RU97110083A - Комбинация, фармацевтическая композиция, способ лечения, использование и упаковка - Google Patents
Комбинация, фармацевтическая композиция, способ лечения, использование и упаковкаInfo
- Publication number
- RU97110083A RU97110083A RU97110083/14A RU97110083A RU97110083A RU 97110083 A RU97110083 A RU 97110083A RU 97110083/14 A RU97110083/14 A RU 97110083/14A RU 97110083 A RU97110083 A RU 97110083A RU 97110083 A RU97110083 A RU 97110083A
- Authority
- RU
- Russia
- Prior art keywords
- mirtazapine
- combination
- treatment
- ssris
- combination according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 9
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 229960001785 Mirtazapine Drugs 0.000 claims 6
- RONZAEMNMFQXRA-UHFFFAOYSA-N Mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 claims 6
- 206010012378 Depression Diseases 0.000 claims 3
- 229960002464 Fluoxetine Drugs 0.000 claims 3
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- FWYRGHMKHZXXQX-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol Chemical compound CN(C)C(C)(CO)CC1=CC=C(Cl)C(Cl)=C1 FWYRGHMKHZXXQX-UHFFFAOYSA-N 0.000 claims 1
- AHOUBRCZNHFOSL-YOEHRIQHSA-N Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims 1
- 229950000303 Cericlamine Drugs 0.000 claims 1
- WSEQXVZVJXJVFP-UHFFFAOYSA-N Citalopram Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 claims 1
- OJSFTALXCYKKFQ-YLJYHZDGSA-N Femoxetine Chemical compound C1=CC(OC)=CC=C1OC[C@@H]1[C@@H](C=2C=CC=CC=2)CCN(C)C1 OJSFTALXCYKKFQ-YLJYHZDGSA-N 0.000 claims 1
- 229960004038 Fluvoxamine Drugs 0.000 claims 1
- 229950006314 Ifoxetine Drugs 0.000 claims 1
- ZHFIAFNZGWCLHU-YPMHNXCESA-N Ifoxetine Chemical compound CC1=CC=CC(O[C@@H]2[C@@H](CNCC2)O)=C1C ZHFIAFNZGWCLHU-YPMHNXCESA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229960002073 Sertraline Drugs 0.000 claims 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N Sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 1
- 230000001430 anti-depressive Effects 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229960001653 citalopram Drugs 0.000 claims 1
- -1 cyanodotiepine Chemical compound 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229950003930 femoxetine Drugs 0.000 claims 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims 1
- 229960002296 paroxetine Drugs 0.000 claims 1
- 231100000486 side effect Toxicity 0.000 claims 1
Claims (10)
1. Комбинация, включающая миртазапин или его фармацевтически приемлемую соль и один или более SSRI или их фармацевтически приемлемые соли.
2. Комбинация по п. 1, отличающаяся тем, что SSRI выбран из следующей группы: зимельдин, флуоксетин, флувоксамин, циталопрам, церикламин, фемоксетин, ифоксетин, цианодотиепин, сертралин, пароксетин и литоксетин.
3. Комбинация по п. 1, отличающаяся тем, что она включает миртазапин и флуоксетин.
4. Комбинация по любому из пп. 1 - 3 полезная при лечении депрессии.
5. Фармацевтическая композиция, включающая комбинацию по любому из пп. 1 - 3 в сочетании с одним или более фармацевтически приемлемым носителем.
6. Способ лечения депрессии у животных, который включает лечение указанного животного терапевтически эффективным количеством комбинации по любому из пп. 1 - 3 или композиции по п. 5.
7. Использование миртазапина и одного или более SSRI в производстве лекарственного средства, обладающего антидепрессантной активностью при минимальных побочных эффектах.
8. Использование одного или более SSRI в производстве лекарственного средства для одновременного или последовательного введения с миртазапином для лечения депрессии.
9. Применение миртазапина в производстве лекарственного средства для одновременного или последовательного введения с одним или более SSRI для лечения депрессии.
10. Упаковка, содержащая отдельные дозированные единицы, из которых одна или более дозированных единиц включают миртазапин, и одна или более дозированных единиц включают SSRI, предпочтительно, флуоксетин.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201703 | 1996-06-19 | ||
| EP96201703.4 | 1996-06-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97110083A true RU97110083A (ru) | 1999-05-27 |
| RU2181287C2 RU2181287C2 (ru) | 2002-04-20 |
Family
ID=8224094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97110083/14A RU2181287C2 (ru) | 1996-06-19 | 1997-06-18 | Комбинация, фармацевтическая композиция и способ лечения пациентов, страдающих депрессией |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5977099A (ru) |
| JP (2) | JP4925074B2 (ru) |
| KR (1) | KR100481254B1 (ru) |
| CN (1) | CN1132581C (ru) |
| AR (1) | AR007609A1 (ru) |
| AT (1) | ATE213159T1 (ru) |
| AU (1) | AU727851B2 (ru) |
| BR (1) | BR9703624A (ru) |
| CA (1) | CA2208199C (ru) |
| CZ (1) | CZ290691B6 (ru) |
| DE (1) | DE69710390T2 (ru) |
| DK (1) | DK0813873T3 (ru) |
| ES (1) | ES2172744T3 (ru) |
| HK (1) | HK1006081A1 (ru) |
| HU (1) | HU225534B1 (ru) |
| ID (1) | ID17051A (ru) |
| IL (1) | IL121076A (ru) |
| NO (1) | NO313177B1 (ru) |
| NZ (1) | NZ328113A (ru) |
| PL (1) | PL188520B1 (ru) |
| PT (1) | PT813873E (ru) |
| RU (1) | RU2181287C2 (ru) |
| SG (1) | SG60073A1 (ru) |
| TR (1) | TR199700522A2 (ru) |
| ZA (1) | ZA975335B (ru) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
| PT1030667E (pt) * | 1997-11-14 | 2005-06-30 | Akzo Nobel Nv | Utilizacao de mirtazapina para o fabrico de um medicamento para o tratamento de apenas do sono |
| US6960577B2 (en) * | 1998-05-22 | 2005-11-01 | Eli Lilly And Company | Combination therapy for treatment of refractory depression |
| US6727283B2 (en) | 1998-10-13 | 2004-04-27 | Pfizer Inc. | Sertraline oral concentrate |
| US6575147B2 (en) * | 1999-02-25 | 2003-06-10 | Go-Tec | Internal combustion system adapted for use of a dual fuel composition including acetylene |
| US6545149B2 (en) | 1999-04-19 | 2003-04-08 | Teva Pharmaceutical Industries Ltd. | Synthesis and crystallization of piperazine ring-containing compounds |
| AU781221B2 (en) * | 1999-04-19 | 2005-05-12 | Teva Pharmaceutical Industries Ltd. | Novel synthesis and crystallization of piperazine ring-containing compounds |
| US6403657B1 (en) * | 1999-10-04 | 2002-06-11 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity |
| US6759437B2 (en) * | 1999-10-04 | 2004-07-06 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity including cysteine |
| RU2268725C2 (ru) * | 2000-01-19 | 2006-01-27 | Акцо Нобель Н.В. | Комбинация лекарственных препаратов, включающая миртазапин, для лечения депрессии и связанных расстройств |
| AU2002212888A1 (en) * | 2000-11-01 | 2002-05-15 | Respiratorius Ab | Composition comprising: serotonin receptor antagonists (5ht-2, 5ht-3) and agonist (5ht-4) |
| JP2004532190A (ja) * | 2001-02-12 | 2004-10-21 | アクゾ・ノベル・エヌ・ベー | アポリポタンパク質ｅ４の遺伝子の遺伝子型決定により大うつ病の治療を改善するための方法 |
| US6399310B1 (en) | 2001-02-12 | 2002-06-04 | Akzo Nobel N.V. | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| US20030105082A1 (en) * | 2001-12-03 | 2003-06-05 | Murphy Greer Marechal | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| US20090311795A1 (en) * | 2002-03-21 | 2009-12-17 | Hinz Martin C | Bilateral control of functions traditionally regulated by only serotonin or only dopamine |
