GB907522A - Improvements in or relating to acylthio-hydroxy-steroids - Google Patents

Improvements in or relating to acylthio-hydroxy-steroids

Info

Publication number
GB907522A
GB907522A GB25662/60A GB2566260A GB907522A GB 907522 A GB907522 A GB 907522A GB 25662/60 A GB25662/60 A GB 25662/60A GB 2566260 A GB2566260 A GB 2566260A GB 907522 A GB907522 A GB 907522A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
epoxy
steroids
dione
acylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25662/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB907522A publication Critical patent/GB907522A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F03—MACHINES OR ENGINES FOR LIQUIDS; WIND, SPRING, OR WEIGHT MOTORS; PRODUCING MECHANICAL POWER OR A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
    • F03H—PRODUCING A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
    • F03H1/00—Using plasma to produce a reactive propulsive thrust
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/48—Generating plasma using an arc
    • H05H1/50—Generating plasma using an arc and using applied magnetic fields, e.g. for focusing or rotating the arc
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/26—Plasma torches
    • H05H1/32—Plasma torches using an arc
    • H05H1/34—Details, e.g. electrodes, nozzles
    • H05H1/40—Details, e.g. electrodes, nozzles using applied magnetic fields, e.g. for focusing or rotating the arc

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Combustion & Propulsion (AREA)
  • Plasma & Fusion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 3b -acetoxy-5a -hydroxy-6b -acetylthiocholestane, 5a -hydroxy-6b - acetylthiopregnane - 3,20 - dione and 2a -acetylthio-3b -hydroxy-5b ,22b -spirostane, and a process for the preparation of 5-hydroxy-6-acylthio- and 2-acylthio-3-hydroxy-steroids by treating 5,6-epoxy- and 2,3-epoxy-steroids respectively with alkylthiolic acids, e.g. by heating, preferably in an inert solvent. The above process may be applied to steroids of the spirostane, androstane, pregnane, cholane and cholestane series, e.g. 3b -acetoxy-5a ,6a -epoxy-cholestane, 2b ,3b -epoxy-5b ,22b -spirostane and 5a ,6a - epoxy-pregnane-3,20-dione 3,20-diethylene ketal (in the latter case the ethylene ketal groups are converted to keto groups during the reaction), and some 6b -acetylthio-4-pregnene-3,20-dione is formed as a by-product and which may also be obtained by dehydrating 5a -hydroxy-6b -acetylthiopregnane-3,20-dione.
GB25662/60A 1959-07-27 1960-07-22 Improvements in or relating to acylthio-hydroxy-steroids Expired GB907522A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2427359 1959-07-27

Publications (1)

Publication Number Publication Date
GB907522A true GB907522A (en) 1962-10-03

Family

ID=12133589

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25662/60A Expired GB907522A (en) 1959-07-27 1960-07-22 Improvements in or relating to acylthio-hydroxy-steroids

Country Status (4)

Country Link
CH (1) CH380114A (en)
DE (1) DE1164403B (en)
FR (1) FR135M (en)
GB (1) GB907522A (en)

Also Published As

Publication number Publication date
CH380114A (en) 1964-07-31
FR135M (en) 1961-02-06
DE1164403B (en) 1964-03-05

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