SE520392C2 - Specifika peptider för behandling av diabetes mellitus - Google Patents
Specifika peptider för behandling av diabetes mellitusInfo
- Publication number
- SE520392C2 SE520392C2 SE9603533A SE9603533A SE520392C2 SE 520392 C2 SE520392 C2 SE 520392C2 SE 9603533 A SE9603533 A SE 9603533A SE 9603533 A SE9603533 A SE 9603533A SE 520392 C2 SE520392 C2 SE 520392C2
- Authority
- SE
- Sweden
- Prior art keywords
- peptide
- insulin
- mixture
- amino acid
- acid sequence
- Prior art date
Links
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- 206010012601 diabetes mellitus Diseases 0.000 title claims description 11
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- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000009057 passive transport Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 201000005572 sensory peripheral neuropathy Diseases 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000028016 temperature homeostasis Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9603533A SE520392C2 (sv) | 1996-09-27 | 1996-09-27 | Specifika peptider för behandling av diabetes mellitus |
| US09/269,439 US6610649B2 (en) | 1996-09-27 | 1997-09-26 | Insulin C-peptides |
| IL12914397A IL129143A0 (en) | 1996-09-27 | 1997-09-26 | Insulin c-peptides |
| HU0000432A HUP0000432A3 (en) | 1996-09-27 | 1997-09-26 | Insulin c-peptides |
| NZ335231A NZ335231A (en) | 1996-09-27 | 1997-09-26 | Human fragments of insulin C-peptides of the sequence ELGGGPGAG or EGSLQ that have Na/K ATPase stimulating activity |
| PCT/GB1997/002627 WO1998013384A1 (en) | 1996-09-27 | 1997-09-26 | Insulin c-peptides |
| CA002266416A CA2266416C (en) | 1996-09-27 | 1997-09-26 | Insulin c-peptides |
| CZ991085A CZ108599A3 (cs) | 1996-09-27 | 1997-09-26 | Peptid, který je fragmentem C-peptidu lidského inzulinu |
| SK394-99A SK39499A3 (en) | 1996-09-27 | 1997-09-26 | Peptide, biomimetic organic compound thereof, pharmaceutical composition containing it and its use |
| DE69737065T DE69737065T2 (de) | 1996-09-27 | 1997-09-26 | Insulin c-peptide |
| BR9711573-8A BR9711573A (pt) | 1996-09-27 | 1997-09-26 | Pepetìdeos c da insulina. |
| EP97942119A EP0938503B1 (en) | 1996-09-27 | 1997-09-26 | Insulin c-peptides |
| AU43915/97A AU741901B2 (en) | 1996-09-27 | 1997-09-26 | Insulin C-peptides |
| KR1019990702585A KR20000048643A (ko) | 1996-09-27 | 1997-09-26 | 인슐린 ｃ-펩티드 |
| PL97332494A PL332494A1 (en) | 1996-09-27 | 1997-09-26 | Peptides of c insulin |
| DK97942119T DK0938503T3 (da) | 1996-09-27 | 1997-09-26 | Insulin C-peptider |
| RU99108434/14A RU2206336C2 (ru) | 1996-09-27 | 1997-09-26 | Фрагмент с-пептида человеческого проинсулина |
| AT97942119T ATE347562T1 (de) | 1996-09-27 | 1997-09-26 | Insulin c-peptide |
| ES97942119T ES2278394T3 (es) | 1996-09-27 | 1997-09-26 | Peptidos c de la insulina. |
| JP10515410A JP2001500893A (ja) | 1996-09-27 | 1997-09-26 | インスリンｃ―ペプチド |
| TR1999/00694T TR199900694T2 (xx) | 1996-09-27 | 1997-09-26 | �nsulin C-peptitleri. |
| IS5008A IS5008A (is) | 1996-09-27 | 1999-03-23 | C-peptíð insúlíns |
