SE505146C2 - Partiklar för fördröjd frisättning - Google Patents

Partiklar för fördröjd frisättning

Info

Publication number
SE505146C2
SE505146C2 SE9503672A SE9503672A SE505146C2 SE 505146 C2 SE505146 C2 SE 505146C2 SE 9503672 A SE9503672 A SE 9503672A SE 9503672 A SE9503672 A SE 9503672A SE 505146 C2 SE505146 C2 SE 505146C2
Authority
SE
Sweden
Prior art keywords
active substance
coating
core particles
polymer
particles
Prior art date
Application number
SE9503672A
Other languages
English (en)
Swedish (sv)
Other versions
SE9503672D0 (sv
SE9503672L (sv
Inventor
Nils-Ove Gustafsson
Timo Laakso
Peter Fyhr
Monica Joensson
Original Assignee
Biogram Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogram Ab filed Critical Biogram Ab
Priority to SE9503672A priority Critical patent/SE505146C2/sv
Publication of SE9503672D0 publication Critical patent/SE9503672D0/xx
Priority to IL12405296A priority patent/IL124052A/xx
Priority to KR1019980702757A priority patent/KR100482262B1/ko
Priority to EP96935641A priority patent/EP0869774B1/en
Priority to AT96935641T priority patent/ATE228826T1/de
Priority to DE69625240T priority patent/DE69625240T2/de
Priority to ES96935641T priority patent/ES2125209T3/es
Priority to JP9515728A priority patent/JP2000501380A/ja
Priority to HU9901205A priority patent/HUP9901205A3/hu
Priority to DK96935641T priority patent/DK0869774T3/da
Priority to DE0869774T priority patent/DE869774T1/de
Priority to ES01117830T priority patent/ES2267637T3/es
Priority to AT01117830T priority patent/ATE326953T1/de
Priority to AU73478/96A priority patent/AU699080B2/en
Priority to PCT/SE1996/001091 priority patent/WO1997014408A1/en
Priority to EP01117830A priority patent/EP1142569B1/en
Priority to US09/051,709 priority patent/US6120787A/en
Priority to PT96935641T priority patent/PT869774E/pt
Priority to DE69636177T priority patent/DE69636177T2/de
Priority to CZ19981173A priority patent/CZ293059B6/cs
Priority to EP06010350A priority patent/EP1716849A1/en
Priority to CA 2234615 priority patent/CA2234615C/en
Priority to HK98112027.5A priority patent/HK1011182B/en
Publication of SE9503672L publication Critical patent/SE9503672L/
Publication of SE505146C2 publication Critical patent/SE505146C2/sv
Priority to NO19981558A priority patent/NO320392B1/no
Priority to HK01108604.0A priority patent/HK1038309B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
SE9503672A 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning SE505146C2 (sv)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE9503672A SE505146C2 (sv) 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning
HK98112027.5A HK1011182B (en) 1995-10-19 1996-09-03 Method for manufacturing sustained release particles
AT01117830T ATE326953T1 (de) 1995-10-19 1996-09-03 Umhüllung kleiner partikel
PCT/SE1996/001091 WO1997014408A1 (en) 1995-10-19 1996-09-03 Sustained release particles
EP96935641A EP0869774B1 (en) 1995-10-19 1996-09-03 Method for manufacturing sustained release particles
AT96935641T ATE228826T1 (de) 1995-10-19 1996-09-03 Methode zur herstellung von partikeln mit verzoegerter freisetzung
DE69625240T DE69625240T2 (de) 1995-10-19 1996-09-03 Methode zur herstellung von partikeln mit verzoegerter freisetzung
ES96935641T ES2125209T3 (es) 1995-10-19 1996-09-03 Metodo para fabricar particulas de liberacion sostenida.
JP9515728A JP2000501380A (ja) 1995-10-19 1996-09-03 持続放出性粒子
HU9901205A HUP9901205A3 (en) 1995-10-19 1996-09-03 Sustained release particles
DK96935641T DK0869774T3 (da) 1995-10-19 1996-09-03 Fremgangsmåde til fremstilling af vedvarende frigivende partikler
DE0869774T DE869774T1 (de) 1995-10-19 1996-09-03 Partikel mit verzögerter freisetzung
ES01117830T ES2267637T3 (es) 1995-10-19 1996-09-03 Revestimiento de pequeñas particulas.
IL12405296A IL124052A (en) 1995-10-19 1996-09-03 Method of preparing parenterally administrable sustained release microparticles and microparticles obtainable thereby
AU73478/96A AU699080B2 (en) 1995-10-19 1996-09-03 Sustained release particles
KR1019980702757A KR100482262B1 (ko) 1995-10-19 1996-09-03 서방성입자
EP01117830A EP1142569B1 (en) 1995-10-19 1996-09-03 Coating of small particles
US09/051,709 US6120787A (en) 1995-10-19 1996-09-03 Sustained release particles
PT96935641T PT869774E (pt) 1995-10-19 1996-09-03 Metodo para a producao de particulas de libertacao retardada
DE69636177T DE69636177T2 (de) 1995-10-19 1996-09-03 Umhüllung kleiner Partikel
CZ19981173A CZ293059B6 (cs) 1995-10-19 1996-09-03 Způsob přípravy mikročástic s trvalým uvolňováním
EP06010350A EP1716849A1 (en) 1995-10-19 1996-09-03 Coating of small particles
CA 2234615 CA2234615C (en) 1995-10-19 1996-09-03 Sustained release particles
NO19981558A NO320392B1 (no) 1995-10-19 1998-04-06 Fremgangsmate for fremstilling av parenteralt administrerbare mikrokapsler med vedvarende frigivelse, og mikropartikler ifolge denne fremgangsmaten
HK01108604.0A HK1038309B (en) 1995-10-19 1998-11-16 Coating of small particles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9503672A SE505146C2 (sv) 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning

Publications (3)

Publication Number Publication Date
SE9503672D0 SE9503672D0 (sv) 1995-10-19
SE9503672L SE9503672L (sv) 1997-04-20
SE505146C2 true SE505146C2 (sv) 1997-06-30

Family

ID=20399887

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9503672A SE505146C2 (sv) 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning

Country Status (16)

Country Link
US (1) US6120787A (cs)
EP (3) EP1716849A1 (cs)
JP (1) JP2000501380A (cs)
KR (1) KR100482262B1 (cs)
AT (2) ATE326953T1 (cs)
AU (1) AU699080B2 (cs)
CZ (1) CZ293059B6 (cs)
DE (3) DE69625240T2 (cs)
DK (1) DK0869774T3 (cs)
ES (2) ES2125209T3 (cs)
HU (1) HUP9901205A3 (cs)
IL (1) IL124052A (cs)
NO (1) NO320392B1 (cs)
PT (1) PT869774E (cs)
SE (1) SE505146C2 (cs)
WO (1) WO1997014408A1 (cs)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198854B1 (en) * 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
US20070212422A1 (en) * 1999-11-10 2007-09-13 Manfred Keller Dry powder for inhalation
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
ES2169980B1 (es) * 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
IT1318380B1 (it) * 2000-03-09 2003-08-25 Intercos Italiana Polvere cosmetica rivestita.
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
DE60039540D1 (de) * 2000-05-26 2008-08-28 Frohwitter Bernhard Mittel zum erhalten und/oder korrigieren der blutglukosekonzentration
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
WO2002028375A1 (en) * 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
DE60138641D1 (de) 2000-10-27 2009-06-18 Baxter Healthcare Sa Herstellung von mikrokügelchen
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US6967234B2 (en) * 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7034037B2 (en) * 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US7030127B2 (en) * 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
DE60226613D1 (de) * 2001-08-16 2008-06-26 Baxter Int Darreichungsformen welche mikropartikel und treibgas enthalten
US7105181B2 (en) 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
AU2003216288B2 (en) 2002-02-13 2009-09-24 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
SE0201599D0 (sv) 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
US7326426B2 (en) * 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
US7368125B2 (en) * 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7026374B2 (en) * 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) * 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
WO2004030631A2 (en) 2002-10-01 2004-04-15 Chiron Corporation Anti-cancer and anti-infectious disease compositions and methods for using same
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
US20040120981A1 (en) * 2002-12-20 2004-06-24 Aruna Nathan Crosslinked alkyd polyesters for medical applications
CA2510320C (en) * 2002-12-20 2012-10-09 St. James Associates Llc/Faber Research Series Coated particles for sustained-release pharmaceutical administration
US7060299B2 (en) * 2002-12-31 2006-06-13 Battelle Memorial Institute Biodegradable microparticles that stabilize and control the release of proteins
CA2530120A1 (en) * 2003-06-26 2005-01-06 Mediolanum Pharmaceuticals Ltd. Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
JP2007531701A (ja) * 2003-07-18 2007-11-08 バクスター・インターナショナル・インコーポレイテッド 制御された相分離により調製される小球状粒子の作製方法、使用および組成物
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
KR100453273B1 (ko) * 2003-09-04 2004-10-15 주식회사 펩트론 초음파 이중공급노즐을 이용한 서방성 미립구의 제조 방법
WO2005110425A1 (en) * 2004-04-15 2005-11-24 Alkermes, Inc. Polymer-based sustained release device
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
CN103393601A (zh) 2004-05-12 2013-11-20 巴克斯特国际公司 含有蛋白并在高浓度蛋白下显示可注射性的微球体
EP1758558B1 (en) * 2004-05-12 2013-10-16 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
JP2007537284A (ja) 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド 核酸マイクロスフェア、その生成および送達
US8728525B2 (en) 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
WO2006053175A2 (en) 2004-11-10 2006-05-18 Qlt Usa Inc. A stabilized polymeric delivery system
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8318210B2 (en) * 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
WO2006116546A1 (en) * 2005-04-27 2006-11-02 Baxter International Inc. Surface-modified microparticles and methods of forming and using the same
EP1726299A3 (en) 2005-05-27 2007-04-18 StratoSphere Pharma AB Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
US8017152B2 (en) * 2005-05-27 2011-09-13 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
EP1931387A4 (en) * 2005-09-07 2012-07-11 Southwest Res Inst BIODEGRADABLE MICROTEILED PHARMACEUTICAL FORMULATIONS WITH IMPROVED RELEASE RATES
US9693967B2 (en) 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US20070092553A1 (en) * 2005-10-21 2007-04-26 Pfab Lp Compositions and methods of making rapidly dissolving lonically masked formulations
US20080286375A1 (en) * 2005-11-15 2008-11-20 Amorepacific Corporation Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate
GB0602897D0 (en) * 2006-02-13 2006-03-22 Jagotec Ag Improvements In Or Relating To Dry Powder Inhaler Devices
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
EP2647712A3 (en) 2006-08-04 2013-11-20 Baxter International Inc Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
ES2398126T3 (es) 2006-08-09 2013-03-13 Intarcia Therapeutics, Inc Sistemas de liberación osmótica y unidades de pistón
JP2010505882A (ja) * 2006-10-06 2010-02-25 バクスター・インターナショナル・インコーポレイテッド 表面改質微粒子を含むマイクロエンカプセルならびに、その形成および使用の方法
GB0622818D0 (en) * 2006-11-15 2006-12-27 Jagotec Ag Improvements in or relating to organic compounds
GB0625303D0 (en) * 2006-12-19 2007-01-24 Jagotec Ag Improvements in and relating to metered dose inhalers
CA2680365A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
GB0707612D0 (en) 2007-04-19 2007-05-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
CN105688191A (zh) 2007-04-23 2016-06-22 精达制药公司 促胰岛素释放肽的混悬制剂及其应用
JP2010529040A (ja) * 2007-05-30 2010-08-26 ネオス・セラピューティクス・エルピー イオン性樹脂系の懸濁液における薬物放出の調節
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
LT2462246T (lt) 2009-09-28 2017-11-27 Intarcia Therapeutics, Inc Esminio stacionaraus vaisto tiekimo greitas įgyvendinimas ir (arba) nutraukimas
KR101331136B1 (ko) 2011-01-12 2013-11-26 아주대학교산학협력단 약물의 초기 과다 방출 제어를 위한 약물전달 제형 및 이의 제조방법
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
SG11201507751YA (en) 2013-03-21 2015-10-29 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
RU2730996C2 (ru) 2015-06-03 2020-08-26 Интарсия Терапьютикс, Инк. Системы установки и извлечения имплантата
PL3206672T3 (pl) 2015-10-27 2018-09-28 Eupraxia Pharmaceuticals Inc. Preparaty o przedłużonym uwalnianiu środków znieczulających miejscowo
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
CA3049034A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
KR102383448B1 (ko) * 2020-04-20 2022-04-06 한국화학연구원 락트산 또는 글리콜산을 포함하는 미립구형 서방출 제제 및 그의 제조방법

