SE9604253D0 - New manufacturing process metoprolol - Google Patents

New manufacturing process metoprolol

Info

Publication number
SE9604253D0
SE9604253D0 SE9604253A SE9604253A SE9604253D0 SE 9604253 D0 SE9604253 D0 SE 9604253D0 SE 9604253 A SE9604253 A SE 9604253A SE 9604253 A SE9604253 A SE 9604253A SE 9604253 D0 SE9604253 D0 SE 9604253D0
Authority
SE
Sweden
Prior art keywords
metoprolol
manufacturing process
new manufacturing
new
solvent
Prior art date
Application number
SE9604253A
Other languages
English (en)
Swedish (sv)
Inventor
Sven Palmer
Michael Sidenqvist
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ335213A priority Critical patent/NZ335213A/en
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9604253A priority patent/SE9604253D0/xx
Priority to US08/973,144 priority patent/US6252113B1/en
Publication of SE9604253D0 publication Critical patent/SE9604253D0/xx
Priority to TW086115698A priority patent/TW412513B/zh
Priority to ZA9710005A priority patent/ZA9710005B/xx
Priority to SA97180599A priority patent/SA97180599B1/ar
Priority to IN3275DE1997 priority patent/IN187175B/en
Priority to RU99109477/04A priority patent/RU2210565C2/ru
Priority to EEP199900202A priority patent/EE03761B1/et
Priority to CA002269941A priority patent/CA2269941A1/en
Priority to EP97913641A priority patent/EP0942899B1/en
Priority to PT97913641T priority patent/PT942899E/pt
Priority to TR1999/01115T priority patent/TR199901115T2/xx
Priority to CN97199796A priority patent/CN1128786C/zh
Priority to BR9713370A priority patent/BR9713370A/pt
Priority to SK564-99A priority patent/SK281990B6/sk
Priority to DK97913641T priority patent/DK0942899T3/da
Priority to ES97913641T priority patent/ES2193365T3/es
Priority to UA99042412A priority patent/UA66769C2/uk
Priority to PCT/SE1997/001926 priority patent/WO1998022426A1/en
Priority to SI9730512T priority patent/SI0942899T1/xx
Priority to KR1019997004401A priority patent/KR100544560B1/ko
Priority to HU0002445A priority patent/HUP0002445A3/hu
Priority to AT97913641T priority patent/ATE234273T1/de
Priority to CZ991744A priority patent/CZ174499A3/cs
Priority to PL333541A priority patent/PL191392B1/pl
Priority to AU50776/98A priority patent/AU728270B2/en
Priority to JP51107298A priority patent/JP4039640B2/ja
Priority to IDW990343D priority patent/ID21505A/id
Priority to EG122697A priority patent/EG21158A/xx
Priority to DE69719788T priority patent/DE69719788T2/de
Priority to IL12974797A priority patent/IL129747A/xx
Priority to MYPI97005544A priority patent/MY119303A/en
Priority to ARP970105420A priority patent/AR010069A1/es
Priority to IS5034A priority patent/IS1964B/is
Priority to NO19992401A priority patent/NO311352B1/no
Priority to HK00101688A priority patent/HK1022684A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE9604253A 1996-11-20 1996-11-20 New manufacturing process metoprolol SE9604253D0 (sv)

Priority Applications (37)

Application Number Priority Date Filing Date Title
NZ335213A NZ335213A (en) 1996-11-20 1996-11-18 Metoprolol and a method of preparing metoprolol by reacting p-(2-methoxyethyl)phenol and epichlorohydrin and isopropylamine
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol
US08/973,144 US6252113B1 (en) 1996-11-20 1996-11-20 Manufacturing process of metoprolol
TW086115698A TW412513B (en) 1996-11-20 1997-10-23 New manufacturing process of metoprolol
ZA9710005A ZA9710005B (en) 1996-11-20 1997-11-06 New manufacturing process of metoprolol.
SA97180599A SA97180599B1 (ar) 1996-11-20 1997-11-12 عملية لتصنيع الميتوبرولول metoprolol
IN3275DE1997 IN187175B (et) 1996-11-20 1997-11-13
IL12974797A IL129747A (en) 1996-11-20 1997-11-18 Process for manufacturing metoprolol
DK97913641T DK0942899T3 (da) 1996-11-20 1997-11-18 Fremgangsmåde til fremstilling af metoprolol.
HU0002445A HUP0002445A3 (en) 1996-11-20 1997-11-18 Manufacturing process of metoprolol
CA002269941A CA2269941A1 (en) 1996-11-20 1997-11-18 New manufacturing process of metoprolol
EP97913641A EP0942899B1 (en) 1996-11-20 1997-11-18 Manufacturing process of metoprolol
PT97913641T PT942899E (pt) 1996-11-20 1997-11-18 Novo processo de fabrico de metoprolol
TR1999/01115T TR199901115T2 (xx) 1996-11-20 1997-11-18 Yeni metoprolol �retim i�lemi.
CN97199796A CN1128786C (zh) 1996-11-20 1997-11-18 制造美多洛尔的方法
BR9713370A BR9713370A (pt) 1996-11-20 1997-11-18 Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol
SK564-99A SK281990B6 (sk) 1996-11-20 1997-11-18 Spôsob výroby metoprololu
RU99109477/04A RU2210565C2 (ru) 1996-11-20 1997-11-18 Новый способ производства метопролола
ES97913641T ES2193365T3 (es) 1996-11-20 1997-11-18 Procedimiento para la preparacion de metoprolol.
UA99042412A UA66769C2 (uk) 1996-11-20 1997-11-18 Спосіб одержання метопрололу
PCT/SE1997/001926 WO1998022426A1 (en) 1996-11-20 1997-11-18 New manufacturing process of metoprolol
SI9730512T SI0942899T1 (en) 1996-11-20 1997-11-18 Manufacturing process of metoprolol
KR1019997004401A KR100544560B1 (ko) 1996-11-20 1997-11-18 메토프롤롤의 신규 제조 방법
EEP199900202A EE03761B1 (et) 1996-11-20 1997-11-18 Metoprolooli valmistamise uus protsess
AT97913641T ATE234273T1 (de) 1996-11-20 1997-11-18 Herstellungsverfahren fuer metoprolol
CZ991744A CZ174499A3 (cs) 1996-11-20 1997-11-18 Způsob přípravy metoprololu
PL333541A PL191392B1 (pl) 1996-11-20 1997-11-18 Sposób wytwarzania 1-(izopropyloamino)-3-[p-(2-metoksyetylo)fenoksy]-2-propanolu
AU50776/98A AU728270B2 (en) 1996-11-20 1997-11-18 New manufacturing process of metoprolol
JP51107298A JP4039640B2 (ja) 1996-11-20 1997-11-18 メトプロロールの新規な製造方法
IDW990343D ID21505A (id) 1996-11-20 1997-11-18 Proses pembuatan metoprolol
EG122697A EG21158A (en) 1996-11-20 1997-11-18 New manufacturing process of metroprolol
DE69719788T DE69719788T2 (de) 1996-11-20 1997-11-18 Herstellungsverfahren fuer metoprolol
ARP970105420A AR010069A1 (es) 1996-11-20 1997-11-19 Metodo para la manufactura de metoprolol, metoprolol obtenido por dicho metodo y metodo para la manufactura de una preparacion farmaceutica
MYPI97005544A MY119303A (en) 1996-11-20 1997-11-19 New manufacturing process of metoprolol
IS5034A IS1964B (is) 1996-11-20 1999-04-26 Ný aðferð við að framleiða metóprólól
NO19992401A NO311352B1 (no) 1996-11-20 1999-05-19 Ny fremgangsmåte for fremstilling av metoprolol
HK00101688A HK1022684A1 (en) 1996-11-20 2000-03-20 Manufacturing process of metoprolol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol

Publications (1)

Publication Number Publication Date
SE9604253D0 true SE9604253D0 (sv) 1996-11-20

Family

ID=20404680

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol

Country Status (36)

