SE0400886D0 - Process of purification - Google Patents

Process of purification

Info

Publication number
SE0400886D0
SE0400886D0 SE0400886A SE0400886A SE0400886D0 SE 0400886 D0 SE0400886 D0 SE 0400886D0 SE 0400886 A SE0400886 A SE 0400886A SE 0400886 A SE0400886 A SE 0400886A SE 0400886 D0 SE0400886 D0 SE 0400886D0
Authority
SE
Sweden
Prior art keywords
chromatography matrix
target compound
ionic polyether
peg
isolating
Prior art date
Application number
SE0400886A
Other languages
English (en)
Swedish (sv)
Inventor
James Van Alstine
Anders Ljungloef
Hamid Houshmand
Per-Mikael Aaberg
Original Assignee
Amersham Biosciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab filed Critical Amersham Biosciences Ab
Priority to SE0400886A priority Critical patent/SE0400886D0/xx
Publication of SE0400886D0 publication Critical patent/SE0400886D0/xx
Priority to AU2005228834A priority patent/AU2005228834A1/en
Priority to PCT/SE2005/000467 priority patent/WO2005094960A1/en
Priority to CA002560012A priority patent/CA2560012A1/en
Priority to AT05722292T priority patent/ATE485880T1/de
Priority to JP2007506111A priority patent/JP4831697B2/ja
Priority to EP05722292A priority patent/EP1729867B1/en
Priority to DE602005024373T priority patent/DE602005024373D1/de
Priority to US10/594,187 priority patent/US20070213513A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
SE0400886A 2004-04-02 2004-04-02 Process of purification SE0400886D0 (sv)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification
AU2005228834A AU2005228834A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
PCT/SE2005/000467 WO2005094960A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
CA002560012A CA2560012A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
AT05722292T ATE485880T1 (de) 2004-04-02 2005-03-31 Verfahren zur chromatographischen reinigung
JP2007506111A JP4831697B2 (ja) 2004-04-02 2005-03-31 精製方法
EP05722292A EP1729867B1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
DE602005024373T DE602005024373D1 (de) 2004-04-02 2005-03-31 Verfahren zur chromatographischen reinigung
US10/594,187 US20070213513A1 (en) 2004-04-02 2005-03-31 Method for Chromatographic Purification

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification

Publications (1)

Publication Number Publication Date
SE0400886D0 true SE0400886D0 (sv) 2004-04-02

Family

ID=32173667

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification

Country Status (9)

Country Link
US (1) US20070213513A1 (OSRAM)
EP (1) EP1729867B1 (OSRAM)
JP (1) JP4831697B2 (OSRAM)
AT (1) ATE485880T1 (OSRAM)
AU (1) AU2005228834A1 (OSRAM)
CA (1) CA2560012A1 (OSRAM)
DE (1) DE602005024373D1 (OSRAM)
SE (1) SE0400886D0 (OSRAM)
WO (1) WO2005094960A1 (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
MX353340B (es) 2006-09-13 2018-01-09 Abbvie Inc Mejoras de cultivos celulares.
JP2010530462A (ja) * 2007-06-19 2010-09-09 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー ポリマー２相システムおよびその使用
AU2009204998B2 (en) 2008-01-18 2014-03-27 F. Hoffmann-La Roche Ag Purification of non-glycosylated proteins
JP5596560B2 (ja) * 2008-02-05 2014-09-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 分離媒体の製造方法
FR2930780B1 (fr) * 2008-04-30 2010-08-20 Moet & Chandon Procede de degorgement de vins mousseux
US20090318674A1 (en) * 2008-06-03 2009-12-24 Gagnon Peter S Process for purification of antibodies
TW201024318A (en) * 2008-10-20 2010-07-01 Abbott Lab Isolation and purification of antibodies using protein A affinity chromatography
SG195577A1 (en) 2008-10-20 2013-12-30 Abbott Lab Viral inactivation during purification of antibodies
ES2656167T5 (es) 2011-03-16 2021-03-26 Hoffmann La Roche Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos mediante la modulación de la fase móvil
JP6147726B2 (ja) 2011-03-29 2017-06-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ タンパク質精製のためのバッファー系
KR101901830B1 (ko) * 2011-06-08 2018-09-27 에이전시 포 사이언스, 테크놀로지 앤드 리서치 제한된 공수화 크로마토그래피를 통한 생물학적 산물의 정제
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
JPWO2015041218A1 (ja) * 2013-09-17 2017-03-02 株式会社カネカ 新規抗体精製方法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎＭｅｔｈｏｄａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎｍｅｔｈｏｄｕｓｉｎｇＣａｔｉｏｎＥｘｃｈａｎｇｅｒａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）
TW201628649A (zh) 2014-10-09 2016-08-16 再生元醫藥公司 減少醫藥調配物中微可見顆粒之方法
KR20230041834A (ko) 2016-08-16 2023-03-24 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
CN119492842A (zh) 2016-10-25 2025-02-21 里珍纳龙药品有限公司 用于色谱数据分析的方法和系统
CN118416215A (zh) 2017-09-19 2024-08-02 里珍纳龙药品有限公司 减少粒子形成的方法以及由其形成的组合物
CN108152104B (zh) * 2017-12-25 2020-08-11 上海微谱化工技术服务有限公司 超支化水性聚氨酯中二氧化硅填料的分离及定量方法
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
WO2019237100A1 (en) * 2018-06-08 2019-12-12 Board Of Regents, The University Of Texas System Systems and methods for separation of olefins from mixtures that contain reducing agents
TWI853823B (zh) 2018-07-02 2024-09-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
EP3934620A1 (en) 2019-03-05 2022-01-12 Regeneron Pharmaceuticals, Inc. Human serum albumin in formulations
EP4038082A1 (en) * 2019-10-04 2022-08-10 Merck Patent GmbH Elution of monoclonal antibodies in protein a affinity chromatography

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
EP0119767B1 (en) * 1983-03-11 1990-11-22 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Method of measuring ligands
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
DE3789413T2 (de) * 1986-10-03 1994-07-28 Ciba Geigy Ag Lymphokin-ähnliche Peptide.
US5151358A (en) * 1989-06-13 1992-09-29 Genencor International, Inc. Processes for the recovery of naturally produced chymosin
DE4321904B4 (de) * 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
US5561064A (en) * 1994-02-01 1996-10-01 Vical Incorporated Production of pharmaceutical-grade plasmid DNA
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
SE9503925D0 (sv) * 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
WO1998017312A1 (en) * 1996-10-22 1998-04-30 Chugai Seiyaku Kabushiki Kaisha Sepsis remedy comprising anti-il-8 antibody as active ingredient
AUPR110100A0 (en) * 2000-10-30 2000-11-23 Life Therapeutics Limited Improved separation of macromolecules
US7514078B2 (en) * 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
US20060275766A1 (en) * 2003-01-07 2006-12-07 Haurum John S Method for manufacturing recombinant polyclonal proteins

Also Published As

Publication number Publication date
WO2005094960A1 (en) 2005-10-13
DE602005024373D1 (de) 2010-12-09
EP1729867A1 (en) 2006-12-13
EP1729867B1 (en) 2010-10-27
JP4831697B2 (ja) 2011-12-07
JP2007530971A (ja) 2007-11-01
US20070213513A1 (en) 2007-09-13
ATE485880T1 (de) 2010-11-15
AU2005228834A1 (en) 2005-10-13
CA2560012A1 (en) 2005-10-13

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