SA519410253B1 - Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبط - Google Patents
Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبطInfo
- Publication number
- SA519410253B1 SA519410253B1 SA519410253A SA519410253A SA519410253B1 SA 519410253 B1 SA519410253 B1 SA 519410253B1 SA 519410253 A SA519410253 A SA 519410253A SA 519410253 A SA519410253 A SA 519410253A SA 519410253 B1 SA519410253 B1 SA 519410253B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- compound
- pyrimidin
- erk1
- inhibitor
- isoindole derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
يتعلق الاختراع الحالي بالمركب (2R)-2-(6-{5- كلورو -2-[(أوكسان -4- يل) أمينو] بيريميدين -4- يل}-1- أوكسو -2، 3- داي هيدرو -1H- أيزو إندول -2- يل)-N-[(1S)-1-(3- فلورو -5- ميثوكسي فينيل) -2- هيدروكسي إيثيل] بروباناميد (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide ، وبصفة خاصة بالأشكال الفيزيائية الجديدة للمركب، وعملية لتحضير المركب والمركبات الوسيطة التخليقية لاستخدامها في العملية، وصيغ جديدة تحتوي على المركب، وكذلك الاستخدامات العلاجية للمركب. شكل 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1706327.2A GB201706327D0 (en) | 2017-04-20 | 2017-04-20 | A pharmaceutical compound |
Publications (1)
Publication Number | Publication Date |
---|---|
SA519410253B1 true SA519410253B1 (ar) | 2023-07-12 |
Family
ID=58795788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA519410253A SA519410253B1 (ar) | 2017-04-20 | 2019-10-03 | Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبط |
Country Status (18)
Country | Link |
---|---|
US (1) | US11142518B2 (ar) |
EP (1) | EP3612524A1 (ar) |
JP (1) | JP7113846B2 (ar) |
KR (1) | KR102652193B1 (ar) |
CN (1) | CN110831939A (ar) |
AU (1) | AU2018255935B2 (ar) |
BR (1) | BR112019019948A2 (ar) |
CA (1) | CA3059674A1 (ar) |
GB (1) | GB201706327D0 (ar) |
IL (1) | IL269803B (ar) |
MA (1) | MA52123A (ar) |
MX (1) | MX2019012471A (ar) |
PH (1) | PH12019502154A1 (ar) |
SA (1) | SA519410253B1 (ar) |
SG (1) | SG11201909189QA (ar) |
TW (1) | TWI813566B (ar) |
WO (1) | WO2018193410A1 (ar) |
ZA (1) | ZA201907484B (ar) |
Families Citing this family (11)
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MA47013A (fr) | 2015-10-21 | 2018-08-29 | Otsuka Pharma Co Ltd | Composés benzolactames utilisés en tant qu'inhibiteurs de protéine kinase |
JP7326305B2 (ja) | 2018-03-02 | 2023-08-15 | 大塚製薬株式会社 | 医薬化合物 |
CN109608444B (zh) * | 2018-11-27 | 2022-02-11 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
WO2021149817A1 (en) * | 2020-01-24 | 2021-07-29 | Taiho Pharmaceutical Co., Ltd. | Enhancement of anti-tumor activity of SHP2 inhibitor pyrimidinone in combination with novel cancer medicines in cancers |
IL297743B2 (en) * | 2020-04-30 | 2024-06-01 | Medshine Discovery Inc | Compounds containing benzosulatum |
CN113967198A (zh) * | 2020-07-24 | 2022-01-25 | 鲁南制药集团股份有限公司 | 一种甾体cyp17抑制剂胶囊及其制备方法 |
CA3190001A1 (en) * | 2020-08-21 | 2022-02-24 | Shanghai Ringene Biopharma Co., Ltd. | Aromatic ring-lactam compound, preparation method therefor and use thereof |
WO2022259222A1 (en) | 2021-06-11 | 2022-12-15 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing an erk inhibitor |
