RU93055026A - Улучшение, вызываемые бензотиофенами - Google Patents
Улучшение, вызываемые бензотиофенамиInfo
- Publication number
- RU93055026A RU93055026A RU93055026/04A RU93055026A RU93055026A RU 93055026 A RU93055026 A RU 93055026A RU 93055026/04 A RU93055026/04 A RU 93055026/04A RU 93055026 A RU93055026 A RU 93055026A RU 93055026 A RU93055026 A RU 93055026A
- Authority
- RU
- Russia
- Prior art keywords
- group
- substituted
- alkanoyloxy
- unsubstituted
- benzotiophenes
- Prior art date
Links
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003435 aroyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N Azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Claims (1)
- Применение соединения формулы 1
где n = 0, 1 или 2; R является окси-группой, метокси-группой, (C1-C7)алканоилокси-группой, (C3-C7)циклоалканоилокси-группой, (C1-C6) алкокси-(C1-C7)алканоилокси-группой, незамещенной или замещенной ароилокси-группой или замещенной или незамещенной ароил- карбоксильной группой; R1 является атомом водорода; окси-группой, атомом галогена, метокси-группой, (C1-C7)алканоилокси-группой, (С3-С7)циклоалканоилокси-группой, (C1-C6)алкокси-(C1-C7)алканоилокси-группой, незамещенной или замещенной ароилокси-группой или замещенной или незамещенной ароилкарбоксильной группой; R2 является гетероциклическим кольцом, выбранным из группы, включающей пирролидиновую группу, пиперидиновую группу или гексаметилениминовую группу; или его фармацевтически приемлемой соли или сольвата, для получения медицинского препарата, используемого для снижения уровня содержания холестерина в сыворотке крови животных.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99522292A | 1992-12-22 | 1992-12-22 | |
US07/995222 | 1992-12-22 | ||
US07/995,222 | 1992-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93055026A true RU93055026A (ru) | 1997-01-20 |
RU2123335C1 RU2123335C1 (ru) | 1998-12-20 |
Family
ID=25541537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93055026A RU2123335C1 (ru) | 1992-12-22 | 1993-12-13 | Средство для снижения содержания холестерина в крови, фармацевтическая композиция |
Country Status (28)
Country | Link |
---|---|
US (1) | US5464845A (ru) |
EP (2) | EP0605193B1 (ru) |
JP (1) | JP3197129B2 (ru) |
KR (1) | KR100278946B1 (ru) |
CN (1) | CN1043608C (ru) |
AT (1) | ATE233559T1 (ru) |
AU (1) | AU669235B2 (ru) |
BG (1) | BG61524B1 (ru) |
BR (1) | BR9305182A (ru) |
CA (1) | CA2112017C (ru) |
CZ (1) | CZ283863B6 (ru) |
DE (1) | DE69332735T2 (ru) |
DK (1) | DK0605193T3 (ru) |
ES (1) | ES2193142T3 (ru) |
HU (1) | HU223342B1 (ru) |
IL (1) | IL108042A (ru) |
MY (1) | MY109345A (ru) |
NO (1) | NO304924B1 (ru) |
NZ (1) | NZ250486A (ru) |
PH (1) | PH30430A (ru) |
PL (1) | PL177349B1 (ru) |
RO (1) | RO113806B1 (ru) |
RU (1) | RU2123335C1 (ru) |
SG (1) | SG52696A1 (ru) |
SK (1) | SK279271B6 (ru) |
TW (1) | TW383306B (ru) |
YU (1) | YU48918B (ru) |
ZA (1) | ZA939427B (ru) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
USRE39049E1 (en) | 1992-07-28 | 2006-03-28 | Eli Lilly And Company | Methods for inhibiting bone loss |
USRE38968E1 (en) | 1992-07-28 | 2006-02-07 | Eli Lilly And Company | Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride |
US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
US6197789B1 (en) * | 1995-06-07 | 2001-03-06 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
US5482950A (en) * | 1993-10-15 | 1996-01-09 | Eli Lilly And Company | Methods for lowering serum cholesterol |
US6489355B2 (en) * | 1993-12-01 | 2002-12-03 | Eli Lilly And Company | Methods of inhibiting the effects of amyloidogenic proteins |
RU2135176C1 (ru) * | 1993-12-14 | 1999-08-27 | Эли Лилли Энд Компани | Водорастворенный комплекс включения соединений бензотиофена с водорастворимым циклодекстрином, способ его получения и фармацевтическая композиция |
