SE410597B - Trijod-isoftalsyra-monoaminosyraamider till anvendning som rontgenkontrastmedel - Google Patents
Trijod-isoftalsyra-monoaminosyraamider till anvendning som rontgenkontrastmedelInfo
- Publication number
- SE410597B SE410597B SE7302156A SE7302156A SE410597B SE 410597 B SE410597 B SE 410597B SE 7302156 A SE7302156 A SE 7302156A SE 7302156 A SE7302156 A SE 7302156A SE 410597 B SE410597 B SE 410597B
- Authority
- SE
- Sweden
- Prior art keywords
- triiodobenzoyl
- carboxy
- acid
- methylamide
- decomposition
- Prior art date
Links
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- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229940043257 glycylglycine Drugs 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- COQRGFWWJBEXRC-UHFFFAOYSA-N hydron;methyl 2-aminoacetate;chloride Chemical compound Cl.COC(=O)CN COQRGFWWJBEXRC-UHFFFAOYSA-N 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000026045 iodination Effects 0.000 description 1
- 238000006192 iodination reaction Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
- 150000002828 nitro derivatives Chemical class 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- XGISHOFUAFNYQF-UHFFFAOYSA-N pentanoyl chloride Chemical compound CCCCC(Cl)=O XGISHOFUAFNYQF-UHFFFAOYSA-N 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229910052705 radium Inorganic materials 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 231100000342 urinary toxicity Toxicity 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2207950A DE2207950C3 (de) | 1972-02-16 | 1972-02-16 | Trijod-isophthalsäure-monoaminosäureamide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE410597B true SE410597B (sv) | 1979-10-22 |
Family
ID=5836524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7302156A SE410597B (sv) | 1972-02-16 | 1973-02-15 | Trijod-isoftalsyra-monoaminosyraamider till anvendning som rontgenkontrastmedel |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3953501A (ja) |
| JP (2) | JPS5741460B2 (ja) |
| AR (2) | AR209257A1 (ja) |
| AT (1) | AT319464B (ja) |
| AU (1) | AU474420B2 (ja) |
| BE (1) | BE795555A (ja) |
| CA (1) | CA987325A (ja) |
| CH (2) | CH576422A5 (ja) |
| CS (2) | CS182796B2 (ja) |
| DD (1) | DD103890A5 (ja) |
| DE (1) | DE2207950C3 (ja) |
| DK (1) | DK135484C (ja) |
| ES (1) | ES411117A1 (ja) |
| FI (1) | FI55294C (ja) |
| FR (1) | FR2181737B1 (ja) |
| GB (1) | GB1428985A (ja) |
| HU (1) | HU165260B (ja) |
| IL (1) | IL41556A (ja) |
| IT (1) | IT1048111B (ja) |
| NL (1) | NL7302174A (ja) |
| NO (1) | NO138168C (ja) |
| SE (1) | SE410597B (ja) |
| SU (2) | SU563912A3 (ja) |
| YU (1) | YU36154B (ja) |
| ZA (1) | ZA731089B (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
| GB1488903A (en) * | 1974-05-31 | 1977-10-19 | Guerbet Sa | X-ray contrast media |
| US4314055A (en) * | 1975-09-29 | 1982-02-02 | Mallinckrodt, Inc. | 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids |
| US4307072A (en) * | 1976-03-12 | 1981-12-22 | Mallinckrodt, Inc. | N-Triiodobenzoylaminoacyl polyhydroxic amines |
| CH626873A5 (ja) * | 1977-03-28 | 1981-12-15 | Bracco Ind Chimica Spa | |
| DE2852094A1 (de) * | 1978-11-30 | 1980-06-12 | Schering Ag | Neue roentgenkontrastmittel |
| DE2928417A1 (de) * | 1979-07-12 | 1981-01-29 | Schering Ag | Trijodierte basen |
