RU97110083A - Комбинация, фармацевтическая композиция, способ лечения, использование и упаковка - Google Patents
Комбинация, фармацевтическая композиция, способ лечения, использование и упаковкаInfo
- Publication number
- RU97110083A RU97110083A RU97110083/14A RU97110083A RU97110083A RU 97110083 A RU97110083 A RU 97110083A RU 97110083/14 A RU97110083/14 A RU 97110083/14A RU 97110083 A RU97110083 A RU 97110083A RU 97110083 A RU97110083 A RU 97110083A
- Authority
- RU
- Russia
- Prior art keywords
- mirtazapine
- combination
- treatment
- ssris
- combination according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 9
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 229960001785 Mirtazapine Drugs 0.000 claims 6
- RONZAEMNMFQXRA-UHFFFAOYSA-N Mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 claims 6
- 206010012378 Depression Diseases 0.000 claims 3
- 229960002464 Fluoxetine Drugs 0.000 claims 3
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- FWYRGHMKHZXXQX-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol Chemical compound CN(C)C(C)(CO)CC1=CC=C(Cl)C(Cl)=C1 FWYRGHMKHZXXQX-UHFFFAOYSA-N 0.000 claims 1
- AHOUBRCZNHFOSL-YOEHRIQHSA-N Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims 1
- 229950000303 Cericlamine Drugs 0.000 claims 1
- WSEQXVZVJXJVFP-UHFFFAOYSA-N Citalopram Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 claims 1
- OJSFTALXCYKKFQ-YLJYHZDGSA-N Femoxetine Chemical compound C1=CC(OC)=CC=C1OC[C@@H]1[C@@H](C=2C=CC=CC=2)CCN(C)C1 OJSFTALXCYKKFQ-YLJYHZDGSA-N 0.000 claims 1
- 229960004038 Fluvoxamine Drugs 0.000 claims 1
- 229950006314 Ifoxetine Drugs 0.000 claims 1
- ZHFIAFNZGWCLHU-YPMHNXCESA-N Ifoxetine Chemical compound CC1=CC=CC(O[C@@H]2[C@@H](CNCC2)O)=C1C ZHFIAFNZGWCLHU-YPMHNXCESA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229960002073 Sertraline Drugs 0.000 claims 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N Sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 1
- 230000001430 anti-depressive Effects 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229960001653 citalopram Drugs 0.000 claims 1
- -1 cyanodotiepine Chemical compound 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229950003930 femoxetine Drugs 0.000 claims 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims 1
- 229960002296 paroxetine Drugs 0.000 claims 1
- 231100000486 side effect Toxicity 0.000 claims 1
Claims (10)
1. Комбинация, включающая миртазапин или его фармацевтически приемлемую соль и один или более SSRI или их фармацевтически приемлемые соли.
2. Комбинация по п. 1, отличающаяся тем, что SSRI выбран из следующей группы: зимельдин, флуоксетин, флувоксамин, циталопрам, церикламин, фемоксетин, ифоксетин, цианодотиепин, сертралин, пароксетин и литоксетин.
3. Комбинация по п. 1, отличающаяся тем, что она включает миртазапин и флуоксетин.
4. Комбинация по любому из пп. 1 - 3 полезная при лечении депрессии.
5. Фармацевтическая композиция, включающая комбинацию по любому из пп. 1 - 3 в сочетании с одним или более фармацевтически приемлемым носителем.
6. Способ лечения депрессии у животных, который включает лечение указанного животного терапевтически эффективным количеством комбинации по любому из пп. 1 - 3 или композиции по п. 5.
7. Использование миртазапина и одного или более SSRI в производстве лекарственного средства, обладающего антидепрессантной активностью при минимальных побочных эффектах.
8. Использование одного или более SSRI в производстве лекарственного средства для одновременного или последовательного введения с миртазапином для лечения депрессии.
9. Применение миртазапина в производстве лекарственного средства для одновременного или последовательного введения с одним или более SSRI для лечения депрессии.
10. Упаковка, содержащая отдельные дозированные единицы, из которых одна или более дозированных единиц включают миртазапин, и одна или более дозированных единиц включают SSRI, предпочтительно, флуоксетин.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201703.4 | 1996-06-19 | ||
| EP96201703 | 1996-06-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97110083A true RU97110083A (ru) | 1999-05-27 |
| RU2181287C2 RU2181287C2 (ru) | 2002-04-20 |
Family
ID=8224094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97110083/14A RU2181287C2 (ru) | 1996-06-19 | 1997-06-18 | Комбинация, фармацевтическая композиция и способ лечения пациентов, страдающих депрессией |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5977099A (ru) |
| JP (2) | JP4925074B2 (ru) |
| KR (1) | KR100481254B1 (ru) |
| CN (1) | CN1132581C (ru) |
| AR (1) | AR007609A1 (ru) |
| AT (1) | ATE213159T1 (ru) |
| AU (1) | AU727851B2 (ru) |
| BR (1) | BR9703624A (ru) |
| CA (1) | CA2208199C (ru) |
| CZ (1) | CZ290691B6 (ru) |
| DE (1) | DE69710390T2 (ru) |
| DK (1) | DK0813873T3 (ru) |
| ES (1) | ES2172744T3 (ru) |
| HK (1) | HK1006081A1 (ru) |
| HU (1) | HU225534B1 (ru) |
| ID (1) | ID17051A (ru) |
| IL (1) | IL121076A (ru) |
| NO (1) | NO313177B1 (ru) |
| NZ (1) | NZ328113A (ru) |
| PL (1) | PL188520B1 (ru) |
| PT (1) | PT813873E (ru) |
| RU (1) | RU2181287C2 (ru) |
| SG (1) | SG60073A1 (ru) |
| TR (1) | TR199700522A2 (ru) |
| ZA (1) | ZA975335B (ru) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
| KR20010032009A (ko) * | 1997-11-14 | 2001-04-16 | 에프.지.엠. 헤르만스 ; 이.에이치. 리링크 | 수면성 무호흡의 치료에 미타자핀을 사용하는 방법 |
| US6960577B2 (en) * | 1998-05-22 | 2005-11-01 | Eli Lilly And Company | Combination therapy for treatment of refractory depression |
| US6727283B2 (en) | 1998-10-13 | 2004-04-27 | Pfizer Inc. | Sertraline oral concentrate |
| US6575147B2 (en) * | 1999-02-25 | 2003-06-10 | Go-Tec | Internal combustion system adapted for use of a dual fuel composition including acetylene |
| US6545149B2 (en) | 1999-04-19 | 2003-04-08 | Teva Pharmaceutical Industries Ltd. | Synthesis and crystallization of piperazine ring-containing compounds |
| AU781221B2 (en) * | 1999-04-19 | 2005-05-12 | Teva Pharmaceutical Industries Ltd. | Novel synthesis and crystallization of piperazine ring-containing compounds |
| US6403657B1 (en) * | 1999-10-04 | 2002-06-11 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity |
| US6759437B2 (en) * | 1999-10-04 | 2004-07-06 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity including cysteine |
| IL150289A0 (en) * | 2000-01-19 | 2002-12-01 | Akzo Nobel Nv | Drug combination for the treatment of depression and related disorders comprising mirtazapine |
| WO2002036113A1 (en) * | 2000-11-01 | 2002-05-10 | Respiratorius Ab | Composition comprising: serotonin receptor antagonists (5ht-2, 5ht-3) and agonist (5ht-4) |
| US6399310B1 (en) | 2001-02-12 | 2002-06-04 | Akzo Nobel N.V. | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| US20030105082A1 (en) * | 2001-12-03 | 2003-06-05 | Murphy Greer Marechal | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| AU2002237847A1 (en) * | 2001-02-12 | 2002-08-28 | Akzo Nobel N.V | Methods for improving the treatment of major depression by genotyping for the gene for apolipoproteine e4 |
| EP1490073A4 (en) * | 2002-03-21 | 2006-02-01 | Martin C Hinz | SEGMENT OPTIMIZATION TECHNOLOGY FOR THE SEROTONIN AND CATECHOLAMINE SYSTEM |
| US20090311795A1 (en) * | 2002-03-21 | 2009-12-17 | Hinz Martin C | Bilateral control of functions traditionally regulated by only serotonin or only dopamine |
| US20070293571A1 (en) * | 2006-06-08 | 2007-12-20 | Hinz Martin C | Adminstration of dopa precursors with sources of dopa to effectuate optimal catecholamine neurotransmitter outcomes |
| AR042806A1 (es) * | 2002-12-27 | 2005-07-06 | Otsuka Pharma Co Ltd | Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo |
| AU2003295235B2 (en) * | 2002-12-27 | 2008-06-19 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
| CA2516653A1 (en) * | 2003-02-21 | 2004-09-10 | Martin C. Hinz | Serotonin and catecholamine system segment optimization technology |
| TW200502222A (en) * | 2003-04-02 | 2005-01-16 | Novartis Ag | Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders |
| DE602004012403T2 (de) | 2003-04-29 | 2009-03-19 | Orexigen Therapeutics, Inc., La Jolla | Zusammensetzungen zur beeinflussung des gewichtsverlusts |
| US20050234093A1 (en) * | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
| US7838029B1 (en) | 2003-07-31 | 2010-11-23 | Watson Laboratories, Inc. | Mirtazapine solid dosage forms |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| WO2005023767A2 (en) | 2003-09-10 | 2005-03-17 | Brentwood Equities Ltd. | Diastereomers of 4-aryloxy-3-hydroxypiperidines |
| US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
| WO2006023702A2 (en) * | 2004-08-20 | 2006-03-02 | Cypress Bioscience, Inc. | Method for treating sleep related breathing disorders with setiptiline |
| US20060122127A1 (en) * | 2004-11-17 | 2006-06-08 | Cypress Bioscience, Inc. | Methods for reducing the side effects associated with mirtzapine treatment |
| CN103316019B (zh) * | 2004-11-19 | 2015-10-28 | 默沙东有限责任公司 | 用于治疗抑郁症的包含选择性5-羟色胺再摄取抑制剂和糖皮质激素受体拮抗剂的药物组合 |
| AU2006323048B2 (en) | 2005-11-22 | 2013-07-04 | Nalpropion Pharmaceuticals Llc | Compositions and methods for increasing insulin sensitivity |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| CA2668885C (en) | 2006-11-09 | 2016-08-02 | Orexigen Therapeutics, Inc. | Methods for administering weight loss medications |
| CA2668884C (en) | 2006-11-09 | 2016-11-01 | Orexigen Therapeutics, Inc. | Layered pharmaceutical formulations |
| EP2167096A4 (en) * | 2007-06-13 | 2010-07-14 | Cypress Bioscience Inc | IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM |
| CN101332193B (zh) * | 2007-06-29 | 2012-12-12 | 杭州民生药业有限公司 | 一种马来酸氟伏沙明药物组合物的制备方法 |
| JP2011521973A (ja) | 2008-05-30 | 2011-07-28 | オレキシジェン・セラピューティクス・インコーポレーテッド | 内臓脂肪の状態を処置するための方法 |
| US8768578B2 (en) | 2009-06-09 | 2014-07-01 | Sumitomo Heavy Industries, Ltd. | Hybrid excavator and method of controlling hybrid excavator |
| WO2011059207A2 (en) * | 2009-11-13 | 2011-05-19 | Green Cross Corporation | Arylpiperazine-containing purine derivatives and uses thereof |
| AU2011203867B2 (en) | 2010-01-11 | 2015-12-03 | Nalpropion Pharmaceuticals Llc | Methods of providing weight loss therapy in patients with major depression |
| CN102000334B (zh) * | 2010-10-15 | 2012-02-22 | 北京大学 | 用于治疗抑郁症的复方制剂 |