US5441966A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting Turner's syndrome |
ES2215270T3 (es) * | 1993-12-21 | 2004-10-01 | Eli Lilly And Company | Inhibicion de productos terminales de glicosilacion avanzada. |
US6417198B1 (en) | 1993-12-21 | 2002-07-09 | Eli Lilly And Company | Methods of inhibiting CNS problems in post-menopausal women |
US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
CO4410191A1 (es) * | 1994-09-19 | 1997-01-09 | Lilly Co Eli | SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS |
US5629425A (en) * | 1994-09-19 | 1997-05-13 | Eli Lilly And Company | Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene |
US6562862B1 (en) | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
WO1996012489A1 (en) * | 1994-10-20 | 1996-05-02 | Eli Lilly And Company | Bicyclic neuropeptide y receptor antagonists |
US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
US5484808A (en) * | 1995-02-09 | 1996-01-16 | Eli Lilly And Company | Methods of inhibiting cell-cell adhesion |
EP0738725A3 (en) * | 1995-04-21 | 1997-03-05 | Lilly Co Eli | Benzothiophenes with basic side chains |
US5731328A (en) * | 1995-10-10 | 1998-03-24 | Eli Lilly And Company | Methods of inhibiting plasminogen activator inhibitor 1 |
US5726168A (en) * | 1995-10-12 | 1998-03-10 | Eli Lilly And Company | Lipophilic benzothiophenes |
TW442286B (en) * | 1996-02-28 | 2001-06-23 | Pfizer | New therapeutic uses of estrogen agonists |
HN1996000101A (es) | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
IL120266A (en) * | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
EP0801066A1 (en) * | 1996-03-12 | 1997-10-15 | Eli Lilly And Company | Heterocyclic substituted benzothiophenes and pharmaceutical compositions |
US6008377A (en) * | 1996-03-19 | 1999-12-28 | Eli Lilly And Company | Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes |
US6458811B1 (en) | 1996-03-26 | 2002-10-01 | Eli Lilly And Company | Benzothiophenes formulations containing same and methods |
US5811437A (en) * | 1996-05-21 | 1998-09-22 | Eli Lilly And Company | Methods of increasing nitric oxide synthesis |
US5747509A (en) * | 1996-06-03 | 1998-05-05 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
CA2206752A1 (en) * | 1996-07-02 | 1998-01-02 | George Joseph Cullinan | Benzothiophene compounds, intermediates, processes, and methods of use |
US5980938A (en) * | 1996-07-15 | 1999-11-09 | Eli Lilly And Company | Effect of compounds that suppress induction of plasminogen activator inhibitor 1 (PAI-1) |
CA2214072C (en) * | 1996-08-29 | 2006-11-14 | Eli Lilly And Company | Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods |
US5773432A (en) * | 1996-10-30 | 1998-06-30 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
UA59384C2 (ru) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Предотвращение потери костной массы и ее восстановление с помощью агонистов простагландина |
WO1998048792A1 (en) * | 1997-04-30 | 1998-11-05 | Eli Lilly And Company | A REGIOSELECTIVE ALKYLATION PROCESS FOR PREPARING SUBSTITUTED BENZO[b]THIOPHENES |
HUP0003187A3 (en) * | 1997-04-30 | 2002-04-29 | Lilly Co Eli | Substituted benzothiophenes and process for preparing them |
CA2287920A1 (en) * | 1997-04-30 | 1998-11-05 | Eli Lilly And Company | Intermediates and a process for preparing benzo¬b|thiophenes |
CA2231013A1 (en) * | 1997-04-30 | 1998-10-30 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals |
JP2001523253A (ja) * | 1997-04-30 | 2001-11-20 | イーライ・リリー・アンド・カンパニー | ベンゾ[b]チオフェン類の製造のための中間体および方法 |
CA2236254A1 (en) * | 1997-04-30 | 1998-10-30 | David Warren Hoard | Process for preparing benzo¬b|thiophenes |
US6124314A (en) * | 1997-10-10 | 2000-09-26 | Pfizer Inc. | Osteoporosis compounds |
