (en) * | 2002-04-22 | 2012-03-28 | Recopharma AB | Mucin fusion polypeptide vaccines, compositions and methods of use thereof |
| JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス， インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
| CA2490703A1 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| US7638323B2 (en) * | 2002-08-09 | 2009-12-29 | Recopharma Ab | Fusion proteins and methods of producing same |
| US20050076759A1 (en) * | 2003-10-08 | 2005-04-14 | Brian Westfall | Linear saw with stab-cut bevel capability |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| US7459523B2 (en) * | 2003-11-12 | 2008-12-02 | Wisconsin Alumni Research Foundation | Equine P-selectin glycoprotein ligand-1 and uses thereof |
| CA2546784A1 (en) * | 2003-11-19 | 2005-06-16 | Glycomimetics, Inc. | Glycomimetic antagonists for both e- and p-selectins |
| DE602004011272T2 (de) * | 2003-11-19 | 2008-12-24 | Glycomimetics, Inc. | Spezifischer antagonist sowohl für e- als auch p-selektine |
| EP1782838A4 (en) * | 2004-06-23 | 2007-08-01 | Japan Science & Tech Agency | INHIBITION OF INFILTRATION AND CELL-COOLING MEDIUM |
| US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
| WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
| DK1928892T3 (da) * | 2005-08-09 | 2012-01-30 | Glycomimetics Inc | Glycomimetiske inhibitorer af PA-IL-lectin PA-IIL-lectin eller begge lectiner fra pseudomonas |
| PL1934236T3 (pl) * | 2005-09-02 | 2013-04-30 | Glycomimetics Inc | Heterobifunkcjonalne inhibitory pan-selektyny |
| US20070113297A1 (en) * | 2005-09-13 | 2007-05-17 | Yongguang Yang | Methods and compositions for inhibition of immune responses |
| AU2007251256B2 (en) * | 2006-01-26 | 2013-03-07 | Recopharma Ab | Compositions and methods for inhibiting viral adhesion |
| US20070178447A1 (en) * | 2006-01-31 | 2007-08-02 | Bethyl Laboratories, Inc. | Method for decreasing interference in results of immunochemical methods |
| WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| CA2666103C (en) | 2006-10-12 | 2014-02-18 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| US7998486B2 (en) * | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
| WO2008100453A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| WO2009152245A1 (en) * | 2008-06-13 | 2009-12-17 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| CA2760292A1 (en) | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012085165A1 (en) * | 2010-12-21 | 2012-06-28 | Recopharma Ab | Tear substitutes |
| WO2013096926A1 (en) | 2011-12-22 | 2013-06-27 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
| PT2928476T (pt) | 2012-12-07 | 2018-05-10 | Glycomimetics Inc | Compostos, composições e métodos que utilizam antagonistas de e-selectina para mobilização de células hematopoiéticas |
| WO2016089872A1 (en) | 2014-12-03 | 2016-06-09 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| JP2019524791A (ja) | 2016-08-08 | 2019-09-05 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ |
| US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| BR112020013198A2 (pt) | 2017-12-29 | 2020-12-01 | Glycomimetics, Inc. | inibidores heterobifuncionais de e-selectina e galectina-3 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| WO2019241386A1 (en) * | 2018-06-12 | 2019-12-19 | Rush University Medical Center | Methods for enhanced endothelialization of implanted material |
| WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0606217T4 (da) * | 1991-06-27 | 2009-03-30 | Bristol Myers Squibb Co | CTL4-receptor, fusionsproteiner indeholdende den samt anvendelse deraf |
| JPH08502886A (ja) * | 1992-10-23 | 1996-04-02 | ジェネティックス・インスティテュート・インコーポレイテッド | 新規ｐ−セレクチンリガンド蛋白質 |
| WO1994021799A1 (en) | 1993-03-16 | 1994-09-29 | Austin Research Institute | USE OF PORCINE GAL α(1,3) GALACTOSYL TRANSFERASE IN XENOGRAFT THERAPIES |
| GB9517758D0 (en) * | 1995-08-31 | 1995-11-01 | Imutran Ltd | Compositions and their uses |
-
1997
- 1997-03-26 SE SE9701127A patent/SE9701127D0/xx unknown
-
1998
- 1998-03-26 CA CA002255765A patent/CA2255765A1/en not_active Abandoned
- 1998-03-26 EP EP06075010A patent/EP1700868A3/en not_active Withdrawn
- 1998-03-26 DE DE69833106T patent/DE69833106T2/de not_active Expired - Lifetime
- 1998-03-26 WO PCT/SE1998/000555 patent/WO1998042750A1/en not_active Ceased
- 1998-03-26 US US09/194,396 patent/US6943239B2/en not_active Expired - Fee Related
- 1998-03-26 JP JP54556998A patent/JP4099239B2/ja not_active Expired - Fee Related
- 1998-03-26 DK DK98912863T patent/DK0923606T3/da active
- 1998-03-26 BR BR9804826-0A patent/BR9804826A/pt not_active Application Discontinuation
- 1998-03-26 AT AT98912863T patent/ATE315047T1/de not_active IP Right Cessation
- 1998-03-26 EP EP98912863A patent/EP0923606B1/en not_active Expired - Lifetime
- 1998-03-26 AU AU67551/98A patent/AU751760B2/en not_active Ceased
- 1998-03-26 ES ES98912863T patent/ES2258297T3/es not_active Expired - Lifetime
-
2005
- 2005-06-15 US US11/153,082 patent/US20050255099A1/en not_active Abandoned
-
2009
- 2009-07-22 US US12/507,626 patent/US20090286963A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0923606B1 (en) | 2006-01-04 |
| AU6755198A (en) | 1998-10-20 |
| US6943239B2 (en) | 2005-09-13 |
| JP2000511782A (ja) | 2000-09-12 |
| US20020028205A1 (en) | 2002-03-07 |
| AU751760B2 (en) | 2002-08-29 |
| EP0923606A1 (en) | 1999-06-23 |
| CA2255765A1 (en) | 1998-10-01 |
| EP1700868A3 (en) | 2007-12-12 |
| DE69833106T2 (de) | 2006-08-31 |
| US20090286963A1 (en) | 2009-11-19 |
| JP4099239B2 (ja) | 2008-06-11 |
| ES2258297T3 (es) | 2006-08-16 |
| DK0923606T3 (da) | 2006-05-22 |
| WO1998042750A1 (en) | 1998-10-01 |
| SE9701127D0 (sv) | 1997-03-26 |
| US20050255099A1 (en) | 2005-11-17 |
| BR9804826A (pt) | 2000-01-25 |
| EP1700868A2 (en) | 2006-09-13 |
| DE69833106D1 (de) | 2006-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0923606 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |