SE329845B - - Google Patents
Info
- Publication number
- SE329845B SE329845B SE01476/67A SE147667A SE329845B SE 329845 B SE329845 B SE 329845B SE 01476/67 A SE01476/67 A SE 01476/67A SE 147667 A SE147667 A SE 147667A SE 329845 B SE329845 B SE 329845B
- Authority
- SE
- Sweden
- Prior art keywords
- acid
- chloride
- ethinylcarbonyl
- acyloxyacetyl
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises glycyrrhetinic acid derivatives of the general formula <FORM:0887011/IV (b)/1> in which A and B and/or C and D can together represent a further bond and X is hydroxy, ethinyl or acyloxymethyl and in which rings Y and Z are cis- or trans-relationship, together with their preparation by brominating the corresponding 3,11-diketo-18a - or 18b -olean-12-ene 20-carboxylic acid to give the corresponding 2-bromo or 2,12,13-tribromo compound, dehydrobrominating to the corresponding 1,12-diene or 1,12,18-triene, and then, if desired, forming the acid chloride and converting it into the corresponding ethinylcarbonyl or acyloxyacetyl derivative. The latter steps are carried out by treatment with thionyl chloride or oxalyl chloride to form the acid chloride, followed by reaction with sodium acetylide to form the ethinylcarbonyl derivatives, or with diazomethane followed by acid treatment of the resulting diazoketone to give the acyloxyacetyl derivative. Detailed examples are given. Specifications 798,655, 843,132, 843,133 and 843,137 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB25564/59A GB887011A (en) | 1959-07-24 | 1959-07-24 | Glycyrrhetinic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE329845B true SE329845B (en) | 1970-10-26 |
Family
ID=10229734
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE01476/67A SE329845B (en) | 1959-07-24 | 1960-07-25 | |
| SE1514/62A SE305209B (en) | 1959-07-24 | 1962-02-12 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE1514/62A SE305209B (en) | 1959-07-24 | 1962-02-12 |
Country Status (4)
| Country | Link |
|---|---|
| ES (2) | ES259842A1 (en) |
| FR (1) | FR727M (en) |
| GB (1) | GB887011A (en) |
| SE (2) | SE329845B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5610766B2 (en) | 2006-06-27 | 2014-10-22 | ウェリントン ラボラトリーズ インコーポレイティッド | Glycyrrhetinic acid derivative |
-
1959
- 1959-07-24 GB GB25564/59A patent/GB887011A/en not_active Expired
-
1960
- 1960-07-23 ES ES0259842A patent/ES259842A1/en not_active Expired
- 1960-07-23 ES ES0259841A patent/ES259841A1/en not_active Expired
- 1960-07-25 SE SE01476/67A patent/SE329845B/xx unknown
- 1960-10-22 FR FR841942A patent/FR727M/fr active Active
-
1962
- 1962-02-12 SE SE1514/62A patent/SE305209B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR727M (en) | 1961-08-07 |
| GB887011A (en) | 1962-01-10 |
| ES259842A1 (en) | 1961-02-01 |
| SE305209B (en) | 1968-10-21 |
| ES259841A1 (en) | 1960-11-01 |
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