HUP0002445A2 - Eljárás metoprolol előállítására - Google Patents

Eljárás metoprolol előállítására

Info

Publication number
HUP0002445A2
HUP0002445A2 HU0002445A HUP0002445A HUP0002445A2 HU P0002445 A2 HUP0002445 A2 HU P0002445A2 HU 0002445 A HU0002445 A HU 0002445A HU P0002445 A HUP0002445 A HU P0002445A HU P0002445 A2 HUP0002445 A2 HU P0002445A2
Authority
HU
Hungary
Prior art keywords
metoprolol
methoxyethyl
manufacturing process
reacted
epichlorohydrin
Prior art date
Application number
HU0002445A
Other languages
English (en)
Inventor
Sven Palmer
Michael Sidenqvist
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUP0002445A2 publication Critical patent/HUP0002445A2/hu
Publication of HUP0002445A3 publication Critical patent/HUP0002445A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Abstract

A találmány tárgya eljárás metoprolol bázis[azaz 1-(izopropil--amino)-3-[p-(2-metoxi-etil)-fenoxi]-2-propanol] előállítására. Atalálmány szerint p-(2-metoxi-etil)-fenolt (A) feleslegben levőepiklórhidrinnel (B) reagáltatnak vizes oldatban 50-70 °C-on majd azepiklórhidrin felesleg ledesztillálása után kapott 1-(2,3-epoxi-propoxi)--4-(2-metoxi-etil)-benzolt izopropil-alkoholban izopropil-aminnal reagáltatják metoprolollá. Ó
HU0002445A 1996-11-20 1997-11-18 Manufacturing process of metoprolol HUP0002445A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol
PCT/SE1997/001926 WO1998022426A1 (en) 1996-11-20 1997-11-18 New manufacturing process of metoprolol

Publications (2)

Publication Number Publication Date
HUP0002445A2 true HUP0002445A2 (hu) 2001-08-28
HUP0002445A3 HUP0002445A3 (en) 2001-09-28

Family

ID=20404680

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002445A HUP0002445A3 (en) 1996-11-20 1997-11-18 Manufacturing process of metoprolol

Country Status (36)

Country Link
US (1) US6252113B1 (hu)
EP (1) EP0942899B1 (hu)
JP (1) JP4039640B2 (hu)
KR (1) KR100544560B1 (hu)
CN (1) CN1128786C (hu)
AR (1) AR010069A1 (hu)
AT (1) ATE234273T1 (hu)
AU (1) AU728270B2 (hu)
BR (1) BR9713370A (hu)
CA (1) CA2269941A1 (hu)
CZ (1) CZ174499A3 (hu)
DE (1) DE69719788T2 (hu)
DK (1) DK0942899T3 (hu)
EE (1) EE03761B1 (hu)
EG (1) EG21158A (hu)
ES (1) ES2193365T3 (hu)
HK (1) HK1022684A1 (hu)
HU (1) HUP0002445A3 (hu)
ID (1) ID21505A (hu)
IL (1) IL129747A (hu)
IN (1) IN187175B (hu)
IS (1) IS1964B (hu)
MY (1) MY119303A (hu)
NO (1) NO311352B1 (hu)
NZ (1) NZ335213A (hu)
PL (1) PL191392B1 (hu)
PT (1) PT942899E (hu)
RU (1) RU2210565C2 (hu)
SA (1) SA97180599B1 (hu)
SE (1) SE9604253D0 (hu)
SK (1) SK281990B6 (hu)
TR (1) TR199901115T2 (hu)
TW (1) TW412513B (hu)
UA (1) UA66769C2 (hu)
WO (1) WO1998022426A1 (hu)
ZA (1) ZA9710005B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107635A1 (en) * 2003-11-14 2005-05-19 Mehra Janakraj K. Metoprolol manufacturing process
WO2007141593A2 (en) * 2005-12-23 2007-12-13 Medichem, S.A. Process for the preparation of metoprolol and its salts
US20080107726A1 (en) * 2006-11-01 2008-05-08 Pramod Kharwade Compositions comprising beta-adrenergic receptor antagonists and diuretics
CN101607918B (zh) * 2008-06-16 2014-02-19 北京德众万全药物技术开发有限公司 一种美托洛尔的制备方法
WO2011056929A1 (en) * 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
US8680303B2 (en) 2010-03-01 2014-03-25 Massachusetts Institute Of Technology Epoxidation catalysts
CN102381995B (zh) * 2010-08-31 2015-04-15 扬子江药业集团北京海燕药业有限公司 美托洛尔的制备方法
CN102432476A (zh) * 2010-09-29 2012-05-02 湖南康普医药研究院 一种规模化制备琥珀酸美托洛尔的方法
CN102503843B (zh) * 2011-10-28 2013-10-23 山东阿如拉药物研究开发有限公司 一种美托洛尔盐的制备方法
KR101379383B1 (ko) * 2012-03-23 2014-04-02 주식회사 알에스텍 고순도 ⒮―메토프롤롤의 제조방법
CN103980134B (zh) * 2014-05-30 2015-09-30 安徽省新星药物开发有限责任公司 一种琥珀酸s-美托洛尔的制备方法
CN105820057B (zh) * 2016-04-22 2017-09-29 上海应用技术学院 一种制备美多心安的方法
CN106543015A (zh) * 2016-11-07 2017-03-29 上海应用技术大学 一种美多心安的制备方法
CN108299279B (zh) * 2018-02-09 2021-03-23 北京梅尔森医药技术开发有限公司 取代芳基胺醇化合物及其制备方法和用途
EP3768378A4 (en) 2018-03-22 2021-11-17 InCarda Therapeutics, Inc. INNOVATIVE METHOD OF SLOWING THE VENTRICULAR RATE
CN111018724B (zh) * 2019-12-27 2022-11-08 江西美晶科技有限公司 一种美托洛尔及其制备方法
CN112645827A (zh) * 2020-12-25 2021-04-13 浙江普洛家园药业有限公司 一种连续合成美多心安及其盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
WO1992016197A1 (en) 1991-03-18 1992-10-01 Sepracor Inc. Composition and method containing optically pure (s) metoprolol