| NO991483A NO991483L (no) | 1996-09-27 | 1999-03-26 | Insulin C-peptider |
| BG103362A BG103362A (en) | 1996-09-27 | 1999-04-27 | Insulin c-peptides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9603533A SE520392C2 (sv) | 1996-09-27 | 1996-09-27 | Specifika peptider för behandling av diabetes mellitus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9603533D0 SE9603533D0 (sv) | 1996-09-27 |
| SE9603533L SE9603533L (sv) | 1998-03-28 |
| SE520392C2 true SE520392C2 (sv) | 2003-07-01 |
Family
ID=20404052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9603533A SE520392C2 (sv) | 1996-09-27 | 1996-09-27 | Specifika peptider för behandling av diabetes mellitus |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6610649B2 (no) |
| EP (1) | EP0938503B1 (no) |
| JP (1) | JP2001500893A (no) |
| KR (1) | KR20000048643A (no) |
| AT (1) | ATE347562T1 (no) |
| AU (1) | AU741901B2 (no) |
| BG (1) | BG103362A (no) |
| BR (1) | BR9711573A (no) |
| CA (1) | CA2266416C (no) |
| CZ (1) | CZ108599A3 (no) |
| DE (1) | DE69737065T2 (no) |
| DK (1) | DK0938503T3 (no) |
| ES (1) | ES2278394T3 (no) |
| HU (1) | HUP0000432A3 (no) |
| IL (1) | IL129143A0 (no) |
| IS (1) | IS5008A (no) |
| NO (1) | NO991483L (no) |
| NZ (1) | NZ335231A (no) |
| PL (1) | PL332494A1 (no) |
| RU (1) | RU2206336C2 (no) |
| SE (1) | SE520392C2 (no) |
| SK (1) | SK39499A3 (no) |
| TR (1) | TR199900694T2 (no) |
| WO (1) | WO1998013384A1 (no) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0022342D0 (en) * | 2000-09-12 | 2000-10-25 | Creative Peptides Sweden Ab | Reduction of the electrocardiographic QT interval |
| DE10055857A1 (de) * | 2000-11-10 | 2002-08-22 | Creative Peptides Sweden Ab Dj | Neue pharmazeutische Depotformulierung |
| US20030198666A1 (en) * | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
| AU2004204727B8 (en) * | 2003-01-06 | 2006-11-09 | Emisphere Technologies, Inc. | Night-time oral insulin therapy |
| US20050026826A1 (en) * | 2003-01-17 | 2005-02-03 | Margarethe Hoenig | Feline proinsulin, insulin and constituent peptides |
| US20050203001A1 (en) | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| GB0323979D0 (en) | 2003-10-13 | 2003-11-19 | Creative Peptides Sweden Ab | Therapeutic applications for c-peptide |
| WO2005117937A2 (en) * | 2004-05-27 | 2005-12-15 | Essential Skincare Llc | Alpha-1- acid glycoprotein for the treatment of diabetes |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| GB0601950D0 (en) * | 2006-01-31 | 2006-03-15 | Creative Peptides Sweden Ab | Compositions and methods of treating diabetes |
| JP5256199B2 (ja) * | 2006-08-07 | 2013-08-07 | テヴァ バイオファーマシューティカルズ ユーエスエー，インコーポレーティッド | アルブミン−インスリン融合タンパク質 |
| JP2010538982A (ja) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 単独でまたはｇｌｐ−１と組み合わせて用いる、治療剤としてのインスリンｃ−ペプチドの使用 |
| GB0723250D0 (en) * | 2007-11-28 | 2008-01-09 | Univ Leeds | Compositions and methods for reducing macrovascular complications in diabetic patients |
