SE455791B - Biologiskt nedbrytbara sampolymerer av en polyol och en ketenacetal, forfarande for framstellning derav samt anvendning av dessa som berare for biologiskt aktiva medel - Google Patents

Biologiskt nedbrytbara sampolymerer av en polyol och en ketenacetal, forfarande for framstellning derav samt anvendning av dessa som berare for biologiskt aktiva medel

Info

Publication number
SE455791B
SE455791B SE8200068A SE8200068A SE455791B SE 455791 B SE455791 B SE 455791B SE 8200068 A SE8200068 A SE 8200068A SE 8200068 A SE8200068 A SE 8200068A SE 455791 B SE455791 B SE 455791B
Authority
SE
Sweden
Prior art keywords
polyol
polymers according
functionality
groups
polymers
Prior art date
Application number
SE8200068A
Other languages
English (en)
Swedish (sv)
Other versions
SE8200068L (sv
Inventor
J Heller
R F Helwing
D W H Penhale
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of SE8200068L publication Critical patent/SE8200068L/xx
Publication of SE455791B publication Critical patent/SE455791B/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Biological Depolymerization Polymers (AREA)
SE8200068A 1980-05-15 1982-01-08 Biologiskt nedbrytbara sampolymerer av en polyol och en ketenacetal, forfarande for framstellning derav samt anvendning av dessa som berare for biologiskt aktiva medel SE455791B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/150,052 US4304767A (en) 1980-05-15 1980-05-15 Polymers of di- (and higher functionality) ketene acetals and polyols

Publications (2)

Publication Number Publication Date
SE8200068L SE8200068L (sv) 1982-01-08
SE455791B true SE455791B (sv) 1988-08-08

Family

ID=22532907

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8200068A SE455791B (sv) 1980-05-15 1982-01-08 Biologiskt nedbrytbara sampolymerer av en polyol och en ketenacetal, forfarande for framstellning derav samt anvendning av dessa som berare for biologiskt aktiva medel

Country Status (20)

