BE885415A - E-5-(2-halogeenvinyl)-2'-deoxycytidinen - Google Patents

E-5-(2-halogeenvinyl)-2'-deoxycytidinen

Info

Publication number
BE885415A
BE885415A BE1/9967A BE1009967A BE885415A BE 885415 A BE885415 A BE 885415A BE 1/9967 A BE1/9967 A BE 1/9967A BE 1009967 A BE1009967 A BE 1009967A BE 885415 A BE885415 A BE 885415A
Authority
BE
Belgium
Prior art keywords
halogenvinyl
deoxycytidines
Prior art date
Application number
BE1/9967A
Other languages
English (en)
Original Assignee
Univ Birmingham
Stichting Rega V Z W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Birmingham, Stichting Rega V Z W filed Critical Univ Birmingham
Publication of BE885415A publication Critical patent/BE885415A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
BE1/9967A 1979-10-03 1980-09-26 E-5-(2-halogeenvinyl)-2'-deoxycytidinen BE885415A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7934248A GB2060604B (en) 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines

Publications (1)

Publication Number Publication Date
BE885415A true BE885415A (nl) 1981-03-26

Family

ID=10508255

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/9967A BE885415A (nl) 1979-10-03 1980-09-26 E-5-(2-halogeenvinyl)-2'-deoxycytidinen

Country Status (11)

Country Link
US (1) US4382925A (nl)
JP (1) JPS5695198A (nl)
BE (1) BE885415A (nl)
CA (1) CA1173438A (nl)
CH (1) CH647245A5 (nl)
DE (1) DE3036131A1 (nl)
FR (1) FR2466472A1 (nl)
GB (1) GB2060604B (nl)
IT (1) IT1209758B (nl)
NL (1) NL8005336A (nl)
SE (1) SE445740B (nl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
EP0080305A1 (en) * 1981-11-19 1983-06-01 Beecham Group Plc Antiviral 2'-deoxyuridines, their preparation and use
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
FI832884A (fi) * 1982-08-17 1984-02-18 Sandoz Ag Desoxiuridinderivat, deras framstaellningsfoerfaranden och anvaendning som farmaceutiska medel
DE3377647D1 (de) * 1982-09-17 1988-09-15 Glaxo Group Ltd 5-halovinyl-2'-deoxyuridine derivatives
HU198393B (en) * 1984-03-06 1989-10-30 Sloan Kettering Inst Cancer Process for production of medical composition suitable for treatment of hepatitis containing as active substance derivatives of piramidin-nucleoside
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
EP0428623A4 (en) * 1988-08-10 1993-12-08 Stephen Leslie Sacks Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
JP2003528138A (ja) * 2000-03-29 2003-09-24 ジョージタウン・ユニバーシティ デルタ肝炎ウイルス感染症の治療法
WO2003053360A2 (en) 2001-12-20 2003-07-03 Pharmassett Ltd. Treatment of ebv and khsv infection and associated abnormal cellular proliferation
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
US4024143A (en) * 1976-03-11 1977-05-17 Pcr, Inc. Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides

Also Published As

Publication number Publication date
IT1209758B (it) 1989-08-30
CA1173438A (en) 1984-08-28
GB2060604B (en) 1983-11-23
CH647245A5 (de) 1985-01-15
GB2060604A (en) 1981-05-07
DE3036131C2 (nl) 1989-07-06
JPS637199B2 (nl) 1988-02-15
IT8009551A0 (it) 1980-10-02
NL8005336A (nl) 1981-04-07
JPS5695198A (en) 1981-08-01
SE8006669L (sv) 1981-04-04
SE445740B (sv) 1986-07-14
DE3036131A1 (de) 1981-04-16
US4382925A (en) 1983-05-10
FR2466472A1 (fr) 1981-04-10
FR2466472B1 (nl) 1983-12-23

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: STICHTING REGA V.Z.W.

Effective date: 19890930

Owner name: THE UNIVERSITY OF BIRMINGHAM

Effective date: 19890930