GB965928A - Processes for the production of steroid compounds,and the new compounds thereby obtained - Google Patents

Processes for the production of steroid compounds,and the new compounds thereby obtained

Info

Publication number
GB965928A
GB965928A GB4220461A GB4220461A GB965928A GB 965928 A GB965928 A GB 965928A GB 4220461 A GB4220461 A GB 4220461A GB 4220461 A GB4220461 A GB 4220461A GB 965928 A GB965928 A GB 965928A
Authority
GB
United Kingdom
Prior art keywords
oestr
epoxy
hydroxy
compounds
acyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4220461A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB965928A publication Critical patent/GB965928A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

9a , 10a -Epoxy-17b -hydroxy-oestr-4-en-3-one is obtained in a process wherein a 17b -acyloxy-9a , 10a -epoxy-oestr-4-en-3-one having the general formula: <FORM:0965928/C1/1> (where -OAc represents an acyloxy radical derived from an organic carboxylic acid) is reduced to form the corresponding 17b -acyloxy-9a , 10a -epoxy-3e -hydroxy-oestr-4-enewhich is then saponified to yield 9a , 10a -epoxy-3#x, 17b -hydroxy-oestr-4-ene which is reoxidised selectively at the 3-position to yield the desired 9a , 10a -epoxy,17b -hydroxy-oestr-4-en-3-one. Reduction may be effected with sodium borohydride and selective reoxidation with manganese dioxide, selenious anhydride or t-butyl chromate. Specifications 936,894 and 965,929 are referred to.
GB4220461A 1960-12-13 1961-11-24 Processes for the production of steroid compounds,and the new compounds thereby obtained Expired GB965928A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR848776 1960-12-13

Publications (1)

Publication Number Publication Date
GB965928A true GB965928A (en) 1964-08-06

Family

ID=8746059

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4220461A Expired GB965928A (en) 1960-12-13 1961-11-24 Processes for the production of steroid compounds,and the new compounds thereby obtained

Country Status (1)

Country Link
GB (1) GB965928A (en)

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