KR950009857B1 - 5-플루오로우라실 유도체의 제조방법 - Google Patents

5-플루오로우라실 유도체의 제조방법 Download PDF

Info

Publication number
KR950009857B1
KR950009857B1 KR1019870002961A KR870002961A KR950009857B1 KR 950009857 B1 KR950009857 B1 KR 950009857B1 KR 1019870002961 A KR1019870002961 A KR 1019870002961A KR 870002961 A KR870002961 A KR 870002961A KR 950009857 B1 KR950009857 B1 KR 950009857B1
Authority
KR
South Korea
Prior art keywords
compound
reaction
general formula
following general
fluorouracil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019870002961A
Other languages
English (en)
Korean (ko)
Other versions
KR880001635A (ko
Inventor
세쓰로 후지이
Original Assignee
오오쓰까 세이야꾸 가부시끼가이샤
오오쓰까 아끼히꼬
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61181027A external-priority patent/JPS63301880A/ja
Priority claimed from JP62034161A external-priority patent/JPS63201127A/ja
Application filed by 오오쓰까 세이야꾸 가부시끼가이샤, 오오쓰까 아끼히꼬 filed Critical 오오쓰까 세이야꾸 가부시끼가이샤
Publication of KR880001635A publication Critical patent/KR880001635A/ko
Application granted granted Critical
Publication of KR950009857B1 publication Critical patent/KR950009857B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019870002961A 1986-07-25 1987-03-30 5-플루오로우라실 유도체의 제조방법 Expired - Fee Related KR950009857B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP17646486 1986-07-25
JP176464 1986-07-25
JP176464/1986 1986-07-25
JP61181027A JPS63301880A (ja) 1985-09-03 1986-07-30 5−フルオロウラシル誘導体
JP181027/1986 1986-07-30
JP181027 1986-07-30
JP34161/1987 1987-02-17
JP34161 1987-02-17
JP62034161A JPS63201127A (ja) 1987-02-17 1987-02-17 5−フルオロウラシル誘導体を含有する制癌剤

Publications (2)

Publication Number Publication Date
KR880001635A KR880001635A (ko) 1988-04-25
KR950009857B1 true KR950009857B1 (ko) 1995-08-29

Family

ID=27288338

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019870002961A Expired - Fee Related KR950009857B1 (ko) 1986-07-25 1987-03-30 5-플루오로우라실 유도체의 제조방법
KR1019870006895A Expired - Fee Related KR950011394B1 (ko) 1986-07-25 1987-07-01 5-플루오로우라실 유도체 및 그의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019870006895A Expired - Fee Related KR950011394B1 (ko) 1986-07-25 1987-07-01 5-플루오로우라실 유도체 및 그의 용도

Country Status (10)

Country Link
KR (2) KR950009857B1 (enrdf_load_stackoverflow)
CH (1) CH671578A5 (enrdf_load_stackoverflow)
DE (1) DE3709699C2 (enrdf_load_stackoverflow)
DK (1) DK169520B1 (enrdf_load_stackoverflow)
ES (1) ES2004904A6 (enrdf_load_stackoverflow)
FR (1) FR2605006B1 (enrdf_load_stackoverflow)
GB (1) GB2192880B (enrdf_load_stackoverflow)
IT (1) IT1207785B (enrdf_load_stackoverflow)
NL (1) NL194043C (enrdf_load_stackoverflow)
SE (1) SE464303B (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
DE69003670T2 (de) 1989-01-05 1994-01-27 Otsuka Pharma Co Ltd Nicht einspritzbares karzinostatisches mittel zur vorbeugung der entzündung durch 5-fluoruracil und verfahren zur behandlung von krebs.
DE69122478T2 (de) * 1990-07-19 1997-05-28 Otsuka Pharma Co Ltd Feste zusammensetzung
DK2495243T3 (en) 2009-10-27 2017-03-27 Delta-Fly Pharma Inc NEW 5-FLUOROURACIL DERIVATE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180897B1 (en) * 1984-10-30 1991-08-07 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
JPS61114739A (ja) * 1984-11-08 1986-06-02 Mitsubishi Rayon Co Ltd 不飽和カルボン酸製造用触媒の調製法

