SE9602263D0 - New amino acid derivatives - Google Patents
New amino acid derivativesInfo
- Publication number
- SE9602263D0 SE9602263D0 SE9602263A SE9602263A SE9602263D0 SE 9602263 D0 SE9602263 D0 SE 9602263D0 SE 9602263 A SE9602263 A SE 9602263A SE 9602263 A SE9602263 A SE 9602263A SE 9602263 D0 SE9602263 D0 SE 9602263D0
- Authority
- SE
- Sweden
- Prior art keywords
- amino acid
- acid derivatives
- new amino
- thrombin
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9602263A SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | New amino acid derivatives |
ZA9704542A ZA974542B (en) | 1996-06-07 | 1997-05-23 | New amino acid derivatives and their use as thrombin inhibitors. |
IDP971884A ID17016A (id) | 1996-06-07 | 1997-06-03 | Turunan-turunan asam yang baru dan penggunaannya sebagai penghambat-penghambat trombin |
PL97330482A PL330482A1 (en) | 1996-06-07 | 1997-06-05 | Novel amino acid derivatives and their application as thrombosin inhibitors |
EE9800425A EE9800425A (et) | 1996-06-07 | 1997-06-05 | Uued aminohappe derivaadid ja nende kasutamine trombiini inhibiitoritena |
NZ332964A NZ332964A (en) | 1996-06-07 | 1997-06-05 | azetidine, pyrrolidine or piperidine substituted amino acid derivatives |
AU31140/97A AU723420B2 (en) | 1996-06-07 | 1997-06-05 | New amino acid derivatives and their use as thrombin inhibitors |
BR9709560A BR9709560A (pt) | 1996-06-07 | 1997-06-05 | Composto formulação farmacéutica uso de um compostoãe processo para tratamento de uma condição em que a inibição da trombina seja necessaria e para a preparação de um composto |
HU0002404A HUP0002404A3 (en) | 1996-06-07 | 1997-06-05 | Amino acid derivatives, pharmaceutical compositions comprising thereof, process for preparation them and their use |
TR1998/02536T TR199802536T2 (xx) | 1996-06-07 | 1997-06-05 | Yeni amino asit t�revleri,trombin inhibit�rleri olarak kullan�lmalar�. |
DK97926356T DK0910573T3 (da) | 1996-06-07 | 1997-06-05 | Nye aminosyrederivater og deres anvendelse som thrombininhibitorer |
US08/860,871 US6255301B1 (en) | 1996-06-07 | 1997-06-05 | Amino acid derivatives and their use as thrombin inhibitors |
ES97926356T ES2191840T3 (es) | 1996-06-07 | 1997-06-05 | Nuevos derivados de aminoacidos y su utilizacion como inhibidores de trombina. |
CA002255625A CA2255625A1 (en) | 1996-06-07 | 1997-06-05 | New amino acid derivatives and their use as thrombin inhibitors |
PCT/SE1997/000989 WO1997046577A1 (en) | 1996-06-07 | 1997-06-05 | New amino acid derivatives and their use as thrombin inhibitors |
AT97926356T ATE231883T1 (de) | 1996-06-07 | 1997-06-05 | Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren |
DE69718791T DE69718791T2 (de) | 1996-06-07 | 1997-06-05 | Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren |
EP97926356A EP0910573B1 (en) | 1996-06-07 | 1997-06-05 | New amino acid derivatives and their use as thrombin inhibitors |
IL12732597A IL127325A0 (en) | 1996-06-07 | 1997-06-05 | Amino acid derivatives and their use as thrombin inhibitors |
JP50050298A JP4237824B2 (ja) | 1996-06-07 | 1997-06-05 | 新規なアミノ酸誘導体およびトロンビン阻害剤としてのその使用 |
SK1653-98A SK165398A3 (en) | 1996-06-07 | 1997-06-05 | New amino acid derivatives and their use as thrombin inhibitors |
CZ983986A CZ398698A3 (cs) | 1996-06-07 | 1997-06-05 | Nový derivát aminokyseliny a jeho použití jako inhibitoru thrombinu |
CN97196864A CN1129604C (zh) | 1996-06-07 | 1997-06-05 | 新的氨基酸衍生物及其作为凝血酶抑制剂的用途 |
