SE469875C - Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen - Google Patents
Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalenInfo
- Publication number
- SE469875C SE469875C SE9102238A SE9102238A SE469875C SE 469875 C SE469875 C SE 469875C SE 9102238 A SE9102238 A SE 9102238A SE 9102238 A SE9102238 A SE 9102238A SE 469875 C SE469875 C SE 469875C
- Authority
- SE
- Sweden
- Prior art keywords
- lactobacillus
- strain
- strains
- treatment
- prophylaxis
- Prior art date
Links
- 241000186660 Lactobacillus Species 0.000 title claims abstract description 54
- 229940039696 lactobacillus Drugs 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 238000011282 treatment Methods 0.000 title claims abstract description 12
- 238000011321 prophylaxis Methods 0.000 title claims abstract description 7
- 230000000968 intestinal effect Effects 0.000 title description 8
- 206010017964 Gastrointestinal infection Diseases 0.000 title 1
- 210000004347 intestinal mucosa Anatomy 0.000 claims abstract description 18
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 13
- 238000001727 in vivo Methods 0.000 claims abstract description 7
- 235000015097 nutrients Nutrition 0.000 claims abstract description 5
- 208000035143 Bacterial infection Diseases 0.000 claims abstract description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract description 4
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 7
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 7
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 229940088710 antibiotic agent Drugs 0.000 claims description 5
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 239000012050 conventional carrier Substances 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 244000005709 gut microbiome Species 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 8
- 244000199866 Lactobacillus casei Species 0.000 abstract description 6
- 238000002955 isolation Methods 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 description 16
- 210000000936 intestine Anatomy 0.000 description 15
- 238000000855 fermentation Methods 0.000 description 13
- 230000004151 fermentation Effects 0.000 description 13
- 210000002429 large intestine Anatomy 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 235000016709 nutrition Nutrition 0.000 description 9
- 210000000813 small intestine Anatomy 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 229920001817 Agar Polymers 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 240000001046 Lactobacillus acidophilus Species 0.000 description 6
- 239000008272 agar Substances 0.000 description 6
- 210000000941 bile Anatomy 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 238000004108 freeze drying Methods 0.000 description 6
- 210000004877 mucosa Anatomy 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 235000007319 Avena orientalis Nutrition 0.000 description 5
- 244000075850 Avena orientalis Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 4
- 239000008186 active pharmaceutical agent Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000013611 chromosomal DNA Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 210000003405 ileum Anatomy 0.000 description 4
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 108091008146 restriction endonucleases Proteins 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 241000186604 Lactobacillus reuteri Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 206010040047 Sepsis Diseases 0.000 description 3
- 210000000683 abdominal cavity Anatomy 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- JVTAAEKCZFNVCJ-UWTATZPHSA-M (R)-lactate Chemical compound C[C@@H](O)C([O-])=O JVTAAEKCZFNVCJ-UWTATZPHSA-M 0.000 description 2
- 229920002498 Beta-glucan Polymers 0.000 description 2
- 101710130006 Beta-glucanase Proteins 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-SOOFDHNKSA-N D-ribopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@@H]1O SRBFZHDQGSBBOR-SOOFDHNKSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
- 235000013958 Lactobacillus casei Nutrition 0.000 description 2
- 241000186606 Lactobacillus gasseri Species 0.000 description 2
- 241000186871 Lactobacillus murinus Species 0.000 description 2
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 2
- 241000186869 Lactobacillus salivarius Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940017800 lactobacillus casei Drugs 0.000 description 2
- 244000005706 microflora Species 0.000 description 2
- 150000004005 nitrosamines Chemical class 0.000 description 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000021391 short chain fatty acids Nutrition 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HOVAGTYPODGVJG-BWSJPXOBSA-N (2r,3s,4s,5s)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O HOVAGTYPODGVJG-BWSJPXOBSA-N 0.000 description 1
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- VBUYCZFBVCCYFD-JJYYJPOSSA-N 2-dehydro-D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-JJYYJPOSSA-N 0.000 description 1
- IZSRJDGCGRAUAR-MROZADKFSA-M 5-dehydro-D-gluconate Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IZSRJDGCGRAUAR-MROZADKFSA-M 0.000 description 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N D-Arabitol Natural products OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
- SHZGCJCMOBCMKK-SVZMEOIVSA-N D-fucopyranose Chemical compound C[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O SHZGCJCMOBCMKK-SVZMEOIVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 206010059017 Intestinal mass Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 description 1
- HEBKCHPVOIAQTA-IMJSIDKUSA-N L-arabinitol Chemical compound OC[C@H](O)C(O)[C@@H](O)CO HEBKCHPVOIAQTA-IMJSIDKUSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 1
- SRBFZHDQGSBBOR-OWMBCFKOSA-N L-ribopyranose Chemical compound O[C@H]1COC(O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-OWMBCFKOSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241000186679 Lactobacillus buchneri Species 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 108010025915 Nitrite Reductases Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-UOWFLXDJSA-N aldehydo-D-lyxose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-UOWFLXDJSA-N 0.000 description 1
- PYMYPHUHKUWMLA-WISUUJSJSA-N aldehydo-L-xylose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WISUUJSJSA-N 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
- BJHIKXHVCXFQLS-OTWZMJIISA-N keto-L-sorbose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-OTWZMJIISA-N 0.000 description 1
- 229940116871 l-lactate Drugs 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 229940001882 lactobacillus reuteri Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- HOVAGTYPODGVJG-ZFYZTMLRSA-N methyl alpha-D-glucopyranoside Chemical compound CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HOVAGTYPODGVJG-ZFYZTMLRSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000513 principal component analysis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000006163 transport media Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/245—Lactobacillus casei
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/25—Lactobacillus plantarum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/856—Lactobacillus casei
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/857—Lactobacillus plantarum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Jellies, Jams, And Syrups (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9102238A SE469875C (sv) | 1991-07-25 | 1991-07-25 | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen |
| DK92916294T DK0554418T3 (da) | 1991-07-25 | 1992-07-24 | Tarmkoloniserende laktobaciller |
| JP5502759A JP2742962B2 (ja) | 1991-07-25 | 1992-07-24 | 腸定着ラクトバシラス |
| ES92916294T ES2114565T3 (es) | 1991-07-25 | 1992-07-24 | Lactobacilos colonizadores del intestino. |
| PCT/SE1992/000528 WO1993001823A1 (en) | 1991-07-25 | 1992-07-24 | Intestine colonizing lactobacilli |
| AU23709/92A AU659669B2 (en) | 1991-07-25 | 1992-07-24 | Intestine colonizing lactobacilli |
| EP92916294A EP0554418B1 (en) | 1991-07-25 | 1992-07-24 | Intestine colonizing lactobacilli |
| US07/989,030 US5474932A (en) | 1991-07-25 | 1992-07-24 | Intestine colonizing strains of lactobacilli |
| CA002091557A CA2091557C (en) | 1991-07-25 | 1992-07-24 | Intestine colonizing lactobacilli |
| AT92916294T ATE164073T1 (de) | 1991-07-25 | 1992-07-24 | Den darm kolonisierende laktobacillen |
| DE69224814T DE69224814T2 (de) | 1991-07-25 | 1992-07-24 | Den darm kolonisierende laktobacillen |
| FI931260A FI109357B (fi) | 1991-07-25 | 1993-03-22 | Menetelmä Lactobacillus-kannan eristämiseksi |
| NO931085A NO306699B1 (no) | 1991-07-25 | 1993-03-24 | Tarmkanal-koloniserende lactobasiller, samt fremgangsmåte for isolering og anvendelse derav, samt blanding |
| US08/417,770 US5587314A (en) | 1991-07-25 | 1995-04-06 | Intestine colonizing lactobacilli |
| US08/470,483 US5591428A (en) | 1991-07-25 | 1995-06-06 | Intestine colonizing lactobacilli |
| FI20012509A FI110611B (fi) | 1991-07-25 | 2001-12-19 | Uudet Lactobacillus-kannat ja niiden käyttö elintarvikkeiden, erityisesti kauravellin valmistamiseen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9102238A SE469875C (sv) | 1991-07-25 | 1991-07-25 | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| SE9102238D0 SE9102238D0 (sv) | 1991-07-25 |
| SE9102238L SE9102238L (sv) | 1993-01-26 |
| SE469875B SE469875B (sv) | 1993-10-04 |
| SE469875C true SE469875C (sv) | 1997-04-14 |
Family
ID=20383375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9102238A SE469875C (sv) | 1991-07-25 | 1991-07-25 | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US5474932A (no) |
| EP (1) | EP0554418B1 (no) |
| JP (1) | JP2742962B2 (no) |
| AT (1) | ATE164073T1 (no) |
| AU (1) | AU659669B2 (no) |
| CA (1) | CA2091557C (no) |
| DE (1) | DE69224814T2 (no) |
| DK (1) | DK0554418T3 (no) |
| ES (1) | ES2114565T3 (no) |
| FI (2) | FI109357B (no) |
| NO (1) | NO306699B1 (no) |
| SE (1) | SE469875C (no) |
| WO (1) | WO1993001823A1 (no) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716615A (en) * | 1992-02-10 | 1998-02-10 | Renata Maria Anna Cavaliere Vesely | Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use |
| JP2789554B2 (ja) * | 1994-09-26 | 1998-08-20 | 全国農業協同組合連合会 | 免疫活性を有するアルカリ処理ヨーグルト粉末の製造法 |
| US5733540A (en) * | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
| SE9501056D0 (sv) * | 1995-03-23 | 1995-03-23 | Probi Ab | Epithelial adherent lactobacilli |
| KR100376954B1 (ko) * | 1995-07-31 | 2003-07-18 | 프로비 에이비 | 장에서집락화하는유산간균 |
| AUPN907296A0 (en) * | 1996-04-02 | 1996-04-26 | Commonwealth Scientific And Industrial Research Organisation | Biocontrol agents for use in treatment of opportunistic infections |
| ATE298363T1 (de) * | 1996-07-09 | 2005-07-15 | Nestle Sa | Verfahren zur sprühtrocknung |
| GB9623068D0 (en) * | 1996-11-06 | 1997-01-08 | Cultech Limited | Microflora |
| SE511524C2 (sv) * | 1997-06-02 | 1999-10-11 | Essum Ab | Lactobacillus casei rhamnosus-stam samt farmaceutisk beredning för bekämpning av patogena tarmbakterier |
| RO112995B1 (ro) * | 1997-08-05 | 1998-03-30 | Rodica Teodorescu | Produs medicamentos pentru terapia colonului |
| SE510753C2 (sv) * | 1997-08-05 | 1999-06-21 | Probi Ab | Användning av en stam av Lactobacillus för tillverkning av ett läkemedel för reduktion av fibrinogenhalten i blod |
| SE511025C2 (sv) * | 1997-10-03 | 1999-07-26 | Probi Ab | Foderprodukt för häst omfattande Lactobacillus plantarum JI:1 samt Lactobacillus plantarum JI:1 och användning därav |
| ES2279534T3 (es) * | 1997-12-12 | 2007-08-16 | KARL MULLER GMBH & CO. | Composicion para curado de salchichas crudas. |
| EP1082964A1 (en) * | 1998-06-05 | 2001-03-14 | Wakamoto Pharmaceutical Co., Ltd. | Lactic acid bacterium-containing compositions, drugs and foods |
| KR20010075495A (ko) * | 1998-10-01 | 2001-08-09 | 추후보정 | 산화성 스트레스 인자의 감소 |
| FR2785809B1 (fr) | 1998-11-18 | 2001-01-12 | Gervais Danone Sa | Selection et utilisations de souches de bacteries lactiques modulatrices de l'immunite non-specifique |
| AU1543400A (en) * | 1998-12-11 | 2000-07-03 | Urex Biotech Inc. | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
| US6696057B1 (en) | 1999-09-22 | 2004-02-24 | Lacpro Industries, Inc. | Composition and method for treatment of gastrointestinal disorders and hyperlipidemia |
| TW588109B (en) * | 2000-07-29 | 2004-05-21 | Tcell Biotechnology Food Co Lt | Lactobacillus rhamnosus strain and uses thereof |
| GB2369777B (en) * | 2000-10-05 | 2004-10-27 | St Ivel Ltd | Food products with antimicrobial lactic acid bacteria |
| US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| IL156490A0 (en) | 2000-12-18 | 2004-01-04 | Probiohealth | Probiotic compounds derived from lactobacillus casei strain ke01 |
| JP4671384B2 (ja) * | 2001-05-15 | 2011-04-13 | 雪印乳業株式会社 | 新規乳酸菌株 |
| WO2003022255A2 (en) * | 2001-09-05 | 2003-03-20 | Vsl Pharmaceuticals, Inc. | Lactic acid bacteria comprising unmethylated cytosine-guanine dinucleotides for use in therapy |
| GB0124580D0 (en) * | 2001-10-12 | 2001-12-05 | Univ Reading | New composition |
| SE0103695D0 (sv) * | 2001-11-07 | 2001-11-07 | Thomas Boren | A novel non-antibiotic strategy against OGIP infections based on a cereal product |
| CA2506932A1 (en) * | 2002-10-22 | 2004-05-06 | University Of Vermont And State Agriculture College | Symbiotic food products comprising oats and methods for manufacturing the same |
| SE527555C2 (sv) | 2003-04-04 | 2006-04-11 | Probi Ab | Anti-inflammatorisk komposition innehållande tannasproducerande Lactobacillusstammar |
| CN1207382C (zh) * | 2003-04-11 | 2005-06-22 | 上海光明乳业股份有限公司 | 植物乳杆菌st－iii菌株及其在调节血脂方面的应用 |
| CN100489086C (zh) * | 2003-08-21 | 2009-05-20 | 大塚制药株式会社 | 能够刺激粘膜免疫性的乳酸菌 |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US7785635B1 (en) * | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
| US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| WO2005085287A1 (en) | 2004-03-03 | 2005-09-15 | En-N-Tech, Inc. | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions |
| EP1807097A2 (en) * | 2004-10-29 | 2007-07-18 | N.V. Nutricia | Peri-operative composition comprising lactobacillus rhamnosus |
| CA2609617C (en) | 2005-05-31 | 2014-07-08 | The Iams Company | Feline probiotic lactobacilli |
| BRPI0611492B1 (pt) | 2005-05-31 | 2021-10-13 | Mars, Incorporated | Bifidobactéria probiótica felina |
| SE529199C2 (sv) * | 2005-07-05 | 2007-05-29 | Probi Ab | Förstärkt absorption |
| EP1769801A1 (en) * | 2005-09-28 | 2007-04-04 | Hans Israelsen | Use of a fermented cereal composition for the treatment of IBD and IBS |
| SI2277524T1 (sl) * | 2005-09-28 | 2016-02-29 | Nordisk Rebalance A/S | Zdravljenje sindroma razdražljivega črevesja z uporabo probiotičnih bakterij in fermentiranih žit kot efektorjev zdravljenja |
| EP1971231A4 (en) | 2005-11-17 | 2010-09-01 | Celac Sweden Ab | PROBIOTIC BREAD AND METHOD FOR THE PRODUCTION THEREOF |
| EP1965809B9 (en) | 2005-11-21 | 2010-07-21 | Bioatlantis Limited | Compositions to improve gut health and animal performance comprising beta-glucans and alfa-fucans |
| FR2909526B1 (fr) * | 2006-12-08 | 2011-04-01 | Gervais Danone Sa | Produit alimentaire comprenant des probiotiques et un monoacide faible protone |
| JP5799299B2 (ja) | 2007-02-01 | 2015-10-21 | ザ・アイムス・カンパニーＴｈｅ Ｉａｍｓ Ｃｏｍｐａｎｙ | ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 |
| DK2136825T3 (da) * | 2007-03-01 | 2014-02-24 | Probi Ab | Anvendelse af Lactobacillus plantarum til forøgelse af bakteriediversiteten |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| SE533778C2 (sv) | 2009-05-14 | 2011-01-11 | Probi Ab | Probiotisk fruktdryck |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| BR112012015033B1 (pt) | 2009-12-22 | 2020-11-03 | Probi Ab | uso de uma composição não fermentada |
| ES2437940T3 (es) | 2010-01-28 | 2014-01-15 | Ab-Biotics S.A. | Composición probiótica para uso en el tratamiento de la inflamación del intestino |
| ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
| SI24570A (sl) | 2013-12-23 | 2015-06-30 | Medis D.O.O. | Novi sevi rodu Lactobacillus in njihova uporaba |
| DE102013022189A1 (de) | 2013-12-31 | 2015-07-02 | Carlo Schmelzer | Funktionelles Getränk und Verfahren zu dessen Herstellung |
| WO2019103198A1 (ko) | 2017-11-24 | 2019-05-31 | 주식회사 고바이오랩 | 락토바실러스 퍼멘텀 kbl 375 균주 및 그 용도 |
| SG10202112104UA (en) | 2018-05-09 | 2021-12-30 | Ko Biolabs Inc | Lactobacillus paracasei strain and use thereof |
| JP7088573B2 (ja) | 2018-05-23 | 2022-06-21 | コバイオラブズ・インコーポレイテッド | ラクトバチルス・ガッセリーｋｂｌ６９７株及びその使用 |
| CN114007434A (zh) | 2019-06-05 | 2022-02-01 | 森永乳业株式会社 | 营养组合物 |
| WO2023002252A1 (en) | 2021-07-21 | 2023-01-26 | Bioatlantis Limited | Composition comprising beta-glucans and alpha-fucans for improving gut health and animal performance and methods of making the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839281A (en) * | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| AU624067B2 (en) * | 1986-12-12 | 1992-06-04 | Biorem C.C. | Preparation suitable for use in the treatment of enteric disorders |
| DK686187D0 (da) * | 1987-12-23 | 1987-12-23 | Hansens Chr Bio Syst | Veterinaert praeparat |
| SE463796B (sv) * | 1988-03-09 | 1991-01-28 | Carl Erik Albertsson | Foerfarande foer framstaellning av en naeringskomposition och daervid framstaelld naeringskomposition |
| WO1991005850A1 (en) * | 1989-10-10 | 1991-05-02 | Tartusky Gosudarstvenny Universitet | Bacterium strain lactobacillus plantarum 38 for production of a bacterial biological preparation |
| WO1991005851A1 (en) * | 1989-10-10 | 1991-05-02 | Tartusky Gosudarstvenny Universitet | Bacterium strain lactobacillus casei subsp. casei 37 for production of a bacterial biological preparation |
| ES2102485T3 (es) * | 1992-07-06 | 1997-08-01 | Nestle Sa | Bacteria lactica. |
-
1991
- 1991-07-25 SE SE9102238A patent/SE469875C/sv not_active IP Right Cessation
-
1992
- 1992-07-24 WO PCT/SE1992/000528 patent/WO1993001823A1/en active IP Right Grant
- 1992-07-24 JP JP5502759A patent/JP2742962B2/ja not_active Expired - Lifetime
- 1992-07-24 AT AT92916294T patent/ATE164073T1/de active
- 1992-07-24 DK DK92916294T patent/DK0554418T3/da active
- 1992-07-24 US US07/989,030 patent/US5474932A/en not_active Expired - Lifetime
- 1992-07-24 CA CA002091557A patent/CA2091557C/en not_active Expired - Lifetime
- 1992-07-24 EP EP92916294A patent/EP0554418B1/en not_active Expired - Lifetime
- 1992-07-24 AU AU23709/92A patent/AU659669B2/en not_active Expired
- 1992-07-24 ES ES92916294T patent/ES2114565T3/es not_active Expired - Lifetime
- 1992-07-24 DE DE69224814T patent/DE69224814T2/de not_active Expired - Lifetime
-
1993
- 1993-03-22 FI FI931260A patent/FI109357B/fi not_active IP Right Cessation
- 1993-03-24 NO NO931085A patent/NO306699B1/no not_active IP Right Cessation
-
1995
- 1995-04-06 US US08/417,770 patent/US5587314A/en not_active Expired - Lifetime
- 1995-06-06 US US08/470,483 patent/US5591428A/en not_active Expired - Lifetime
-
2001
- 2001-12-19 FI FI20012509A patent/FI110611B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2370992A (en) | 1993-02-23 |
| JP2742962B2 (ja) | 1998-04-22 |
| SE9102238L (sv) | 1993-01-26 |
| WO1993001823A1 (en) | 1993-02-04 |
| DE69224814T2 (de) | 1998-09-03 |
| FI109357B (fi) | 2002-07-15 |
| US5474932A (en) | 1995-12-12 |
| EP0554418A1 (en) | 1993-08-11 |
| DE69224814D1 (de) | 1998-04-23 |
| CA2091557A1 (en) | 1993-01-26 |
| AU659669B2 (en) | 1995-05-25 |
| CA2091557C (en) | 1999-12-21 |
| EP0554418B1 (en) | 1998-03-18 |
| ATE164073T1 (de) | 1998-04-15 |
| US5587314A (en) | 1996-12-24 |
| ES2114565T3 (es) | 1998-06-01 |
| JPH06501624A (ja) | 1994-02-24 |
| US5591428A (en) | 1997-01-07 |
| NO931085L (no) | 1993-03-24 |
| NO306699B1 (no) | 1999-12-13 |
| FI931260A (fi) | 1993-03-22 |
| SE469875B (sv) | 1993-10-04 |
| FI110611B (fi) | 2003-02-28 |
| DK0554418T3 (da) | 1999-01-11 |
| FI931260A0 (fi) | 1993-03-22 |
| FI20012509A (fi) | 2001-12-19 |
| NO931085D0 (no) | 1993-03-24 |
| SE9102238D0 (sv) | 1991-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE469875C (sv) | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen | |
| US5709857A (en) | Lactobacillus strains of human origin, their compositons and uses thereof | |
| EP1036160B1 (en) | Strain of bacteria of the species lactobacillus paracasei subsp. paracasei, composition thereof for use in food and product containing said strain | |
| JP4022776B2 (ja) | コレステロールを低下および同化する能力を有する酸および胆汁酸塩耐性のＬａｃｔｏｂａｃｉｌｌｕｓ分離株 | |
| EP0861905B1 (en) | Novel lactobacilli strains useful in the treatment of disorders of the gastrointestinal system | |
| KR102146429B1 (ko) | 비피도박테리움 아니말리스 아종 아니말리스 균주 | |
| EP2427566B1 (en) | Probiotic microorganisms isolated from donkey milk | |
| JPH07250670A (ja) | ラクトバチルス属乳酸菌 | |
| CN113549567B (zh) | 一株具有促排便功能的鼠李糖乳杆菌nsl0401及其应用 | |
| CN114891675B (zh) | 胃源性植物乳杆菌lpf-01及其应用 | |
| EP1424075A2 (en) | Acid and bile-resistant lactobacillus isolates having the ability to lower and addimilate cholesterol | |
| EP1332223B1 (en) | Method for screening probiotic strains of the genus bifidobacterium | |
| KR100376954B1 (ko) | 장에서집락화하는유산간균 | |
| EP0949330A2 (en) | Lactobacilli strains having inhibitory and/or microbicidal activity against pathogenic microorganisms and a method for inducing and keeping said activity in lactobacilli cultures | |
| KR20000007623A (ko) | 내산성 및 생장속도가 높고 혈중 콜레스테롤저하능이 우수한젖산균 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |