ATE315047T1 - Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten. - Google Patents

Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.

Info

Publication number
ATE315047T1
ATE315047T1 AT98912863T AT98912863T ATE315047T1 AT E315047 T1 ATE315047 T1 AT E315047T1 AT 98912863 T AT98912863 T AT 98912863T AT 98912863 T AT98912863 T AT 98912863T AT E315047 T1 ATE315047 T1 AT E315047T1
Authority
AT
Austria
Prior art keywords
gal
polypeptide
alpha
fusion proteins
proteins containing
Prior art date
Application number
AT98912863T
Other languages
German (de)
English (en)
Inventor
Jan Holgersson
Jining Liu
Original Assignee
Absorber Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Absorber Ab filed Critical Absorber Ab
Application granted granted Critical
Publication of ATE315047T1 publication Critical patent/ATE315047T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98912863T 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten. ATE315047T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Publications (1)

Publication Number Publication Date
ATE315047T1 true ATE315047T1 (de) 2006-02-15

Family

ID=20406335

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98912863T ATE315047T1 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.

Country Status (12)

Country Link
US (3) US6943239B2 (enExample)
EP (2) EP0923606B1 (enExample)
JP (1) JP4099239B2 (enExample)
AT (1) ATE315047T1 (enExample)
AU (1) AU751760B2 (enExample)
BR (1) BR9804826A (enExample)
CA (1) CA2255765A1 (enExample)
DE (1) DE69833106T2 (enExample)
DK (1) DK0923606T3 (enExample)
ES (1) ES2258297T3 (enExample)
SE (1) SE9701127D0 (enExample)
WO (1) WO1998042750A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010201A2 (en) * 2001-07-20 2003-02-06 Absorber, Ab Blood group antigen fusion polypeptides and methods of use thereof
AU2003228067B2 (en) * 2002-04-22 2008-05-29 Recopharma Ab Mucin fusion polypeptide vaccines, compositions and methods of use thereof
WO2003089450A2 (en) * 2002-04-22 2003-10-30 Recopharma Ab Fusion polypeptides and methods for inhibiting microbial adhesion
JP5183010B2 (ja) 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
AU2003245595A1 (en) * 2002-07-03 2004-01-23 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
US7638323B2 (en) * 2002-08-09 2009-12-29 Recopharma Ab Fusion proteins and methods of producing same
US20050076759A1 (en) * 2003-10-08 2005-04-14 Brian Westfall Linear saw with stab-cut bevel capability
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US7459523B2 (en) * 2003-11-12 2008-12-02 Wisconsin Alumni Research Foundation Equine P-selectin glycoprotein ligand-1 and uses thereof
CA2546784A1 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
WO2006001348A1 (ja) * 2004-06-23 2006-01-05 Japan Science And Technology Agency 浸潤抑制及び細胞殺傷剤
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
WO2007021721A2 (en) * 2005-08-09 2007-02-22 Glycomimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
SI2264043T1 (en) 2005-09-02 2018-01-31 Glycomimetics, Inc. HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
WO2007033221A2 (en) * 2005-09-13 2007-03-22 The General Hospital Corporation Methods and compositions for inhibition of immune responses
WO2007132355A2 (en) * 2006-01-26 2007-11-22 Recopharma Ab Compositions and methods for inhibiting viral adhesion
US20070178447A1 (en) * 2006-01-31 2007-08-02 Bethyl Laboratories, Inc. Method for decreasing interference in results of immunochemical methods
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
US7964569B2 (en) 2006-10-12 2011-06-21 Glycomimetics, Inc. Glycomimetic replacements for hexoses and N-acetyl hexosamines
US7998486B2 (en) 2006-10-25 2011-08-16 Newlink Genetics Corporation Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
WO2008100453A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) * 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8518896B2 (en) * 2008-06-13 2013-08-27 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
AU2010241807B2 (en) 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CN103501804A (zh) * 2010-12-21 2014-01-08 雷科制药公司 眼泪替代物
EP2794626B3 (en) 2011-12-22 2020-08-05 GlycoMimetics, Inc. E-selectin antagonist compounds
HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US20210260250A1 (en) * 2018-06-12 2021-08-26 Rush University Medical Center Methods for Enhanced Endothelialization of Implanted Material
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69226871T3 (de) * 1991-06-27 2009-09-24 Bristol-Myers Squibb Co. CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
AU677261B2 (en) 1992-10-23 1997-04-17 Genetics Institute, Llc Novel P-selectin ligand protein
CA2157659C (en) * 1993-03-16 2003-10-21 Mauro S. Sandrin Use of porcine gal .alpha. (1,3) galactosyl transferase in xenograft therapies
GB9517758D0 (en) * 1995-08-31 1995-11-01 Imutran Ltd Compositions and their uses