Also Published As

Publication number Publication date
DK0942899T3 (da) 2003-06-02
IL129747A (en) 2003-01-12
ES2193365T3 (es) 2003-11-01
JP4039640B2 (ja) 2008-01-30
SK281990B6 (sk) 2001-09-11
AR010069A1 (es) 2000-05-15
ZA9710005B (en) 1998-05-20
PL191392B1 (pl) 2006-05-31
PT942899E (pt) 2003-06-30
IS1964B (is) 2004-12-15
ATE234273T1 (de) 2003-03-15
NO311352B1 (no) 2001-11-19
IL129747A0 (en) 2000-02-29
EG21158A (en) 2000-12-31
NZ335213A (en) 2001-02-23
TW412513B (en) 2000-11-21
NO992401D0 (no) 1999-05-19
IS5034A (is) 1999-04-26
KR20000057134A (ko) 2000-09-15
CN1237958A (zh) 1999-12-08
EE9900202A (et) 1999-12-15
DE69719788D1 (de) 2003-04-17
SA97180599B1 (ar) 2006-03-25
EP0942899B1 (en) 2003-03-12
CN1128786C (zh) 2003-11-26
HUP0002445A3 (en) 2001-09-28
SE9604253D0 (sv) 1996-11-20
JP2001503388A (ja) 2001-03-13
NO992401L (no) 1999-07-13
DE69719788T2 (de) 2004-02-12
AU728270B2 (en) 2001-01-04
EE03761B1 (et) 2002-06-17
BR9713370A (pt) 2000-03-21
KR100544560B1 (ko) 2006-01-24
RU2210565C2 (ru) 2003-08-20
IN187175B (hu) 2002-02-23
CA2269941A1 (en) 1998-05-28
WO1998022426A1 (en) 1998-05-28
AU5077698A (en) 1998-06-10
SK56499A3 (en) 2000-03-13
HK1022684A1 (en) 2000-08-18
EP0942899A1 (en) 1999-09-22
MY119303A (en) 2005-04-30
CZ174499A3 (cs) 1999-11-17
TR199901115T2 (xx) 1999-07-21
US6252113B1 (en) 2001-06-26
UA66769C2 (uk) 2004-06-15
ID21505A (id) 1999-06-17

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees