SE464303B - 5-fluorouracilderivat, foerfarande foer framstaellning av detta och en anticancerkomposition - Google Patents
5-fluorouracilderivat, foerfarande foer framstaellning av detta och en anticancerkompositionInfo
- Publication number
- SE464303B SE464303B SE8701118A SE8701118A SE464303B SE 464303 B SE464303 B SE 464303B SE 8701118 A SE8701118 A SE 8701118A SE 8701118 A SE8701118 A SE 8701118A SE 464303 B SE464303 B SE 464303B
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- formula
- fluorouracil
- reaction
- cyano
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 13
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- 229960002949 fluorouracil Drugs 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002365 multiple layer Substances 0.000 description 1
- XRPITCBWOUOJTH-UHFFFAOYSA-N n,n-diethylpyridin-2-amine Chemical compound CCN(CC)C1=CC=CC=N1 XRPITCBWOUOJTH-UHFFFAOYSA-N 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 231100001090 no gastrointestinal toxicity Toxicity 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 238000006884 silylation reaction Methods 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000005051 trimethylchlorosilane Substances 0.000 description 1
- SIOVKLKJSOKLIF-HJWRWDBZSA-N trimethylsilyl (1z)-n-trimethylsilylethanimidate Chemical compound C[Si](C)(C)OC(/C)=N\[Si](C)(C)C SIOVKLKJSOKLIF-HJWRWDBZSA-N 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17646486 | 1986-07-25 | ||
| JP61181027A JPS63301880A (ja) | 1985-09-03 | 1986-07-30 | ５−フルオロウラシル誘導体 |
| JP62034161A JPS63201127A (ja) | 1987-02-17 | 1987-02-17 | ５−フルオロウラシル誘導体を含有する制癌剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8701118D0 SE8701118D0 (sv) | 1987-03-18 |
| SE8701118L SE8701118L (sv) | 1988-01-26 |
| SE464303B true SE464303B (sv) | 1991-04-08 |
Family
ID=27288338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8701118A SE464303B (sv) | 1986-07-25 | 1987-03-18 | 5-fluorouracilderivat, foerfarande foer framstaellning av detta och en anticancerkomposition |
Country Status (10)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
| KR0133555B1 (ko) | 1989-01-05 | 1998-04-23 | 오오쓰까 아끼히꼬 | 5-플루오로우라실계 화합물에 기인한 염증의 발생을 억제할 수 있는 비-주사제 형태의 항암조성물 |
| ES2093106T3 (es) * | 1990-07-19 | 1996-12-16 | Otsuka Pharma Co Ltd | Preparacion solida. |
| EP2495243B1 (en) | 2009-10-27 | 2016-12-28 | Delta-Fly Pharma, Inc. | Novel 5-fluorouracil derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0180897B1 (en) * | 1984-10-30 | 1991-08-07 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
| JPS61114739A (ja) * | 1984-11-08 | 1986-06-02 | Mitsubishi Rayon Co Ltd | 不飽和カルボン酸製造用触媒の調製法 |
-
1987
- 1987-03-16 DK DK133387A patent/DK169520B1/da not_active IP Right Cessation
- 1987-03-18 ES ES8700756A patent/ES2004904A6/es not_active Expired
- 1987-03-18 SE SE8701118A patent/SE464303B/sv not_active IP Right Cessation
- 1987-03-23 CH CH1091/87A patent/CH671578A5/de not_active IP Right Cessation
- 1987-03-24 GB GB8706972A patent/GB2192880B/en not_active Expired - Fee Related
- 1987-03-25 DE DE3709699A patent/DE3709699C2/de not_active Expired - Fee Related
- 1987-03-30 KR KR1019870002961A patent/KR950009857B1/ko not_active Expired - Fee Related
- 1987-03-30 IT IT8705150A patent/IT1207785B/it active
- 1987-03-30 NL NL8700742A patent/NL194043C/nl not_active IP Right Cessation
- 1987-03-31 FR FR878704500A patent/FR2605006B1/fr not_active Expired - Fee Related
- 1987-07-01 KR KR1019870006895A patent/KR950011394B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK133387D0 (da) | 1987-03-16 |
| GB2192880A (en) | 1988-01-27 |
| DE3709699A1 (de) | 1988-02-04 |
| GB8706972D0 (en) | 1987-04-29 |
| ES2004904A6 (es) | 1989-02-16 |
| NL8700742A (nl) | 1988-02-16 |
| FR2605006A1 (fr) | 1988-04-15 |
| SE8701118D0 (sv) | 1987-03-18 |
| IT1207785B (it) | 1989-06-01 |
| NL194043B (nl) | 2001-01-02 |
| NL194043C (nl) | 2001-05-03 |
| GB2192880B (en) | 1990-05-09 |
| CH671578A5 (enrdf_load_stackoverflow) | 1989-09-15 |
| FR2605006B1 (fr) | 1990-01-12 |
| IT8705150A0 (it) | 1987-03-30 |
| DK133387A (da) | 1988-01-26 |
| DK169520B1 (da) | 1994-11-21 |
| KR950011394B1 (ko) | 1995-10-02 |
| KR880001635A (ko) | 1988-04-25 |
| SE8701118L (sv) | 1988-01-26 |
| KR880001630A (ko) | 1988-04-25 |
| KR950009857B1 (ko) | 1995-08-29 |
| DE3709699C2 (de) | 1996-09-05 |
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