| RU2475235C2 (ru) * | 2011-03-15 | 2013-02-20 | Общество с ограниченной ответственностью "ЭР ЭНД ДИ ФАРМА" | Фармацевтическая композиция для профилактики и лечения депрессивных состояний |
| JOP20120083B1 (ar) * | 2011-04-05 | 2021-08-17 | Otsuka Pharma Co Ltd | توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns |
| EP2858640B1 (en) | 2012-06-06 | 2020-03-25 | Nalpropion Pharmaceuticals LLC | Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| AU8770282A (en) * | 1981-08-27 | 1983-03-03 | Shaun R. Coughlin | Composition for the treatment of atherosclerosis |
| US4940585A (en) * | 1989-02-17 | 1990-07-10 | Hapworth William E | Method for the treatment of nicotine withdrawal syndrome |
| ATE99943T1 (de) * | 1989-12-06 | 1994-01-15 | Akzo Nv | Psychotropische wirkstoffe enthaltende stabilisierte loesungen. |
| US5208261A (en) * | 1989-12-06 | 1993-05-04 | Akzo N.V. | Stabilized solutions of psychotropic agents |
| US5512593A (en) * | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
| TW587938B (en) * | 1997-03-27 | 2004-05-21 | Akzo Nobel Nv | Pharmaceutical composition for the treatment and/or prophylaxis of psychotic disorder |
| CN1155410C (zh) * | 1997-10-03 | 2004-06-30 | 卡里药品公司 | 治疗尼古丁成瘾的含有尼古丁受体拮抗剂和抗抑郁药或抗焦虑药的组合物 |
-
1997
- 1997-06-13 IL IL12107697A patent/IL121076A/xx not_active IP Right Cessation
- 1997-06-16 SG SG1997002068A patent/SG60073A1/en unknown
- 1997-06-16 US US08/876,346 patent/US5977099A/en not_active Expired - Fee Related
- 1997-06-17 DE DE69710390T patent/DE69710390T2/de not_active Expired - Fee Related
- 1997-06-17 DK DK97201853T patent/DK0813873T3/da active
- 1997-06-17 NZ NZ328113A patent/NZ328113A/en unknown
- 1997-06-17 PT PT97201853T patent/PT813873E/pt unknown
- 1997-06-17 CZ CZ19971870A patent/CZ290691B6/cs not_active IP Right Cessation
- 1997-06-17 ZA ZA9705335A patent/ZA975335B/xx unknown
- 1997-06-17 AT AT97201853T patent/ATE213159T1/de not_active IP Right Cessation
- 1997-06-17 ES ES97201853T patent/ES2172744T3/es not_active Expired - Lifetime
- 1997-06-18 NO NO19972816A patent/NO313177B1/no unknown
- 1997-06-18 BR BR9703624A patent/BR9703624A/pt not_active Application Discontinuation
- 1997-06-18 CA CA002208199A patent/CA2208199C/en not_active Expired - Fee Related
- 1997-06-18 KR KR1019970025307A patent/KR100481254B1/ko not_active IP Right Cessation
- 1997-06-18 HU HU9701068A patent/HU225534B1/hu not_active IP Right Cessation
- 1997-06-18 RU RU97110083/14A patent/RU2181287C2/ru not_active IP Right Cessation
- 1997-06-18 PL PL97320628A patent/PL188520B1/pl not_active IP Right Cessation
- 1997-06-19 JP JP16257697A patent/JP4925074B2/ja not_active Expired - Fee Related
- 1997-06-19 ID IDP972117A patent/ID17051A/id unknown
- 1997-06-19 AR ARP970102687A patent/AR007609A1/es active IP Right Grant
- 1997-06-19 AU AU26129/97A patent/AU727851B2/en not_active Ceased
- 1997-06-19 CN CN97115549A patent/CN1132581C/zh not_active Expired - Fee Related
- 1997-06-19 TR TR97/00522A patent/TR199700522A2/xx unknown
-
1998
- 1998-06-16 HK HK98105337A patent/HK1006081A1/xx not_active IP Right Cessation
-
2008
- 2008-12-12 JP JP2008317326A patent/JP2009137970A/ja active Pending
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