JPH039127B2 - - Google Patents

Info

Publication number
JPH039127B2
JPH039127B2 JP50181281A JP50181281A JPH039127B2 JP H039127 B2 JPH039127 B2 JP H039127B2 JP 50181281 A JP50181281 A JP 50181281A JP 50181281 A JP50181281 A JP 50181281A JP H039127 B2 JPH039127 B2 JP H039127B2
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50181281A
Other versions
JPS57500613A (ja
Inventor
Jooji Heraa
Robaato Furanku Heruingu
Donarudo Uiriamu Henrii Penheiru
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US06/150,052 priority Critical patent/US4304767A/en
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of JPS57500613A publication Critical patent/JPS57500613A/ja
Publication of JPH039127B2 publication Critical patent/JPH039127B2/ja
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups
JP50181281A 1980-05-15 1981-05-08 Expired - Lifetime JPH039127B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06/150,052 US4304767A (en) 1980-05-15 1980-05-15 Polymers of di- (and higher functionality) ketene acetals and polyols

Publications (2)

Publication Number Publication Date
JPS57500613A JPS57500613A (ja) 1982-04-08
JPH039127B2 true JPH039127B2 (ja) 1991-02-07

Family

ID=22532907

Family Applications (5)

Application Number Title Priority Date Filing Date
JP50181281A Expired - Lifetime JPH039127B2 (ja) 1980-05-15 1981-05-08
JP26966984A Expired - Lifetime JPH0216930B2 (ja) 1980-05-15 1984-12-22
JP26967084A Expired - Lifetime JPH047729B2 (ja) 1980-05-15 1984-12-22
JP1248233A Expired - Lifetime JPH0355492B2 (ja) 1980-05-15 1989-09-26
JP9658090A Pending JPH03732A (en) 1980-05-15 1990-04-13 Biodegradable polymer from polyketene acetal and polyol

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP26966984A Expired - Lifetime JPH0216930B2 (ja) 1980-05-15 1984-12-22
JP26967084A Expired - Lifetime JPH047729B2 (ja) 1980-05-15 1984-12-22
JP1248233A Expired - Lifetime JPH0355492B2 (ja) 1980-05-15 1989-09-26
JP9658090A Pending JPH03732A (en) 1980-05-15 1990-04-13 Biodegradable polymer from polyketene acetal and polyol

Country Status (20)

Country Link
US (1) US4304767A (ja)
EP (1) EP0051667B1 (ja)
JP (5) JPH039127B2 (ja)
AT (1) AT384615B (ja)
AU (1) AU543991B2 (ja)
BE (1) BE888829A (ja)
CA (1) CA1186438A (ja)
CH (1) CH657369A5 (ja)
DE (1) DE3148618C2 (ja)
DK (1) DK16082A (ja)
ES (1) ES502255A0 (ja)
GB (1) GB2086404B (ja)
GR (1) GR74902B (ja)
IE (1) IE51287B1 (ja)
NL (1) NL188166C (ja)
NZ (1) NZ197036A (ja)
PT (1) PT73035B (ja)
SE (1) SE455791B (ja)
WO (1) WO1981003278A1 (ja)
ZA (1) ZA8103269B (ja)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4513143A (en) * 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) * 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4754745A (en) * 1984-11-21 1988-07-05 Horowitz Bruce S Conformable sheet material for use in brachytherapy
US4697575A (en) * 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4780319A (en) * 1985-07-08 1988-10-25 Merck & Co., Inc. Organic acids as catalysts for the erosion of polymers
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4855132A (en) * 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4763642A (en) * 1986-04-07 1988-08-16 Horowitz Bruce S Intracavitational brachytherapy
AT97929T (de) * 1986-05-15 1993-12-15 Hoechst Ag Biologisch abbaubare polymere fuer depotzubereitungen mit kontrollierter wirkstoffabgabe.
US4713441A (en) * 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4842868A (en) * 1986-09-26 1989-06-27 Helwing Robert F Covalently bonded active agents with carbonium ion base groups
DE3700128A1 (de) * 1987-01-03 1988-07-14 Hoechst Ag Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US4913903A (en) * 1987-02-04 1990-04-03 Alza Corporation Post-surgical applications for bioerodible polymers
US4957986A (en) * 1988-08-02 1990-09-18 E. I. Du Pont De Nemours And Company Partially fluorinated polyesters from ketene acetals and fluorine monomers
US4906714A (en) * 1988-08-02 1990-03-06 E. I. Du Pont De Nemours And Company Partially fluorinated polyesters from ketene acetals and fluorinated vinyl monomers
US4957998A (en) * 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US4946931A (en) * 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
US5013821A (en) * 1989-06-15 1991-05-07 Pharmaceutical Delivery Systems, Inc. Ortho and thio-ortho ester polymer
AU6402490A (en) * 1989-08-28 1991-04-08 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5047464A (en) * 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5217712A (en) * 1989-09-20 1993-06-08 Merck & Co., Inc. Bioerodible thermoset elastomers
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
NZ239370A (en) * 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
JPH04120376U (ja) * 1991-04-16 1992-10-28
US5211951A (en) * 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
US5254345A (en) * 1991-10-11 1993-10-19 Merck & Co., Inc. Poly(orthocarbonate acetal) bioerodible polymers
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
DE69411844T2 (de) * 1993-05-03 1999-02-25 Loctite Corp Polymerdispergierte flüssigkristalle in copolymeren aus thiolen und elektronenreichen alkenen
US5401885A (en) * 1993-06-01 1995-03-28 Huls America, Inc. Method of preparing ortho esters and 1.1-dialkoxycycloalkanes
US5442033A (en) * 1993-07-20 1995-08-15 Ethicon, Inc. Liquid copolymers of epsilon-caprolactone and lactide
ES2109136B1 (es) * 1994-04-22 1998-07-01 Vita Invest Sa Polimeros biodegradables de esqueleto carbonado de acetales de centeno y alcoholes, procedimiento para su obtencion y composicion y utilizacion correspondientes.
US5811510A (en) * 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
FI98136C (fi) * 1995-09-27 1997-04-25 Biocon Oy Kudosolosuhteissa hajoava materiaali ja menetelmä sen valmistamiseksi
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
NZ509797A (en) * 1998-07-10 2003-11-28 Univ Sydney Prophylactic treatments of neovascularisation in macular degeneration using a steroid
AUPQ496500A0 (en) * 2000-01-06 2000-02-03 University Of Sydney, The Kit
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
CA2453050A1 (en) 2000-09-06 2002-03-14 A.P. Pharma, Inc. Degradable polyacetal polymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
EP1395626A1 (en) * 2001-05-11 2004-03-10 AP Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040062778A1 (en) * 2002-09-26 2004-04-01 Adi Shefer Surface dissolution and/or bulk erosion controlled release compositions and devices
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US6863782B2 (en) * 2002-11-15 2005-03-08 A.P. Pharma, Inc. Method of preparing di(ketene acetals)
BRPI0408925A (pt) * 2003-03-31 2006-04-04 Alza Corp veìculos de fase simples não-aquosos e formulações utilizando tais veìculos
US7056591B1 (en) * 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US7083803B2 (en) * 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US7329413B1 (en) * 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US7220816B2 (en) 2003-12-16 2007-05-22 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same
US7435788B2 (en) 2003-12-19 2008-10-14 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
EP1711186A4 (en) * 2004-02-04 2009-03-18 Retmed Pty Ltd Slow release steroid composition
US20050192257A1 (en) * 2004-02-26 2005-09-01 Peyman Gholam A. Predictors for patients at risk for glaucoma from steroid therapy
CA2557215A1 (en) * 2004-02-26 2005-09-09 Advanced Ocular Systems Limited Tetracycline derivatives for the treatment of ocular pathologies
US8685431B2 (en) 2004-03-16 2014-04-01 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same
US8778014B1 (en) 2004-03-31 2014-07-15 Advanced Cardiovascular Systems, Inc. Coatings for preventing balloon damage to polymer coated stents
CA2562356A1 (en) 2004-04-08 2005-10-27 Retmed Pty Ltd Treatment of ophthalmic conditions with mineralcorticoids
WO2005102303A2 (en) * 2004-04-21 2005-11-03 Advanced Ocular Systems Limited Antiprostaglandins for the treatment of ocular pathologies
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050288481A1 (en) * 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
US20050271700A1 (en) * 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
US20050287184A1 (en) 2004-06-29 2005-12-29 Hossainy Syed F A Drug-delivery stent formulations for restenosis and vulnerable plaque
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US7166680B2 (en) 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
US7390497B2 (en) 2004-10-29 2008-06-24 Advanced Cardiovascular Systems, Inc. Poly(ester amide) filler blends for modulation of coating properties
US8609123B2 (en) 2004-11-29 2013-12-17 Advanced Cardiovascular Systems, Inc. Derivatized poly(ester amide) as a biobeneficial coating
US20060122152A1 (en) * 2004-12-03 2006-06-08 Peyman Gholam A Heparin for the treatment of ocular pathologies
