GB896980A - Process for the production of 6-methyl-3-keto-í~-steroid compounds - Google Patents

Process for the production of 6-methyl-3-keto-í~-steroid compounds

Info

Publication number
GB896980A
GB896980A GB39186/60A GB3918660A GB896980A GB 896980 A GB896980 A GB 896980A GB 39186/60 A GB39186/60 A GB 39186/60A GB 3918660 A GB3918660 A GB 3918660A GB 896980 A GB896980 A GB 896980A
Authority
GB
United Kingdom
Prior art keywords
methyl
keto
steroid compounds
production
epoxides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39186/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB896980A publication Critical patent/GB896980A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J53/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002Carbocyclic rings fused
    • C07J53/0043 membered carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

6 - Methyl - 3 - keto - D 4,6- steroid compounds are prepared by treating 6a -methyl-4a ,5- and/or 6a -methyl-4b ,5-epoxides with concentrated sulphuric acid in acetic acid. A mixture of the 4a ,5-and 4b ,5-epoxides for the above process may be prepared by treating 6a - methyl - 3 - keto - D 4 - steroids with alkaline hydrogen peroxide. The steroid compounds may be of the androstane or pregnane series, and the preferred products have the general formula <FORM:0896980/IV (b)/1> wherein R represents hydrogen, OH or OR1, X represents hydrogen or fluorine, and R1 represents an acyl radical of a carboxylic acid having not more than 9 carbon atoms. Reference has been directed by the Comptroller to Specification 843,353.
GB39186/60A 1959-11-20 1960-11-15 Process for the production of 6-methyl-3-keto-í~-steroid compounds Expired GB896980A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT896980X 1959-11-20

Publications (1)

Publication Number Publication Date
GB896980A true GB896980A (en) 1962-05-23

Family

ID=11331669

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39186/60A Expired GB896980A (en) 1959-11-20 1960-11-15 Process for the production of 6-methyl-3-keto-í~-steroid compounds

Country Status (1)

Country Link
GB (1) GB896980A (en)

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