SE445740B - E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin - Google Patents

E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin

Info

Publication number
SE445740B
SE445740B SE8006669A SE8006669A SE445740B SE 445740 B SE445740 B SE 445740B SE 8006669 A SE8006669 A SE 8006669A SE 8006669 A SE8006669 A SE 8006669A SE 445740 B SE445740 B SE 445740B
Authority
SE
Sweden
Prior art keywords
deoxycytidine
halovinyl
virus
halogenevinyl
deoxicytidine
Prior art date
Application number
SE8006669A
Other languages
English (en)
Swedish (sv)
Other versions
SE8006669L (sv
Inventor
A S Jones
R T Walker
Clercq E De
G A Verhelst
Original Assignee
Univ Birmingham
Stichting Rega V Z W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Birmingham, Stichting Rega V Z W filed Critical Univ Birmingham
Publication of SE8006669L publication Critical patent/SE8006669L/xx
Publication of SE445740B publication Critical patent/SE445740B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SE8006669A 1979-10-03 1980-09-24 E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin SE445740B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7934248A GB2060604B (en) 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines

Publications (2)

Publication Number Publication Date
SE8006669L SE8006669L (sv) 1981-04-04
SE445740B true SE445740B (sv) 1986-07-14

Family

ID=10508255

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8006669A SE445740B (sv) 1979-10-03 1980-09-24 E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin

Country Status (11)

Country Link
US (1) US4382925A (es)
JP (1) JPS5695198A (es)
BE (1) BE885415A (es)
CA (1) CA1173438A (es)
CH (1) CH647245A5 (es)
DE (1) DE3036131A1 (es)
FR (1) FR2466472A1 (es)
GB (1) GB2060604B (es)
IT (1) IT1209758B (es)
NL (1) NL8005336A (es)
SE (1) SE445740B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
EP0080305A1 (en) * 1981-11-19 1983-06-01 Beecham Group Plc Antiviral 2'-deoxyuridines, their preparation and use
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
FR2531962B1 (fr) * 1982-08-17 1986-11-14 Sandoz Sa Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
EP0104066B1 (en) * 1982-09-17 1988-08-10 Glaxo Group Limited 5-halovinyl-2'-deoxyuridine derivatives
HU198393B (en) * 1984-03-06 1989-10-30 Sloan Kettering Inst Cancer Process for production of medical composition suitable for treatment of hepatitis containing as active substance derivatives of piramidin-nucleoside
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
EP0428623A4 (en) * 1988-08-10 1993-12-08 Stephen Leslie Sacks Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
CA2405502A1 (en) 2000-03-29 2001-10-04 Georgetown University Method of treating hepatitis delta viral infection
JP4651942B2 (ja) * 2001-12-20 2011-03-16 フアーマセツト・インコーポレイテッド Ｅｂｖ及びｋｈｓｖ感染並びにそれに伴う異常細胞増殖の治療
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
US4024143A (en) * 1976-03-11 1977-05-17 Pcr, Inc. Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides

Also Published As

Publication number Publication date
CH647245A5 (de) 1985-01-15
SE8006669L (sv) 1981-04-04
BE885415A (nl) 1981-03-26
DE3036131A1 (de) 1981-04-16
IT8009551A0 (it) 1980-10-02
DE3036131C2 (es) 1989-07-06
IT1209758B (it) 1989-08-30
GB2060604A (en) 1981-05-07
US4382925A (en) 1983-05-10
CA1173438A (en) 1984-08-28
JPS5695198A (en) 1981-08-01
FR2466472A1 (fr) 1981-04-10
FR2466472B1 (es) 1983-12-23
JPS637199B2 (es) 1988-02-15
GB2060604B (en) 1983-11-23
NL8005336A (nl) 1981-04-07

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