SE318283B - - Google Patents

Info

Publication number
SE318283B
SE318283B SE1570567A SE1570567A SE318283B SE 318283 B SE318283 B SE 318283B SE 1570567 A SE1570567 A SE 1570567A SE 1570567 A SE1570567 A SE 1570567A SE 318283 B SE318283 B SE 318283B
Authority
SE
Sweden
Application number
SE1570567A
Inventor
O Keller
N Steiger
E Reeder
L Sternbach
W Metlesics
R Freyer
G Saucy
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE318283B publication Critical patent/SE318283B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/26Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE1570567A 1959-12-10 1967-11-15 SE318283B (US20100012521A1-20100121-C00001.png)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
SE318283B true SE318283B (US20100012521A1-20100121-C00001.png) 1969-12-08

Family

ID=27485190

Family Applications (2)

Application Number Title Priority Date Filing Date
SE12149/65A SE310887B (US20100012521A1-20100121-C00001.png) 1959-12-10 1965-09-17
SE1570567A SE318283B (US20100012521A1-20100121-C00001.png) 1959-12-10 1967-11-15

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE12149/65A SE310887B (US20100012521A1-20100121-C00001.png) 1959-12-10 1965-09-17

Country Status (11)

Country Link
BE (4) BE598015A (US20100012521A1-20100121-C00001.png)
BR (1) BR6024755D0 (US20100012521A1-20100121-C00001.png)
CH (9) CH408940A (US20100012521A1-20100121-C00001.png)
CY (1) CY324A (US20100012521A1-20100121-C00001.png)
DE (5) DE1290143B (US20100012521A1-20100121-C00001.png)
ES (2) ES263124A1 (US20100012521A1-20100121-C00001.png)
GB (13) GB972962A (US20100012521A1-20100121-C00001.png)
MY (1) MY6500178A (US20100012521A1-20100121-C00001.png)
NL (2) NL6412251A (US20100012521A1-20100121-C00001.png)
OA (7) OA00816A (US20100012521A1-20100121-C00001.png)
SE (2) SE310887B (US20100012521A1-20100121-C00001.png)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795231C3 (de) * 1963-05-29 1978-07-13 American Home Products Corp., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von 5-Aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-on-4-oxyden
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
IL159105A0 (en) 2001-06-07 2004-05-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
CA2485681C (en) * 2002-05-24 2012-10-16 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
OA00958A (fr) 1968-03-22
DE1290143B (de) 1969-03-06
GB972970A (en) 1964-10-21
BE598013A (fr) 1961-06-09
GB972967A (en) 1964-10-21
BE598008A (fr) 1961-06-09
CH396016A (de) 1965-07-31
GB972966A (en) 1964-10-21
GB972976A (en) 1964-10-21
GB972968A (en) 1964-10-21
CH408045A (de) 1966-02-28
CY324A (en) 1965-11-03
DE1445908A1 (de) 1969-04-17
CH414652A (de) 1966-06-15
OA00817A (fr) 1967-11-15
NL6412251A (US20100012521A1-20100121-C00001.png) 1966-01-25
GB972962A (en) 1964-10-21
GB972969A (en) 1964-10-21
GB972965A (en) 1964-10-21
CH408029A (de) 1966-02-28
ES263124A1 (es) 1961-06-01
OA02384A (fr) 1970-05-05
ES263123A1 (es) 1961-06-01
OA02385A (fr) 1970-05-05
GB972973A (en) 1964-10-21
CH411910A (de) 1966-04-30
CH418342A (de) 1966-08-15
MY6500178A (en) 1965-12-31
GB972964A (en) 1964-10-21
DE1288609B (de) 1969-02-06
OA00953A (fr) 1968-03-22
CH414653A (de) 1966-06-15
OA00959A (fr) 1968-03-22
OA00816A (fr) 1967-11-15
NL6412250A (US20100012521A1-20100121-C00001.png) 1966-01-25
SE310887B (US20100012521A1-20100121-C00001.png) 1969-05-19
DE1288610B (de) 1969-02-06
GB972963A (en) 1964-10-21
CH418341A (de) 1966-08-15
GB972961A (en) 1964-10-21
BE598012A (fr) 1961-06-09
CH408940A (de) 1966-03-15
BE598015A (fr) 1961-06-09
DE1445073A1 (de) 1968-10-31
BR6024755D0 (pt) 1973-05-24
GB972972A (en) 1964-10-21

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