IL127325A0 - Amino acid derivatives and their use as thrombin inhibitors - Google Patents

Amino acid derivatives and their use as thrombin inhibitors

Info

Publication number
IL127325A0
IL127325A0 IL12732597A IL12732597A IL127325A0 IL 127325 A0 IL127325 A0 IL 127325A0 IL 12732597 A IL12732597 A IL 12732597A IL 12732597 A IL12732597 A IL 12732597A IL 127325 A0 IL127325 A0 IL 127325A0
Authority
IL
Israel
Prior art keywords
amino acid
acid derivatives
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
IL12732597A
Other languages
English (en)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL127325A0 publication Critical patent/IL127325A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12732597A 1996-06-07 1997-06-05 Amino acid derivatives and their use as thrombin inhibitors IL127325A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9602263A SE9602263D0 (sv) 1996-06-07 1996-06-07 New amino acid derivatives
PCT/SE1997/000989 WO1997046577A1 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors

Publications (1)

Publication Number Publication Date
IL127325A0 true IL127325A0 (en) 1999-09-22

Family

ID=20402928

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12732597A IL127325A0 (en) 1996-06-07 1997-06-05 Amino acid derivatives and their use as thrombin inhibitors
IL127325A IL127325A (en) 1996-06-07 1998-11-30 History of amino acids, process for their preparation, pharmaceutical preparations containing them and their uses in the preparation of drugs as thrombin inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL127325A IL127325A (en) 1996-06-07 1998-11-30 History of amino acids, process for their preparation, pharmaceutical preparations containing them and their uses in the preparation of drugs as thrombin inhibitors

Country Status (26)

Country Link
US (2) US6255301B1 (id)
EP (1) EP0910573B1 (id)
JP (1) JP4237824B2 (id)
CN (1) CN1129604C (id)
AR (1) AR008046A1 (id)
AT (1) ATE231883T1 (id)
AU (1) AU723420B2 (id)
BR (1) BR9709560A (id)
CA (1) CA2255625A1 (id)
CZ (1) CZ398698A3 (id)
DE (1) DE69718791T2 (id)
DK (1) DK0910573T3 (id)
EE (1) EE9800425A (id)
ES (1) ES2191840T3 (id)
HU (1) HUP0002404A3 (id)
ID (1) ID17016A (id)
IL (2) IL127325A0 (id)
IS (1) IS4906A (id)
NO (1) NO317135B1 (id)
NZ (1) NZ332964A (id)
PL (1) PL330482A1 (id)
SE (1) SE9602263D0 (id)
SK (1) SK165398A3 (id)
TR (1) TR199802536T2 (id)
WO (1) WO1997046577A1 (id)
ZA (1) ZA974542B (id)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) * 1997-12-05 1997-12-05 Astra Ab New compounds
US6417161B1 (en) 1998-04-24 2002-07-09 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
DE60037183T2 (de) 1999-01-13 2008-10-09 Astrazeneca Ab Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
PT1311480E (pt) * 2000-08-16 2008-11-11 Astrazeneca Ab Novos derivados amidino e sua utilização como inibidores da trombina
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
BRPI0908353B8 (pt) 2008-02-06 2021-05-25 Astrazeneca Ab composto ou um sal farmaceuticamente aceitavel do mesmo e composição farmaceutica
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
KR101181918B1 (ko) * 2010-11-09 2012-09-11 주식회사 세라젬 온열치료기용 상하운동 조절장치
WO2015044951A1 (en) 2013-09-30 2015-04-02 Council Of Scientific & Industrial Research 3,7-diazabicyclo[3.3.1 ]nonane carboxamides as antithrombotic agents
EP3102200B1 (en) * 2014-02-07 2023-04-05 Exithera Pharmaceuticals Inc. Therapeutic compounds and compositions
CN108530297B (zh) * 2017-03-03 2021-09-24 联化科技股份有限公司 2-氯-3-甲基苯甲酸及其中间体的制备方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (id) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CZ333492A3 (en) 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
EP0629212B1 (en) 1992-03-04 1997-10-08 Gyogyszerkutato Intezet Kft. New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
TW223629B (id) 1992-03-06 1994-05-11 Hoffmann La Roche
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
US5783563A (en) 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
IL112795A (en) 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
US5726159A (en) 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
KR19980702112A (ko) 1995-02-10 1998-07-15 페라 스타르크,요헨 카르크 트롬빈 억제제
JPH11500120A (ja) 1995-02-17 1999-01-06 ビーエーエスエフ アクチェンゲゼルシャフト 新規なトロンビンインヒビター
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
AU698911B2 (en) 1995-04-04 1998-11-12 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
SE9704543D0 (sv) * 1997-12-05 1997-12-05 Astra Ab New compounds