ARP970102484A AR008046A1 (es) | 1996-06-07 | 1997-06-06 | Nuevos derivados de aminoacidos, formulacion farmaceutica que los incluye, metodos para la elaboracion de medicamentos y proceso para la preparacion dedichos derivados. |
IS4906A IS4906A (is) | 1996-06-07 | 1998-11-25 | Nýjar amínósýruafleiður og notkun þeirra sem þrombínhemla |
IL127325A IL127325A (en) | 1996-06-07 | 1998-11-30 | History of amino acids, process for their preparation, pharmaceutical preparations containing them and their uses in the preparation of drugs as thrombin inhibitors |
NO19985700A NO317135B1 (no) | 1996-06-07 | 1998-12-04 | Nye aminosyrederivater, farmasoytisk formulering inneholdende slike derivater, fremgangsmate for og deres fremstilling, og deres anvendelse som trombininhibitorer |
US09/844,427 US6838478B2 (en) | 1996-06-07 | 2001-04-30 | Amino acid derivatives and their use as thrombin inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9602263A SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | New amino acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9602263D0 true SE9602263D0 (sv) | 1996-06-07 |
Family
ID=20402928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9602263A SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | New amino acid derivatives |
Country Status (26)
Country | Link |
---|---|
US (2) | US6255301B1 (id) |
EP (1) | EP0910573B1 (id) |
JP (1) | JP4237824B2 (id) |
CN (1) | CN1129604C (id) |
AR (1) | AR008046A1 (id) |
AT (1) | ATE231883T1 (id) |
AU (1) | AU723420B2 (id) |
BR (1) | BR9709560A (id) |
CA (1) | CA2255625A1 (id) |
CZ (1) | CZ398698A3 (id) |
DE (1) | DE69718791T2 (id) |
DK (1) | DK0910573T3 (id) |
EE (1) | EE9800425A (id) |
ES (1) | ES2191840T3 (id) |
HU (1) | HUP0002404A3 (id) |
ID (1) | ID17016A (id) |
IL (2) | IL127325A0 (id) |
IS (1) | IS4906A (id) |
NO (1) | NO317135B1 (id) |
NZ (1) | NZ332964A (id) |
PL (1) | PL330482A1 (id) |
SE (1) | SE9602263D0 (id) |
SK (1) | SK165398A3 (id) |
TR (1) | TR199802536T2 (id) |
WO (1) | WO1997046577A1 (id) |
ZA (1) | ZA974542B (id) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
CA2329929A1 (en) | 1998-04-24 | 1999-11-04 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
PL349769A1 (en) | 1999-01-13 | 2002-09-09 | Astrazeneca Ab | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
ES2311538T3 (es) * | 2000-08-16 | 2009-02-16 | Astrazeneca Ab | Nuevos derivados amidino y su uso como inhibidores de trombina. |
US6433186B1 (en) * | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
UA100400C2 (uk) | 2008-02-06 | 2012-12-25 | Астразенека Аб | Похідні спіроциклічних амідів |
GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
KR101181918B1 (ko) * | 2010-11-09 | 2012-09-11 | 주식회사 세라젬 | 온열치료기용 상하운동 조절장치 |
EP3052498A1 (en) | 2013-09-30 | 2016-08-10 | Council of Scientific & Industrial Research | 3,7-diazabicyclo[3.3.1]nonane carboxamides as antithrombotic agents |
KR102256242B1 (ko) * | 2014-02-07 | 2021-05-26 | 엑시테라 파마슈티컬스 인코퍼레이티드 | 치료 화합물 및 조성물 |
CN108530297B (zh) * | 2017-03-03 | 2021-09-24 | 联化科技股份有限公司 | 2-氯-3-甲基苯甲酸及其中间体的制备方法 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
CA1341029C (en) | 1985-02-04 | 2000-06-20 | Michael Kolb | Peptidase inhibitors |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
ZA897514B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
TW201303B (id) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
NZ245039A (en) | 1991-11-12 | 1994-12-22 | Lilly Co Eli | N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions |
SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
DE69314478T2 (de) | 1992-03-04 | 1999-02-11 | Gyogyszerkutato Intezet Kft., Budapest | Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren |
TW223629B (id) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
US5583146A (en) | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5780631A (en) | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
CA2140598C (en) | 1994-01-27 | 2010-03-09 | Masahiro Ohshima | Prolineamide derivatives |
US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
US5726159A (en) | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
DE4443390A1 (de) | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
EA002767B1 (ru) | 1995-02-10 | 2002-08-29 | Басф Акциенгезельшафт | Ингибиторы тромбина |
JPH11500120A (ja) * | 1995-02-17 | 1999-01-06 | ビーエーエスエフ アクチェンゲゼルシャフト | 新規なトロンビンインヒビター |
US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5914319A (en) | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
EP0820453A4 (en) | 1995-04-04 | 2001-08-29 | Merck & Co Inc | THROMBIN INHIBITORS |
US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
TW541316B (en) | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
JPH1095898A (ja) | 1996-09-25 | 1998-04-14 | Sumitomo Bakelite Co Ltd | 難燃性樹脂組成物およびこれを用いた積層板 |
DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
-
1996
- 1996-06-07 SE SE9602263A patent/SE9602263D0/xx unknown
-
1997
- 1997-05-23 ZA ZA9704542A patent/ZA974542B/xx unknown
- 1997-06-03 ID IDP971884A patent/ID17016A/id unknown
- 1997-06-05 NZ NZ332964A patent/NZ332964A/xx not_active IP Right Cessation
- 1997-06-05 CA CA002255625A patent/CA2255625A1/en not_active Abandoned
- 1997-06-05 IL IL12732597A patent/IL127325A0/xx active IP Right Grant
- 1997-06-05 AT AT97926356T patent/ATE231883T1/de not_active IP Right Cessation
- 1997-06-05 BR BR9709560A patent/BR9709560A/pt active Search and Examination
- 1997-06-05 WO PCT/SE1997/000989 patent/WO1997046577A1/en active IP Right Grant
- 1997-06-05 DE DE69718791T patent/DE69718791T2/de not_active Expired - Fee Related
- 1997-06-05 HU HU0002404A patent/HUP0002404A3/hu unknown
- 1997-06-05 JP JP50050298A patent/JP4237824B2/ja not_active Expired - Fee Related
- 1997-06-05 TR TR1998/02536T patent/TR199802536T2/xx unknown
- 1997-06-05 CZ CZ983986A patent/CZ398698A3/cs unknown
- 1997-06-05 PL PL97330482A patent/PL330482A1/xx unknown
- 1997-06-05 CN CN97196864A patent/CN1129604C/zh not_active Expired - Fee Related
- 1997-06-05 ES ES97926356T patent/ES2191840T3/es not_active Expired - Lifetime
- 1997-06-05 US US08/860,871 patent/US6255301B1/en not_active Expired - Fee Related
- 1997-06-05 EP EP97926356A patent/EP0910573B1/en not_active Expired - Lifetime
- 1997-06-05 SK SK1653-98A patent/SK165398A3/sk unknown
- 1997-06-05 AU AU31140/97A patent/AU723420B2/en not_active Ceased
- 1997-06-05 DK DK97926356T patent/DK0910573T3/da active
- 1997-06-05 EE EE9800425A patent/EE9800425A/xx unknown
- 1997-06-06 AR ARP970102484A patent/AR008046A1/es not_active Application Discontinuation
-
1998
- 1998-11-25 IS IS4906A patent/IS4906A/is unknown
- 1998-11-30 IL IL127325A patent/IL127325A/en not_active IP Right Cessation
- 1998-12-04 NO NO19985700A patent/NO317135B1/no not_active IP Right Cessation
-
2001
- 2001-04-30 US US09/844,427 patent/US6838478B2/en not_active Expired - Fee Related
Also Published As
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