Country Link
US (1) US4304767A (de)
EP (1) EP0051667B1 (de)
JP (5) JPH039127B2 (de)
AT (1) AT384615B (de)
AU (1) AU543991B2 (de)
BE (1) BE888829A (de)
CA (1) CA1186438A (de)
CH (1) CH657369A5 (de)
DE (1) DE3148618A1 (de)
DK (1) DK16082A (de)
ES (1) ES8207564A1 (de)
GB (1) GB2086404B (de)
GR (1) GR74902B (de)
IE (1) IE51287B1 (de)
NL (1) NL188166C (de)
NZ (1) NZ197036A (de)
PT (1) PT73035B (de)
SE (1) SE455791B (de)
WO (1) WO1981003278A1 (de)
ZA (1) ZA813269B (de)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4513143A (en) * 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) * 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4754745A (en) * 1984-11-21 1988-07-05 Horowitz Bruce S Conformable sheet material for use in brachytherapy
US4697575A (en) * 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4780319A (en) * 1985-07-08 1988-10-25 Merck & Co., Inc. Organic acids as catalysts for the erosion of polymers
US4855132A (en) * 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4763642A (en) * 1986-04-07 1988-08-16 Horowitz Bruce S Intracavitational brachytherapy
DE3788301D1 (de) * 1986-05-15 1994-01-13 Hoechst Ag Biologisch abbaubare Polymere für Depotzubereitungen mit kontrollierter Wirkstoffabgabe.
US4713441A (en) * 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4842868A (en) * 1986-09-26 1989-06-27 Helwing Robert F Covalently bonded active agents with carbonium ion base groups
DE3700128A1 (de) * 1987-01-03 1988-07-14 Hoechst Ag Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US4913903A (en) * 1987-02-04 1990-04-03 Alza Corporation Post-surgical applications for bioerodible polymers
US4906714A (en) * 1988-08-02 1990-03-06 E. I. Du Pont De Nemours And Company Partially fluorinated polyesters from ketene acetals and fluorinated vinyl monomers
US4957986A (en) * 1988-08-02 1990-09-18 E. I. Du Pont De Nemours And Company Partially fluorinated polyesters from ketene acetals and fluorine monomers
US4957998A (en) * 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US4946931A (en) * 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
US5013821A (en) * 1989-06-15 1991-05-07 Pharmaceutical Delivery Systems, Inc. Ortho and thio-ortho ester polymer
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
JPH05502465A (ja) * 1989-08-28 1993-04-28 ファーマスーティカル デリバリー システムズ 治療薬剤の制御放出のために有用な生体内で分解し得るポリマー
US5047464A (en) * 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5217712A (en) * 1989-09-20 1993-06-08 Merck & Co., Inc. Bioerodible thermoset elastomers
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
NZ239370A (en) * 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
JPH04120376U (ja) * 1991-04-16 1992-10-28 横河電機株式会社 リレ−検査回路
US5211951A (en) * 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
US5254345A (en) * 1991-10-11 1993-10-19 Merck & Co., Inc. Poly(orthocarbonate acetal) bioerodible polymers
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
ES2118408T3 (es) * 1993-05-03 1998-09-16 Loctite Corp Cristales liquidos dispersados en polimeros de tiol y alquenos ricos en electrones.
US5401885A (en) * 1993-06-01 1995-03-28 Huls America, Inc. Method of preparing ortho esters and 1.1-dialkoxycycloalkanes
US5442033A (en) * 1993-07-20 1995-08-15 Ethicon, Inc. Liquid copolymers of epsilon-caprolactone and lactide
ES2109136B1 (es) * 1994-04-22 1998-07-01 Vita Invest Sa Polimeros biodegradables de esqueleto carbonado de acetales de centeno y alcoholes, procedimiento para su obtencion y composicion y utilizacion correspondientes.
US5811510A (en) * 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
FI98136C (fi) * 1995-09-27 1997-04-25 Biocon Oy Kudosolosuhteissa hajoava materiaali ja menetelmä sen valmistamiseksi
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
JP2002520287A (ja) * 1998-07-10 2002-07-09 ザ・ユニバーシティ・オブ・シドニー 黄斑変性における血管新生の予防的治療
AUPQ496500A0 (en) * 2000-01-06 2000-02-03 University Of Sydney, The Kit
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
ATE377048T1 (de) 2000-09-06 2007-11-15 Ap Pharma Inc Abbaubare polyacetal-polymere
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
WO2002092661A1 (en) * 2001-05-11 2002-11-21 Ap Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040062778A1 (en) * 2002-09-26 2004-04-01 Adi Shefer Surface dissolution and/or bulk erosion controlled release compositions and devices
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US6863782B2 (en) * 2002-11-15 2005-03-08 A.P. Pharma, Inc. Method of preparing di(ketene acetals)
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
CA2520775A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Non-aqueous single phase vehicles and formulations utilizing such vehicles
US7056591B1 (en) 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US7083803B2 (en) * 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7329413B1 (en) * 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US7220816B2 (en) 2003-12-16 2007-05-22 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same
US7435788B2 (en) 2003-12-19 2008-10-14 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
JP2007520496A (ja) * 2004-02-04 2007-07-26 レットメッド ピーティーワイ リミテッド 徐放性ステロイド組成物
CA2557216A1 (en) * 2004-02-26 2005-09-09 Advanced Ocular Systems Limited Heparin for the treatment of ocular pathologies
US20050192257A1 (en) * 2004-02-26 2005-09-01 Peyman Gholam A. Predictors for patients at risk for glaucoma from steroid therapy
US8685431B2 (en) 2004-03-16 2014-04-01 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same
US8778014B1 (en) 2004-03-31 2014-07-15 Advanced Cardiovascular Systems, Inc. Coatings for preventing balloon damage to polymer coated stents
SI1755616T1 (sl) 2004-04-08 2014-04-30 Eye Co Pty Ltd. Zdravljenje eksudativne retinopatije z mineralkortikoidi
US20050261243A1 (en) * 2004-04-21 2005-11-24 Peyman Gholam A Antiprostaglandins for the treatment of ocular pathologies
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050288481A1 (en) * 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
US20050271700A1 (en) * 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
US20050287184A1 (en) 2004-06-29 2005-12-29 Hossainy Syed F A Drug-delivery stent formulations for restenosis and vulnerable plaque
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US7166680B2 (en) 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
US7390497B2 (en) 2004-10-29 2008-06-24 Advanced Cardiovascular Systems, Inc. Poly(ester amide) filler blends for modulation of coating properties
US8609123B2 (en) 2004-11-29 2013-12-17 Advanced Cardiovascular Systems, Inc. Derivatized poly(ester amide) as a biobeneficial coating
US20060122152A1 (en) * 2004-12-03 2006-06-08 Peyman Gholam A Heparin for the treatment of ocular pathologies
US7419504B2 (en) 2004-12-27 2008-09-02 Advanced Cardiovascular Systems, Inc. Poly(ester amide) block copolymers
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US7202325B2 (en) * 2005-01-14 2007-04-10 Advanced Cardiovascular Systems, Inc. Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
EP1865989A2 (de) * 2005-03-31 2007-12-19 AP Pharma, Inc. Peg-poly(orthoester)-pfropfcopolymere und pharmazeutische zusammensetzungen
AU2006230201A1 (en) * 2005-03-31 2006-10-05 A.P. Pharma, Inc. PEG-polyacetal diblock and triblock copolymers and pharmaceutical compositions
US20070014760A1 (en) 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
AU2006270041B2 (en) 2005-07-18 2011-08-18 Minu, Llc Enhanced ocular neuroprotection/neurostimulation
US20070020312A1 (en) * 2005-07-20 2007-01-25 Desnoyer Jessica R Method of fabricating a bioactive agent-releasing implantable medical device
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8377462B2 (en) * 2005-07-29 2013-02-19 Advanced Cardiovascular Systems, Inc. PEA-TEMPO/PEA-BZ coatings for controlled delivery of drug from implantable medical devices
US7713916B2 (en) 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
US20070066493A1 (en) * 2005-09-22 2007-03-22 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
