JPS6024764B2 - インドメタシンを含む局所薬 - Google Patents
インドメタシンを含む局所薬Info
- Publication number
- JPS6024764B2 JPS6024764B2 JP56021633A JP2163381A JPS6024764B2 JP S6024764 B2 JPS6024764 B2 JP S6024764B2 JP 56021633 A JP56021633 A JP 56021633A JP 2163381 A JP2163381 A JP 2163381A JP S6024764 B2 JPS6024764 B2 JP S6024764B2
- Authority
- JP
- Japan
- Prior art keywords
- polyethylene glycol
- indomethacin
- ether
- molecular weight
- topical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 title claims description 53
- 229960000905 indomethacin Drugs 0.000 title claims description 26
- 229940079593 drug Drugs 0.000 title claims description 14
- 239000003814 drug Substances 0.000 title claims description 14
- 230000000699 topical effect Effects 0.000 title claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 34
- 239000002202 Polyethylene glycol Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 19
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 9
- 239000002674 ointment Substances 0.000 claims description 8
- 150000005215 alkyl ethers Chemical class 0.000 claims description 5
- LTSWUFKUZPPYEG-UHFFFAOYSA-N 1-decoxydecane Chemical compound CCCCCCCCCCOCCCCCCCCCC LTSWUFKUZPPYEG-UHFFFAOYSA-N 0.000 claims description 4
- 230000009974 thixotropic effect Effects 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 15
- 238000009472 formulation Methods 0.000 description 11
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 10
- 125000004432 carbon atom Chemical group C* 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 8
- 229960001047 methyl salicylate Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 208000034656 Contusions Diseases 0.000 description 3
- 239000012049 topical pharmaceutical composition Substances 0.000 description 3
- 208000025978 Athletic injury Diseases 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- -1 polyethylene glycol Chemical compound 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3006024.3 | 1980-02-18 | ||
| DE3006024A DE3006024C2 (de) | 1980-02-18 | 1980-02-18 | Topisches, Indomethacin enthaltendes Arzneimittel in Salbenform |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56135413A JPS56135413A (en) | 1981-10-22 |
| JPS6024764B2 true JPS6024764B2 (ja) | 1985-06-14 |
Family
ID=6094913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56021633A Expired JPS6024764B2 (ja) | 1980-02-18 | 1981-02-18 | インドメタシンを含む局所薬 |
Country Status (11)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815940A (ja) * | 1981-07-23 | 1983-01-29 | Eisai Co Ltd | ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬 |
| JPS59227818A (ja) * | 1983-06-09 | 1984-12-21 | Mitsubishi Chem Ind Ltd | ゲル状軟膏剤 |
| CH643138A5 (de) * | 1983-08-29 | 1984-05-30 | Mepha Ag | Indomethacin enthaltende, gelartige salbe. |
| WO1985004106A1 (fr) * | 1984-03-14 | 1985-09-26 | Corbiere Jerome | Ppocede de solubilisation de principes actifs et compositions pharmaceutiques ainsi obtenues |
| JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| JPH07112984B2 (ja) * | 1989-04-28 | 1995-12-06 | 久光製薬株式会社 | 泡状エアゾール製剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624197A (en) * | 1969-09-04 | 1971-11-30 | Philip Schain | Water-soluble tissue infiltrating and embedding compositions |
| BE756975A (fr) * | 1970-06-09 | 1971-04-02 | Merck & Co Inc | Suppositoires |
| US4011313A (en) * | 1974-06-07 | 1977-03-08 | Syntex (U.S.A.) Inc. | Medicament preparations |
| JPS5320417A (en) * | 1976-08-10 | 1978-02-24 | Yamanouchi Pharmaceut Co Ltd | New composition of preparation for rectal application |
| GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
-
1980
- 1980-02-18 DE DE3006024A patent/DE3006024C2/de not_active Expired
-
1981
- 1981-01-29 GB GB8102674A patent/GB2069334B/en not_active Expired
- 1981-01-29 SE SE8100623A patent/SE447060B/sv not_active IP Right Cessation
- 1981-02-02 CH CH67181A patent/CH645541A5/de not_active IP Right Cessation
- 1981-02-03 NL NL8100503A patent/NL8100503A/nl not_active Application Discontinuation
- 1981-02-05 AT AT0051381A patent/AT373148B/de not_active IP Right Cessation
- 1981-02-17 FR FR8103119A patent/FR2475897A1/fr active Granted
- 1981-02-17 BE BE0/203809A patent/BE887541A/fr not_active IP Right Cessation
- 1981-02-18 ES ES500421A patent/ES8201826A1/es not_active Expired
- 1981-02-18 IT IT19824/81A patent/IT1136564B/it active
- 1981-02-18 JP JP56021633A patent/JPS6024764B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE887541A (fr) | 1981-06-15 |
| DE3006024C2 (de) | 1983-08-04 |
| SE447060B (sv) | 1986-10-27 |
| GB2069334B (en) | 1983-10-19 |
| DE3006024A1 (de) | 1981-08-20 |
| NL8100503A (nl) | 1981-09-16 |
| JPS56135413A (en) | 1981-10-22 |
| AT373148B (de) | 1983-12-27 |
| SE8100623L (sv) | 1981-08-19 |
| ES500421A0 (es) | 1982-01-16 |
| ES8201826A1 (es) | 1982-01-16 |
| IT8119824A0 (it) | 1981-02-18 |
| CH645541A5 (de) | 1984-10-15 |
| ATA51381A (de) | 1982-06-15 |
| GB2069334A (en) | 1981-08-26 |
| FR2475897A1 (fr) | 1981-08-21 |
| FR2475897B1 (enrdf_load_stackoverflow) | 1984-02-10 |
| IT1136564B (it) | 1986-09-03 |
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