US7419504B2 (en) 2004-12-27 2008-09-02 Advanced Cardiovascular Systems, Inc. Poly(ester amide) block copolymers
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US7202325B2 (en) 2005-01-14 2007-04-10 Advanced Cardiovascular Systems, Inc. Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
JP2008537757A (ja) * 2005-03-31 2008-09-25 エーピー ファーマ, インコーポレイテッド Peg−ポリ(オルトエステル)グラフトコポリマーおよび医薬組成物
EP1865988A2 (en) * 2005-03-31 2007-12-19 AP Pharma, Inc. Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions
US20070014760A1 (en) 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
EP1904056B1 (en) * 2005-07-18 2009-04-29 Minu, L.L.C. Use of a macrolide to restore corneal sensation
US20070020312A1 (en) * 2005-07-20 2007-01-25 Desnoyer Jessica R Method of fabricating a bioactive agent-releasing implantable medical device
US8377462B2 (en) * 2005-07-29 2013-02-19 Advanced Cardiovascular Systems, Inc. PEA-TEMPO/PEA-BZ coatings for controlled delivery of drug from implantable medical devices
US20070066493A1 (en) * 2005-09-22 2007-03-22 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
US7713916B2 (en) 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
CN101287739B (zh) 2005-10-11 2011-05-25 富士胶片株式会社 含氟螺缩醛化合物及其制备方法
CA2629300C (en) 2005-11-17 2014-07-08 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US7910152B2 (en) * 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
PL2374472T3 (pl) 2006-03-16 2018-11-30 Dyax Corp. Kompozycje i sposoby leczenia zaburzeń okulistycznych
US20070265329A1 (en) * 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US7306040B1 (en) * 2006-06-02 2007-12-11 Halliburton Energy Services, Inc. Stimuli-degradable gels
US20070281870A1 (en) * 2006-06-02 2007-12-06 Halliburton Energy Services, Inc. Stimuli-degradable gels
US20090258028A1 (en) * 2006-06-05 2009-10-15 Abbott Cardiovascular Systems Inc. Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug
US7458953B2 (en) * 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US7771739B2 (en) * 2006-06-30 2010-08-10 Abbott Cardiovascular Systems Inc. Implantable medical devices comprising semi-crystalline poly(ester-amide)
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
AU2007272224B2 (en) * 2006-07-10 2013-05-02 Esbatech, An Alcon Biomedical Research Unit Llc scFv antibodies which pass epithelial and/or endothelial layers
US7731987B2 (en) * 2006-07-13 2010-06-08 Advanced Cardiovascular Systems, Inc. Implantable medical device comprising a pro-healing poly(ester-amide)
US20090181063A1 (en) * 2006-07-13 2009-07-16 Michael Huy Ngo Implantable medical device comprising a pro-healing poly(ester-amide)
US8030436B2 (en) * 2006-07-13 2011-10-04 Advanced Cardiovascular Systems, Inc. Poly(ester-amide) elastomers and their use with implantable medical devices
US20080014245A1 (en) * 2006-07-14 2008-01-17 Stephen Pacetti Drug-eluting implantable medical device with free radical scavenger for protecting drugs during sterilization and related method
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
BRPI0718696A2 (pt) * 2006-11-09 2013-12-31 Alcon Res Ltd Matriz de polímero insolúvel em água para liberação de fármaco.
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
US20080175882A1 (en) * 2007-01-23 2008-07-24 Trollsas Mikael O Polymers of aliphatic thioester
US8252361B2 (en) * 2007-06-05 2012-08-28 Abbott Cardiovascular Systems Inc. Implantable medical devices for local and regional treatment
US20080306584A1 (en) * 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US9737638B2 (en) * 2007-06-20 2017-08-22 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
US7927621B2 (en) * 2007-06-25 2011-04-19 Abbott Cardiovascular Systems Inc. Thioester-ester-amide copolymers
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
EP2756756B1 (en) 2008-04-28 2016-01-06 Zogenix, Inc. Novel formulations for treatment of migraine
US8889172B1 (en) 2008-04-30 2014-11-18 Abbott Cardiovascular Systems Inc. Amorphous or semi-crystalline poly(ester amide) polymer with a high glass transition temperature
JP2011519638A (ja) * 2008-05-07 2011-07-14 オービージェイ・リミテッド 経皮拡散促進のための方法および装置
US8323676B2 (en) * 2008-06-30 2012-12-04 Abbott Cardiovascular Systems Inc. Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug
US8765162B2 (en) * 2008-06-30 2014-07-01 Abbott Cardiovascular Systems Inc. Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same
JP2011528379A (ja) 2008-07-17 2011-11-17 エイピー ファーマ ポリオルトエステルの安定性を増強する方法及びそれらの処方物
US20100047319A1 (en) * 2008-08-21 2010-02-25 Michael Huy Ngo Biodegradable Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices With Enhanced Bioabsorption Times
WO2010068827A1 (en) * 2008-12-11 2010-06-17 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
US20120207770A1 (en) 2009-10-14 2012-08-16 Nanyang Technological University Antiproliferative agent
EP2343046A1 (en) 2010-01-08 2011-07-13 Nirvana's Tree House B.V. Functionalised triblock copolymers and compositions containing such polymers
US9452037B2 (en) 2010-05-25 2016-09-27 International Scientific Pty Ltd Delivery of oral care products
US9463330B2 (en) 2010-06-17 2016-10-11 International Scientific Pty Ltd Delivery of skin care products
EP2677960A4 (en) 2011-02-23 2016-11-16 Boston Scient Scimed Inc Pelvic implant and therapeutic agent system and method
WO2012116209A1 (en) 2011-02-23 2012-08-30 Ams Research Corporation Drug releasing pelvic treatment system and method
EP2790681A1 (en) 2011-11-18 2014-10-22 Regeneron Pharmaceuticals, Inc. Polymer protein microparticles
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
WO2014143635A1 (en) 2013-03-15 2014-09-18 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
WO2015164283A1 (en) 2014-04-21 2015-10-29 Heron Therapeutics, Inc. Compositions of a polyorthoester and an organic acid excipient
US20170035777A1 (en) 2014-04-21 2017-02-09 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
EP3134068A2 (en) 2014-04-21 2017-03-01 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
US9849180B2 (en) 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
WO2018200425A1 (en) 2017-04-24 2018-11-01 Cocrystal Pharma, Inc. Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2687407A (en) * 1951-07-18 1954-08-24 Dynamit Nobel Ag Production of resins from diallylidene pentaerythritol and a polyhydroxy alcohol
US2909506A (en) * 1956-07-10 1959-10-20 Union Carbide Corp Modified acrolein-pentaerythritol resins
US3087918A (en) * 1957-08-01 1963-04-30 Union Carbide Corp Modified acrolein-pentaerythritol resins
US2957856A (en) * 1958-08-29 1960-10-25 Union Carbide Corp Phosphorus-containing spirobi(metadioxane) resins
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4180646A (en) * 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4066747A (en) * 1976-04-08 1978-01-03 Alza Corporation Polymeric orthoesters housing beneficial drug for controlled release therefrom