Also Published As

Publication number Publication date
FR2605006A1 (fr) 1988-04-15
KR950011394B1 (ko) 1995-10-02
DK133387A (da) 1988-01-26
GB2192880A (en) 1988-01-27
NL194043B (nl) 2001-01-02
NL8700742A (nl) 1988-02-16
DE3709699A1 (de) 1988-02-04
GB8706972D0 (en) 1987-04-29
DE3709699C2 (de) 1996-09-05
IT1207785B (it) 1989-06-01
CH671578A5 (enrdf_load_stackoverflow) 1989-09-15
GB2192880B (en) 1990-05-09
IT8705150A0 (it) 1987-03-30
DK169520B1 (da) 1994-11-21
ES2004904A6 (es) 1989-02-16
KR880001635A (ko) 1988-04-25
SE464303B (sv) 1991-04-08
SE8701118D0 (sv) 1987-03-18
NL194043C (nl) 2001-05-03
KR880001630A (ko) 1988-04-25
SE8701118L (sv) 1988-01-26
DK133387D0 (da) 1987-03-16
FR2605006B1 (fr) 1990-01-12

Similar Documents

Publication Publication Date Title
TW202304911A (zh) 吡啶醯胺類化合物
DK2495243T3 (en) NEW 5-FLUOROURACIL DERIVATE
JP7651694B2 (ja) 化合物、前記化合物の互変異性体、前記化合物の立体異性体、前記化合物の水和物、前記化合物の溶媒和物または前記化合物の薬学的に許容される塩、及び薬物組成物
CN102731492A (zh) 环己烷类衍生物、其制备方法及其在医药上的应用
KR102142796B1 (ko) 피리디닐아미노피리미딘 유도체의 염, 그의 제조 방법, 및 그의 용도
EA032315B1 (ru) Замещенные трициклические гетероциклические соединения
KR20240125035A (ko) 이환 인다졸 글루코코르티코이드 수용체 길항제
EP2882744A1 (en) Process for the preparation of c-fms kinase inhibitors
KR950009857B1 (ko) 5-플루오로우라실 유도체의 제조방법
EP4032890A1 (en) Heterocyclic amide compound, pharmaceutically acceptable salt thereof, and preparation method therefor and use thereof
JPH0236184A (ja) イミダゾキノキサリン化合物、その製造方法並びにその使用
JP2025500318A (ja) ピペラジンインダゾールグルココルチコイド受容体拮抗薬
CN113278013B (zh) 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用
JPH0564931B2 (enrdf_load_stackoverflow)
CZ20993A3 (en) Antibacterially active penem esters
WO2005037837A1 (ja) 置換2−アミノ−[1,2,4]トリアゾロ[1,5−a]ピリミジン誘導体及びその用途
CN118344386A (zh) 取代桥环类抑制剂及其制备方法和应用
JP2023542161A (ja) 縮合三環式誘導体及び薬学上のその使用
KR20230104117A (ko) 붕산계 화합물
RU2823875C1 (ru) Гетероциклическое амидное соединение, его фармацевтически приемлемая соль, способ его получения и применение
JPH04225955A (ja) 置換されたベンズヒドリル2−ヒドロキシプロピルピペラジン誘導体類
TW202017927A (zh) 作爲RET激酶抑制劑的取代的[1,2,4]三唑[1,5-a]吡啶化合物
JPH0571594B2 (enrdf_load_stackoverflow)
CN108864114A (zh) 选择性a2a受体拮抗剂
JPS6360929A (ja) 抗腫瘍剤

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

FPAY Annual fee payment

Payment date: 20050824

Year of fee payment: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20060830

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20060830

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000