| DK162045C (da) * | 1982-10-01 | 1992-02-10 | Nyegaard & Co As | Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser |
| US4584401A (en) * | 1983-10-20 | 1986-04-22 | Biophysica Foundation | Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media |
| US5866100A (en) * | 1995-12-19 | 1999-02-02 | Bracco Research S.A. | Compositions for imaging of the gastrointestinal tract |
| US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
| CN117986193A (zh) * | 2022-11-01 | 2024-05-07 | 科睿驰（深圳）医疗科技发展有限公司 | 显影化合物及其制备方法、显影栓塞材料及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA616717A (en) * | 1961-03-21 | Distelmaier Alfred | Halogenated aminoisophthalic acids | |
| DE1125587B (de) * | 1957-03-06 | 1962-03-15 | Schering Ag | Roentgenkontrastmittel |
| US3009952A (en) * | 1957-04-17 | 1961-11-21 | Sterling Drug Inc | Preparation of halogenated isophthalic acids |
| US3145197A (en) * | 1961-06-26 | 1964-08-18 | Mallinckrodt Chemical Works | 5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds |
| US3102880A (en) * | 1960-09-06 | 1963-09-03 | Mallinckrodt Chemical Works | Isophthaloylbis-amino acid compounds |
| CH467626A (de) * | 1965-03-31 | 1969-01-31 | Chemie Linz Ag | Röntgenkontrastmittel |
| FR6777M (ja) * | 1967-07-10 | 1969-03-10 | ||
| IL34803A (en) * | 1969-06-27 | 1975-03-13 | Nyegaard & Co As | N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them |
-
0
- BE BE795555D patent/BE795555A/xx not_active IP Right Cessation
-
1972
- 1972-02-16 DE DE2207950A patent/DE2207950C3/de not_active Expired
- 1972-12-27 DD DD167918A patent/DD103890A5/xx unknown
-
1973
- 1973-01-05 SU SU7301873501A patent/SU563912A3/ru active
- 1973-01-26 FI FI220/73A patent/FI55294C/fi active
- 1973-01-30 ES ES411117A patent/ES411117A1/es not_active Expired
- 1973-01-30 DK DK50273A patent/DK135484C/da active
- 1973-02-01 CS CS7600002559A patent/CS182796B2/cs unknown
- 1973-02-01 CS CS7300000781A patent/CS182780B2/cs unknown
- 1973-02-05 AU AU51814/73A patent/AU474420B2/en not_active Expired
- 1973-02-05 YU YU276/73A patent/YU36154B/xx unknown
- 1973-02-09 US US05/331,110 patent/US3953501A/en not_active Expired - Lifetime
- 1973-02-12 GB GB682273A patent/GB1428985A/en not_active Expired
- 1973-02-14 AT AT130273A patent/AT319464B/de not_active IP Right Cessation
- 1973-02-15 FR FR7305347A patent/FR2181737B1/fr not_active Expired
- 1973-02-15 SE SE7302156A patent/SE410597B/sv unknown
- 1973-02-15 NO NO610/73A patent/NO138168C/no unknown
- 1973-02-15 HU HUSCHE424*1A patent/HU165260B/hu unknown
- 1973-02-16 ZA ZA731089A patent/ZA731089B/xx unknown
- 1973-02-16 IL IL41556A patent/IL41556A/en unknown
- 1973-02-16 CH CH213476A patent/CH576422A5/xx not_active IP Right Cessation
- 1973-02-16 IT IT20486/73A patent/IT1048111B/it active
- 1973-02-16 CH CH227873A patent/CH590823A5/xx not_active IP Right Cessation
- 1973-02-16 CA CA163,941A patent/CA987325A/en not_active Expired
- 1973-02-16 JP JP48019136A patent/JPS5741460B2/ja not_active Expired
- 1973-02-16 NL NL7302174A patent/NL7302174A/xx not_active Application Discontinuation
- 1973-02-16 AR AR246650A patent/AR209257A1/es active
-
1974
- 1974-01-01 AR AR253241A patent/AR207951A1/es active
- 1974-07-17 SU SU2043817A patent/SU555846A3/ru active
-
1982
- 1982-01-22 JP JP57007722A patent/JPS6059224B2/ja not_active Expired
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