WO2007043672A1 (en) 2005-10-11 2007-04-19 Fujifilm Corporation Novel fluorine-containing spiroacetal compound and method of producing the same
ES2437581T3 (es) 2005-11-17 2014-01-13 Zogenix, Inc. Suministro de formulaciones viscosas por inyección sin aguja
US7910152B2 (en) * 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
EP2374472B9 (de) 2006-03-16 2019-06-12 Dyax Corp. Zusammensetzungen und Verfahren zur Behandlung von Augenerkrankungen
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070265329A1 (en) * 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
US7306040B1 (en) * 2006-06-02 2007-12-11 Halliburton Energy Services, Inc. Stimuli-degradable gels
US20070281870A1 (en) * 2006-06-02 2007-12-06 Halliburton Energy Services, Inc. Stimuli-degradable gels
US20090258028A1 (en) * 2006-06-05 2009-10-15 Abbott Cardiovascular Systems Inc. Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug
US8323676B2 (en) * 2008-06-30 2012-12-04 Abbott Cardiovascular Systems Inc. Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug
US7458953B2 (en) * 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
EP2044142A2 (de) * 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester)polymere sowie herstellungs- und verwendungsverfahren dafür
US7771739B2 (en) * 2006-06-30 2010-08-10 Abbott Cardiovascular Systems Inc. Implantable medical devices comprising semi-crystalline poly(ester-amide)
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
RU2438708C2 (ru) * 2006-07-10 2012-01-10 Эсбатек, Эн Элкон Биомедикал Рисёрч Юнит Ллк ScFv-АНТИТЕЛА, КОТОРЫЕ ПРОХОДЯТ ЧЕРЕЗ ЭПИТЕЛИАЛЬНЫЙ И/ИЛИ ЭНДОТЕЛИАЛЬНЫЙ СЛОИ
US20090181063A1 (en) * 2006-07-13 2009-07-16 Michael Huy Ngo Implantable medical device comprising a pro-healing poly(ester-amide)
US7731987B2 (en) * 2006-07-13 2010-06-08 Advanced Cardiovascular Systems, Inc. Implantable medical device comprising a pro-healing poly(ester-amide)
US8030436B2 (en) * 2006-07-13 2011-10-04 Advanced Cardiovascular Systems, Inc. Poly(ester-amide) elastomers and their use with implantable medical devices
US20080014245A1 (en) * 2006-07-14 2008-01-17 Stephen Pacetti Drug-eluting implantable medical device with free radical scavenger for protecting drugs during sterilization and related method
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
EP2409687B1 (de) 2006-11-09 2014-06-11 Alcon Research, Ltd. Wasserunlösliche Polymermatrix zur Verabreichung von Medikamenten
US20080175882A1 (en) * 2007-01-23 2008-07-24 Trollsas Mikael O Polymers of aliphatic thioester
US20080306584A1 (en) * 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US8252361B2 (en) * 2007-06-05 2012-08-28 Abbott Cardiovascular Systems Inc. Implantable medical devices for local and regional treatment
US9737638B2 (en) * 2007-06-20 2017-08-22 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
US7927621B2 (en) * 2007-06-25 2011-04-19 Abbott Cardiovascular Systems Inc. Thioester-ester-amide copolymers
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
EP2756756B1 (de) 2008-04-28 2016-01-06 Zogenix, Inc. Neuartige Formulierungen zur Behandlung von Migräne
US8889172B1 (en) 2008-04-30 2014-11-18 Abbott Cardiovascular Systems Inc. Amorphous or semi-crystalline poly(ester amide) polymer with a high glass transition temperature
US20110201869A1 (en) * 2008-05-07 2011-08-18 Obj Limited Method and apparatus for enhanced transdermal diffusion
US8765162B2 (en) * 2008-06-30 2014-07-01 Abbott Cardiovascular Systems Inc. Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same
US20100120811A1 (en) 2008-07-17 2010-05-13 Peter Hanson Long-acting injectable analgesic formulations for animals
US20100047319A1 (en) * 2008-08-21 2010-02-25 Michael Huy Ngo Biodegradable Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices With Enhanced Bioabsorption Times
JP2012512163A (ja) * 2008-12-11 2012-05-31 エーピー ファーマ, インコーポレイテッド ポリオルトエステルおよびそれらの製剤の安定性を高めるための方法
EP2488640B1 (de) 2009-10-14 2018-09-26 Nanyang Technological University Antiproliferationsmittel
