RU94016158A - Полимерный конъюгат, способ его получения, фармацевтическая композиция - Google Patents

Полимерный конъюгат, способ его получения, фармацевтическая композиция

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Publication number
RU94016158A
RU94016158A RU94016158/04A RU94016158A RU94016158A RU 94016158 A RU94016158 A RU 94016158A RU 94016158/04 A RU94016158/04 A RU 94016158/04A RU 94016158 A RU94016158 A RU 94016158A RU 94016158 A RU94016158 A RU 94016158A
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RU
Russia
Prior art keywords
formula
mol
conjugat
polymeric
obtaining
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Application number
RU94016158/04A
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English (en)
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RU2130462C1 (ru
Inventor
Монгелли Николо
Ангелуччи Франческо
Пезенти Энрико
Суарато Антонио
Биазоли Джованни
Original Assignee
Фармиталиа Карло Эрба С.Р.Л.
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Priority claimed from GB929213077A external-priority patent/GB9213077D0/en
Application filed by Фармиталиа Карло Эрба С.Р.Л. filed Critical Фармиталиа Карло Эрба С.Р.Л.
Publication of RU94016158A publication Critical patent/RU94016158A/ru
Application granted granted Critical
Publication of RU2130462C1 publication Critical patent/RU2130462C1/ru

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Claims (1)

  1. Полимерный конъюгат состоит по существу из 90 - 99,9 мол.% звеньев формулы:
    Figure 00000001

    0,1 - 5 мол.% звеньев формулы
    Figure 00000002

    в которой один из R1 и R2 представляет остаток сополимера формулы
    Figure 00000003

    с другой - водород, 0 - 9,9 мол.% звеньев формулы:
    Figure 00000004

    где R-фенил или трет-бутоксигруппа, R3 - водород или ацетил A и A1, которые могут быть одинаковыми или различными, представляют простую химическую связь, аминокислотный остаток или пептидный спейсер, выбранный из:
    Figure 00000005

    Соединения обладают противоопухолевой активностью и характеризуются улучшенной растворимостью в воде и пониженной токсичностью по сравнению с паклитакселем или его известными аналогами. Кроме того, раскрыты способ получения таких соединений и содержащие их фармацевтические препараты.
RU94016158A 1992-06-19 1993-06-07 Полимерный конъюгат, способ его получения и фармацевтическая композиция RU2130462C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB92130772 1992-06-19
GB9213077.2 1992-06-19
GB929213077A GB9213077D0 (en) 1992-06-19 1992-06-19 Polymerbound taxol derivatives
PCT/EP1993/001433 WO1994000156A1 (en) 1992-06-19 1993-06-07 Polymer-bound paclitaxel derivatives

Publications (2)

Publication Number Publication Date
RU94016158A true RU94016158A (ru) 1995-09-27
RU2130462C1 RU2130462C1 (ru) 1999-05-20

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US (4) US5362831A (ru)
EP (1) EP0600062B1 (ru)
JP (1) JP3693340B2 (ru)
KR (1) KR100281606B1 (ru)
CN (1) CN1041281C (ru)
AT (1) ATE205725T1 (ru)
AU (2) AU659750B2 (ru)
CA (1) CA2112482A1 (ru)
CZ (1) CZ62094A3 (ru)
DE (1) DE69330776T2 (ru)
ES (1) ES2164663T3 (ru)
FI (1) FI940733A (ru)
GB (1) GB9213077D0 (ru)
HU (2) HUT67914A (ru)
IL (1) IL106023A (ru)
MX (1) MX9303598A (ru)
MY (1) MY109213A (ru)
NZ (1) NZ253116A (ru)
PL (1) PL173898B1 (ru)
RU (1) RU2130462C1 (ru)
SG (1) SG49248A1 (ru)
TW (1) TW266201B (ru)
UA (1) UA39926C2 (ru)
WO (1) WO1994000156A1 (ru)
ZA (1) ZA934388B (ru)

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