| US20110165112A1 (en) * | 2008-09-19 | 2011-07-07 | Nektar Therapeutics | Polymer conjugates of c-peptides |
| EP2341942A1 (en) | 2008-09-19 | 2011-07-13 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
| US8410049B2 (en) * | 2009-10-28 | 2013-04-02 | Cebix | Methods and kits for preventing hypoglycemia |
| KR20130115086A (ko) | 2010-05-17 | 2013-10-21 | 세빅스 인코포레이티드 | 페길화된 c-펩티드 |
| CN103458911B (zh) | 2011-02-11 | 2016-02-24 | 密歇根大学董事会 | 肽组合物和用于治疗患者的方法 |
| CN104220086A (zh) | 2011-11-17 | 2014-12-17 | 塞比克斯股份公司 | Peg化的c-肽 |
| RU2522897C1 (ru) * | 2013-04-16 | 2014-07-20 | Закрытое акционерное общество "ФАРМ-ХОЛДИНГ" | Твердая кишечнорастворимая лекарственная форма с-пептида проинсулина для перорального применения (варианты) и способ ее получения (варианты) |
| KR101676542B1 (ko) * | 2014-12-30 | 2016-11-16 | 건국대학교 산학협력단 | 프로인슐린의 면역학적 용도 |
| CN104888201B (zh) * | 2015-06-29 | 2018-04-27 | 齐锦生 | 用于防治糖尿病及其慢性并发症的肽类药物 |
| ES2927977T3 (es) | 2017-02-06 | 2022-11-14 | Biotempt Bv | Moduladores peptídicos de la interacción entre el péptido C humano y el receptor de elastina humana para uso terapéutico |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU166913B (no) * | 1972-05-15 | 1975-06-28 | ||
| JPS5210872B2 (no) * | 1973-07-14 | 1977-03-26 | ||
| JPS55105653A (en) * | 1978-10-02 | 1980-08-13 | Shionogi & Co Ltd | Tyrosyl c-peptides |
| CH650679A5 (de) | 1981-08-27 | 1985-08-15 | Lilly Co Eli | Gegen diabetes mellitus wirksames pharmazeutisches mittel. |
| DE3326473A1 (de) | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| US4581165A (en) | 1984-06-14 | 1986-04-08 | Eli Lilly And Company | Anti-diabetic compounds |
| US5104854A (en) | 1989-02-01 | 1992-04-14 | Washington University | Antiviral peptides |
| PT93057B (pt) | 1989-02-09 | 1995-12-29 | Lilly Co Eli | Processo para a preparacao de analogos da insulina |
| US5364757A (en) | 1990-05-21 | 1994-11-15 | Administrators Of The Tulane Educational Fund | Methods of supporting a diagnosis of systemic lupus erythematosus |
| IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| JPH05268982A (ja) | 1992-03-27 | 1993-10-19 | Hoechst Japan Ltd | 骨形成作用を有する新規な蛋白質およびその製造法 |
| AU679443B2 (en) | 1992-04-13 | 1997-07-03 | Oklahoma Medical Research Foundation | Methods and reagents for diagnosis of autoantibodies |
| WO1994025071A1 (en) | 1993-05-05 | 1994-11-10 | Keith Rose | Polyoxime compounds and their preparation |
| AT400723B (de) | 1993-08-27 | 1996-03-25 | Biomay Prod & Handel | Rekombinante alternaria alternata allergene |
| WO1996001846A1 (en) | 1994-07-08 | 1996-01-25 | Trustees Of Dartmouth College | Proinsulin peptide compounds for detecting and treating type i diabetes |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| GB9422175D0 (en) | 1994-11-03 | 1994-12-21 | Univ Dundee | Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof |
| GB9509164D0 (en) | 1995-05-05 | 1995-06-28 | Smithkline Beecham Plc | Novel compounds |
| EP0914335A2 (en) | 1996-03-15 | 1999-05-12 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
| US6150500A (en) | 1996-07-12 | 2000-11-21 | Salerno; John C. | Activators of endothelial nitric oxide synthase |
-
1996
- 1996-09-27 SE SE9603533A patent/SE520392C2/sv not_active IP Right Cessation
-
1997
- 1997-09-26 KR KR1019990702585A patent/KR20000048643A/ko not_active Application Discontinuation
- 1997-09-26 DE DE69737065T patent/DE69737065T2/de not_active Expired - Lifetime
- 1997-09-26 AU AU43915/97A patent/AU741901B2/en not_active Ceased
- 1997-09-26 NZ NZ335231A patent/NZ335231A/xx unknown
- 1997-09-26 WO PCT/GB1997/002627 patent/WO1998013384A1/en active IP Right Grant
- 1997-09-26 CA CA002266416A patent/CA2266416C/en not_active Expired - Fee Related
- 1997-09-26 EP EP97942119A patent/EP0938503B1/en not_active Expired - Lifetime
- 1997-09-26 ES ES97942119T patent/ES2278394T3/es not_active Expired - Lifetime
- 1997-09-26 DK DK97942119T patent/DK0938503T3/da active
- 1997-09-26 CZ CZ991085A patent/CZ108599A3/cs unknown
- 1997-09-26 PL PL97332494A patent/PL332494A1/xx unknown
- 1997-09-26 US US09/269,439 patent/US6610649B2/en not_active Expired - Fee Related
- 1997-09-26 HU HU0000432A patent/HUP0000432A3/hu unknown
- 1997-09-26 AT AT97942119T patent/ATE347562T1/de not_active IP Right Cessation
- 1997-09-26 JP JP10515410A patent/JP2001500893A/ja not_active Ceased
- 1997-09-26 BR BR9711573-8A patent/BR9711573A/pt not_active Application Discontinuation
- 1997-09-26 TR TR1999/00694T patent/TR199900694T2/xx unknown
- 1997-09-26 IL IL12914397A patent/IL129143A0/xx unknown
- 1997-09-26 SK SK394-99A patent/SK39499A3/sk unknown
- 1997-09-26 RU RU99108434/14A patent/RU2206336C2/ru not_active IP Right Cessation
-
1999
- 1999-03-23 IS IS5008A patent/IS5008A/is unknown
- 1999-03-26 NO NO991483A patent/NO991483L/no not_active Application Discontinuation
- 1999-04-27 BG BG103362A patent/BG103362A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IS5008A (is) | 1999-03-23 |
| HUP0000432A3 (en) | 2000-10-30 |
| IL129143A0 (en) | 2000-02-17 |
| KR20000048643A (ko) | 2000-07-25 |
| US6610649B2 (en) | 2003-08-26 |
| RU2206336C2 (ru) | 2003-06-20 |
| TR199900694T2 (xx) | 1999-06-21 |
| CA2266416C (en) | 2008-04-29 |
| SE9603533D0 (sv) | 1996-09-27 |
| JP2001500893A (ja) | 2001-01-23 |
| ATE347562T1 (de) | 2006-12-15 |
| CA2266416A1 (en) | 1998-04-02 |
| WO1998013384A1 (en) | 1998-04-02 |
| BR9711573A (pt) | 2000-01-18 |
| NO991483L (no) | 1999-05-18 |
| DK0938503T3 (da) | 2007-04-10 |
| EP0938503A1 (en) | 1999-09-01 |
| BG103362A (en) | 2000-05-31 |
| DE69737065T2 (de) | 2007-06-28 |
| AU4391597A (en) | 1998-04-17 |
| NZ335231A (en) | 2000-11-24 |
| DE69737065D1 (en) | 2007-01-18 |
| AU741901B2 (en) | 2001-12-13 |
| PL332494A1 (en) | 1999-09-13 |
| HUP0000432A2 (hu) | 2000-08-28 |
| US20020107175A1 (en) | 2002-08-08 |
| SK39499A3 (en) | 1999-10-08 |
| SE9603533L (sv) | 1998-03-28 |
| ES2278394T3 (es) | 2007-08-01 |
| NO991483D0 (no) | 1999-03-26 |
| CZ108599A3 (cs) | 1999-08-11 |
| EP0938503B1 (en) | 2006-12-06 |
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