SE509700C2 - Nya isoindolderivat och salter därav, förfaranden för framställning därav samt anti-tumörmedel som innehåller dem - Google Patents

Nya isoindolderivat och salter därav, förfaranden för framställning därav samt anti-tumörmedel som innehåller dem

Info

Publication number
SE509700C2
SE509700C2 SE9003476A SE9003476A SE509700C2 SE 509700 C2 SE509700 C2 SE 509700C2 SE 9003476 A SE9003476 A SE 9003476A SE 9003476 A SE9003476 A SE 9003476A SE 509700 C2 SE509700 C2 SE 509700C2
Authority
SE
Sweden
Prior art keywords
group
compound
general formula
unsubstituted
dicarboximide
Prior art date
Application number
SE9003476A
Other languages
English (en)
Swedish (sv)
Other versions
SE9003476L (sv
SE9003476D0 (sv
Inventor
Takashi Nagai
Isao Myokan
Keishi Funaki
Kenji Ohta
Nobuhisa Taya
Shinji Miyabara
Masaaki Shibata
Hidetada Mikami
Takako Hori
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2-288069A external-priority patent/JP3027599B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of SE9003476D0 publication Critical patent/SE9003476D0/xx
Publication of SE9003476L publication Critical patent/SE9003476L/xx
Publication of SE509700C2 publication Critical patent/SE509700C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE9003476A 1989-11-01 1990-10-31 Nya isoindolderivat och salter därav, förfaranden för framställning därav samt anti-tumörmedel som innehåller dem SE509700C2 (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28554889 1989-11-01
JP20544390 1990-08-02
JP2-288069A JP3027599B2 (ja) 1990-08-02 1990-10-25 新規なイソインドール誘導体およびその塩

Publications (3)

Publication Number Publication Date
SE9003476D0 SE9003476D0 (sv) 1990-10-31
SE9003476L SE9003476L (sv) 1992-05-01
SE509700C2 true SE509700C2 (sv) 1999-02-22

Family

ID=27328497

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003476A SE509700C2 (sv) 1989-11-01 1990-10-31 Nya isoindolderivat och salter därav, förfaranden för framställning därav samt anti-tumörmedel som innehåller dem

Country Status (11)

Country Link
US (1) US5166204A (da)
BE (1) BE1004069A3 (da)
CA (1) CA2028960C (da)
CH (1) CH682151A5 (da)
DE (1) DE4034687C2 (da)
DK (1) DK261890A (da)
FR (1) FR2655345B1 (da)
GB (1) GB2239013B (da)
IT (1) IT1242004B (da)
NL (1) NL9002366A (da)
SE (1) SE509700C2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215361D0 (en) * 1992-07-20 1992-09-02 Wellcome Found Heterocyclic compounds
ES2123873T3 (es) * 1994-08-04 1999-01-16 Hoffmann La Roche Pirrolocarbazol.
AU4889496A (en) * 1995-03-09 1996-10-02 Kyowa Hakko Kogyo Co. Ltd. Pyrrolocarbazole derivatives
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19744257B4 (de) * 1997-10-07 2004-04-15 Zentaris Gmbh Beta-Carboline und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen
US20060276497A1 (en) * 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
EP1464645A1 (en) * 2001-12-18 2004-10-06 Kyowa Hakko Kogyo Co., Ltd. Indole derivative
CA2483496A1 (en) * 2002-04-26 2003-11-06 Warner-Lambert Company Llc Inhibitors of checkpoint kinases (wee1 and chk1)
CN100400529C (zh) * 2003-10-08 2008-07-09 中国科学院化学研究所 含氟芳香族有机四酸二酐及制备方法和用途
JP4857452B2 (ja) 2004-03-15 2012-01-18 ピーティーシー セラピューティクス，インコーポレーテッド 血管新生の抑制に有用なカルボリン誘導体
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8940896B2 (en) * 2004-03-15 2015-01-27 Ptc Therapeutics, Inc. Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis
US8076353B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
CN101102765A (zh) * 2004-11-23 2008-01-09 Ptc医疗公司 通过翻译控制抑制vegf产生的活性物质四氢咔唑
US8946444B2 (en) * 2004-11-23 2015-02-03 Ptc Therapeutics, Inc. Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control
CN110464722B (zh) * 2019-06-06 2023-05-23 暨南大学 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用
CN115594681B (zh) * 2022-10-21 2024-06-18 广州六顺生物科技有限公司 一种异吲哚啉-1,3-二酮衍生物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3752123T2 (de) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
DE3833008A1 (de) * 1988-09-29 1990-04-05 Goedecke Ag Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
US5166204A (en) 1992-11-24
NL9002366A (nl) 1991-06-03
DE4034687C2 (de) 1999-12-02
CH682151A5 (da) 1993-07-30
DK261890D0 (da) 1990-10-31
DE4034687A1 (de) 1991-05-02
BE1004069A3 (fr) 1992-09-15
IT9048430A1 (it) 1992-05-01
IT1242004B (it) 1994-02-02
GB2239013A (en) 1991-06-19
GB2239013B (en) 1993-06-02
IT9048430A0 (it) 1990-10-31
FR2655345A1 (da) 1991-06-07
SE9003476L (sv) 1992-05-01
DK261890A (da) 1991-05-02
CA2028960C (en) 1999-01-19
SE9003476D0 (sv) 1990-10-31
FR2655345B1 (da) 1993-02-26
GB9023568D0 (en) 1990-12-12
CA2028960A1 (en) 1991-05-02

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