EP2343046A1 (de) 2010-01-08 2011-07-13 Nirvana's Tree House B.V. Funktionalisierte Triblockcopolymere und Zusammensetzungen, die solche Polymere enthalten
EP2575950A4 (de) 2010-05-25 2014-07-09 Internat Scient Pty Ltd Verabreichung von mundpflegeprodukten
EP2582424A4 (de) 2010-06-17 2014-08-06 Internat Scient Pty Ltd Abgabe von hautpflegeprodukten
US9949811B2 (en) 2011-02-23 2018-04-24 Boston Scientific Scimed, Inc. Pelvic implant and therapeutic agent system and method
AU2012220564A1 (en) 2011-02-23 2013-08-29 Ams Research Corporation Drug releasing pelvic treatment system and method
AU2012340107B2 (en) 2011-11-18 2017-06-15 Regeneron Pharmaceuticals, Inc. Polymer protein microparticles
US9849180B2 (en) 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
US9744163B2 (en) 2013-03-15 2017-08-29 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
EP3936115A1 (de) 2014-04-21 2022-01-12 Heron Therapeutics, Inc. Systeme zur langzeitwirkenden polymerabgabe
SI3134070T1 (sl) 2014-04-21 2021-03-31 Heron Therapeutics, Inc. Sestave poliortoestra in pomožne snovi iz organske kisline
WO2018048460A1 (en) 2014-04-21 2018-03-15 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
CN106456663A (zh) 2014-06-11 2017-02-22 国际科学私人有限公司 治疗或预防关节退化的装置和方法
AU2016342374B2 (en) 2015-10-23 2022-08-04 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
KR20180090881A (ko) 2015-12-08 2018-08-13 린드라 인코퍼레이티드 위 체류 시스템을 위한 기하 구성형태
PL3389636T3 (pl) 2015-12-16 2022-11-28 Regeneron Pharmaceuticals, Inc. Kompozycje i metody wytwarzania mikrocząstek białkowych
AU2017268840B2 (en) 2016-05-27 2022-02-10 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
AU2017336154B2 (en) 2016-09-30 2023-11-09 Lyndra Therapeutics, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
US11014941B2 (en) 2017-04-24 2021-05-25 Cocrystal Pharma, Inc. Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
WO2018227147A1 (en) 2017-06-09 2018-12-13 Lyndra, Inc. Gastric residence systems with release rate-modulating films
CA3067558A1 (en) 2017-06-16 2018-12-20 Avery Therapeutics, Inc. Three dimensional tissue compositions and methods of use
WO2019060458A1 (en) 2017-09-20 2019-03-28 Lyndra, Inc. ENCAPSULATION OF GASTRIC SYSTEMS
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
MX2021000917A (es) 2018-07-27 2021-06-23 Cocrystal Pharma Inc Derivados de pirrolo[2,3-b]piridina como inhibidores de la replicación del virus de la gripe.
CN113286793B (zh) 2018-09-10 2024-04-05 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
MX2021004215A (es) 2018-10-17 2021-07-15 Cocrystal Pharma Inc Combinaciones de inhibidores de la replicación del virus de la gripe.
EP3887355A1 (de) 2018-11-26 2021-10-06 Cocrystal Pharma, Inc. Inhibitoren der influenzavirenreplikation
MX2022006236A (es) 2019-11-25 2022-06-22 Regeneron Pharma Formulaciones de liberacion sostenida con emulsiones no acuosas.
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
WO2021188620A1 (en) 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
KR20230008079A (ko) 2020-04-10 2023-01-13 코크리스탈 파마, 아이엔씨. 노로바이러스 및 코로나바이러스 복제 억제제
AU2021385363A1 (en) 2020-11-25 2023-06-08 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous membrane emulsification
CA3227602A1 (en) 2021-08-03 2023-02-09 Irina C. Jacobson Inhibitors for coronaviruses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2687407A (en) * 1951-07-18 1954-08-24 Dynamit Nobel Ag Production of resins from diallylidene pentaerythritol and a polyhydroxy alcohol
US2909506A (en) * 1956-07-10 1959-10-20 Union Carbide Corp Modified acrolein-pentaerythritol resins
US3087918A (en) * 1957-08-01 1963-04-30 Union Carbide Corp Modified acrolein-pentaerythritol resins
US2957856A (en) * 1958-08-29 1960-10-25 Union Carbide Corp Phosphorus-containing spirobi(metadioxane) resins
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4180646A (en) * 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4066747A (en) * 1976-04-08 1978-01-03 Alza Corporation Polymeric orthoesters housing beneficial drug for controlled release therefrom

