SE447060B - Topiskt, indometacinhaltigt lekemedel - Google Patents
Topiskt, indometacinhaltigt lekemedelInfo
- Publication number
- SE447060B SE447060B SE8100623A SE8100623A SE447060B SE 447060 B SE447060 B SE 447060B SE 8100623 A SE8100623 A SE 8100623A SE 8100623 A SE8100623 A SE 8100623A SE 447060 B SE447060 B SE 447060B
- Authority
- SE
- Sweden
- Prior art keywords
- polyethylene glycol
- indomethacin
- ether
- alkyl
- glycol
- Prior art date
Links
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 title claims description 35
- 229960000905 indomethacin Drugs 0.000 title claims description 18
- 229920001223 polyethylene glycol Polymers 0.000 claims description 27
- 239000002202 Polyethylene glycol Substances 0.000 claims description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002674 ointment Substances 0.000 claims description 9
- 230000000699 topical effect Effects 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 5
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000013543 active substance Substances 0.000 description 4
- 229960001047 methyl salicylate Drugs 0.000 description 4
- 150000005690 diesters Chemical class 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 229940113116 polyethylene glycol 1000 Drugs 0.000 description 3
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 208000025978 Athletic injury Diseases 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002848 endoanesthetic effect Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- -1 polyethylene glycol Chemical compound 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3006024A DE3006024C2 (de) | 1980-02-18 | 1980-02-18 | Topisches, Indomethacin enthaltendes Arzneimittel in Salbenform |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8100623L SE8100623L (sv) | 1981-08-19 |
| SE447060B true SE447060B (sv) | 1986-10-27 |
Family
ID=6094913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8100623A SE447060B (sv) | 1980-02-18 | 1981-01-29 | Topiskt, indometacinhaltigt lekemedel |
Country Status (11)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815940A (ja) * | 1981-07-23 | 1983-01-29 | Eisai Co Ltd | ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬 |
| JPS59227818A (ja) * | 1983-06-09 | 1984-12-21 | Mitsubishi Chem Ind Ltd | ゲル状軟膏剤 |
| CH643138A5 (de) * | 1983-08-29 | 1984-05-30 | Mepha Ag | Indomethacin enthaltende, gelartige salbe. |
| WO1985004106A1 (fr) * | 1984-03-14 | 1985-09-26 | Corbiere Jerome | Ppocede de solubilisation de principes actifs et compositions pharmaceutiques ainsi obtenues |
| JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| JPH07112984B2 (ja) * | 1989-04-28 | 1995-12-06 | 久光製薬株式会社 | 泡状エアゾール製剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624197A (en) * | 1969-09-04 | 1971-11-30 | Philip Schain | Water-soluble tissue infiltrating and embedding compositions |
| BE756975A (fr) * | 1970-06-09 | 1971-04-02 | Merck & Co Inc | Suppositoires |
| US4011313A (en) * | 1974-06-07 | 1977-03-08 | Syntex (U.S.A.) Inc. | Medicament preparations |
| JPS5320417A (en) * | 1976-08-10 | 1978-02-24 | Yamanouchi Pharmaceut Co Ltd | New composition of preparation for rectal application |
| GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
-
1980
- 1980-02-18 DE DE3006024A patent/DE3006024C2/de not_active Expired
-
1981
- 1981-01-29 GB GB8102674A patent/GB2069334B/en not_active Expired
- 1981-01-29 SE SE8100623A patent/SE447060B/sv not_active IP Right Cessation
- 1981-02-02 CH CH67181A patent/CH645541A5/de not_active IP Right Cessation
- 1981-02-03 NL NL8100503A patent/NL8100503A/nl not_active Application Discontinuation
- 1981-02-05 AT AT0051381A patent/AT373148B/de not_active IP Right Cessation
- 1981-02-17 FR FR8103119A patent/FR2475897A1/fr active Granted
- 1981-02-17 BE BE0/203809A patent/BE887541A/fr not_active IP Right Cessation
- 1981-02-18 ES ES500421A patent/ES8201826A1/es not_active Expired
- 1981-02-18 IT IT19824/81A patent/IT1136564B/it active
- 1981-02-18 JP JP56021633A patent/JPS6024764B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE887541A (fr) | 1981-06-15 |
| DE3006024C2 (de) | 1983-08-04 |
| GB2069334B (en) | 1983-10-19 |
| DE3006024A1 (de) | 1981-08-20 |
| NL8100503A (nl) | 1981-09-16 |
| JPS56135413A (en) | 1981-10-22 |
| AT373148B (de) | 1983-12-27 |
| SE8100623L (sv) | 1981-08-19 |
| ES500421A0 (es) | 1982-01-16 |
| ES8201826A1 (es) | 1982-01-16 |
| IT8119824A0 (it) | 1981-02-18 |
| CH645541A5 (de) | 1984-10-15 |
| ATA51381A (de) | 1982-06-15 |
| JPS6024764B2 (ja) | 1985-06-14 |
| GB2069334A (en) | 1981-08-26 |
| FR2475897A1 (fr) | 1981-08-21 |
| FR2475897B1 (enrdf_load_stackoverflow) | 1984-02-10 |
| IT1136564B (it) | 1986-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8100623-1 Effective date: 19691201 Format of ref document f/p: F |