| CA2479218A1 (en) * | 2002-03-21 | 2003-10-02 | Martin C. Hinz | Serotonin and catecholamine system segment optimization technology |
| US20070293571A1 (en) * | 2006-06-08 | 2007-12-20 | Hinz Martin C | Adminstration of dopa precursors with sources of dopa to effectuate optimal catecholamine neurotransmitter outcomes |
| AR042806A1 (es) | 2002-12-27 | 2005-07-06 | Otsuka Pharma Co Ltd | Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo |
| EP1723957A3 (en) | 2002-12-27 | 2013-01-23 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
| MXPA05008943A (es) * | 2003-02-21 | 2005-11-08 | C Hinz Martin | Tecnologia de optimizacion del segmento de sistema de serotonina y catecolamina. |
| TW200502222A (en) * | 2003-04-02 | 2005-01-16 | Novartis Ag | Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders |
| CN1784221B (zh) | 2003-04-29 | 2010-07-07 | 奥雷西根治疗公司 | 影响体重减轻的组合物 |
| US20050234093A1 (en) * | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
| US7838029B1 (en) * | 2003-07-31 | 2010-11-23 | Watson Laboratories, Inc. | Mirtazapine solid dosage forms |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| ES2426915T3 (es) | 2003-09-10 | 2013-10-25 | Brentwood Equities Ltd. | Diastereoisómeros de 4-ariloxi-3-hidroxipiperidinas |
| US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
| US20060039866A1 (en) * | 2004-08-20 | 2006-02-23 | Cypress Bioscience, Inc. | Method for treating sleep-related breathing disorders |
| WO2006055854A2 (en) * | 2004-11-17 | 2006-05-26 | Cypress Bioscience, Inc. | Methods for reducing the side effects associated with mirtazapine treatment |
| BRPI0517847A (pt) * | 2004-11-19 | 2008-10-21 | Organon Nv | combinação, usos de um inibidor de reabsorção de serotonina seletiva e de um antagonista do receptor de glicocorticóide, e, método para o tratamento de um indivìduo de uma espécie vertebrada sofrendo de depressão ou um distúrbio relacionado |
| MX337422B (es) | 2005-11-22 | 2016-03-04 | Orexigen Therapeutics Inc | Composiciones y metodos para incrementar la sencibilidad a la insulina. |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| KR20140088619A (ko) | 2006-11-09 | 2014-07-10 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
| TWI609702B (zh) | 2006-11-09 | 2018-01-01 | 歐瑞根治療有限公司 | 層狀醫藥調配物 |
| EP2167096A4 (en) * | 2007-06-13 | 2010-07-14 | Cypress Bioscience Inc | IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM |
| CN101332193B (zh) * | 2007-06-29 | 2012-12-12 | 杭州民生药业有限公司 | 一种马来酸氟伏沙明药物组合物的制备方法 |
| JP2011521973A (ja) | 2008-05-30 | 2011-07-28 | オレキシジェン・セラピューティクス・インコーポレーテッド | 内臓脂肪の状態を処置するための方法 |
| US8768578B2 (en) | 2009-06-09 | 2014-07-01 | Sumitomo Heavy Industries, Ltd. | Hybrid excavator and method of controlling hybrid excavator |
| US8785453B2 (en) * | 2009-11-13 | 2014-07-22 | Green Cross Corporation | Arylpiperazine-containing purine derivatives and uses thereof |
| KR101841442B1 (ko) | 2010-01-11 | 2018-03-23 | 오렉시젠 세러퓨틱스 인크. | 주우울증 환자들에 있어서 체중 감량 치료를 제공하는 방법 |
| CN102000334B (zh) * | 2010-10-15 | 2012-02-22 | 北京大学 | 用于治疗抑郁症的复方制剂 |
| RU2475235C2 (ru) * | 2011-03-15 | 2013-02-20 | Общество с ограниченной ответственностью "ЭР ЭНД ДИ ФАРМА" | Фармацевтическая композиция для профилактики и лечения депрессивных состояний |
| AR085840A1 (es) * | 2011-04-05 | 2013-10-30 | Otsuka Pharma Co Ltd | Medicamento que contiene un compuesto que es 7-[4-(4-benzo[b]tiofen-4-il-piperazin-1-il)butoxi]-1h-quinolin-2-ona |
| CA2875056C (en) | 2012-06-06 | 2024-03-26 | Orexigen Therapeutics, Inc. | Methods of treating overweight and obesity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| AU8770282A (en) * | 1981-08-27 | 1983-03-03 | Shaun R. Coughlin | Composition for the treatment of atherosclerosis |
| US4940585A (en) * | 1989-02-17 | 1990-07-10 | Hapworth William E | Method for the treatment of nicotine withdrawal syndrome |
| ES2062310T3 (es) * | 1989-12-06 | 1994-12-16 | Akzo Nv | Un procedimiento para fabricar un preparado farmaceutico acuoso estabilizado. |
| US5208261A (en) * | 1989-12-06 | 1993-05-04 | Akzo N.V. | Stabilized solutions of psychotropic agents |
| US5512593A (en) * | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
| IL123716A (en) * | 1997-03-27 | 2001-03-19 | Akzo Nobel Nv | Therapeutic combinations of mirtazapine and an antipsychotic agent |
| CN1155410C (zh) * | 1997-10-03 | 2004-06-30 | 卡里药品公司 | 治疗尼古丁成瘾的含有尼古丁受体拮抗剂和抗抑郁药或抗焦虑药的组合物 |
-
1997
- 1997-06-13 IL IL12107697A patent/IL121076A/xx not_active IP Right Cessation
- 1997-06-16 US US08/876,346 patent/US5977099A/en not_active Expired - Fee Related
- 1997-06-16 SG SG1997002068A patent/SG60073A1/en unknown
- 1997-06-17 PT PT97201853T patent/PT813873E/pt unknown
- 1997-06-17 ES ES97201853T patent/ES2172744T3/es not_active Expired - Lifetime
- 1997-06-17 NZ NZ328113A patent/NZ328113A/en unknown
- 1997-06-17 ZA ZA9705335A patent/ZA975335B/xx unknown
- 1997-06-17 DK DK97201853T patent/DK0813873T3/da active
- 1997-06-17 CZ CZ19971870A patent/CZ290691B6/cs not_active IP Right Cessation
- 1997-06-17 AT AT97201853T patent/ATE213159T1/de not_active IP Right Cessation
- 1997-06-17 DE DE69710390T patent/DE69710390T2/de not_active Expired - Fee Related
- 1997-06-18 KR KR1019970025307A patent/KR100481254B1/ko not_active IP Right Cessation
- 1997-06-18 RU RU97110083/14A patent/RU2181287C2/ru not_active IP Right Cessation
- 1997-06-18 PL PL97320628A patent/PL188520B1/pl not_active IP Right Cessation
- 1997-06-18 NO NO19972816A patent/NO313177B1/no unknown
- 1997-06-18 BR BR9703624A patent/BR9703624A/pt not_active Application Discontinuation
- 1997-06-18 HU HU9701068A patent/HU225534B1/hu not_active IP Right Cessation
- 1997-06-18 CA CA002208199A patent/CA2208199C/en not_active Expired - Fee Related
- 1997-06-19 JP JP16257697A patent/JP4925074B2/ja not_active Expired - Fee Related
- 1997-06-19 ID IDP972117A patent/ID17051A/id unknown
- 1997-06-19 AU AU26129/97A patent/AU727851B2/en not_active Ceased
- 1997-06-19 AR ARP970102687A patent/AR007609A1/es active IP Right Grant
- 1997-06-19 TR TR97/00522A patent/TR199700522A2/xx unknown
- 1997-06-19 CN CN97115549A patent/CN1132581C/zh not_active Expired - Fee Related
-
1998
- 1998-06-16 HK HK98105337A patent/HK1006081A1/xx not_active IP Right Cessation
-
2008
- 2008-12-12 JP JP2008317326A patent/JP2009137970A/ja active Pending
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