Also Published As

Publication number Publication date
JPS60214745A (ja) 1985-10-28
GB2086404B (en) 1984-06-27
JPH0216930B2 (de) 1990-04-18
NL8120177A (nl) 1982-04-01
ES502255A0 (es) 1982-10-01
EP0051667A1 (de) 1982-05-19
DK16082A (da) 1982-01-15
NL188166C (nl) 1992-04-16
US4304767A (en) 1981-12-08
PT73035B (en) 1984-10-22
JPH039127B2 (de) 1991-02-07
JPH03732A (ja) 1991-01-07
JPH047729B2 (de) 1992-02-12
JPS57500613A (de) 1982-04-08
CH657369A5 (de) 1986-08-29
DE3148618C2 (de) 1990-10-18
JPS60221424A (ja) 1985-11-06
EP0051667B1 (de) 1986-03-05
SE8200068L (sv) 1982-01-08
ZA813269B (en) 1982-06-30
JPH02218719A (ja) 1990-08-31
ES8207564A1 (es) 1982-10-01
AT384615B (de) 1987-12-10
BE888829A (fr) 1981-08-28
NZ197036A (en) 1984-02-03
DE3148618A1 (en) 1982-07-15
GB2086404A (en) 1982-05-12
IE811098L (en) 1981-11-15
AU543991B2 (en) 1985-05-09
ATA904081A (de) 1987-05-15
EP0051667A4 (de) 1982-09-15
CA1186438A (en) 1985-04-30
JPH0355492B2 (de) 1991-08-23
AU7175381A (en) 1981-12-07
IE51287B1 (en) 1986-11-26
PT73035A (en) 1981-06-01
WO1981003278A1 (en) 1981-11-26
GR74902B (de) 1984-07-12

Similar Documents

Publication Publication Date Title
SE455791B (sv) Biologiskt nedbrytbara sampolymerer av en polyol och en ketenacetal, forfarande for framstellning derav samt anvendning av dessa som berare for biologiskt aktiva medel
US4079038A (en) Poly(carbonates)
US4549010A (en) Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
CA1112798A (en) Polymeric orthoesters and process for making same
US4155992A (en) Pharmaceutical composition of poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality with drug
CA2022817A1 (en) Polymers containing acetal, carboxy-acetal, ortho ester and carboxy-ortho ester linkages
US3096344A (en) Perfluoroalkyloxetanes
Vogl et al. Poly (alkylene oxide) Ionomers. V. Polymers and Copolymers of Cyclic Ethers with Pendant Carboxylate Groups
Nishikubo et al. Novel Syntheses of Poly (phosphonate) s and Poly (phosphate) s by Addition Reactions of Bisepoxides with Phosphonic Dichlorides and Dichlorophosphates
Nishida et al. Catalytic double ring-opening polyaddition of spiro orthoester with acid chloride for shrinkage-controlled molding
US4220753A (en) Alkyl alkoxymethylbenzoates
EP0628023A1 (de) Herstellung und reinigung von oligomeren formaldiolen aus poly(tetrametylenäther)glykolen und poly(oxybutylen)glykolen
Lenz Structure, Properties, and Cross-linking Reactions of Poly (ester acetals)
US3389112A (en) Unsaturated cyclic acetals and polymers thereof
KR20160047220A (ko) 폴리(부틸렌 카보네이트-코-테레프탈레이트) 수지의 제조방법
JPH0526807B2 (de)
Motoi et al. Oxetane derivatives and their polymers for designing functional polymers containing a soft, somewhat polar polyether network as a polymer support.
EP0215543B1 (de) Verfahren zur Herstellung von Polyestern, Polyamiden und Polyketonen
US4188473A (en) High temperature polymers
US5098990A (en) Method for making polyesters, polyamides and polyketones
Haack et al. Investigations on synthesis and polymerization of difunctional 7-membered cyclic ketenacetals
JPH0788417B2 (ja) 液状変性エポキシ樹脂
Muggee Synthesis and Polymerization of Several Ester Substituted Epoxides
JPS60224687A (ja) 2−メチレン−1,3−ジオキソカン
JPH09110975A (ja) 含フッ素ポリエステル及びその製造方法

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8200068-8

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8200068-8

Format of ref document f/p: F