SA519410253B1 - Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبط - Google Patents

Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبط

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Publication number
SA519410253B1
SA519410253B1 SA519410253A SA519410253A SA519410253B1 SA 519410253 B1 SA519410253 B1 SA 519410253B1 SA 519410253 A SA519410253 A SA 519410253A SA 519410253 A SA519410253 A SA 519410253A SA 519410253 B1 SA519410253 B1 SA 519410253B1
Authority
SA
Saudi Arabia
Prior art keywords
compound
pyrimidin
erk1
inhibitor
isoindole derivative
Prior art date
Application number
SA519410253A
Other languages
English (en)
Inventor
إيوا أدامكزيك بوزينا
أنتوني باجولي بول
كريج ميلينج روبرت
توماس ليندلي كولين
هنري ساوندرز مارك
ريدر مايكل
سكاراتي ميركا
اليزابيث ويلشير نيكولا
Original Assignee
أوتسوكا فارماسوتيكال كو.، ليمتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by أوتسوكا فارماسوتيكال كو.، ليمتد filed Critical أوتسوكا فارماسوتيكال كو.، ليمتد
Publication of SA519410253B1 publication Critical patent/SA519410253B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

يتعلق الاختراع الحالي بالمركب (2R)-2-(6-{5- كلورو -2-[(أوكسان -4- يل) أمينو] بيريميدين -4- يل}-1- أوكسو -2، 3- داي هيدرو -1H- أيزو إندول -2- يل)-N-[(1S)-1-(3- فلورو -5- ميثوكسي فينيل) -2- هيدروكسي إيثيل] بروباناميد (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide ، وبصفة خاصة بالأشكال الفيزيائية الجديدة للمركب، وعملية لتحضير المركب والمركبات الوسيطة التخليقية لاستخدامها في العملية، وصيغ جديدة تحتوي على المركب، وكذلك الاستخدامات العلاجية للمركب. شكل 1.
SA519410253A 2017-04-20 2019-10-03 Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبط SA519410253B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1706327.2A GB201706327D0 (en) 2017-04-20 2017-04-20 A pharmaceutical compound

Publications (1)

Publication Number Publication Date
SA519410253B1 true SA519410253B1 (ar) 2023-07-12

Family

ID=58795788

Family Applications (1)

Application Number Title Priority Date Filing Date
SA519410253A SA519410253B1 (ar) 2017-04-20 2019-10-03 Erk1/2 مشتق 6- بيريميدين أيزوإندول كمثبط

Country Status (17)

Country Link
US (2) US11142518B2 (ar)
EP (1) EP3612524A1 (ar)
JP (1) JP7113846B2 (ar)
KR (1) KR102652193B1 (ar)
CN (1) CN110831939A (ar)
AU (1) AU2018255935B2 (ar)
BR (1) BR112019019948A2 (ar)
CA (1) CA3059674A1 (ar)
GB (1) GB201706327D0 (ar)
IL (1) IL269803B (ar)
MA (1) MA52123A (ar)
MX (1) MX2019012471A (ar)
PH (1) PH12019502154A1 (ar)
SA (1) SA519410253B1 (ar)
SG (1) SG11201909189QA (ar)
TW (1) TWI813566B (ar)
WO (1) WO2018193410A1 (ar)

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Also Published As

Publication number Publication date
SG11201909189QA (en) 2019-10-30
JP2020517598A (ja) 2020-06-18
RU2019135029A3 (ar) 2021-07-16
BR112019019948A2 (pt) 2020-04-28
AU2018255935B2 (en) 2022-03-17
US20210101889A1 (en) 2021-04-08
CA3059674A1 (en) 2018-10-25
JP7113846B2 (ja) 2022-08-05
KR20190140957A (ko) 2019-12-20
MA52123A (fr) 2020-02-26
CN110831939A (zh) 2020-02-21
MX2019012471A (es) 2019-12-11
TW201842912A (zh) 2018-12-16
IL269803B (en) 2022-09-01
RU2019135029A (ru) 2021-05-20
US11142518B2 (en) 2021-10-12
EP3612524A1 (en) 2020-02-26
KR102652193B1 (ko) 2024-03-29
PH12019502154A1 (en) 2020-06-29
IL269803A (en) 2019-11-28
TWI813566B (zh) 2023-09-01
WO2018193410A1 (en) 2018-10-25
AU2018255935A1 (en) 2019-11-07
GB201706327D0 (en) 2017-06-07
US20220169638A1 (en) 2022-06-02

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