Also Published As

Publication number Publication date
US20090286963A1 (en) 2009-11-19
EP1700868A2 (en) 2006-09-13
DK0923606T3 (da) 2006-05-22
EP1700868A3 (en) 2007-12-12
ES2258297T3 (es) 2006-08-16
AU751760B2 (en) 2002-08-29
SE9701127D0 (sv) 1997-03-26
US20020028205A1 (en) 2002-03-07
CA2255765A1 (en) 1998-10-01
US20050255099A1 (en) 2005-11-17
DE69833106D1 (de) 2006-03-30
DE69833106T2 (de) 2006-08-31
EP0923606A1 (en) 1999-06-23
BR9804826A (pt) 2000-01-25
WO1998042750A1 (en) 1998-10-01
JP4099239B2 (ja) 2008-06-11
US6943239B2 (en) 2005-09-13
EP0923606B1 (en) 2006-01-04
AU6755198A (en) 1998-10-20
JP2000511782A (ja) 2000-09-12

Similar Documents

Publication Publication Date Title
DE69833106D1 (de) Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten.
CA2118010A1 (en) Antibodies specific for carcinoma-associated antigens
DK0739413T3 (da) Fremgangsmåde til udvælgelse af specifikke bakteriofager
ES2106195T3 (es) Anticuerpo igg aglicosilado anti cd3.
EP0699755A3 (en) Process for obtaining modified immunoglobulins with reduced immunogenicity of the variable domains of a murine antibody, compositions containing them
ATE320448T1 (de) Gereinigte primate clta-8 antigene und verwandte reagenzien
ES2087323T3 (es) Metodo para producir peptidos exentos de cisteina.
RU2003129528A (ru) Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
GB2128630A (en) Method of affinity purification employing monoclonal antibodies
KR960022559A (ko) 슈도모나스 에루지노사 막 단백질로부터 유도된 면역원성 하이브리드 단백질 OprF-Oprl
DE69227041D1 (de) Expression und reinigung von rekombinantem, löslichem gewebefaktor
DE59208982D1 (de) Verfahren zur Reinigung von IgG-monoklonalen Antikörpern
ZA874558B (en) Monoclonal antibodies to unreduced,nonenzymatically-glycated proteins
WO1999003987A3 (fr) Epitopes du vrs et anticorps les comportant, utiles dans le diagnostic et la therapie
NZ524429A (en) Catalytic antibodies and a method of producing same
ES2179824T3 (es) Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia.
CA2067584A1 (en) Agglutinant complex as blood typing reagent
NO913037D0 (no) Peptider med for alfal-mikroglobulin karakteristiske antigene determinanter.
ATE207935T1 (de) Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
AU625398B2 (en) Monoclonal antibody recognizing gamma atrial natriuretic polypeptide
WO1999024835A3 (en) An immunoassay for procollagen-iii-c-terminal propeptide
SE9000931L (sv) Antikroppar mot proteiner
KR100315596B1 (ko) 인간의 자연형 ＩｇＭ 항체
DE68919553D1 (de) Rekombinantes Treponema hyodysenteriae-Antigen und seine Verwendungen.
DK0476059T3 (da) Fremgangsmåder til forøgelse af modificeringshastigheden for metastabile bindinger

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0923606

Country of ref document: EP

REN Ceased due to non-payment of the annual fee