US11931370B2 (en) * | 2021-10-08 | 2024-03-19 | Slayback Pharma Llc | Stable pharmaceutical compositions of cyclophosphamide |
AU2022376165A1 (en) | 2021-10-26 | 2024-05-16 | Otsuka Pharmaceutical Co., Ltd. | Compositions comprising an erk inhibitor |
CN114085213B (zh) * | 2022-01-20 | 2022-03-25 | 苏州国匡医药科技有限公司 | 一种arv-471的制备方法 |
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CA2524221A1 (en) | 2003-04-30 | 2004-11-18 | The Institutes For Pharmaceutical Discovery, Llc | Substituted heteroaryls as inhibitors of protein tyrosine phosphatases |
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TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Erk抑制劑 |
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MA47013A (fr) * | 2015-10-21 | 2018-08-29 | Otsuka Pharma Co Ltd | Composés benzolactames utilisés en tant qu'inhibiteurs de protéine kinase |
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WO2018019204A1 (zh) | 2016-07-26 | 2018-02-01 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物 |
-
2017
- 2017-04-20 GB GBGB1706327.2A patent/GB201706327D0/en not_active Ceased
-
2018
- 2018-04-20 US US16/604,002 patent/US11142518B2/en active Active
- 2018-04-20 AU AU2018255935A patent/AU2018255935B2/en active Active
- 2018-04-20 JP JP2019555918A patent/JP7113846B2/ja active Active
- 2018-04-20 IL IL269803A patent/IL269803B/en unknown
- 2018-04-20 CA CA3059674A patent/CA3059674A1/en active Pending
- 2018-04-20 MX MX2019012471A patent/MX2019012471A/es unknown
- 2018-04-20 SG SG11201909189Q patent/SG11201909189QA/en unknown
- 2018-04-20 BR BR112019019948A patent/BR112019019948A2/pt unknown
- 2018-04-20 MA MA052123A patent/MA52123A/fr unknown
- 2018-04-20 EP EP18722731.9A patent/EP3612524A1/en active Pending
- 2018-04-20 CN CN201880024602.7A patent/CN110831939A/zh active Pending
- 2018-04-20 TW TW107113537A patent/TWI813566B/zh active
- 2018-04-20 WO PCT/IB2018/052745 patent/WO2018193410A1/en unknown
- 2018-04-20 KR KR1020197033128A patent/KR102652193B1/ko active IP Right Grant
-
2019
- 2019-09-20 PH PH12019502154A patent/PH12019502154A1/en unknown
- 2019-10-03 SA SA519410253A patent/SA519410253B1/ar unknown
- 2019-11-12 ZA ZA2019/07484A patent/ZA201907484B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR102652193B1 (ko) | 2024-03-29 |
MX2019012471A (es) | 2019-12-11 |
EP3612524A1 (en) | 2020-02-26 |
US11142518B2 (en) | 2021-10-12 |
SG11201909189QA (en) | 2019-10-30 |
WO2018193410A1 (en) | 2018-10-25 |
BR112019019948A2 (pt) | 2020-04-28 |
ZA201907484B (en) | 2024-05-30 |
RU2019135029A (ru) | 2021-05-20 |
KR20190140957A (ko) | 2019-12-20 |
GB201706327D0 (en) | 2017-06-07 |
PH12019502154A1 (en) | 2020-06-29 |
TW201842912A (zh) | 2018-12-16 |
MA52123A (fr) | 2020-02-26 |
IL269803B (en) | 2022-09-01 |
CA3059674A1 (en) | 2018-10-25 |
TWI813566B (zh) | 2023-09-01 |
CN110831939A (zh) | 2020-02-21 |
RU2019135029A3 (ar) | 2021-07-16 |
IL269803A (en) | 2019-11-28 |
US20210101889A1 (en) | 2021-04-08 |
JP7113846B2 (ja) | 2022-08-05 |
AU2018255935B2 (en) | 2022-03-17 |
JP2020517598A (ja) | 2020-06-18 |
AU2018255935A1 (en) | 2019-11-07 |
US20220169638A1 (en) | 2022-06-02 |
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