KR980000447A - 미르타자핀과 하나 이상의 선택적인 세로토닌 재이용 저해제로 이루어진 약학 조성물 - Google Patents

미르타자핀과 하나 이상의 선택적인 세로토닌 재이용 저해제로 이루어진 약학 조성물 Download PDF

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KR980000447A
KR980000447A KR1019970025307A KR19970025307A KR980000447A KR 980000447 A KR980000447 A KR 980000447A KR 1019970025307 A KR1019970025307 A KR 1019970025307A KR 19970025307 A KR19970025307 A KR 19970025307A KR 980000447 A KR980000447 A KR 980000447A
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mirtazapine
composition
ssris
depression
pharmaceutically acceptable
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KR1019970025307A
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KR100481254B1 (ko
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요한네스 니콜슨 빅토르
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에프. 지. 엠. 헤르만스; 이. 에이치. 리링크
악조 노벨 엔. 브이
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Application filed by 에프. 지. 엠. 헤르만스; 이. 에이치. 리링크, 악조 노벨 엔. 브이 filed Critical 에프. 지. 엠. 헤르만스; 이. 에이치. 리링크
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

본 발명은 미르타자핀, 선택적인 세로토닌 재이용 저해제(SSRI) 그리고 약학적 허용 보조제를 포함하는 약학 조성물에 관한 것이다. 특히 SSRI는 플루옥세틴(fluoxetin), 플루복사민(fluvoxamine), 시타로프람(citalopram), 세리클라민(cericlamine) 페목세틴(femoxetin), 세르트랄린(sertraline), 파록세틴(paroxetin), 이폭세틴(ifoxetine) 시아노도티에핀(cyanodothiepin) 및 리톡세틴(litoxetine)으로부터 선택된다. 우울증 환자를 치료하기 위해 이용될 수 있는 상기 조성물은 미르타자핀 또는 SSRI만으로 환자를 치료하는 것보다 더 적은 부작용을 가진다.

Description

미르타자핀과 하나 이상의 선택적인 세로토닌 재이용 저해제로 이루어진 약학 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 미르타자핀 또는 그들의 약학적 허용염과 하나 또는 그 이상의 SSRI 또는 그들의 약학적 허용염을 포함하는 조성물.
  2. 제1항에 있어서, 상기 SSRI가 지멜딘, 플루옥세틴, 플루복사민, 시타로프람, 세리클라민, 페목세틴, 이폭세틴, 시아노도티에핀, 세르트랄린, 파록세틴, 및 리톡세틴으로부터 선택된 조성물.
  3. 제1항에 있어서, 미르타자핀과 플루옥세틴을 포함하는 조성물.
  4. 제1항 내지 제3항 중의 어느 한 항에 있어서, 우울증 치료 용도를 위한 조성물.
  5. 제1항 내지 제3항 중의 어느 한 항에 따른 조성물을, 그들을 위한 하나 또는 그 이상의 약학적 허용 담체와 결합하여 포함하는 약학 제제.
  6. 제1항 내지 제3항 중의 어느 한 항에 정의된 조성물 또는 제5항에 설명된 제제를 치료적으로 유효한 양으로 동물을 치료하는 것을 포함하는, 동물의 우울증 치료 방법.
  7. 최소의 부작용을 가지는 항우울증 활성을 가지는 약제 제조에서 미르타자핀과 하나 또는 그 이상의 SSRI의 용도.
  8. 우울증 치료를 위해 미르타자핀과 동시에 또는 순차적으로 투여하기 위한 약제 제조에서 하나 또는 그 이상의 SSRI의 용도.
  9. 우울증 치료를 위해 하나 또는 그 이상의 SSRI와 동시에 또는 순차적으로 투여하기 위한 약제 제조에서 미르타자핀의 용도.
  10. 하나 또는 그 이상의 투여 단위가 미르타자핀을 함유하고 하나 또는 그 이상의 다른 투여 단위가 SSRI, 바람직하게는 플루옥세틴을 함유하는, 분리된 투여 단위를 포함하는 패키지(package).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970025307A 1996-06-19 1997-06-18 미르타자핀과하나이상의선택적인세로토닌재흡수저해제를포함하는약학조성물 KR100481254B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201703.4 1996-06-19
EP96201703 1996-06-19

Publications (2)

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KR980000447A true KR980000447A (ko) 1998-03-30
KR100481254B1 KR100481254B1 (ko) 2005-09-12

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Country Status (25)

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US (1) US5977099A (ko)
JP (2) JP4925074B2 (ko)
KR (1) KR100481254B1 (ko)
CN (1) CN1132581C (ko)
AR (1) AR007609A1 (ko)
AT (1) ATE213159T1 (ko)
AU (1) AU727851B2 (ko)
BR (1) BR9703624A (ko)
CA (1) CA2208199C (ko)
CZ (1) CZ290691B6 (ko)
DE (1) DE69710390T2 (ko)
DK (1) DK0813873T3 (ko)
ES (1) ES2172744T3 (ko)
HK (1) HK1006081A1 (ko)
HU (1) HU225534B1 (ko)
ID (1) ID17051A (ko)
IL (1) IL121076A (ko)
NO (1) NO313177B1 (ko)
NZ (1) NZ328113A (ko)
PL (1) PL188520B1 (ko)
PT (1) PT813873E (ko)
RU (1) RU2181287C2 (ko)
SG (1) SG60073A1 (ko)
TR (1) TR199700522A2 (ko)
ZA (1) ZA975335B (ko)

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ES2172744T3 (es) 2002-10-01
DE69710390D1 (de) 2002-03-21
HU9701068D0 (en) 1997-08-28
HU225534B1 (en) 2007-02-28
IL121076A0 (en) 1997-11-20
CA2208199A1 (en) 1997-12-19
JPH1067663A (ja) 1998-03-10
NO972816D0 (no) 1997-06-18
CZ187097A3 (cs) 1998-01-14
JP4925074B2 (ja) 2012-04-25
TR199700522A3 (tr) 1998-01-21
ZA975335B (en) 1998-01-26
IL121076A (en) 2000-10-31
ATE213159T1 (de) 2002-02-15
TR199700522A2 (xx) 1998-01-21
DE69710390T2 (de) 2002-08-14
HUP9701068A2 (hu) 1998-08-28
AU2612997A (en) 1998-01-08
NO313177B1 (no) 2002-08-26
SG60073A1 (en) 1999-02-22
NZ328113A (en) 1999-09-29
KR100481254B1 (ko) 2005-09-12
CN1173330A (zh) 1998-02-18
PT813873E (pt) 2002-06-28
BR9703624A (pt) 1998-09-01
HK1006081A1 (en) 1999-02-12
CZ290691B6 (cs) 2002-09-11
AU727851B2 (en) 2001-01-04
PL320628A1 (en) 1997-12-22
JP2009137970A (ja) 2009-06-25
PL188520B1 (pl) 2005-02-28
RU2181287C2 (ru) 2002-04-20
NO972816L (no) 1997-12-22
CN1132581C (zh) 2003-12-31
AR007609A1 (es) 1999-11-10
HUP9701068A3 (en) 2000-07-28
CA2208199C (en) 2006-10-24
ID17051A (id) 1997-12-04
MX9704579A (es) 1998-07-31
DK0813873T3 (da) 2002-05-27
US5977099A (en) 1999-11-02

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