SE305209B - - Google Patents

Info

Publication number
SE305209B
SE305209B SE1514/62A SE151462A SE305209B SE 305209 B SE305209 B SE 305209B SE 1514/62 A SE1514/62 A SE 1514/62A SE 151462 A SE151462 A SE 151462A SE 305209 B SE305209 B SE 305209B
Authority
SE
Sweden
Prior art keywords
acid
chloride
ethinylcarbonyl
acyloxyacetyl
derivative
Prior art date
Application number
SE1514/62A
Inventor
S Gottfried
L Baxendale
Original Assignee
Biorex Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Laboratories Ltd filed Critical Biorex Laboratories Ltd
Publication of SE305209B publication Critical patent/SE305209B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Abstract

The invention comprises glycyrrhetinic acid derivatives of the general formula <FORM:0887011/IV (b)/1> in which A and B and/or C and D can together represent a further bond and X is hydroxy, ethinyl or acyloxymethyl and in which rings Y and Z are cis- or trans-relationship, together with their preparation by brominating the corresponding 3,11-diketo-18a - or 18b -olean-12-ene 20-carboxylic acid to give the corresponding 2-bromo or 2,12,13-tribromo compound, dehydrobrominating to the corresponding 1,12-diene or 1,12,18-triene, and then, if desired, forming the acid chloride and converting it into the corresponding ethinylcarbonyl or acyloxyacetyl derivative. The latter steps are carried out by treatment with thionyl chloride or oxalyl chloride to form the acid chloride, followed by reaction with sodium acetylide to form the ethinylcarbonyl derivatives, or with diazomethane followed by acid treatment of the resulting diazoketone to give the acyloxyacetyl derivative. Detailed examples are given. Specifications 798,655, 843,132, 843,133 and 843,137 are referred to.
SE1514/62A 1959-07-24 1962-02-12 SE305209B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB25564/59A GB887011A (en) 1959-07-24 1959-07-24 Glycyrrhetinic acid derivatives

Publications (1)

Publication Number Publication Date
SE305209B true SE305209B (en) 1968-10-21

Family

ID=10229734

Family Applications (2)

Application Number Title Priority Date Filing Date
SE01476/67A SE329845B (en) 1959-07-24 1960-07-25
SE1514/62A SE305209B (en) 1959-07-24 1962-02-12

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE01476/67A SE329845B (en) 1959-07-24 1960-07-25

Country Status (4)

Country Link
ES (2) ES259842A1 (en)
FR (1) FR727M (en)
GB (1) GB887011A (en)
SE (2) SE329845B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008000068A1 (en) * 2006-06-27 2008-01-03 Wellington Laboratories Inc. Method for preparing 2-iodo triterpenoid compounds

Also Published As

Publication number Publication date
GB887011A (en) 1962-01-10
ES259842A1 (en) 1961-02-01
ES259841A1 (en) 1960-11-01
FR727M (en) 1961-08-07
SE329845B (en) 1970-10-26

Similar Documents

Publication Publication Date Title
SE329845B (en)
GB1060793A (en) Improvements in or relating to steroids and the manufacture thereof
GB1093908A (en) New derivatives of glycyrrhetinic acid
GB929158A (en) Improvements in or relating to the production of estradiol and its derivatives
GB916097A (en) New penicillin
GB1369819A (en) Process for the manufacture of pentafluoroethyl iodide
GB923946A (en) Improvements in or relating to steroids and the manufacture thereof
GB1077393A (en) New steroids
GB936224A (en) Novel steroids and their preparation
GB942877A (en) Improvements in or relating to a thiaxanthene derivative
GB1550823A (en) Preparation of 2-chloroalkanals
GB1019569A (en) Esters of 1ª‡,2ª‡-methylene-í¸-androstene-3,17ª‰-diol and a process for their manufacture
GB937598A (en) Process for the production of reserpic acid diesters
ES369990A1 (en) Procedure to produce a composite of prostaglandinas. (Machine-translation by Google Translate, not legally binding)
GB971591A (en) Process for the manufacture of pseudocumene-5-carboxylic acid
ES372061A1 (en) 6,9,21-trihalogenosteroids
GB993005A (en) New steroid compound
GB845442A (en) Manufacture of steroid compounds
GB1397807A (en) Process for preparing alpha-keto esters
GB1207048A (en) Novel 2-alkyl-4-oxa-steroids and a process for the manufacture thereof
GB777995A (en) Allopregnan-3,6,11,20-tetrone and processes for its preparation
GB965928A (en) Processes for the production of steroid compounds,and the new compounds thereby obtained
GB606480A (en) Improvements in and relating to a method for the production of esters of dioles and trioles of cyclopentane-polyhydro-phenanthrene series
GB890473A (en) New steroid compounds and processes for their preparation and conversion
GB930670A (en) 16:17-methylene-20-keto-steroids and a process for their manufacture