SA515361061B1 - مجالات سيطرة جاما- حمض كربوكسي جلوتاميك كعوامل استهدافية - Google Patents
مجالات سيطرة جاما- حمض كربوكسي جلوتاميك كعوامل استهدافية Download PDFInfo
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- SA515361061B1 SA515361061B1 SA515361061A SA515361061A SA515361061B1 SA 515361061 B1 SA515361061 B1 SA 515361061B1 SA 515361061 A SA515361061 A SA 515361061A SA 515361061 A SA515361061 A SA 515361061A SA 515361061 B1 SA515361061 B1 SA 515361061B1
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- cancer
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- polypeptide
- gla
- annexin
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| NZ255256A (en) | 1992-08-27 | 1997-02-24 | Deakin Res Ltd | Synthetic peptide antigen analogues with retro, inverso or retro-inverso modification, their use and antibodies against them |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5446128A (en) | 1993-06-18 | 1995-08-29 | The Board Of Trustees Of The University Of Illinois | Alpha-helix mimetics and methods relating thereto |
| AU6985594A (en) * | 1993-06-30 | 1995-01-24 | Bonno Nammen Bouma | Protein s deletion variants deficient in c4bp binding activity, but having apc cofactor activity, compositions and therapeutic methods |
| US5597457A (en) | 1995-01-23 | 1997-01-28 | The Regents Of The University Of California | System and method for forming synthetic protein crystals to determine the conformational structure by crystallography |
| US5840833A (en) | 1995-10-27 | 1998-11-24 | Molecumetics, Ltd | Alpha-helix mimetics and methods relating thereto |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| WO1998029453A1 (en) * | 1996-12-27 | 1998-07-09 | Mochida Pharmaceutical Co., Ltd. | Cell membrane-directed drugs |
| US6093573A (en) | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
| CA2331789C (en) * | 1998-07-13 | 2013-09-10 | Board Of Regents, The University Of Texas System | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
| AU5483699A (en) | 1998-08-13 | 2000-03-06 | American Home Products Corporation | Crystal structure of escherichia coli gdp-fucose synthetase and methods of its use |
| EP1108055A1 (en) | 1998-08-25 | 2001-06-20 | The Scripps Research Institute | Methods and systems for predicting protein function |
| US6801860B1 (en) | 1999-02-15 | 2004-10-05 | Genetics Institute, Llc | Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| JP2002003407A (ja) * | 2000-06-20 | 2002-01-09 | Medei Sci Puraningu:Kk | ハイドロキシアパタイトカルシウム指向性薬物輸送担体 |
| US8275595B2 (en) | 2001-08-14 | 2012-09-25 | Dana-Farber Cancer Institute, Inc. | Computer-based methods of designing molecules |
| US20040253606A1 (en) * | 2002-11-26 | 2004-12-16 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
| US20070142273A1 (en) * | 2003-04-18 | 2007-06-21 | Sherif Daouti | Methods and compositions targeting tyrosine kinases for the diagnosis and treatment of osteoarthritis |
| WO2004111242A1 (en) * | 2003-06-19 | 2004-12-23 | Maxygen Holdings Ltd. | FACTOR VII OR VIIa GLA DOMAIN VARIANTS |
| EP1744734A2 (en) | 2004-02-20 | 2007-01-24 | Novo Nordisk A/S | Therapeutic combination comprising a tissue factor antagonist and anti-cancer compounds |
| US7511016B2 (en) | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
| JP2008509688A (ja) * | 2004-08-17 | 2008-04-03 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 改変ビタミンｋ依存性ポリペプチド |
| DK1853631T3 (en) | 2005-01-24 | 2016-03-29 | Univ Texas | Fc-FUSION CONSTRUCTIONS BINDING TO PHOSPHATIDYLSERINE AND THERAPEUTIC APPLICATION THEREOF |
| EP1858546A4 (en) | 2005-03-04 | 2009-03-04 | Biorexis Pharmaceutical Corp | MODIFIED TRANSFERRINFUSION PROTEINS |
| WO2007047504A2 (en) | 2005-10-14 | 2007-04-26 | Biorexis Pharmaceutical Corporation | Natriuretic peptide modified transferrin fusion proteins |
| US7624557B2 (en) * | 2006-05-02 | 2009-12-01 | Box Partition Technologies, Inc. | Assembling machine with continuous periodic assembly motion |
| NZ579985A (en) * | 2007-04-13 | 2012-02-24 | Catalyst Biosciences Inc | Modified factor vii polypetides and uses thereof |
| KR100968839B1 (ko) | 2008-02-25 | 2010-07-09 | 경북대학교 산학협력단 | 포스파티딜세린과 특이적으로 결합하는 폴리펩티드 및 이의용도 |
| WO2010006136A2 (en) | 2008-07-09 | 2010-01-14 | Mayo Foundation For Medical Education And Research | Adenovirus targeting |
| WO2010018847A1 (ja) * | 2008-08-13 | 2010-02-18 | 協和発酵キリン株式会社 | 遺伝子組換えプロテインs組成物 |
| US10369204B2 (en) * | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US8283167B2 (en) | 2009-02-11 | 2012-10-09 | Clear Vascular Inc. | Preparation of annexin derivatives |
| ES2524974T3 (es) * | 2009-06-25 | 2014-12-16 | The University Of North Carolina At Chapel Hill | Moléculas del Factor VII quimérico |
| US20140004601A1 (en) | 2010-12-20 | 2014-01-02 | Agency For Science, Technology And Research | Method of purifying exosomes |
| WO2012120130A1 (en) | 2011-03-09 | 2012-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods to characterize patients suffering from hemolysis |
| US9023604B2 (en) | 2011-07-18 | 2015-05-05 | Iba Gmbh | Method of reversibly staining a target cell |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| WO2014018535A1 (en) | 2012-07-25 | 2014-01-30 | Salk Institute For Biological Studies | Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine |
| US9406314B1 (en) | 2012-10-04 | 2016-08-02 | Magnecomp Corporation | Assembly of DSA suspensions using microactuators with partially cured adhesive, and DSA suspensions having PZTs with wrap-around electrodes |
| FI3524617T3 (fi) * | 2013-03-15 | 2023-06-26 | Gladiator Biosciences Inc | Gla-domeenit terapeuttisina aineina |
| MX2017014656A (es) | 2015-05-14 | 2018-01-23 | Simplot Co J R | Cultivar de papa v11. |
| WO2017118764A1 (en) | 2016-01-07 | 2017-07-13 | Thomas Brocker | Novel approaches for the in vivo and in vitro visualization of dying cells |
| JP2020533404A (ja) | 2017-09-05 | 2020-11-19 | グラディエーター バイオサイエンシーズ インコーポレイテッド | 細胞内送達法 |
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