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117027A (en) * 1960-01-08 1964-01-07 Wisconsin Alumni Res Found Apparatus for coating particles in a fluidized bed
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4479911A (en) * 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
CA1236641A (en) * 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
SE459005B (sv) * 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
JP2541835B2 (ja) * 1986-04-07 1996-10-09 ローヌ―プーラン ローラー インターナショナル（ホウルディングス） インコーポレイテッド 持続放出型薬理組成物の製法およびこれにより得られる組成物
SE8701479L (sv) * 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
US5019397A (en) * 1988-04-21 1991-05-28 Alza Corporation Aqueous emulsion for pharmaceutical dosage form
US5275819A (en) * 1989-02-06 1994-01-04 Amer Particle Technologies Inc. Drug loaded pollen grains with an outer coating for pulsed delivery
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
EP0550436A1 (en) * 1989-11-06 1993-07-14 Alkermes Controlled Therapeutics, Inc. Protein microspheres and methods of using them
FR2663207B1 (fr) * 1990-06-15 1993-04-30 Rhone Poulenc Nutrition Animal Procede d'enrobage par un polymere ph sensible de principes actifs.
EP0576675A4 (en) * 1991-03-25 1994-06-01 Fujisawa Pharmaceutical Co Long-acting pharmaceutical preparation
EP0535937B2 (en) * 1991-10-01 2008-05-21 Takeda Chemical Industries, Ltd. Prolonged release microparticle preparation and production of the same
US5288502A (en) * 1991-10-16 1994-02-22 The University Of Texas System Preparation and uses of multi-phase microspheres
DE69329295T2 (de) * 1992-12-02 2001-03-15 Alkermes Controlled Therapeutics, Inc. Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5417982A (en) * 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres

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ATE228826T1 (de) 2002-12-15
EP1716849A1 (en) 2006-11-02
IL124052A (en) 2000-11-21
SE9503672D0 (sv) 1995-10-19
HK1011182A1 (en) 1999-07-09
NO981558L (no) 1998-04-06
AU7347896A (en) 1997-05-07
CZ293059B6 (cs) 2004-01-14
EP1142569B1 (en) 2006-05-24
JP2000501380A (ja) 2000-02-08
KR19990064267A (ko) 1999-07-26
EP0869774B1 (en) 2002-12-04
DE869774T1 (de) 1999-06-02
ES2125209T1 (es) 1999-03-01
DK0869774T3 (da) 2003-03-24
DE69625240D1 (de) 2003-01-16
DE69636177D1 (de) 2006-06-29
DE69636177T2 (de) 2007-03-29
KR100482262B1 (ko) 2006-04-14
DE69625240T2 (de) 2003-09-11
US6120787A (en) 2000-09-19
NO981558D0 (no) 1998-04-06
HUP9901205A3 (en) 2001-04-28
HUP9901205A2 (hu) 1999-08-30
CZ117398A3 (cs) 1998-09-16
EP0869774A1 (en) 1998-10-14
NO320392B1 (no) 2005-11-28
EP1142569A2 (en) 2001-10-10
EP1142569A3 (en) 2003-05-21
ATE326953T1 (de) 2006-06-15
AU699080B2 (en) 1998-11-19
ES2267637T3 (es) 2007-03-16
SE9503672L (sv) 1997-04-20
PT869774E (pt) 2003-04-30
ES2125209T3 (es) 2003-07-01
WO1997014408A1 (en) 1997-04-24

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