US6096781A (en) | 1997-11-14 | 2000-08-01 | Eli Lilly And Company | 2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome |
US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US6353003B1 (en) | 1998-06-17 | 2002-03-05 | Eli Lilly And Company | Method for reducing levels of homocysteine and C-reactive protein |
US6087378A (en) * | 1998-10-13 | 2000-07-11 | Eli Lilly And Company | Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome |
OA12117A (en) | 1999-12-22 | 2006-05-04 | Pfizer Prod Inc | EP4 receptor selective agonists in the treatment of osteoporosis. |
ATE346159T1 (de) * | 2000-05-08 | 2006-12-15 | Pfizer Prod Inc | Enzymatische spaltung von selektiven modulatoren des östrogenrezeptors |
US20030216358A1 (en) * | 2001-07-05 | 2003-11-20 | Muchmore Douglas Boyer | Method for enhancing bone mineral density gain |
US20060106010A1 (en) * | 2003-05-27 | 2006-05-18 | Black Larry J | Methods for inhibiting bone loss |
MXPA06006810A (es) * | 2003-12-17 | 2006-08-23 | Pfizer Prod Inc | Tratamiento de afecciones que se presentan con un nivel bajo de masa osea por terapia de combinacion continua con agonistas selectivos del receptor de prostaglandina ep4 y un estrogeno. |
WO2009018165A2 (en) | 2007-07-27 | 2009-02-05 | Container Stuffers, Llc | Cargo loader |
CN101669557B (zh) * | 2009-08-20 | 2012-07-25 | 杭州六易科技有限公司 | 一种清热解毒凉茶的制作方法 |
WO2016021706A1 (ja) * | 2014-08-08 | 2016-02-11 | カズマパートナーズ株式会社 | 縮合複素環化合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
US5441964A (en) * | 1993-10-15 | 1995-08-15 | Eli Lilly And Company | Methods for inhibiting bone loss using substituted benzothiophene |
-
1993
- 1993-02-04 TW TW082100751A patent/TW383306B/zh not_active IP Right Cessation
- 1993-11-30 US US08/159,159 patent/US5464845A/en not_active Expired - Fee Related
- 1993-12-13 RU RU93055026A patent/RU2123335C1/ru not_active IP Right Cessation
- 1993-12-15 MY MYPI93002719A patent/MY109345A/en unknown
- 1993-12-15 ZA ZA939427A patent/ZA939427B/xx unknown
- 1993-12-15 SK SK1421-93A patent/SK279271B6/sk unknown
- 1993-12-16 IL IL108042A patent/IL108042A/en not_active IP Right Cessation
- 1993-12-16 NZ NZ250486A patent/NZ250486A/en active IP Right Revival
- 1993-12-16 CZ CZ932790A patent/CZ283863B6/cs not_active IP Right Cessation
- 1993-12-17 PH PH47481A patent/PH30430A/en unknown
- 1993-12-20 YU YU79893A patent/YU48918B/sh unknown
- 1993-12-20 HU HU9303676A patent/HU223342B1/hu not_active IP Right Cessation
- 1993-12-20 PL PL93301579A patent/PL177349B1/pl not_active IP Right Cessation
- 1993-12-20 RO RO93-01739A patent/RO113806B1/ro unknown
- 1993-12-21 BR BR9305182A patent/BR9305182A/pt not_active Application Discontinuation
- 1993-12-21 BG BG98317A patent/BG61524B1/bg unknown
- 1993-12-21 AU AU52578/93A patent/AU669235B2/en not_active Ceased
- 1993-12-21 CA CA002112017A patent/CA2112017C/en not_active Expired - Fee Related
- 1993-12-21 KR KR1019930028895A patent/KR100278946B1/ko not_active IP Right Cessation
- 1993-12-21 NO NO934740A patent/NO304924B1/no unknown
- 1993-12-22 DE DE69332735T patent/DE69332735T2/de not_active Expired - Fee Related
- 1993-12-22 DK DK93310438T patent/DK0605193T3/da active
- 1993-12-22 EP EP93310438A patent/EP0605193B1/en not_active Expired - Lifetime
- 1993-12-22 JP JP32382593A patent/JP3197129B2/ja not_active Expired - Fee Related
- 1993-12-22 CN CN93121277A patent/CN1043608C/zh not_active Expired - Fee Related
- 1993-12-22 EP EP02013421A patent/EP1238667A3/en not_active Withdrawn
- 1993-12-22 SG SG1996008021A patent/SG52696A1/en unknown
- 1993-12-22 AT AT93310438T patent/ATE233559T1/de not_active IP Right Cessation
- 1993-12-22 ES ES93310438T patent/ES2193142T3/es not_active Expired - Lifetime
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