Country Link
US (1) US6252113B1 (et)
EP (1) EP0942899B1 (et)
JP (1) JP4039640B2 (et)
KR (1) KR100544560B1 (et)
CN (1) CN1128786C (et)
AR (1) AR010069A1 (et)
AT (1) ATE234273T1 (et)
AU (1) AU728270B2 (et)
BR (1) BR9713370A (et)
CA (1) CA2269941A1 (et)
CZ (1) CZ174499A3 (et)
DE (1) DE69719788T2 (et)
DK (1) DK0942899T3 (et)
EE (1) EE03761B1 (et)
EG (1) EG21158A (et)
ES (1) ES2193365T3 (et)
HK (1) HK1022684A1 (et)
HU (1) HUP0002445A3 (et)
ID (1) ID21505A (et)
IL (1) IL129747A (et)
IN (1) IN187175B (et)
IS (1) IS1964B (et)
MY (1) MY119303A (et)
NO (1) NO311352B1 (et)
NZ (1) NZ335213A (et)
PL (1) PL191392B1 (et)
PT (1) PT942899E (et)
RU (1) RU2210565C2 (et)
SA (1) SA97180599B1 (et)
SE (1) SE9604253D0 (et)
SK (1) SK281990B6 (et)
TR (1) TR199901115T2 (et)
TW (1) TW412513B (et)
UA (1) UA66769C2 (et)
WO (1) WO1998022426A1 (et)
ZA (1) ZA9710005B (et)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107635A1 (en) * 2003-11-14 2005-05-19 Mehra Janakraj K. Metoprolol manufacturing process
EP1971570A2 (en) * 2005-12-23 2008-09-24 Medichem, S.A. Process for the preparation of metoprolol and its salts
US20080107726A1 (en) * 2006-11-01 2008-05-08 Pramod Kharwade Compositions comprising beta-adrenergic receptor antagonists and diuretics
CN101607918B (zh) * 2008-06-16 2014-02-19 北京德众万全药物技术开发有限公司 一种美托洛尔的制备方法
WO2011056929A1 (en) * 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
WO2011109276A1 (en) 2010-03-01 2011-09-09 Massachussets Institute Of Technology Epoxidation catalysts
CN102381995B (zh) * 2010-08-31 2015-04-15 扬子江药业集团北京海燕药业有限公司 美托洛尔的制备方法
CN102432476A (zh) * 2010-09-29 2012-05-02 湖南康普医药研究院 一种规模化制备琥珀酸美托洛尔的方法
CN102503843B (zh) * 2011-10-28 2013-10-23 山东阿如拉药物研究开发有限公司 一种美托洛尔盐的制备方法
KR101379383B1 (ko) * 2012-03-23 2014-04-02 주식회사 알에스텍 고순도 ⒮―메토프롤롤의 제조방법
CN103980134B (zh) * 2014-05-30 2015-09-30 安徽省新星药物开发有限责任公司 一种琥珀酸s-美托洛尔的制备方法
CN105820057B (zh) * 2016-04-22 2017-09-29 上海应用技术学院 一种制备美多心安的方法
CN106543015A (zh) * 2016-11-07 2017-03-29 上海应用技术大学 一种美多心安的制备方法
CN108299279B (zh) * 2018-02-09 2021-03-23 北京梅尔森医药技术开发有限公司 取代芳基胺醇化合物及其制备方法和用途
EP3768378A4 (en) 2018-03-22 2021-11-17 InCarda Therapeutics, Inc. INNOVATIVE METHOD OF SLOWING THE VENTRICULAR RATE
CN111018724B (zh) * 2019-12-27 2022-11-08 江西美晶科技有限公司 一种美托洛尔及其制备方法
CN112645827A (zh) * 2020-12-25 2021-04-13 浙江普洛家园药业有限公司 一种连续合成美多心安及其盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
AU660984B2 (en) 1991-03-18 1995-07-13 Sepracor, Inc. Composition and method containing optically pure (S) metoprolol

Also Published As

Publication number Publication date
CZ174499A3 (cs) 1999-11-17
EP0942899A1 (en) 1999-09-22
CN1237958A (zh) 1999-12-08
DE69719788T2 (de) 2004-02-12
HUP0002445A2 (hu) 2001-08-28
NO992401L (no) 1999-07-13
SK281990B6 (sk) 2001-09-11
EE9900202A (et) 1999-12-15
MY119303A (en) 2005-04-30
PT942899E (pt) 2003-06-30
NO992401D0 (no) 1999-05-19
SA97180599B1 (ar) 2006-03-25
RU2210565C2 (ru) 2003-08-20
KR100544560B1 (ko) 2006-01-24
AU5077698A (en) 1998-06-10
AR010069A1 (es) 2000-05-15
JP4039640B2 (ja) 2008-01-30
ID21505A (id) 1999-06-17
EE03761B1 (et) 2002-06-17
IL129747A0 (en) 2000-02-29
SK56499A3 (en) 2000-03-13
TR199901115T2 (xx) 1999-07-21
HUP0002445A3 (en) 2001-09-28
IS5034A (is) 1999-04-26
EP0942899B1 (en) 2003-03-12
EG21158A (en) 2000-12-31
KR20000057134A (ko) 2000-09-15
HK1022684A1 (en) 2000-08-18
PL191392B1 (pl) 2006-05-31
US6252113B1 (en) 2001-06-26
DE69719788D1 (de) 2003-04-17
JP2001503388A (ja) 2001-03-13
DK0942899T3 (da) 2003-06-02
NO311352B1 (no) 2001-11-19
CA2269941A1 (en) 1998-05-28
ZA9710005B (en) 1998-05-20
UA66769C2 (uk) 2004-06-15
ATE234273T1 (de) 2003-03-15
IS1964B (is) 2004-12-15
NZ335213A (en) 2001-02-23
ES2193365T3 (es) 2003-11-01
IL129747A (en) 2003-01-12
TW412513B (en) 2000-11-21
BR9713370A (pt) 2000-03-21
AU728270B2 (en) 2001-01-04
CN1128786C (zh) 2003-11-26
WO1998022426A1 (en) 1998-05-28
IN187175B (et) 2002-02-23

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