Also Published As

Publication number Publication date
DE3148618A1 (en) 1982-07-15
SE8200068L (sv) 1982-01-08
JPH0216930B2 (ja) 1990-04-18
PT73035B (en) 1984-10-22
CA1186438A1 (ja)
EP0051667B1 (en) 1986-03-05
ATA904081A (de) 1987-05-15
ES502255A0 (es) 1982-10-01
PT73035A (en) 1981-06-01
SE455791B (sv) 1988-08-08
IE51287B1 (en) 1986-11-26
NZ197036A (en) 1984-02-03
DK16082A (da) 1982-01-15
CH657369A5 (de) 1986-08-29
GB2086404B (en) 1984-06-27
BE888829A (fr) 1981-08-28
BE888829A1 (ja)
JPH03732A (en) 1991-01-07
DE3148618T0 (ja)
AT384615B (de) 1987-12-10
CA1186438A (en) 1985-04-30
NL8120177A (nl) 1982-04-01
NL188166C (nl) 1992-04-16
AU7175381A (en) 1981-12-07
GB2086404A (en) 1982-05-12
DE3148618C2 (ja) 1990-10-18
ES8207564A1 (es) 1982-10-01
JPS57500613A (ja) 1982-04-08
JPH0355492B2 (ja) 1991-08-23
JPS60214745A (en) 1985-10-28
EP0051667A4 (en) 1982-09-15
JPH047729B2 (ja) 1992-02-12
ZA8103269B (en) 1982-06-30
JPS60221424A (en) 1985-11-06
GR74902B (ja) 1984-07-12
ES502255D0 (ja)
IE811098L (en) 1981-11-15
JPH02218719A (en) 1990-08-31
AU543991B2 (en) 1985-05-09
WO1981003278A1 (en) 1981-11-26
US4304767A (en) 1981-12-08
EP0051667A1 (en) 1982-05-19

Similar Documents

Publication Publication Date Title
DE3001874C2 (ja)
DE3006460C2 (ja)
DE3002410C2 (ja)
DE3008332C2 (ja)
DE3007743C2 (ja)
DE3003869C2 (ja)
CH655460B (ja)
DE3000953C2 (ja)
DE3006112C2 (ja)
DE3001935C2 (ja)
DE3002297C2 (ja)
DE3001215C2 (ja)
CH653577B (ja)
CH655498B (ja)
DE3007049C2 (ja)
DE3001474C2 (ja)
DE3004199C2 (ja)
DE3004591C2 (ja)
DE3006835C2 (ja)
DE3007546C2 (ja)
DE3001570C2 (ja)
DE3002773C2 (ja)
DE3006475C2 (ja)
DE3006895C2 (ja)
DE3003270C2 (ja)