Also Published As

Publication number Publication date
JP4237824B2 (ja) 2009-03-11
NO985700L (no) 1999-02-05
US6838478B2 (en) 2005-01-04
SK165398A3 (en) 1999-08-06
NO985700D0 (no) 1998-12-04
DK0910573T3 (da) 2003-06-23
HUP0002404A2 (hu) 2000-10-28
NZ332964A (en) 2000-08-25
DE69718791D1 (de) 2003-03-06
WO1997046577A1 (en) 1997-12-11
BR9709560A (pt) 1999-08-10
ATE231883T1 (de) 2003-02-15
AU3114097A (en) 1998-01-05
ID17016A (id) 1997-12-04
EP0910573A1 (en) 1999-04-28
AR008046A1 (es) 1999-12-09
CZ398698A3 (cs) 1999-07-14
US20020019371A1 (en) 2002-02-14
US6255301B1 (en) 2001-07-03
IS4906A (is) 1998-11-25
CA2255625A1 (en) 1997-12-11
SE9602263D0 (sv) 1996-06-07
DE69718791T2 (de) 2003-10-23
ZA974542B (en) 1997-12-08
TR199802536T2 (xx) 1999-03-22
EE9800425A (et) 1999-06-15
NO317135B1 (no) 2004-08-23
EP0910573B1 (en) 2003-01-29
CN1129604C (zh) 2003-12-03
CN1226895A (zh) 1999-08-25
IL127325A (en) 2006-10-31
HUP0002404A3 (en) 2001-02-28
ES2191840T3 (es) 2003-09-16
AU723420B2 (en) 2000-08-24
PL330482A1 (en) 1999-05-24
JP2000512631A (ja) 2000-09-26

Similar Documents

Publication Publication Date Title
IL127325A0 (en) Amino acid derivatives and their use as thrombin inhibitors
HUP0104500A3 (en) Thrombin inhibitor dipeptide derivatives and their use
IL127885A0 (en) Amidino derivatives and their use as thrombin inhibitors
GB9623908D0 (en) Amino acid derivatives
PL344589A1 (en) COMPOSITION COMPRISING β-HYDROXY-β-METHYLBUTYRIC ACID AND AT LEAST ONE AMINO ACID AND METHODS OF USE
HUP0000427A3 (en) Benzamidoaldehydes and their use as cysteine protease inhibitors
IL128514A0 (en) Novel acetamide derivatives and protease inhibitors
IL128664A (en) Heterocyclic metalloprotease inhibitors and pharmaceutical compositions comprising them
IL122813A0 (en) Thrombin inhibitors their preparation and use
HUP9800634A3 (en) P-amidino-benzylamide derivatives as thrombin inhibitors, intermediates and use thereof
EP1024130A4 (en) BIPHENYL-5-ALKANIC ACID DERIVATIVES AND THEIR USE
DK0934301T3 (da) Aminothiophencarboxylsyreamider og anvendelse deraf som phosphodiesteraseinhibitorer
ZA9710646B (en) Aminoguanidines and alkoxyguanidines as protease inhibitors
IL133490A0 (en) New amidino derivatives and their use as thrombin inhibitors
EP0927035A4 (en) THROMBIN INHIBITORS
HUP0001826A3 (en) Thrombin inhibitors
IL126350A0 (en) Novel alpha-hydroxy acid derivatives their preparation and use
IL143987A0 (en) New amidinobenzylamine derivatives and their use as thrombin inhibitors
AU5050198A (en) Beta-thiopropionyl-amino acid derivatives and their use as beta-lactamase inhibitors
GB9613718D0 (en) Thrombin inhibitors
IL121474A0 (en) Thrombin inhibitors
NZ288940A (en) 4-amino-2-oxo-1-piperidineacetic acid tripeptide derivatives as thrombin inhibitors
ZA985036B (en) New amidino derivatives and their use as thrombin inhibitors
SI1150996T1 (sl) Novi amidinobenzilaminski derivati in njihova uporaba kot trombinski inhibitorji
ZA979406B (en) Metalloproteinase inhibitors pharmaceutical compositions containing them and their use

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed